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Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections

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Bioactive Materials 2021年第8期6卷 2331-2345页

作者： Viviane Ständert Kai Borcherding Nicole Bormann Gerhard Schmidmaier ingo grunwald Britt Wildemann Julius Wolff Institute BIH Center for Regenerative TherapiesCharitéUniversitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität zu BerlinBerlin Institute of Health13353BerlinGermany Department of Adhesive Bonding Technology and Surfaces Fraunhofer Institute for Manufacturing Technology and Advanced Materials(IFAM)28359BremenGermany Center for Orthopedics Trauma Surgery and Spinal Cord InjuryHTRG-Heidelberg Trauma Research GroupHeidelberg University Hospital69118HeidelbergGermany Industrial and Environmental Biology Hochschule Bremen-City University of Applied Sciences28199BremenGermany Experimental Trauma Surgery Department of TraumaHand and Reconstructive SurgeryJena University HospitalFriedrich Schiller University Jena07747JenaGermany

Artificial prostheses for joint replacement are indispensable in orthopedic ***,the implanted surface is attractive to not only host cells but also *** enable better osteointegration,a mechanically stable porous structure was created on a titanium surface using laser treatment and metallic silver particles were embedded in a hydrophilic titanium oxide layer on *** laser structuring resulted in unique amphora-shaped *** to their hydrophilic surface conditions and capillary forces,the pores can be loaded preoperative with the antibiotic of choice/need,such as *** and differentiation assays with primary human osteoblast-like cells revealed no negative effect of the surface modification with or without gentamicin *** in vivo biocompatibility study showed significantly enhanced osteointegration as measured by push-out testing and histomorphometry 56 days after the implantation of the K-wires into rat *** a *** infection model,the porous,silver-coated K-wires slightly reduced the signs of bone destruction,while the wires were still colonized after 28 *** the amphora-shaped pores with gentamicin significantly reduced the histopathological signs of bone destruction and no bacteria were detected on the *** together,this novel surface modification can be applied to new or established orthopedic *** enables preoperative loading with the antibiotic of choice/need without further equipment or post-coating,and supports osteointegration without a negative effect of the released dug,such as gentamicin.

关键词： Titanium implants Laser structuring Amphora-shaped pores Gentamicin loading Antimicrobial silver particles

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Spatial/temporal indexing and information visualization genre for environmental digital libraries

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第11期6卷 1235-1248页

作者： CHEN Su-shing grunwald Sabine Department of Computer ＆ Information Science ＆ Engineering University of Florida Gainesville Florida 32611 USA Department of Soil and Water Science University of Florida Gainesville Florida 32611 USA

Protecting and preserving our environmental systems require the ability to understand the spatio-temporal distri- bution of soils, parent material, topography, and land cover as well as the effects of human activities on ecosystems. Space-time modelling of ecosystems in an environmental digital library is essential for visualizing past, present, and future impacts of changes occurring within such landscapes (e.g., shift in land use practices). In this paper, we describe three novel features, spa- tio-temporal indexing, visualization, and geostatistical genre, for the environmental digital library, Environmental Visualization and Geographic Enterprise System (ENVISAGE), currently in progress at the University of Florida.

关键词： Spatio-temporal indexing Geostatistics GIS (Geographic Information System) Visualization Environmentaldigital library Spatio-temporal search

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Transferability and Scalability of Soil Total Carbon Prediction Models in Florida, USA

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Pedosphere 2018年第6期28卷 856-872页

作者： Sabine grunwald Congrong YU Xiong XIONG Department of Soil and Water Sciences University of Florida State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University College of Hydrology and Water Resource Hohai University Agricultural and Biological Engineering Department University of Florida

