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The debris disk candidates:eleven 24μm excess stars in the Spitzer SWIRE fields

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Research in Astronomy and Astrophysics 2012年第5期12卷 513-528页

作者： hong Wu Chao-Jian Wu Chen Cao Sebastian wolf Jing-Yao hu Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Astronomy Beijing Normal University Beijing 100875 China Institute of Space Science and Physics Shandong University at Weihai Weihai 264209 China Shandong Provincial Key Laboratory of Optical Astronomy ＆ Solar-Terrestrial Environment Weihai 264209 China Max Planck Institute for Astronomy K6nigstuhl 17 69117 Heidelberg Germany

We present the optical to mid-infrared SEDs of 11 debris disk candidates from Spitzer SWIRE fields. All the candidates are selected from SWIRE 24 μm sources matched with both the SDSS star catalog and the 2MASS point source catalog. They show an excess in the mid-infrared at 24 μm （Ks-[24]vega 〉 0.44）, indicating the presence of a circumstellar dust disk. The observed optical spectra show that they are all late-type main-sequence stars covering the spectral types of FgKM. Their fractional luminosities are well above 5× 10-5, even up to the high fractional luminosity of 1×10-3. The high galactic latitudes of SWIRE fields indicate that most of these candidates could belong to the oldest stars in the thick disk. Our results indicate that high fractional luminosity debris disks could exist in old solar-like star systems, though they are still quite rare. Their discovery at high galactic latitudes also provides an exellent opportunity for further study of the properties and evolution of debris disks in regions of the galaxy with low densities of ISM, called ISM poor environments.

关键词： infrared stars -- planetary systems protoplanetary disks - stars for marion

Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture

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World Journal of gastroenterology 2017年第6期23卷 1044-1050页

作者： Dirk Walter Sylvia hartmann Eva herrmann Jan Peveling-Oberhag wolf O Bechstein Stefan Zeuzem Martin-Leo hansmann Mireen Friedrich-Rust Jorg g Albert Department of Internal Medicine I Johann Wolfgang Goethe-University Hospital Dr.Senckenberg Institute for Pathology Johann Wolfgang Goethe-University Hospital Institute of Biostatistics and Mathematical Modeling Johann Wolfgang Goethe-University Hospital Department for gastroenterology Hepatology and EndocrinologyRobert-Bosch Hospital Department of general and Visceral Surgery Johann Wolfgang Goethe-University Hospital

To investigate presence and extent of eosinophilic cholangitis (EC) as well as Igg4-related disease in patients with indeterminate biliary stricture (IBS).METhODSAll patients with diagnosis of sclerosing cholangitis (SC) and histopathological samples such as biopsies or surgical specimens at University hospital Frankfurt from 2005-2015 were included. histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regarding presence of eosinophilic infiltration and Igg4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing *** hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30% (3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of Igg4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with Igg4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to Igg4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n = 27) and patients with primary sclerosing cholangitis (n = 14).CONCLUSIONEC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS.

关键词： Indeterminate biliary stricture endoscopy endoscopic retrograde cholangiopancreatography eosinophilic cholangitis bile duct stenosis Igg4-related disease primary sclerosing cholangitis

Ernst Ludwig Kirchner, 1880-1938

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Ernst Ludwig Kirchner, 1880-1938

Plasmonic nanostructure design and characterization via Deep Learning

作者： wolf Norbert.

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Light(Science & Applications) 2018年第1期7卷 475-482页

作者： Itzik Malkiel Michael Mrejen Achiya Nagler Uri Arieli Lior wolf haim Suchowski School of Computer Science Faculty of Exact SciencesTel Aviv UniversityTel Aviv 69978Israel School of Physics and Astronomy Faculty of Exact SciencesTel Aviv UniversityTel Aviv 69978Israel

Nanophotonics,the field that merges photonics and nanotechnology,has in recent years revolutionized the field of optics by enabling the manipulation of light–matter interactions with subwavelength ***,despite the many advances in this field,the design,fabrication and characterization has remained widely an iterative process in which the designer guesses a structure and solves the Maxwell’s equations for *** contrast,the inverse problem,i.e.,obtaining a geometry for a desired electromagnetic response,remains a challenging and time-consuming task within the boundaries of very specific ***,we experimentally demonstrate that a novel Deep Neural Network trained with thousands of synthetic experiments is not only able to retrieve subwavelength dimensions from solely farfield measurements but is also capable of directly addressing the inverse *** approach allows the rapid design and characterization of metasurface-based optical elements as well as optimal nanostructures for targeted chemicals and biomolecules,which are critical for sensing,imaging and integrated spectroscopy applications.

关键词： characterization inverse dimensions

Caspar David Friedrich

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Caspar David Friedrich

A deep learning-enabled portable imaging flow cytometer for cost-effective, highthroughput, and label-free analysis of natural water samples

作者： Norbert wolf.

