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VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab

World Journal of Gastroenterology 2008年第26期14卷 4156-4167页

作者： Markus Moehler Christian Frings Annett Mueller ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann 1st Department of Medicine Johannes Gutenberg University Mainz 55101 Germany Department of General and Abdominal Surgery Johannes Gutenberg University Mainz 55101 Germany

AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab.

关键词： Human colorectal cancer Lymphangiogenesis Vascular endothelial growth factor-C Vascular endothelial growth factor-D Epidermal growth factor receptor

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Diel and seasonal patterns of variation in the singing behaviour of Savannah Sparrows (Passerculus sandwichensis)

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Avian Research 2019年第3期10卷 336-343页

作者： ines G.Moran Katrina C.Lukianchuk Stephanie.M.Doucet Amy E.M.Newman Heather Williams D.Ryan Norris Daniel J.Mennill Department of Biological Sciences University of WindsorWindsorON N9B3P4Canada Department of Integrative Biology University of GuelphGuelphON N1G2W1Canada Biology Department Williams CollegeWilliamstownMD 01267USA

Background:The vocalizations of birds are dynamic traits that often vary in output with time of day and time of *** quantifying patterns of diel and seasonal variation in vocal output,we can gain insight into the ecology and evolution of birds and the function of their *** this investigation,we quantified diel and seasonal variation in song output by studying a breeding population of Savannah Sparrows (Passerculus sandwichensis).Methods:We used autonomous recorders to collect extensive recordings across the breeding season in a long-term, colour-marked study population of Savannah Sparrows in eastern *** described diel and seasonal variation across five different breeding stages based on recordings of more than 50,000 songs from 34 ***:During the pre-breeding stage, prior to female arrival, males sang a pronounced dawn chorus with a peak in song output during the early *** the breeding stage,in contrast,the dawn chorus was diminished and males instead exhibited a pronounced dusk chorus with a peak in song output during the *** the breeding season,the highest levels of song output occurred in late April and early May,soon after males arrived on the breeding grounds,and the lowest levels occurred in August,prior to the departure of birds for the wintering ***:These patterns suggest that Savannah Sparrows' early-season dawn choruses are directed at males and serve a territorial defense ***-season dusk choruses,in contrast, appear to play a role in attracting mates and possibly acoustic mate guarding.

关键词： Bird song Breeding activities Circadian rhythms Seasonal variation in song

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Box Behnken design-based optimized extraction of non-dioxin-like PCBs for GC-ECD and GC-MS analyses in milk samples

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Emerging Contaminants 2020年第1期6卷 303-311页

作者： Valeria Nardelli Valeria D’Amico ines Della Rovere Francesco Casamassima Wadir Mario Valentino Marchesiello Donatella Nardiello Maurizio Quinto Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Via Manfredonia 20Foggia71121Italy Dipartimento di Scienze Agrarie degli Alimenti e dell’Ambiente-Universita degli Studi di FoggiaVia Napoli2571122FoggiaItaly Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules Yanbian UniversityPark Road 977133002YanjiChina

A multivariate optimization process of the sample extraction procedure by Box-Behnken design through a global desirability function is described for the determination of six non-dioxin-like polychlorinated biphenyls(NDL-PCBs#28,52,101,153,138 and 180)in milk by GC-ECD and mass *** factors were involved in refining the extraction conditions:the acetone percentage in the extraction mixture,the sample/solvent ratio,and the extraction *** three-factor design required 26 experiments that were carried out in duplicate and in a randomized order to minimize the bias effects of uncontrolled *** optimized factors(acetone percentage:30%;sample-to-solvent ratio:0.11 g mL^-1;extraction time:45 min)ensured a low solvent consumption and a reduced extraction time,allowing a rapid and simultaneous preparation of multiple sample *** method was validated according to the European directives(Decision 657/2002/EC,SANTE 2017/11813/EC)through the evaluation of linearity,selectivity,LOD,LOQ,recovery,precision,and ruggedness.

