检索结果-南通市图书馆

Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第3期19卷 578-582页

作者： Markley Silva Oliveira Junior Laura Reiche Emerson Daniele ines Kortebi Maryam Faiz Patrick Küry Department of Neurology Neuroregeneration laboratoryMedical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Institute of Medical Science University of TorontoTorontoCanada Division of Anatomy Department of SurgeryUniversity of TorontoTorontoCanada

Astrocytes are indispensable for central nervous system development and homeostasis.In response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair response.In this review,we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal models.We will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate demyelination.Finally,we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.

关键词： astrocytes demyelination drug-based therapies myelin repair oligodendrocyte precursor cells reactive astrogliosis

Neonatal Morbidity and Mortality at Hospital Saint Camille de Ouagadougou (HOSCO): A Study from 2017 to 2020

在线全文

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2024年第1期14卷 63-77页

作者： Nicaise Zagre ines Kinda Abdoul Karim Ouattara Paul Ouedraogo Théodora Mahoukèdè Zohoncon Caroline Yonaba Fla Koueta Jacques Simpore Hô pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculté des Sciences de la Santé Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculté des Sciences de la Santé Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Introduction: Neonatal pathology remains a real public health problem in developing countries. In Burkina Faso, this mortality has declined over the last ten years but remains below compared to the Sustainable Development Goals, which is 12 per 1000 living births at most by 2030. This study aims to identify specific causes of neonatal morbidity and mortality and will contribute to the implementation of preventive and curative measures aimed at reducing neonatal mortality at HOSCO. Method: This was a retrospective study using the records and database of newborns hospitalized from January 1srt, 2017 to December 31srt, 2020. Using logistic regression, the factors associated with mortality were determined. Results: During the study period, 3020 newborns were hospitalized. Most newborns (83.71%) were referred by a peripheral health facility. The average age at admission was 0.3 days ± 0.9 and the sex ratio was 1.2. Prematurity was the leading cause of hospitalization (61.13%) followed by neonatal infection (38.34%) and neonatal suffering (23.88%). The mortality rate was 40.6% with 82.71% cases of death in the early neonatal period. The main causes of death were low birth weight (47.39%), respiratory distress (18.76%), neonatal suffering (17.37%) and neonatal infection (13.87%). Home delivery, gestational age 36 weeks, number of PNC 4, concept of resuscitation, Apgar at the 5th minute 7, birth weight 2000 g and >4000 g, respiratory distress, hypothermia, neurological disorders were factors associated with deaths. Conclusion: Neonatal mortality is influenced by both maternal and fetal factors and many of them are preventable.

关键词： Morbidity Mortality Newborns Neonatology HOSCO

Predictive Factors for Pre-Eclampsia: A Case-Control Study in Two Hospitals in Yaounde

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2024年第4期14卷 565-574页

作者： Junie Annick Metogo Ntsama ines Winnie Gouanfo Claude Hector Mbia Wilfried Loic Tatsipie Pascal Mpono Madye Ngo Dingom Felix Essiben Claude Cyrille Noa Ndoua Faculty of Medicine and Biomedical Sciences University of Yaound&#233 I Yaound&#233 Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

Introduction: Pre-eclampsia is a major cause of maternal and prenatal morbidity and mortality, that complicates 2% to 8% of pregnancies worldwide. The aim of this study was to determine the predictive factors for pre-eclampsia in two hospitals in the city of Yaoundé. Methods: A case-control study was conducted at the Gynaecology & Obstetrics department of the Yaoundé Gynaeco-Obstetric and Paediatric Hospital (YGOPH) and the Main Maternity of the Yaoundé Central Hospital (MM-YCH) from February 1 to July 30, 2022. The cases were all pregnant women presenting with pre-eclampsia. The control group included pregnant women without pre-eclampsia. Descriptive statistics followed by logistic regression analyses were conducted with level of significance set at p-value Results: Included in the study were 33 cases and 132 controls, giving a total of 165 participants. The predictive factors for pre-eclampsia after multivariate analysis were: primiparity (aOR = 51.86, 95% CI: 3.01 - 1230.96, p = 0.045), duration of exposure to partner’s sperm Conclusion: The odds of pre-eclampsia increased with primiparity, duration of exposure to partner’s sperm < 3 months, personal history of pre-eclampsia and maternal history of pre-eclampsia. Recognition of these predictor factors would improve the ability to diagnose and monitor women likely to develop pre-eclampsia before the onset of disease for timely interventions.

