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Variability in Glucosinolate Content among CamelinaSpecies

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American Journal of Plant Sciences 2014年第3期5卷 294-298页

作者： Roberto Russo incoronata galasso Remo Reggiani Istituto di Biologia e Biotecnologia Agraria CNR Milano Italy

Glucosinolate content in Camelina sativa (L.) Crantz (false flax, gold-of-pleasure) and its relatives C. microcarpa, C. alyssum, C. rumelica and C. hispida was investigated. With the exception of C. hispida in which GSL3 was absent, in all remaining species, three characteristic glucosinolates (GSL1, GSL2 and GSL3) were identified. Camelina genotypes of spring type (C. sativa CAM134, C. alyssum CAM21) showed a typical pattern of glucosenolates with GSL1 > GSL3. GSL1 was present in traces in C. microcarpa and at low levels in C. rumelica and C. alyssum subsp. alyssum. In C. hispida, the GSL1 content was greater than GSL2 and, only in this specie, GSL2 represented less than 50% of total glucosinolates. These differences in the glucosinolate pattern among Camelina species could be exploited to reduce the total content of glucosinolates in C. sativa.

关键词： Camelina Species Glucosinolate Flour Winter and Spring Type Oilseed Crop

Genomic Fingerprinting of CamelinaSpecies Using cTBP as Molecular Marker

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American Journal of Plant Sciences 2015年第8期6卷 1184-1200页

作者： incoronata galasso Antonella Manca Luca Braglia Elena Ponzoni Diego Breviario Istituto di Biologia e Biotecnologia Agraria (IBBA-CNR) Milan Italy

Interest on the genus Camelina has recently increased due to the biofuel, or jet fuel, potential of the oil extracted from seeds of the cultivated species Camelina sativa (L.) Crantz. While our knowledge on C. sativa is constantly augmenting, only few studies have been performed on the other species of the genus, which could be a potentially useful material for the genetic improvement of C. sativa. The genus Camelina consists of 11 species, but only six (C. sativa, C. microcarpa, C. alyssum, C. rumelica, C. hispida and C. laxa) could be retrieved from germplasm banks to carry out genomic fingerprinting studies based on the use of the cTBP molecular marker. Each species, with the exception of C. alyssum that is proposed to be a subspecies of C. sativa, shows a distinct cTBP profile resulting from multiple DNA length polymorphisms present in the second intron of the members of the β-tubulin gene family. In contrast to the high level of genetic diversity detected among the six Camelina species, low variability is observed among and within the accessions of the same species, except for C. hispida that is characterized by an intra-accession high number of cTBP polymorphic bands. In addition, cTBP is also able to identify incorrectly classified accessions and provide information on the ploidy level of each species.

关键词： Genetic Diversity Polymorphism β-Tubulin Gene Family False Flax Chromosome Number

Shear-wave elastography to predict hepatocellular carcinoma after hepatitis C virus eradication:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第10期30卷 1450-1460页

作者： Giorgio Esposto Paolo Santini Linda galasso Irene Mignini Maria Elena Ainora Antonio Gasbarrini Maria Assunta Zocco CEMAD Digestive Disease Center Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione Policlinico Universitario Agostino Gemelli IRCCS Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BACKGROUND Direct-acting antiviral agents(DAAs)are highly effective treatment for chronic hepatitis C(CHC)with a significant rate of sustained virologic response(SVR).The achievement of SVR is crucial to prevent additional liver damage and slow down fibrosis *** assessment of fibrosis degree can be performed with transient elastography,magnetic resonance elastography or shear-wave elastography(SWE).Liver elastography could function as a predictor for hepato-cellular carcinoma(HCC)in CHC patients treated with *** To explore the predictive value of SWE for HCC development after complete clearance of hepatitis C virus(HCV).METHODS A comprehensive literature search of clinical studies was performed to identify the ability of SWE to predict HCC occurrence after HCV *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** At baseline and after 12 wk of follow-up,a trend was shown towards greater liver stiffness(LS)in those who go on to develop HCC compared to those who do not[baseline LS standardized mean difference(SMD):1.15,95%confidence interval(95%CI):020-2.50;LS SMD after 12 wk:0.83,95%CI:0.33-1.98].The absence of a statistically significant difference between the mean LS in those who developed HCC or not may be related to the inability to correct for confounding factors and the absence of raw source *** was a statist-ically significant LS SMD at 24 wk of follow-up between patients who developed HCC vs not(0.64;95%CI:0.04-1.24).CONCLUSION SWE could be a promising tool for prediction of HCC occurrence in patients treated with *** studies with larger cohorts and standardized timing of elastographic evaluation are needed to confirm these data.