关键词： NDL-PCBs Box behnken experimental design Milk GC-ECD Extraction process optimization Method validation

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Intraoperative reperfusion assessment of human pancreas allografts using hyperspectral imaging(HSI)

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 67-77页

作者： Robert Sucher Uwe Scheuermann Sebastian Rademacher Andri Lederer Elisabeth Sucher Hans-Michael Hau Gerald Brandacher Stefan Schneeberger ines Gockel Daniel Seehofer Department of Visceral TransplantThoracic and Vascular SurgeryUniversity Hospital LeipzigLeipzigGermany Division of Hepatology Clinic and Polyclinic for GastroenterologyHepatologyInfectiologyand PneumologyUniversity Hospital LeipzigLeipzigGermany Department of Visceral TransplantationVascular and Thoracic SurgeryUniversity Hospital of DresdenDresdenGermany Department of Plastic and Reconstructive Surgery Vascularized Composite Allotransplantation(VCA)LaboratoryJohns Hopkins UniversityBaltimoreMDUSA Department of Visceral Transplant and Thoracic SurgeryInnsbruck Medical UniversityInnsbruckAustria

Background:The most common causes of early graft loss in pancreas transplantation are insufficient blood supply and leakage of the intestinal ***,it is critical to monitor graft perfusion and oxygenation during the early post-transplant *** goal of our pilot study was to evaluate the utility of hyperspectral imaging(HSI)in monitoring the microcirculation of the graft and adequate perfusion of the intestinal anastomosis during pancreatic ***:We imaged pancreatic grafts and intestinal anastomosis in real-time in three consecutive,simultaneous pancreas-kidney transplantations using the TIVITA®HSI ***,the intraoperative oxygen saturation(StO_(2)),tissue perfusion(near-infrared perfusion index,NIR),organ hemoglobin index(OHI),and tissue water index(TWI)were measured 15 minutes after reperfusion by ***:All pancreas grafts showed a high and homogeneous StO_(2)(92.6%±10.45%).Intraoperative HSI analysis of the intestinal anastomosis displayed significant differences of StO_(2)(graft duodenum 67.46%±5.60%*** jejunum:75.93%±4.71%,P<0.001)and TWI{graft duodenum:0.63±0.09[I(Index)]*** jejunum:0.72±0.09[I],P<0.001}.NIR and OHI did not display remarkable differences{NIR duodenum:0.68±0.06[I]*** jejunum:0.69±0.04[I],P=0.747;OHI duodenum:0.70±0.12[I]*** jejunum:0.68±0.13[I],P=0.449}.All 3 patients had an uneventful postoperative course with one displaying a Banff 1a rejection which was responsive to steroid ***:Our study shows that contact-free HSI has potential utility as a novel tool for real-time monitoring of human pancreatic grafts after reperfusion,which could improve the outcome of pancreas *** investigations are required to determine the predictive value of intraoperative HSI imaging.

关键词： Hyperspectral imaging(HSI) pancreas transplantation intraoperative imaging

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欧洲难民危机与欧盟的应对研究

欧洲难民危机与欧盟的应对研究

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作者： Abenkou Sandra Laetitia ines 上海外国语大学

学位级别：硕士

从2015年以来,难民危机在欧洲等愈演愈烈,续发酵的难民危机对欧洲经济复苏、文化价值理念、政治生态稳定以及社会安全等方面产生了较大影响,这也是欧洲自二战以来面临的最大难民危机问题,并引发了全世界的关注。因此,本文针对当前欧洲... 详细信息