关键词： Pre-Eclampsia Predictive Factors Yaoundé

减少营养损失和提高生长猪可持续性的饲养策略

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国外畜牧学（猪与禽） 2024年第2期44卷 1-11页

作者：孙丹彤(译) 王祎汀(校) 张配配(复校) 孟祥光(制图表) Candido Pomar ines Andretta Aline Remus 不详

多年来,利用营养物质养猪的效率有所提高。给猪饲喂能够满足其估算营养需要的饲料可以提高营养物质的利用率,利用率的提高相当于增加养猪生产的经济收益,同时最大限度地改善环境的影响。撰写本文的目的是回顾不同的日粮配伍法对动物营... 详细信息

多年来,利用营养物质养猪的效率有所提高。给猪饲喂能够满足其估算营养需要的饲料可以提高营养物质的利用率,利用率的提高相当于增加养猪生产的经济收益,同时最大限度地改善环境的影响。撰写本文的目的是回顾不同的日粮配伍法对动物营养物质利用率的影响,这些方法能向畜禽提供能够满足其所需营养水平的日粮,同时又能最大限度地减少营养物质的排泄量和温室气体的排放量。调整日粮配方来降低日粮中粗蛋白含量,可帮助畜禽最大限度利用日粮中氮和能量。减少动物生产碳足迹的重要技术是使用养殖场所在地的饲料原料和非人类食用产品(如菜籽粕),并在日粮中添加合成氨基酸。精准的饲喂和营养供给不仅可以通过每天定制畜禽所需的日粮,最大限度地提高动物对营养物质的利用率,还可以降低饲料成本,并提高日粮中氮的利用率。我们利用数学模型研究了减少日粮中粗蛋白水平对氮和能量利用率的影响。与不添加合成氨基酸的对照日粮相比,使用粗蛋白含量减少8%的试验日粮,可使氮利用率提高54%,同时使饲料成本降低11%。由于减少了由蛋白质脱氨基作用引发的能量损失,日粮中粗蛋白含量的同步减少意味着可利用能量有了较大的提高。与对照日粮相比,猪饲喂低蛋白日粮后,通过尿液和后肠发酵引发的能量损失降低了24%。与群体(group phase)饲喂相比,精准的饲喂和营养供给可以使畜禽减少30%的氮排泄量。用低蛋白日粮和精准饲喂技术可使养猪绩效具有相加性,产生61%的氮利用率。猪营养需要量的估算方法还有改进的空间。提高不同个体之间存在营养利用差异的认识,有助于进一步改善养猪生产对环境的影响。

关键词：低蛋白日粮可持续养猪生产精准饲喂精准营养营养物质利用营养物质利用率

在线全文

学校读者我要写书评

暂无评论

首尔双子星

现代装饰 2024年第3期 184-187页

作者： Ben van Berkel(设计) Gerard Loozekoot with Harlen Miller(设计) Crystal Tang and ines Verna(设计) 不详

近期,UNStudio与奥雅纳和当地的Heerim建筑事务所联手,为新的和平公园摩天轮设计了一个愿景方案,这是首尔市政府为首尔上岩世界杯公园发起的一个地标项目。UNStudio的设计在初赛中脱颖而出,被选定与首尔住房社区公司合作,向首尔市提交... 详细信息

