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Effects of Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel Alone and in Combination with Low-Dose Metformin on Glucose and Lipid Homeostasis and Androgenic Hormone Profile in Hirsute Women with Polycystic Ovary Syndrome: A Randomized, Double-blind, Triple-Dummy Study

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Journal of biosciences and Medicines 2019年第8期7卷 13-26页

作者： Sanjeewani Fonseka Dilan D.J.bandara Chandrika N.Wijeyaratne indika b.gawarammana Nishan S.Kalupahana Shanthini Rosairo Ranjith Kumarasiri Faculty of Medicine University of PeradeniyaPeradeniyaSri Lanka Department of Obstetrics and Gynaecology Faculty of MedicineUniversity of ColomboColomboSri Lanka

background: The effects of combined oral contraceptive pills and metformin on glucose and lipid metabolism and androgenic hormone profile of hirsute women with polycystic ovary syndrome (PCOS) are not clearly known. Aims: To determine the effect of ethinylestradiol (35 microg)/cyproterone acetate (2 mg) (EE/CPA) and ethinylestradiol (20 microg)/desogestrel 0.15 mg (EE/DES) alone and in combination with metformin on glucose and lipid metabolism and androgenic hormone profile in hirsute women with PCOS. Settings and Design: This randomised, double-blind, triple dummy study was conducted at the Department of Pharmacology, Faulty of Science, University of Peradeniya, Sri Lanka. Methods and Material: A total of 107 patients with PCOS (Rotterdam Consensus Conference Criteria 2003) having hirsutism of 8 or more in the modified Ferriman-Gallwey Score (mFGS), were randomised to receive four drug therapies (arm A: EE/CPA, arm b: EE/DES, arm C: EE/CPA plus metformin, arm D: EE/DES plus metformin). body mass index, fasting plasma glucose, area under the curve of the oral glucose tolerance test, fasting serum insulin, serum leptin, fasting lipids, serum total testosterone, serum sex hormone-binding globulin were determined at initiation and 12 months. Homeostasis model assessment of beta cell function (HOMA-β), homeostasis model assessment-estimated insulin resistance (HOMA-IR) and free androgen index were calculated. Statistical analysis was done with two ways ANOVA. Results: There was no significant difference in outcome measures at 12 months between the treatment arms. Within the treatment arms, there was reduction of HOMA-β in arm b, serum leptin in arm C, CHO/HDL ratio in arm D and an increase in total cholesterol and LDL-cholesterol in arms b and C. Conclusions: EE/DES and EE/CPA with and without low-dose metformin did not have a significant overall effect on glucose and lipid metabolism and androgenic hormonal profile in hirsute women with PCOS. However, desogestrel has r

关键词： Polycystic Ovary Syndrome Ethinylestradiol Cyproterone Acetate Desogestrel Metformin

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The in-vitro colchicine release and binding affinity to activated charcoal in simulated gastrointestinal fluids from Gloriosa Superba

The in-vitro colchicine release and binding affinity to acti...

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第八届亚太医学毒理学大会暨全国中毒控制与救治论坛（2009）

作者： Shukry Zawahir indika gawarammana Andrew.H.Dawson SACTRC Faculty of MedicineUniversity of PeradeniyaSri Lanka

Introduction: Data from our prospective observational study demonstrated case fatality ratios from Gloriosa superba that varied between 9 and 50%depending on the geographical area in Sri *** is no affordable antidote available for colchicine poisoning and there is no data demonstrating the extent to which activated charcoal adsorbs the colchicine content found in Gloriosa Superba,this may relate to dissolution characteristics of colchicine from the plant matrix.

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Dynamic Control of Human Eye on Head System

Dynamic Control of Human Eye on Head System

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第二十九届中国控制会议

作者： bijoy K.GHOSH indika b.WIJAYASINGHE Laboratory for bioCybernetics and Intelligent Systems Texas Tech University

In this paper we study the human eye movement,when the eye shifts its gaze between two possible gaze directions,as a simple mechanical control *** the head is restrained to remain fixed,eye movements obey Listing’s constraint,which states that the allowed orientations of the eye are obtained by rotating a fixed’primary gaze direction’by a subclass of rotation *** rotation matrices have their axes of rotation restricted to a fixed plane perpendicular to the primary gaze *** head fixed restriction,eye movement satisfies the Listing’s constraint throughout its entire *** the other hand,when the head is allowed to move,the eye orientations satisfy the Listing’s constraint only at the beginning and at the end of a *** points of the trajectory,do not satisfy the Listing’s *** this paper,we study the dynamic control of eye movement with or without satisfaction of the Listing’s *** control has been synthesized by a suitable choice of a potential function and an externally added damping term.

关键词： Eye Movement Listing’s Law Euler Lagrange Equation Head Fixed Head Free

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