The applicability, transferability, and scalability of visible/near-infrared(VNIR)-derived soil total carbon(TC) models are still poorly understood. The objectives of this study were to: i) compare models of three multivariate statistical methods, partial least squares regression(PLSR), support vector machine(SVM), and random forest methods, to predict soil logarithm-transformed TC(logTC) using five fields(local scale) and a pooled(regional-scale) VNIR spectral dataset(a total of 560 TC spectral datasets), ii)assess the model transferability among fields, and iii) evaluate their up-and downscaling behaviors in Florida, USA. The transferability and up-and downscaling of the models were limited by the following factors: i) the spectral data domain, ii) soil attribute domain,iii) methods that describe the internal model structure of VNIR-TC relationships, and iv) environmental domain space of attributes that control soil carbon dynamics. All soil logTC models showed excellent performance based on all three methods with R^2> 0.86,bias 2.70%, and ratio of prediction error to interquartile range(RPIQ) > 4.54. The PLSR method performed substantially better than the SVM method to scale and transfer the TC models. This could be attributed to the tendency of SVM to overfit models, while the asset of the PLSR method was its robustness when the models were validated with independent datasets, transferred, and/or scaled. The upscaled soil TC models performed somewhat better in terms of model fit(R2), RPD, and RPIQ, whereas the downscaled models showed less bias and smaller RMSE based on PLSR. We found no universal trend indicating which of the four limiting factors mentioned above had the most impact that constrained the transferability and scalability of the models. Given that several factors can impinge on the empirically derived soil spectral prediction models, as demonstrated by this study,

关键词： attribute domain multivariate statistical methods partial least squares regression random forest support vector machine soil carbon dynamics visible-near infrared spectroscopy

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Spatial/temporal indexing and information visualization genre for environmental digital libraries

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第11期 69-82页

作者： grunwald Sabine USA Florida 32611 Department of Soil and Water Science University of Florida Gainesville

关键词： Spatio-temporal indexing Geostatistics GIS (Geographic Information System) Visualization Environmental - - --digital library Spatio-temporal search

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To bridge or not to bridge:summary of the new evidence in endovascular stroke treatment

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Stroke & Vascular Neurology 2022年第3期7卷 179-181页

作者： Anna Podlasek Permesh Singh Dhillon Waleed Butt Iris Q grunwald Timothy J England Tayside Innovation MedTech Ecosystem(TIME) University of DundeeDundeeUK NIHR Nottingham Biomedical Research Centre University of NottinghamNottinghamUK Interventional Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Interventional Neuroradiology University Hospitals Birmingham NHS TrustBirminghamUK Stroke Division of Mental Health and Clinical NeurosciencesSchool of MedicineUniversity of NottinghamNottinghamUK Stroke University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK

WHAT IS ALREADY KNOWN Recently published summaries and meta-analyses of four randomised controlled trials(RCTs)1-5 comparing direct mechan-ical thrombectomy(dMT)and bridging therapy with intravenous(IV)thrombolytics(alteplase)suggested that dMT is non-inferior to bridging therapy to achieve good functional outcome 3 months after stroke(modified Rankin Score 0-2)with the non-inferiority margin(NIM)<−5%.

关键词： intravenous bridging treatment

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Immune-mediated anti-neoplastic effect of intratumoral RSV envelope glycoprotein expression is related to apoptotic death of tumor cells but not to the size of syncytia

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World Journal of Gastroenterology 2008年第12期14卷 1842-1850页

作者： Dennis Hoffmann Thomas grunwald Wibke Bayer Oliver Wildner Ruhr-University Bochum Institute of Microbiology and Hygiene Department of Molecular and Medical Virology Bldg. MA Rm. 6/40 Bochum 44801 Germany

AIM： To promote the development of improved tumor vaccination strategies relying on the intratumoral expression of viral fusogenic membrane proteins, we elucidated whether the size of syncytia or the way tumor cells die has an effect on the therapeutic outcome. METHODS： In two syngeneic subcutaneous murine colon cancer models we assessed the anti-neoplastic effect on vector-treated and contralateral untreated tumors. RESULTS： Intratumoral injection of a replication-defective adenovirus encoding respiratory syncytial virus fusion protein （RSV-F） alone （***-F） or together with the attachment glycoprotein RSV-G （***-F/G） led to a significant growth reduction of the vector-treated and contralateral untreated tumors. The treatment response was associated with a strong tumor-specific CTL response and significantly improved survival with medians of 46 d and 44 d, respectively. Intratumoral injection of Ad,RSV-G or a soluble RSV-F encoding adenovirus （***-Fsol） had no significant anti-neoplastic effect. The median survival of these treabnent groups and of ***-treated control animals was about 30 d. CONCLUSION： Although in vitro transduction of colon cancer cell lines with ***-F/G resulted in about 8-fold larger syncytia than with ***-F, the in vivo outcome was not sig nificantly different, Transduction of murinecolon cancer cell lines with *** or ***-F/G caused apoptotic cell death, in contrast to transduction with ***-G or ***-Fsol, suggesting an importance of the mode of cell death. Overall, these findings provide insight into improved tumor vaccination strategies relying on the intratumoral expression of viral fusogenic membrane proteins.