近期,UNStudio与奥雅纳和当地的Heerim建筑事务所联手,为新的和平公园摩天轮设计了一个愿景方案,这是首尔市政府为首尔上岩世界杯公园发起的一个地标项目。UNStudio的设计在初赛中脱颖而出,被选定与首尔住房社区公司合作,向首尔市提交设计方案。首尔市政府最近公布了UNStudio的设计方案,并暂时将其命名为“首尔双子星”。该项目是首尔市长提出的“汉江千般日落”愿景的一部分,旨在打造汉江沿岸的一千个景点,作为首尔市民的公共空间。

关键词：建筑事务所公共空间双子星摩天轮首尔市世界杯设计方案

Epidemiological, Clinical Aspects and Outcome of Measles in a Low-Income Country in 2023

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2024年第1期14卷 139-148页

作者： Sime Tchouamo Arielle Annick Enyama Dominique Noukeu Diomède Atyam Ekotto Marie Christine Abouame Palma Haoua Epee Ngoue Jeannette Kago Tague Daniel Armand Touka Eric Brice Tasse Simo Nathalie ines Nguéfack Félicité Faculty of Medicine and Pharmaceutical Sciences of University of Dschang Dschang Cameroon Gynaeco-Obstetric and Pediatric Hospital of Yaounde Yaounde Cameroon Gynaeco-Obstetric and Pediatric Hospital of Douala Douala Cameroon Regional Annex Hospital of Dschang Dschang Cameroon Faculty of Medicine and Biomedical Sciences of University of Garoua Garoua Cameroon Faculty of Medicine and Biomedical Sciences of University of Yaounde 1 Yaounde Cameroon West Regional Delegation of Public Health Bafoussam Cameroon

Introduction: Measles remains a worrying health problem in sub-Saharan African countries. There have been measles outbreaks in Cameroon with the most recent occurring between October 2022 and September 2023. The Centre region of Cameroon was the most affected in the country and being at the frontline of the fight against this illness, we conducted this study in order to determine the epidemiological and clinical characteristics as well as the outcome of children who contracted the measles and were hospitalized at the Yaoundé Gynaeco-Obstetric and Pediatric Hospital. Methodology: We conducted a cross-sectional descriptive and prospective study for one year from October 2022 to November 2023 corresponding to the duration of the outbreak. We included all children admitted in the pediatric unit for measles and its complications during this period. Results: In total, 60 children were enrolled. Their caregivers were mostly their mothers who had a mean age of 34.71 ± 9.55 years living in significant precarious conditions for the majority. The median age of children was 16 months (09 - 30 months). Twenty six percent of children (16) were less than 9 months. Girls were predominant (55%). Most children were not up to date with their routine EPI vaccination (80%) and most did not receive the measles and Rubella vaccine (76.67%). Clinical manifestations, included fever, conjunctivitis, and cough. Skin rash and catarrh (98.33% and 86.67% respectively) are the case definition signs of measles. The outcome was unfavorable for 4 children. One had a neurological disorder: coma and three presented with pneumonia and severe respiratory distress (6.67%). Conclusion: Measles is still being a reality and claiming lives in our context, emphasis should be made on immunization coverage and if possible, advocacies should be formulated to decrease the age of measles vaccine administration.

关键词： Measles Complications Low-Income Countries

Stachel-mediated activation of adhesion G protein-coupled receptors:insights from cryo-EM studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第8期7卷 2636-2637页

作者： ines Liebscher Torsten Schöneberg Doreen Thor Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig University04103 LeipzigGermany

Recently,a set of cryo-electron microscopy(cryo-EM)structures of different adhesion G protein-coupled receptors(aGPCRs)has been published by Xiao et al.1,Ping et al.2,Qu et al.3,and Barros-Álvarez et al.4 shedding light on the activation of the seven-helix transmembrane domain(7TMD)via their tethered peptide agonist.Adhesion GPCRs are an evolutionary old class of receptors that play a key role in several physiological processes including neuron and synapse formation,immune response,and metabolism.They are unique within the superfamily of GPCRs because they combine the structural features of adhesive molecules,mediating cell–cell or cell–matrix interaction,with intracellular G protein-mediated signalling.The long extracellular N terminus of the receptor harbours distinct functional domains including the highly conserved GPCR autoproteolysis-inducing(GAIN)domain with the GPCR proteolysis site(GPS).Many,but not all aGPCRs are autoproteolytically cleaved at the GPS into a N-and a C-terminal fragment(NTF and CTF,respectively),which remain non-covalently attached.

