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Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications

Bone Research 2024年第1期12卷 1-19页

作者： Xiwei Fan Antonia Rujia Sun Reuben S.E.Young Isaac O.Afara Brett R.Hamilton Louis Jun Ye Ong Ross Crawford indira Prasadam Centre for Biomedical Technologies Queensland University of TechnologyBrisbaneQLDAustralia School of Mechanical Medical&Process EngineeringQueensland University of TechnologyBrisbaneQLDAustralia Central Analytical Research Facility Queensland University of TechnologyBrisbaneQLDAustralia Molecular Horizons University of WollongongWollongongNSWAustralia Department of Technical Physics University of Eastern FinlandKuopioFinland School of Electrical Engineering and Computer Science Faculty of EngineeringArchitecture and Information TechnologyUniversity of QueenslandBrisbaneQLDAustralia Centre for Microscopy and Microanalysis University of QueenslandBrisbaneQLDAustralia The Prince Charles Hospital BrisbaneQLDAustralia

Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose *** presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial ***,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic *** analysis of bulk OA tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint *** issue has led to standardization difficulties and hindered the success of clinical *** insights into the spatial variations of the cellular and molecular structures in OA tissues,encompassing DNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease *** resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular *** advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial *** fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial ***,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and *** these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease *** review summarizes the rec

关键词： insight Spatial enable

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埋地天然气管线的地震损伤与易损性评估

埋地天然气管线的地震损伤与易损性评估

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作者： Yergaliyeva indira（丽娃）哈尔滨工业大学

学位级别：硕士

生命线是人类生活和城市必需的基础设施体系，它通常用于输送污水、燃料、能源、信息、石油和天然气等城市居民的必需品。因此，避免震区的管道系统出现严重破坏对各个国家的防震减灾决策均非常重要。鉴于此，本文针对天然气管网系统开... 详细信息

生命线是人类生活和城市必需的基础设施体系，它通常用于输送污水、燃料、能源、信息、石油和天然气等城市居民的必需品。因此，避免震区的管道系统出现严重破坏对各个国家的防震减灾决策均非常重要。鉴于此，本文针对天然气管网系统开展了地震破坏和易损性评估。本文针对阿拉木图地区开展详细的研究和数据收集。采用ABAQUS软件从静力和动力两个方面研究地管道在地震作用下的反应，在分析过程中进行了土壤和管道相互作用的三维模型的简化，考虑了管道-土相互作用，考虑了影响静态和地震荷载作用下连续管道的因素，包括：载荷材料、直径、边界条件、土壤特性等因素。本文用位于哈萨克斯坦的天然气管道在8级地震作用下的反应分析对本文所建立的天然气管网有限元模型进行了验证。进一步运用地震易损性理论，给出了天然气管网的地震易损性曲线，并对管网的概率地震安全进行了评估。研究发现：对于天然气管道，最可能的损伤将发生在带铰链边界条件的粘土中，铰链边界条件取决于其他类型的土壤。

关键词：埋地天然气管道地震损伤地震易损性地震波的传播

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Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?

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Stroke & Vascular Neurology 2024年第3期9卷 279-288,I0247页

作者： Adam Ingleton Marko Raseta Rui-En Chung Kevin Jun Hui Kow Jake Weddell Sanjeev Nayak Changez Jadun Zafar Hashim Noman Qayyum Phillip Ferdinand indira Natarajan Christine Roffe Neurosciences University Hospitals of North Midlands NHS TrustStoke-on TrentUK Statistics and Mathematical Modelling Department of Molecular GeneticsErasmus Medical CenterRotterdamZuid-HollandThe Netherlands Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK School of Medicine Keele UniversityKeeleUK Interventional Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK Stroke Research Keele UniversityKeeleUK