关键词： Adenoviral vectors Tumor vaccination Fuso-genic membrane protein Colorectal cancer Syngeneictumor model

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Environmental soil-landscape modeling: geographic information technologies and pedometrics, Volume 111

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丛书名： Books in Soils, Plants, and the Environment 111

2006年

作者： Sabine grunwald

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Enhancement of photocatalytic activity by femtosecond-laser induced periodic surface structures of Si

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Journal of Semiconductors 2020年第3期41卷 39-44页

作者： P.Satapathy A.Pfuch R.grunwald S.K.Das Department of Physics School of Applied SciencesKIIT Deemed to be UniversityBhubaneswarOdisha751024India Department of Surface Engineering INNOVENT e.V.Prüssingstraße 27bD-07745 JenaGermany Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy Max Born Straße 2aD-12489BerlinGermany

Laser induced periodic surface structures(LIPSS)represent a kind of top down approach to produce highly reproducible nano/microstructures without going for any sophisticated process of *** method is much simpler and cost *** this work,LIPSS on Si surfaces were generated using femtosecond laser pulses of 800 nm *** substrates were prepared by depositing TiO2 thin films on top of the structured and unstructured Si *** coatings were produced by sputtering from a Ti target in two different types of oxygen *** first case,the oxygen pressure within the sputtering chamber was chosen to be high(3×10^–2 mbar)whereas it was one order of magnitude lower in second case(2.1×10^–3 mbar).In photocatalytic dye decomposition study of Methylene blue dye it was found that in the presence of LIPSS the activity can be enhanced by 2.1 and 3.3 times with high pressure and low pressure grown TiO2 thin films,*** increase in photocatalytic activity is attributed to the enlargement of effective surface *** comparative study,the dye decomposition rates of TiO2 thin films grown on LIPSS are found to be much higher than the value for standard reference thin film material Pilkington Activ^TM.

关键词： laser induced periodic surface structures nanoripples silicon photocatalytic dye decomposition TiO2 thin film femtosecond laser pulses

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Perioperative myocardial ischemia and infarction: Triggers and prevention

Perioperative myocardial ischemia and infarction: Triggers a...

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2006年中华医学会全国麻醉学术年会

作者： Z grunwald J Seltzer Department of Anesthesiology Jefferson University Hospital Thomas Jefferson University．PhiladelphiaPA USA Department of Anesthesiology Jefferson University Hospital Thomas Jefferson UniversityPhiladelphiaPA USA

The number of patients referred for surgery will increase markedly: Two general trends - the accelerated aging of the population and the growing reliance on surgery for treatment of diseases -will dramatically affect health care throughout the world, especially in the developed countries. Surgery always has been a critical component of medical care - evolving most rapidly over the last 3 decades. For many diseases, its efficacy is without question, even life saving - leading to widespread acceptance, despite its high cost and potential serious complications. Presently, more than 33 million US residents undergo surgery annually - that is, more than 10% of the population - resulting in surgical expenditures of $ 450 billion per year nearly 40% of the entire health care budget. It is estimated that the number of patients eligible for surgery will increase by 25% by

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Loss of CD103^+ intestinal dendritic cells during colonic inflammation

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World Journal of Gastroenterology 2010年第1期16卷 21-29页

作者： Ulrike G Strauch Nicole grunwald Florian Obermeier Sonja Gürster Heiko C Rath Department of Internal Medicine I University of Regensburg

AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) *** of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory *** contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine *** induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic ***,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and ***103 + DC could mediate this important function.

关键词： Dendritic cell Colitis Cytokines Integrin CD103

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