关键词： activation insight attached

Semaglutide might be a key for breaking the vicious cycle of metabolically associated fatty liver disease spectrum?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第20期10卷 6759-6768页

作者： Maja Cigrovski Berkovic Tanja Rezic ines Bilic-Curcic Anna Mrzljak Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Endocrinology and Diabetes Clinical Hospital DubravaZagreb 10000Croatia Department of Endocrinology and Diabetes University Hospital Centre OsijekOsijek 31000Croatia Department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

Metabolically associated fatty liver disease(MAFLD)is a liver manifestation of metabolic syndrome potentially related to unfavorable hepatic and extrahepatic outcomes and progression to cirrhosis.Up to date,there are no approved pharmacotherapies for the treatment of MAFLD,so management focused on lifestyle interventions to encourage weight loss,and treatment of coexisting conditions is the only available option.Unfortunately,the aforementioned is often not potent enough to offer reversal or slow down hepatic inflammation and fibrosis.Glucagon-like peptide-1 receptor agonists have a favorable effect on glycemic management and weight loss of patients with type 2 diabetes mellitus and recently published data suggest their potential in MAFLD treatment.In addition,some of the agents have proven cardiovascular and renal benefits in dedicated cardiovascular outcome trials,making them an interesting therapeutic option.In this opinion review,we discuss the role of semaglutide in MAFLD.

关键词： Semaglutide Non-alcoholic fatty liver disease Glucagon-like peptide-1 receptor agonists Metabolically associated fatty liver disease

Road traffic nanoparticle characteristics:Sustainable environment and mobility

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2022年第1期13卷 388-403页

作者： ines Belkacem Ali Helali Salah Khardi Amani Chrouda Khalifa Slimi Laboratory of Thermal and Energy Systems Studies(LESTE) National Engineering SchoolUniversity of MonastirTunisia Environment PlanningSafety and Eco-design LaboratoryDepartment of MobilityPlanning and the EnvironmentGustave Eiffel UniversityUniversity of Lyon–LyonFrance Mechanical Laboratory of Sousse National Engineering School of SousseUniversity of SousseTunisia Department of Transportation Technology and Engineering Higher Institute of Transportation and LogisticsUniversity of SousseTunisia Contact and Structure Mechanics Laboratory LaMCoS Campus LyonTech La Doua–INSA Lyon.27bisAvenue Jean CapelleF69621 Villeurbanne cedexFrance Department of Chemistry College of Science at ZulfiMajmaah UniversityZulfi 11932Saudi Arabia

Human effects and environment impacts associated with nanoparticles generated from road traffic have recently attracted wide attention.Knowledge of the influencing variables on both number and mass of nanoparticles,sources,characteristics and limitations of advanced commercially accessible instruments for monitoring nanoparticles,are still scarce and not sufficient to make regulatory decision on solid particles smaller than 23 nm(SPN<23 nm).Given the harmful effects of nanoparticles on human health(i.***.visibility impairment,cardiac-rhythm disturbance,heart attacks,premature death,etc.),their control and assessment seem to be an absolute priority.In this overview,we classify and analyze the existing knowledge of nanoparticles in road traffic atmosphere,recent progress,and emerging priorities in research related to these topics.The major aspects of ongoing research in this field,and a brief discussion of the main sources of atmosphere nanoparticles are presented.The subsequent section focuses on the influencing parameters of nanoparticles including climate conditions,height above the road surface and distance between source(road traffic)and sampling site.The next section provides a comprehensive summary on sampling measurement methodologies and instrumental techniques.We also review the health and environment implications associated with particle exposure.Finally,an evaluation of the state of research related to nanoparticles together with highlights for future research activities are also presented.

关键词： Road traffic Nanoparticles Sustainable environment Air pollution Health