Background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy(MT).Most patients undergoing MT are also given *** agents are contraindicated within 24 hours of *** evaluated outcomes and complications of patients stented with and without intravenous aspirin during *** All patients who underwent emergent extracranial stenting during MT at the Royal Stoke University Hospital,UK between 2010 and 2020,were *** were thrombolysed before MT,unless *** 500 mg intravenously was given intraoperatively at the discretion of the *** intracranial haemorrhage(sICH)and the National Institutes for Health Stroke Scale score(NIHSS)were recorded at 7 days,and mortality and functional recovery(modified Rankin Scale:mRS≤2)at 90 *** Out of 565 patients treated by MT 102 patients(median age 67 IQR 57–72 years,baseline median NIHSS 18 IQR 13–23,76(75%)thrombolysed)had a stent *** these 49(48%)were given aspirin and 53(52%)were *** treated with aspirin had greater NIHSS improvement(median 8 IQR 1–16 vs median 3 IQR-9–8 points,p=0.003),but there were no significant differences in sICH(2/49(4%)vs 9/53(17%)),mRS≤2(25/49(51%)vs 19/53(36%))and mortality(10/49(20%)vs 12/53(23%))with and without *** improvement(median 12 IQR 4–18 vs median 7 IQR-7–10,p=0.01)was greater,and mortality was lower(4/33(12%)vs 6/15(40%),p=0.05)when aspirin was combined with thrombolysis,than for aspirin alone,with no increase in *** Our findings based on registry data derived from routine clinical care suggest that intraprocedural intravenous aspirin in patients undergoing emergent stenting during MT does not increase sICH and is associated with good clinical outcomes,even when combined with intravenous thrombolysis.

关键词： patients aspirin intravenous

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Effect of Cyclodextrin Complexation on the Aqueous Solubility of Diazepam and Nitrazepam:Phase-Solubility Analysis,Thermodynamic Properties

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American Journal of Analytical Chemistry 2012年第12期3卷 811-819页

作者： Jasmina Hadziabdic Alisa Elezovic Ognjenka Rahic indira Mujezin Department of Pharmaceutical Technology Faculty of PharmacyUniversity of SarajevoSarajevoBosnia and Herzegovina

The solubility enhancement of diazepam and nitrazepam in water was analyzed depending on temperature and amount of α-cyclodextrin ( α-CD), β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). The interactions of drug-cyclodextrin in solution were investigated by the phase-solubility analysis. Diazepam (nitrazepam) content in aqueous complexation medium was analyzed UV spectrophotometrically. Classical solubility data were used to derive apparent stability constants (K1:1) which were used to derive thermodynamic parameters for the diazepam (nitrazepam)-cyclodextrin complexes. Since all phase solubility plots were of AL–types, and calculated Slopes after linear regression analysis were found to be less than 1, it could be assumed that stoichiometry of the formed binary systems was 1:1. According to the calculated K1:1 values, the stability of the complexes of diazepam and nitrazepam with a-CD, β-CD and 2-HP-β-CD varies as follows: 2-HP-β-CD > β-CD > β-CD. The a-CD has higher affinity for dissolving nitrazepam compared to diazepam. While all parameters lead to an improvement in solubility, the largest effect was obtained for guest-host complexation with 2-HP-β-CD. The solubility of diazepam and nitrazepam in water increased 93.02 times and 64.23 times, respectively, in the presence of 40% (w/w) 2-HP-β-CD, at 25°C. Solubility data for diazepam and nitrazepam in aqueous 2-HP-b-CD were used to derive thermodynamic parameters, ΔG° at 298 K = –14.43 kJ·mol–1, ΔH° = 0.79 kJ·mol–1, ΔS° at 298 K = 51.17 J·mol–1·K–1 and ΔG° at 298 K = –13.43 kJ·mol–1, ΔH° = 2.38 kJ·mol–1, ΔS° at 298 K = 53.01 J·mol–1·K–1, respectively. Formation of inclusion complexes substantially increases the water solubility of diazepam and nitrazepam. Diazepam and nitrazepam dissolution thermodynamics in aqueous 2-HP-β-CD were characterized by spontaneous and endothermic dissolution and hydrophobic interactions.

关键词： Diazepam Nitrazepam Phase-Solubility Analysis Thermodynamic Parameters

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Ameliorative effect of alkaloid extract of Cyclea peltata(Poir.) Hook.f.& ***(ACP) on APAP/CC1_4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 143-151页

作者： Varghese Jancy Shine Panikamparambil Gopalakrishnan Latha Somasckharan Nair Rajam Suja Gangadharan indira Anuja Gopan Raj Sreedharan Nair Rajasekharan Division of Ethnomedicine and Ethnopharmacology Jawaharlal Nehru Tropical Botanic Garden and Research Institute(JNTBGRI)TrivandrumKerala 695562India Deparment of Chemistry Sree Narayana CollegePunalurKollam- 691305KeralaIndia