从2015年以来,难民危机在欧洲等愈演愈烈,续发酵的难民危机对欧洲经济复苏、文化价值理念、政治生态稳定以及社会安全等方面产生了较大影响,这也是欧洲自二战以来面临的最大难民危机问题,并引发了全世界的关注。因此,本文针对当前欧洲难民危机发展态势进行研究,从难民输出和难民流向两个角度分析欧洲难民危机爆发的原因,总体来看,欧洲难民危机的产生有其复杂而深刻的原因,其中包括欧洲和西亚北非地区便捷的地理条件,欧洲发达经济条件和较好的社会福利待遇,非法人口组织对难民的宣传和输送等,可以说,欧洲难民危机是由多方面的各种因素共同导致的。本课题还从经济层面、政治层面、社会文化价值层面以及社会安全层面论述了欧洲难民危机对欧洲一体化影响。综合来看,欧洲难民危机的爆发在经济层面加重了欧洲各国财政负担,对欧洲经济恢复产生消极作用,进一步加深了欧洲劳动力失业状态;在政治上引发了欧洲各国分歧和隔阂,影响欧盟内部团结,助长了右倾民族主义和脱欧倾向;在社会文化层面上加剧了民族和宗教冲突,撕裂了欧洲文化价值观,对欧洲文化多元化政策产生冲击;在社会安全层面上导致了多起恐怖主义事件的产生,激化了欧洲居民与难民矛盾,加剧了欧洲社会动荡情况。本文分析了不同阶段欧盟针对难民危机所采取的政策,总体来说,欧盟在难民危机中的立场和政策由最初的谨慎观念到积极应对。并且本文在欧盟对难民危机采取政策以及实施效果的基础上,对欧盟一体化的困境进行分析,欧盟在难民政策的推进过程中开展缓慢,多项政策难以落实到位折射出了欧盟一体化过程中面临的机制困境、认同困境和主权困境,这成为了欧盟难民政策难以落实重要原因所在。最后,本文还针对欧盟应对难民危机提出建议策略。未来,欧盟各国需要积极从难民根源、内部体制、难民融入以及边境管理都层面采取有效措施,争取早日解决难民问题。

关键词：欧洲难民危机欧盟一体化欧盟

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农业法的全球性挑战与回应

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中国农业大学学报（社会科学版） 2014年第4期31卷 5-9页

作者： ines Hrtel 李玉梅奥德河畔法兰克福欧洲大学法学院中国农业大学人文与发展学院法学系

农业面临着全球化不断推进、粮食安全和食品质量保证、世界人口增加、全球环境问题四方面的挑战。农业法有必要对此予以回应,为可持续农业发展创建具有强制力和可靠性的法律框架,支持和保障农民务农知识的提高和农业科技的发展,对第三... 详细信息

农业面临着全球化不断推进、粮食安全和食品质量保证、世界人口增加、全球环境问题四方面的挑战。农业法有必要对此予以回应,为可持续农业发展创建具有强制力和可靠性的法律框架,支持和保障农民务农知识的提高和农业科技的发展,对第三次农业革命进行法律调整,解决全球农业法支离破碎的问题。由于农业全球化,硬法和软法在多层次的农业法体系中作用重要,食品安全不仅需要国内法规范,还需要构建国际规范。行之有效的全球食品安全法律体系尚未形成,应该建立对全球粮食安全具有约束力的目标和原则。对中德法律制度进行比较研究,不仅有利于这一法律体系的构建,还有助于克服全球农业法的支离破碎。

关键词：农业法可持续发展粮食安全

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Association of hepatitis C virus infection and diabetes in central Tunisia

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World Journal of Gastroenterology 2009年第22期15卷 2778-2781页

作者： Naoufel Kaabia Elhem Ben Jazia ines Slim Imen Fodha Wissem Hachfi Rafika Gaha Mabrouk Khalifa Aoutef Hadj Kilani Halim Trabelsi Ahmed Abdelaziz Fethi Bahri Amel Letaief Department of Internal Medicine and Infectious Disease Unit of Research:04/UR/08-21University Hospital Farhat Hached Microbiology Unit University Hospital Sahloul Epidemiology Unit University Hospital Farhat Hached Department of Medicine Msaken hospital

AIM：To investigate hepatitis C virus （HCV） seroprevalence in Tunisian patients with diabetes mellitus and in a control group. METHODS： A cross-sectional study was conducted to determine the HCV seroprevalence in 1269 patients with diabetes （452 male, 817 female） and 1315 nondiabetic patients, attending health centers in Sousse, Tunisia. HCV screening was performed in both groups using a fourth-generation enzyme immunoassay. RESULTS： In the diabetic group, 17 （1.3%） were found to be HCV-infected compared with eight （0.6%） in the control group, although the difference was not significant （P = 0.057）. Quantitative PCR was performed in 20 patients. Eleven patients were positive and showed HCV genotype lb in all cases. CONCLUSION： Frequency of HCV antibodies was low in patients with diabetes and in the control group in central Tunisia, with no significant difference between the groups.

