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The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development

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Plant Communications 2024年第7期5卷 178-199页

作者： Simon Amiard Léa Feit Emmanuel Vanrobays Lauriane Simon Samuel Le Goff Loriane Loizeau Léa wolff Falk Butter Clara Bourbousse Fredy Barneche Christophe Tatout Aline V.Probst iGReD CNRSInsermUniversite´Clermont Auvergne63000 Clermont-FerrandFrance Institut de biologie de I’Ecole normale supe´rieure(IBENS) Ecole normale supe´rieureCNRSINSERMUniversite´PSLParisFrance Institute of Molecular Biology 55128 MainzGermany

Plant-specific transcriptional regulators called TELOMERE REPEAT BINDING proteins(TRBs)combine two DNA-binding domains,the GH1 domain,which binds to linker DNA and is shared with H1 histones,and the Myb/SANT domain,which specifically recognizes the telobox DNA-binding site ***1,TRB2,and TRB3 proteins recruit Polycomb group complex 2(PRC2)to deposit H3K27me3 and JMJ14 to remove H3K4me3 at gene promoters containing telobox motifs to repress ***,we demonstrate that TRB4 and TRB5,two related paralogs belonging to a separate TRB clade conserved in spermatophytes,regulate the transcription of several hundred genes involved in developmental responses to environmental ***4 binds to several thousand sites in the genome,mainly at transcription start sites and promoter regions of transcriptionally active and H3K4me3-marked genes,but,unlike TRB1,it is not enriched at H3K27me3-marked gene ***,TRB4 can physically interact with the catalytic components of PRC2,SWINGER,and CURLY LEAF(CLF).Unexpectedly,we show that TRB4 and TRB5 are required for distinctive phenotypic traits observed in clf mutant plants and thus function as transcriptional activators of several hundred CLF-controlled genes,including key flowering *** further demonstrate that TRB4 shares multiple target genes with TRB1 and physically and genetically interacts with members of both TRB ***,these results reveal that TRB proteins engage in both positive and negative interactions with other members of the family to regulate plant development through both PRC2-dependent and-independent mechanisms.

关键词： chromatin TRB proteins transcriptional regulation PRC2 plant development

Improving the operational stability of perovskite solar cells with cesium-doped graphene oxide interlayer

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Journal of Energy Chemistry 2024年第9期96卷 483-490页

作者： Masaud Almalki Katerina Anagnostou Konstantinos Rogdakis Felix T.Eickemeyer Mostafa Othman Minas M.Stylianakis Dimitris Tsikritzis Anwar Q.Alanazi Nikolaos Tzoganakis Lukas Pfeifer Rita Therisod Xiaoliang Mo Christian M.wolff Aïcha Hessler-Wyser Shaik M.Zakeeruddin Hong Zhang Emmanuel Kymakis Michael Grätzel Laboratory of Photonics and Interfaces École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Electrical and Computer Engineering Hellenic Mediterranean UniversityHeraklionCrete 71410Greece Institute of Electrical and Microengineering(IEM)Photovoltaics and Thin-Film Electronics Laboratory(PV-Lab) École Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel 2000Switzerland Department of Nursing Faculty of Health SciencesHellenic Mediterranean UniversityCrete 71410Greece Centre Interdisciplinaire de Microscopie Electronique École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Future Energy Technology Institute King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Saudi Arabia State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionInstitute of OptoelectronicsDepartment of Materials ScienceFudan UniversityShanghai 200433China

Perovskite solar cells(PSCs)have made great advances in terms of power conversion efficiency(PCE),yet their subpar stability continues to hinder their *** interface between the perovskite layer and the charge-carrier transporting layers plays a crucial role in undermining the stability of *** this work,we propose a strategy to stabilize high-performance PSCs with PCE over 23%by introducing a cesium-doped graphene oxide(GO-Cs)as an interlayer between the perovskite and hole-transporting *** GO-Cs treated PSCs exhibit excellent operational stability with a projected T80(the time where the device PCE reduces to 80%of its initial value)of 2143 h of operation at the maximum powering point under one sun illumination.