Objective:To evaluate the hepatoprotective and antioxidant properties of alkaloid extract of Cyclea peltata(***) against paracetamol/carbon tetra chloride induced liver damage in Wistar ***:In viro paracetamol/carbon tetrachloride induced liver damage in Wistar rats,in vitro free radical scavenging studies,HPTLC estimation of letrandrine and direct analysis in real timemass spectrometry of alkaloid extract of *** were used for the ***:The results showed that pretreatment with alkaloid extract of *** caused significant reduction of serum glutamate pyruvate transaminase,serum glutamate oxaloacetate transaminase,serum alkaline phosphatase,serum cholesterol,liver malondialdehyde *** reduced glutathione,catalase,superoxide dismutase levels in liver were increased with alkaloid extract of *** *** results were almost comparable to silymarin and normal *** studies also substantiated the biochemical *** in vitro hydroxyl,superoxide and DPPH scavenging study of alkaloid extract of C. peltata showed significant free radical scavenging ***:The hepatoprotective property of alkaloid extract of *** against paracetamol/carbon tetrachloride may be due the synergistic action of alkaloids especially tetrandrine,fangchinoline through free radical scavenging and thus preventing oxidative stress.

关键词： Tetrandrine Glutathione Catalase Superoxide dismutase Hydroxyl Malondialdehyde

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Chronic Refractory Idiopathic Urticaria

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Journal of Biosciences and Medicines 2023年第11期11卷 13-22页

作者： indira Acharya Ashik Pokharel Ashbina Pokharel Lanaya Williams Smith Department of Internal Medicine MedStar Union Memorial Hospital Baltimore Maryland USA Department of Internal Medicine William Beaumont Hospital Royal Oak Michigan USA Department of Internal Medicine MedStar Good Samaritan Hospital Baltimore Maryland USA

Background: Chronic spontaneous urticaria (CSU) is a complex medical condition characterized by substantial morbidity and a negative impact on one’s quality of life. There are several treatment approaches available, tailored to the severity of the condition, which can enhance overall quality of life. Aim: In this article, we outline a systematic approach to managing chronic urticaria, while also elucidating the available treatment strategies for cases that prove resistant to conventional therapies. To illustrate our points, we present a clinical case as a practical example. Case Presentation: Here, we present a patient with CSU since childhood who presented in the context of refractory hives and generalized arthralgia that responded well to omalizumab therapy with no further relapse. Conclusion: Omalizumab is a biological agent that offers a potential treatment option for CSU. It is available for individuals twelve years and older who have not responded well to conventional treatments. It has demonstrated good efficacy with a relatively low rate of clinically significant adverse effects. Nonetheless, there is a dearth of research regarding the optimal method for tapering the dosage and determining the duration of treatment.

关键词： Omalizumab Biological Agent Chronic Spontaneous Urticaria (CSU) Conventional Treatment Relapse

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The first laboratory-confirmed neonatal Mpox infection in Sri Lanka

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 237-240页

作者： Thulani Thivanshika Pattiyakumbura Denagama Vitharanage Rishan Geeth Ruwan Jinadari Maduwanthi Munasinghe Gamage Don Diluk Chathuranga Janaki indira Abeynayake Department of Virology Medical Research InstituteNo-527Dr Danister De Silva MawathaColombo 08Colombo 00800Sri Lanka

In 2022-2023,a global outbreak of Mpox was reported especially in nonendemic *** report the first laboratory-confirmed neonatal case of Mpox infection complicated by bronchopneumonia in Sri Lanka.

关键词： Mpox Neonatal case of Mpox infection Sri Lanka Global outbreak 2022-2023

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The Impact of the Brics on the Future of Global Governance

The Impact of the Brics on the Future of Global Governance

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作者： Nickola indira Browne（尼克拉）山东大学

学位级别：硕士

“金砖四国”自2001年成立后,巴西、印度、俄罗斯和中国等新兴经济体随之引起了强烈关注。南非于2011年加入到该组织,重新被定义的“新金砖五国”在四大洲的范围中进而扩大了自身的影响。这五个国家已经引起了国际社会的广泛关注,不仅... 详细信息