关键词： Hepatitis C virus Diabetes mellitus Tunisia Epidemiology Autoantibodies Hepatitis

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Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men

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Asian Journal of Andrology 2015年第1期17卷 68-73,I0008页

作者： Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray Laboratoire de Biologie Moleculaire et Cellulaire Faculte des Sciences de la Nature et de la Vie Universite Constantine I Algerie Clinique Ibn Rochd Centre de Medecine de la Reproduction Constantine Algerie Universite Grenoble Alpes Grenoble France Equipe Genetique Epigenetique et Therapies de I'lnfertilitE CNRS AGIM Grenoble France Laboratoire de GEnetique Chromosomique CHU Grenoble Grenoble France Laboratoire de Biochimie et Genetique Moleculaire CHU Grenoble Grenoble France Equipe Muscle et Pathologies INSERM U836 Grenoble Institut des Neurosciences Grenoble France.

Klinefelter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests offered to infertile men. Analyses of aurora kinase C （AURKCj and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia, respectively, two rare forms of teratozoospermia particularly frequent among North African men. We carried out genetic analyses on Algerian patients, to evaluate the prevalence of these syndromes in this population and to compare it with the expected frequency of Klinefelter syndrome and Y-microdeletions. We carried out a retrospective study on 599 consecutive patients consulting for couple infertility at the assisted reproduction unit of the Ibn Rochd Clinique, Constantine, Algeria. Abnormal sperm parameters were observed in 404 men. Fourteen and seven men had typical macrozoospermia and globozoospermia profiles, respectively. Molecular diagnosis was carried out for these patients, for the AURKC and DPY19L2 genes. Eleven men with macrozoospermia had a homozygous AURKC mutation （79%）, corresponding to 2.7% of all patients with abnormal spermograms. All the men with globozoospermia studied （n = 5）, corresponding to 1.2% of all infertile men, presented a homozygous DPY19L2deletion. By comparison, we would expect 1.6% of the patients in this cohort to have Klinefelter syndrome and 0.23% to have Y-microdeletion. Our findings thus indicate that AURKCmutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men. Furthermore, we estimate that AURKCand DPY19L2 molecular defects are 10 and 5 times more frequent, respectively, than Y-microdeletions.

关键词： aurora kinase C DPY19L2 globozoospermia intracytoplasmic sperm injection infertility macrozoospermia

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Glucagon-like-1 receptor agonists and sodium/glucose cotransporter-2 inhibitors combination—are we exploiting their full potential in a real life setting?

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World Journal of Diabetes 2020年第11期11卷 540-552页