关键词： Perovskite solar cells Doped graphene oxide Graphene related material Long-term operational stability

Selection criteria for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gastric cancer

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World Journal of Gastroenterology 2011年第37期17卷 4153-4156页

作者： ingmar Knigsrainer Department of General Visceral and Transplant SurgeryTübingen University Hospital

Peritoneal carcinomatosis in gastric cancer is associated with a dismal *** chemotherapy is not effective because of the existence of a blood-peritoneal *** surgery and intraperitoneal chemotherapy can improve survival and quality of life in selected *** selection for this multimodal approach is one of the most critical issues,and calls for interdisciplinary evaluation by radiologists,medical and surgical oncologists,and *** article sets forth criteria for selection of gastric cancer patients suffering from peritoneal carcinomatosis.

关键词： Peritoneal carcinomatosis Gastric cancer Hyperthermic intraperitoneal chemotherapy Cytoreductive surgery Selection criteria

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Where are we?

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World Journal of Gastroenterology 2012年第38期18卷 5317-5320页

作者： ingmar Knigsrainer Stefan Beckert Department of General Visceral and Transplant Surgery Tübingen University HospitalD-72076 Tübingen Germany

Peritoneal surface malignancies are generally associated with poor prognosis. In daily clinical routine, systemic chemotherapy is still considered the only reasonable therapy despite of encouraging results of cytoreductive surgery (CRS) along with intraperitoneal hyperthermic chemotherapy (HIPEC). The Achilles heel of CRS and HIPEC is appropriate patient selection and precise surgical technique preventing patients from excessive morbidity and mortality. Given these findings, new concepts of second look surgery for high risk patients allow detection of peritoneal spread ahead of clinical symptoms or presence of peritoneal masses reducing perioperative morbidity. In addition, personalized intraperitoneal chemotherapy might further improve outcome by appreciating individual tumor biology. These days, every physician should be aware of CRS and HIPEC for treatment of peritoneal surface malignancies. Since there is now sufficient data for the superiority of CRS and HIPEC to systemic chemotherapy in selected patients, our next goal should be providing this strategy with minimal morbidity and mortality even in the presence of higher tumor load.

关键词： Peritoneal carcinomatosis Hyperthermic intraperitoneal chemotherapy Cytoreductive surgery

Necrotizing Pneumonia and Conservative Treatment: A Case Report and Review of the Literature

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Open Journal of Respiratory Diseases 2024年第3期14卷 69-76页

作者： Pedro Rogerio Magalhães Braga Eduarda Kipper Beck Carolina de Mello Viera Cecília Gatti wolff Laura Gazal Passos Guilherme Bastos de Mello Luis Felipe Pilar Gomes Giacomo Farias Tramontin Taíse Rosa de Carvalho Department of Internal Medicine Hospital So Lucas da PUCRS Porto Alegre Brazil School of Medicine Pontifcia Universidade Catlica do Rio Grande do Sul Porto Alegre Brazil Department of Radiology Hospital So Lucas da PUCRS Porto Alegre Brazil

We present a case of necrotizing pneumonia in an 87-year-old man without severe respiratory instability. Clinical suspicion arose due to the need for supplementary oxygen and persistent fever during treatment for community-acquired pneumonia. The diagnosis was confirmed by chest computed tomography. Although necrotizing pneumonia typically requires major surgical intervention upon diagnosis, we chose conservative management with antimicrobials and chest drainage alone. The patient experienced significant improvement and resolution of pneumonia with conservative management.

关键词： Respiratory Tract Infections Lung Disease Bacterial Pneumonia

Social biology of rodents

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Integrative Zoology 2007年第4期2卷 193-204页

作者： Jerry O.wolff Department of Biology St.Cloud State UniversitySt.CloudMinnesotaUSA

