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颈腰痛杂志 1986年第3期9卷 30-30页

作者：储肖林 inger o.skalpe 第105医院

1969年Almén提出使用无离子型化合物合成水溶性造影剂,能降低水溶性造影剂的溶质度,减少付作用的发生,根据他的提议,在挪威的奥斯陆(首都)。

关键词：脊髓造影腰部水溶性剂量病人椎管造影神经放射造影腰区解剖部位用药量 X光乳剂造影剂投照

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Prediabetes and atrial fibrillation risk stratification,phenotyping,and possible reversal to normoglycemia

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World Journal of Diabetes 2025年第1期16卷 7-11页

作者： Hyder o Mirghani Department of Internal Medicine University of TabukTabuk 51941TabukSaudi Arabia

Patients admitted with prediabetes and atrial fibrillation are at high risk for major adverse cardiac or cerebrovascular events independent of confounding *** shared pathophysiology between these three serious but common diseases and their association with atherosclerotic cardiovascular risk factors establish a vicious circle culminating in high *** of that,it is of paramount importance to perform risk stratification of patients with prediabetes to define phenotypes that benefit from various ***,stress hyperglycemia assessment of hospitalized patients and consensus on the definition of prediabetes is *** roles lifestyle and metformin play in prediabetes are well ***,the role of glucagon-like peptide agonists and metabolic surgery is less *** is considered an intermediate between normoglycemia and diabetes along the blood glucose *** billion people are expected to suffer from prediabetes by the year ***,realworld randomized controlled trials to assess major adverse cardiac or cerebrovascular event risk reduction and reversal/prevention of type 2 diabetes among patients are needed to determine the proper interventions.

关键词： Major adverse cardiac or cerebrovascular event Prediabetes Risk stratification Phenotype Stress hyperglycemia Reversal to normoglycemia

Cochlear homeostasis and its role in genetic deafness

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Journal of otology 2009年第1期4卷 15-22页

作者： inger Uhlen Department of Clinical Sciences InterventionDepartment of AudiologyKarolinska Institutet

Each component of the human ear performs a specific function in *** actual process of sound transduction takes place in the auditory portion of the inner ear,the fluid-filled *** the cochlea,the sensitivity and efficiency of sensory apparatus to convert mechanical energy into neural activity,largely depends on the fluidic and ionic *** the lateral wall of cochlea,the secretory epithelium stria vascularis plays an important role in the maintenance of fluidic and ionic homeostasis.A variety of gene mutations disturbs the cochlear homeostasis and subsequently leads to hearing *** review covers several aspects of cochlear homeostasis,from cochlear fluid and the functional role of stria vascularis,cochlear K+ recycling and its molecular substrates to genetic deafness with abnormal cochlear homeostasis.

关键词： Cochlear homeostasis and its role in genetic deafness

Auditory neuropathy-a rare condition where CI provides improved hearing and speech development

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Journal of otology 2009年第1期4卷 -页

作者： inger Uhlén Department of Clinical Sciences InterventionDepartment of AudiologyDepartment of Clinical NeuroscienceDepartment of Otolaryngology Head and NeckKarolinska University HospitalStockholm

Auditory neuropathy (AN) was reported 30 years ago in 1979 when Davis and Hirsh presented the first case with normal or near normal hearing threshold but absent auditory brainstem *** names have been given since then including paradoxical hearing loss,brainstem auditory processing syndrome,central auditory dysfunction,neural synchrony disorder or neural *** term auditory neuropathy was first given by Sininger and colleagues in *** and more AN articles have been published in recent *** present short review and case report focus on the most important characteristics from a clinical point of view in order to let young physicians know AN,and consequently make correct diagnosis.

关键词： ABR Auditory neuropathy-a rare condition where CI provides improved hearing and speech development

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla o Magro Marcello Imbrizi Ellen CS De oliveira Luiz C Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Impacts of Norwegian large carnivore management strategy on national grazing sector

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Journal of Mountain Science 2019年第11期16卷 2470-2483页

作者： inger HANSEN Geir-Harald STRAND Auvikki de BooN Camilla SANDSTRoM Norwegian Institute of Bioeconomy Research Box 115N-1431 AsNorway Department of Political Science Umea University90187 UmeaSweden

Increasing populations of large carnivores are leading to tension and conflicts with livestock production,a situation that potentially might *** Norway the objective of the large carnivore policy is two-folded:to ensure viable carnivore populations and to secure a sustainable grazing *** main instrument is zonation,with carnivore management zones(CMZs)prioritized for reproduction of the large carnivore species separated from other areas prioritized for grazing *** objective of this paper is to describe current knowledge about the impact of the zoning management strategy on the grazing *** is done by documenting status and changes in sheep production,losses of livestock to predating carnivores,and the use of grazing areas inside and outside the *** protection for lynx,wolverine,bear and wolf cover 55%of the Norwegian mainland.30%of the sheep and 50%of the Sami reindeer grazing areas are found inside the ***(semi-domestic reindeer excluded)is using 59%of the available natural pasture areas outside the CMZs,but only 26%inside the *** lowest use of available grazing areas was found inside zones for wolves(12%)and brown bears(6%).Livestock in these zones are confined to fenced enclosures,mostly on the farm itself,or moved to pastures outside the management zone for summer *** losses increased in the affected regions during the period when carnivores were ***,losses declined when CMZs were established and mitigation efforts were implemented in these *** bulk of sheep and reindeer killed by carnivores are now found in boundary areas within 50 km off the CMZs,where sheep are still grazing on open mountain and forest ***,instruments to protect livestock in areas close to the CMZs are also *** number of sheep declined inside the CMZs from 1999 to 2014,but increased outside the *** reduction in the absolute number of sheep in the CMZs is balanced by

关键词： Carnivore management Depredation Management zones Rangeland Sheep Large carnivore policy