“金砖四国”自2001年成立后,巴西、印度、俄罗斯和中国等新兴经济体随之引起了强烈关注。南非于2011年加入到该组织,重新被定义的“新金砖五国”在四大洲的范围中进而扩大了自身的影响。这五个国家已经引起了国际社会的广泛关注,不仅因为自身经济的持续增长,也因为他们重组了现有国际机构和改变了全球布局。由于其成员的政治、经济和社会的异质性,金砖国家都面临着一场在一个统一集团战略发展中的攻坚战。在该论文中,笔者考察了金砖国成员间的合作协议,以及其正面临的挑战,这也预示着金砖国家能否在未来成为一个单一实体。为了找寻日益强大的金砖成员国合作中的优势与劣势,笔者运用了Keohane口Nye的相互依赖理论以及Polachek的贸易冲突关系理论观点,同时也通过评估金砖成员国的战略方针,来推断他们是否会利用彼此的战略合作关系来追求绝对或相对的利益。在金砖国家经济持续增长的同时,他们也正努力将自身的经济实力转化为政治影响力。他们发表联合声明表达对重组这些国际机构,如联合国(UN)和国际货币基金组织(IMF)等的强烈意愿,但经多次协商,仍无法取得实质进展。此外,他们最近兴建的金砖国家发展银行,由于资金和选址难以达成共识,已经暂时搁置。如果金砖国家想加强在国际事务中的话语权,并且在全球变革中承担重任,他们将需要增加彼此间各个层面的合作。

关键词：金砖国家新兴国家经济合作全球影响力国际性重组

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Characterization of Acidity in Acid Sulphate Soils of Kerala

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Journal of Life Sciences 2013年第8期7卷 907-912页

作者： Beena Viswanathan Nair indira Manorama Thampatti Kizhekke Covilakom Department of Soil Science and Agricultural Chemistry College of Horticulture Kerala Agricultural University VellanikkaraThrissur lndia Department of Soil Science and Agricultural Chemistry College of Agriculture Kerala Agricultural University VellayaniThiruvananthapuram India

The acidity characteristics of acid sulphate soils of Kuttanad, Kerala, were studied in detail by collecting surface, profile and subsurface soil samples from 20 locations of six soil series viz., Ambalapuzha, Purakkad, Thotapally, Thuravur, Kallara and - Thakazhi that belonged to acid sulphate soils. The soils were extremely acidic showing a range of pH （H：O） varying from 2.5 to 5.2. Lowest pH was recorded by Thakazhi series and the highest by Thotapally. The potential acidity of soils ranged from 14.71 ***-1 to 110.5 cmol-kg1 with Thakazhi series showing the highest value. The contribution of hydrolytic acidity to potential acidity ranged from 70.2% to 97.2%. In all soil series, exchangeable A13＋ was greater than exchangeable H~. A significant correlation was observed among pH （KCI）, pH （H20） and pH （CaCI2） in all series.

关键词： Kuttanad Kerala acid sulphate soils potential acidity exchangeable acidity hydrolytic acidity pH.

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Diagnostic Dilemma of Intracardiac Mass: Tumor versus Thrombus-Case Series and Systematic Review

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Journal of Biosciences and Medicines 2024年第7期12卷 141-150页

作者： indira Acharya Ashik Pokharel Raktim Ghosh Christopher J. Haas Department of Internal Medicine Internal Medicine Residency Program Medstar Health Baltimore MD USA Department of Cardiology MedStar Union Memorial Hospital MedStar Health Baltimore MD USA School of Medicine Georgetown University Washington D.C. USA

Background: The differential diagnosis for intracavitary cardiac masses is limited, typically including vegetations, tumors, or thrombi. Cardiac thrombi can often mimic cardiac tumors on imaging, creating a diagnostic challenge. Primary cardiac tumors are rare and usually benign, whereas most cardiac tumors result from metastases, commonly originating from malignancies in the breast, lung, or melanoma. Aim: This report highlights the importance of distinguishing various cardiac masses based on clinical presentations, clinical courses, and radiological features. Case Presentation: We describe two cases of cardiac masses with unique and diverse clinical features. Each case posed significant diagnostic challenges due to their distinct presentations and clinical progressions. Conclusion: These cases underscore the importance of considering both benign and metastatic origins in the differential diagnosis of intracavitary cardiac masses. Accurate differentiation between thrombi and tumors is crucial for appropriate management and treatment.

关键词： Echocardiography Cardiac Masses Arrhythmias Cardiac Magnetic Resonance Imaging Cardiac Thrombi

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