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Light(Science & Applications) 2018年第1期7卷 416-427页

作者： Zoltán gӧrӧcs Miu Tamamitsu Vittorio Bianco Patrick wolf Shounak Roy Koyoshi Shindo Kyrollos Yanny Yichen Wu hatice Ceylan Koydemir Yair Rivenson Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA

We report a deep learning-enabled field-portable and cost-effective imaging flow cytometer that automatically captures phase-contrast color images of the contents of a continuously flowing water sample at a throughput of 100 mL/*** device is based on partially coherent lens-free holographic microscopy and acquires the diffraction patterns of flowing micro-objects inside a microfluidic *** holographic diffraction patterns are reconstructed in real time using a deep learning-based phase-recovery and image-reconstruction method to produce a color image of each micro-object without the use of external *** blur is eliminated by simultaneously illuminating the sample with red,green,and blue light-emitting diodes that are *** by a laptop computer,this portable device measures 15.5 cm×15 cm×12.5 cm,weighs 1 kg,and compared to standard imaging flow cytometers,it provides extreme reductions of cost,size and weight while also providing a high volumetric throughput over a large object size *** demonstrated the capabilities of this device by measuring ocean samples at the Los Angeles coastline and obtaining images of its micro-and nanoplankton ***,we measured the concentration of a potentially toxic alga(Pseudo-nitzschia)in six public beaches in Los Angeles and achieved good agreement with measurements conducted by the California Department of Public *** cost-effectiveness,compactness,and simplicity of this computational platform might lead to the creation of a network of imaging flow cytometers for largescale and continuous monitoring of the ocean microbiome,including its plankton composition.

关键词： flow holographic simplicity

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Landscape painting

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Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors

作者： Norbert wolf.

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World Journal of gastroenterology 2006年第24期12卷 3835-3840页

作者： P Baier g wolf-Vorbeck S hempel UT hopt E von Dobschuetz Department of general and Visceral Surgery Albert-Ludwigs-University FreiburgGermany

AIM： To investigate the effects of experimental partial hepatectomy and normothermic ischemia-reperfusion damage on the time course of the expression of four different growth factor receptors in liver regeneration. This is relevant due to the potential therapeutic use of growth factors in stimulating liver regeneration. METhODS： For partial hepatectomy （Ph） 80% of the liver mass was resected in Sprague Dawley rats. Ischemia and reperfusion （I/R） were induced by occlusion of the portal vein and the hepatic artery for 15 min. The epidermal growth factor receptor, hepatic growth factor receptor, fibroblast growth factor receptor and tumour necrosis factor receptor-1 were analysed by immunohistochemistry up to 72 h after injury. Quantitative RT-PCR was performed at the time point of minimal receptor expression （24 h）. RESULTS： In immunohistochemistry, EgFR, hgFR, FgFR and TNFR1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h, a nadir after 24 h and another weak increase up to 72 h. During liver regeneration, after ischemia and reperfusion, the receptor expression was lower; the nadir at 24 h after reperfusion was the same. To evaluate whether this nadir was caused by a lack of mRNA transcription, or due to a posttranslational regulation, RT-PCR was performed at 24 h and compared to resting liver. In every probe there was specific mRNA for the receptors. EgFR, FgFR and TNFR1 mRNA expression was equal or lower than in resting liver, hgFR expression after I/R was stronger than in the control. CONCLUSION： At least partially due to a post-transcriptional process, there is a nadir in the expression of the analysed receptors 24 h after liver injury. Therefore, a therapeutic use of growth factors to stimulate liverregeneration 24 h after the damage might be not successful.

关键词： Partial hepatectomy Liver ischemia growthfactor receptors

Neurovascular complications due to the hippocrates method for reducing anterior shoulder dislocations

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World Journal of Orthopedics 2014年第1期5卷 57-61页

作者： Markus Regauer hans Polzer wolf Mutschler Department of Trauma Surgery Campus Innenstadt Ludwig-Maximilians-University

In spite of the fact that the hippocrates method hardly has been evaluated in a scientific manner and numerous associated iatrogenic complications have been reported, this method remains to be one of the most common techniques for reducing anterior shoulder dislocations. We report the case of a 69-year-old farmer under coumarin anticoagulant therapy who sustained acute first time anterior dislocation of his dominant right shoulder. By using the hippocrates method with the patient under general anaesthesia, the brachial vein was injured and an increasing hematoma subsequently caused brachial plexus paresis by pressure. After surgery for decompression and vascular suturing, symptoms declined rapidly, but brachial plexus paresis still was not fully reversible after 3 mo of follow-up. The hazardousness of using the hippocrates method can be explained by traction on the outstretched arm with force of the operator's body weight, direct trauma to the axillary region by the physician's heel, and the topographic relations of neurovascular structures and the dislocated humeral head. As there is a variety of alternative reduction techniques which have been evalu-ated scientifically and proofed to be safe, we strongly caution against the use of the hippocrates method as a first line technique for reducing anterior shoulder dislocations, especially in elder patients with fragile vessels or under anticoagulant therapy, and recommend the scapular manipulation technique or the Milch technique, for example, as a first choice.

关键词： Anterior shoulder dislocation Reduction technique hippocrates method Complications Brachial plexus paresis Brachial vein injury Scapular manipulation technique