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How can probiotic improve irritable bowel syndrome symptoms?

World Journal of Gastrointestinal Surgery 2021年第9期13卷 923-940页

作者： indira benjak horvat Ivana Gobin Andrea Kresović Goran Hauser Department of Gastroenterology Varaždin General HospitalVaražin 42000Croatia Department of Microbiology and Parasitology Faculty of MedicineUniversity of RijekaRijeka 51000Croatia Department of Gastroenterology Clinical Hospital Center RijekaRijeka 51000Croatia Department of Gastroenterology Faculty of MedicineClinical Hospital Center RijekaUniversity of RijekaRijeka 51000Croatia

The onset and manifestations of irritable bowel syndrome(IBS)is associated with several factors,and the pathophysiology involves various central and peripheral *** studies indicate that the management of gut microbiota could significantly affect the improvement of subjective disorders in patients with *** clinical trials have assessed the efficacy of probiotics for IBS with controversial *** clinical trials have suggested that probiotics can improve global IBS symptoms,while others only improve individual IBS symptoms,such as bloating scores and abdominal pain *** a few clinical trials have found no apparent effect of probiotics on IBS ***,probiotics appear to be safe for patients with ***,the question of which probiotics should be used for certain IBS subtypes remains *** everyday practice,the dose of the recommended probiotic remains questionable,as well as how long the probiotic should be used in *** use of probiotics in the M subtype and non-classified IBS is particularly problematic,in which combination therapy should be recommended due to the change in ***,new approaches are needed in the design of clinical studies that should address certain subtypes of IBS.

关键词： Irritable bowel syndrome Obstipation Diarrhoea Abdominal pain Probiotic Prebiotic Symbiotic Microbiota

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