作者： Maja Cigrovski Berkovic ines Bilic-Curcic Tomislav Bozek Davorka Herman Mahecic Sanja KlobucarMajanovic Silvija Canecki-Varzic Jelena Andric Srecko Marusic Anna Mrzljak Faculty of Medicine J.J.Strossmayer University OsijekOsijek 31000Croatia Department for Endocrinology Diabetes and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia Department of Endocrinology and Metabolism Disorders Clinical Hospital CenterOsijek 31000Croatia University Clinic for Diabetes“Vuk Vrhovac” Merkur University HospitalZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department for Endocrinology Diabetes and MetabolismUniversity Hospital Centre“Sestre milosrdnice”Zagreb 10000Croatia Department for Endocrinology Diabetes and MetabolismUniversity Hospital Centre RijekaSchool of MedicineUniversity of Rijeka51000 RijekaCroatia Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND The sodium/glucose cotransporter-2 inhibitors(SGLT-2i)and glucagon-like-1 receptor agonists(GLP-1RA)are antidiabetic agents effective both in hemoglobin A1c(HbA1c)reduction(with a low risk of hypoglycemia)and cardiovascular event *** patients with type 2 diabetes,the add-on value of combination therapy of GLP-1RA and an SGLT-2i seems *** To investigate whether the efficacy of GLP-1RA and SGLT-2i combination observed in randomized controlled trials translates into therapeutic benefits in the Croatian population during routine clinical practice and *** We included 200 type 2 diabetes patients with poor glycemic control and analyzed the effects of treatment intensification with(1)GLP-1RA on top of SGLT-2i,(2)SGLT-2i on top of GLP-1RA compared to(3)simultaneous addition of both *** primary study endpoint was the proportion of participants with HbA1c<7.0%and/or 5%bodyweight *** outcomes included changes in fasting plasma glucose(FPG),prandial plasma glucose,lowdensity lipoprotein cholesterol,estimated glomerular filtration rate(eGFR),and cardiovascular(CV)incidents assessment over a follow-up period of 12 *** The majority of patients were over 65-years-old,had diabetes duration for more than 10 *** initial body mass index was 39.41±5.49 kg/m2 and HbA1c 8.32±1.26%.Around half of the patients in all three groups achieved target HbA1c below 7%.A more pronounced decrease in the HbA1c seen with simultaneous SGLT-2i and GLP-1RA therapy was a result of higher baseline HbA1c and not the effect of initiating combination *** number of patients achieving FPG below 7.0 mmol/L was significantly higher in the SGLT-2i group(P=0.021),and 5%weight loss was dominantly achieved in the simultaneous therapy group(P=0.044).A composite outcome(reduction of HbA1c below 7%(53 mmol/mol)with 5%weight loss)was achieved in 32.3%of total patients included in the *** 18.2%of patients attained composite outc

关键词： Sodium/glucose cotransporter-2 inhibitors Glucagon-like-1 receptor agonists Type 2 diabetes mellitus Body weight Glycemic control Cardiovascular complications

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High Temperature and Abscisic Acid Modified the Profile of Anthocyanins in Grape （Vitis vinifera L,）

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Journal of Life Sciences 2012年第7期6卷 758-765页

作者： Leonor Deis Maria ines de Rosas Juan Bruno Cavagnaro Instituto de Biologla Agricola Mendoza Consejo Nacional de Investigaciones Cientifieas y Teenol6gicas (CON1CET) AIte Brown 500 PC. 5507 Chacras de Coria Argentina Facultad de Ciencias Agrarias Universidad Naeional de Cuyo Alte Brown 500 PC. 5507 Chacras de Coria Argentina

The predicted increase of temperature by effect of climatic change （1.5 ℃ to 4.5 ℃）, will affect some berry components. Anthocyanins and flavonols concentration are responsible of wine color. The level of anthocyanin is affected by light intensity, temperature, sugars, growth regulators and vineyard management. Abscisic acid （ABA） increases the synthesis of anthocyanin in grape. The object of study was to evaluate the effect of different temperature in berries in vitro, of two cultivars combined with ABA treatments. The treatments were control （C, water） and ABA treatment （1,000 ppm） and temperature： 25, 33 and 40 ℃. In Cabemet Sauvignon, 25 and 33 ~C did not affect anthocyanin total concentration but 40 ℃ produced a 30% decrease in anthocyanin. ABA treatment increased anthocyanin vs. C at 25 and 33 ℃, mainly due to glucosylated forms. But ABA ＋ 40 ℃ showed a 44-60% decrease in all anthocyanins forms compounds. Response of Malbec to the highest temperature （40 ℃）, at the end of ripening, was different; higher temperature produced only slight decrease of total anthocyanins concentration （decrease of 7%）. Combination of temperature ＋ ABA at 20℃ and 33℃ increased anthocyanin. But ABA ＋ 40℃ decreased glucosylated and cumarylated forms of anthocyanin.

关键词： Temperature ABA anthocyanins grape Malbec Cabernet Sauvignon.

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