Herein, I summarize some basic components of rodent social biology. The material in this paper is summarized andcondensed from a recent book “Rodent Societies: An Ecological and Evolutionary Perspective” edited by J. *** and P. W. Sherman (2007). I describe the four basic spacing patterns and illustrate how female territoriality isa function of offspring defense and male mating tactics are a function of female defensibility. The vulnerability ofyoung to infanticide shapes female spacing and mating behavior. Food does not appear to be a defensible resourcefor rodents, except for those species that larder hoard nonperishable items such as seeds. Philopatry and theformation of kin groups result in genetic sub-structuring of the population, which in turn affects effectivepopulation size and genetic diversity. Dispersal is male biased and typically involves emigration from the maternalsite to avoid female relatives and to seek unrelated mates. Scent marking is a major form of communication and isused in reproductive competition and to assess prospective mates, but it is also eavesdropped by predators to locateprey. Females do not appear to alter the sex ratio of litters in response to maternal condition but among arvicolinerodents daughters appear to be favored in spring and sons in autumn. Rodents are relatively monomorphic;however, females tend to be larger than males in the smallest species and smaller in the larger species. Predationrisk results from an interaction among foraging time and vulnerability and in turn affects behavioral and life historycharacteristics.

关键词： chemosignals dispersal infanticide mating systems predation risk rodents social behavior

The past 800 ka viewed through Antarctic ice cores

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Episodes 2008年第2期31卷 219-221页

作者： Eric W wolff British Antarctic Survey High Cross Madingley Road Cambridge CB3 0ET UK.

The later parts of the Quaternary are of particular importance for assessing our ability to understand the future operation of the Earth because the main boundary conditions are similar to those of today, and because we have a density of data that allows hypotheses to be tested rigorously. An important source of such data is Antarctic ice cores, now extending back 800 ka, and containing signals both of climate, and of climate forcing factors. The Antarctic ice core deuterium record, representing Antarctic temperature, is one of the iconic Quaternary records.

关键词：第四纪地质时代南极冰川地球

A cost-effective, simple and high-throughput method for DNA extraction from insects

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Insect Science 2010年第5期17卷 465-470页

作者： Malgorzata Lagisz Gordon Port Kirsten wolff School of Biology Newcastle University Newcastle upon Tyne UK

We present a high-throughput cost-effective method to extract DNA suitable for polymerase chain reaction （PCR） from insect tissue. The method uses standard 200μL- deep 96-well plates in which samples are ground, digested and subsequently purified. The test extraction using four different insect species and controlling for potential contamination showed that the method yields good-quantity and quality DNA. PCR with mitochondrial and nuclear primers was reliable. The proposed extraction protocol combines the speed of commercial 96-well plate methods with the economies associated with readily available and cheap laboratory chemicals, consumables and equipment. Therefore, this method is particularly suitable for low-budget research projects and for laboratories with only basic equipment present.

关键词： DNA extraction genetic isolation molecular technique

Axogenesis in the central and peripheral nervous system of the amphipod crustacean Orchestia cavimana

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Integrative Zoology 2011年第1期6卷 28-44页

作者： Petra UNGERER Maria GEPPERT Carsten wolff Humboldt University Berlin Department of BiologyComparative ZoologyBerlinGermany Queen Mary University of London School of Biological and Chemical SciencesLondonUK Charité-Campus Virchow-Klinikum Department of Forensic GeneticsBerlinGermany

We describe the formation of the major axon pathways in the embryonic central and peripheral nervous systems of the amphipod crustacean Orchestia cavimana Heller,1865 by means of antibody staining against acetylated *** data add to a long list of previous studies of various other aspects of development in Orchestia and provide a basis for future studies of neurogenesis on a deeper cellular and molecular *** exhibits a tripartite dorsal brain,which is a characteristic feature of *** anlagen are the first detectable structures in the developing nervous system and can be traced back to distinct neuronal cell clusters in the early *** development of the ventral nervous system proceeds with an anteroposterior gradient of *** each trunk segment,the longitudinal connectives and the anterior commissure form first,followed by the intersegmental nerve,the posterior commissure and segmental nerves,respectively.A single commissure of a vestigial seventh pleonal segment is *** the peripheral nervous system we observe a spatial and temporal pattern of leg innervation,which is strikingly similar in both limb types,the uniramous pereopods and the biramous pleopods.A proximal leg nerve splitting distally into two separated nerves probably reflects a general feature of crustaceans.

关键词： alpha-tubulin Arthropoda brain development Malacostraca