关键词： Shear-wave elastography Hepatocellular carcinoma Hepatitis C virus Sustained virologic response

Dynamic contrast enhanced ultrasound in differential diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2804-2815页

作者： Giorgio Esposto Paolo Santini Fabrizio Termite Linda galasso Irene Mignini Maria Elena Ainora Antonio Gasbarrini Maria Assunta Zocco Department of CEMAD Digestive Disease Center Fondazione Policlinico Universitario A Gemelli IRCCSCatholic University of RomeRome 00168Italy Department of Fondazione Policlinico Universitario Agostino Gemelli IRCCS UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterFondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Non-invasive differential diagnosis between hepatocellular carcinoma(HCC)and other liver cancer(*** or metastasis)is highly challenging and definitive diagnosis still relies on histological *** patterns of enhancement and wash-out of liver nodules can be used to stratify the risk of malignancy only in cirrhotic patients and HCC frequently shows atypical *** contrast-enhanced ultrasound(DCEUS)with standardized software could help to overcome these obstacles,providing functional and quantitative parameters and potentially improving accuracy in the evaluation of tumor *** To explore clinical evidence regarding the application of DCEUS in the differential diagnosis of liver *** A comprehensive literature search of clinical studies was performed to identify the parameters of DCEUS that could relate to histological *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** Rise time was significantly higher in HCC patients with a standardized mean difference(SMD)of 0.83(95%CI:0.48-1.18).Similarly,other statistically significant parameters were mean transit time local with a SMD of 0.73(95%CI:0.20-1.27),peak enhancement with a SMD of 0.37(95%CI:0.03-0.70),area wash-in area under the curve with a SMD of 0.47(95%CI:0.13-0.81),wash-out area under the curve with a SMD of 0.55(95%CI:0.21-0.89)and wash-in and wash-out area under the curve with SMD of 0.51(95%CI:0.17-0.85).SMD resulted not significant in fall time and wash-in rate,but the latter presented a trend towards greater values in HCC compared to intrahepatic *** DCEUS could improve non-invasive diagnosis of HCC,leading to less liver biopsy and early *** quantitative analysis needs to be applied on larger cohorts to confirm these preliminary results.

关键词： Dynamic contrast enhanced ultrasound Hepatocellular carcinoma Intracellular cholangiocarcinoma Quantitative ultrasound Liver cancer Time-intensity curve

Engineering Analysis of Strong Motion Data from Recent Earthquakes in Sichuan, China

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工程科学与技术 2018年第3期50卷 112-124页

作者： HUANG Chen galasso Carmine Department of Civil Environmental and Geomatic Engineering University College London (UCL) London WC1E 6BT UK

Recent earthquakes in the Sichuan Province have contributed to significantly expand the existing ground-motion database for China with new,high-quality ground-motion *** study investigated the compatibility of ground-motion prediction equations(GMPEs)established by the NGA-West2 project in the US and local GMPEs for China,with respect to magnitude scaling,distance scaling,and site scaling implied by recent Chinese strong-motion *** NGA-West2 GMPEs for shallow crustal earthquakes in tectonically active regions are considerably more sophisticated than widely used previous models,particularly in *** a mixed-effects procedure,the study evaluated event terms(inter-event residuals)and intra-event residuals of Chinese data relative to the NGA-West2 *** scaling was investigated by examining trends of intra-event residuals with source-to-site *** with respect to site conditions was investigated by examining trends of intra-event residuals with soil *** study also investigated other engineering characteristics of Chinese strong ground *** particular,the records were analyzed for evidence of pulse-like forward-directivity *** elastic median response spectra of the selected stations were compared to code-mandated design spectra for various mean return *** showed that international and local GMPEs can be applied for seismic hazard analysis in Sichuan with minor modification of the regression coefficients related to the source-to-site distance and soil ***,the Chinese data attenuated faster than implied by the considered GMPEs and the differences were statistically significant in some ***-source,pulse-like ground motions were identified at two recording stations for the 2008 Wenchuan earthquake,possibly implying rupture *** median recorded spectra were consistent with the code-based spectra in terms of amplitude and *** new ground-motion data can be used to deve

关键词： ground motion prediction equations NGA-West2 project code-based spectrum pulse-like ground motions

Antiplatelet therapy in very elderly and comorbid patients with acute coronary syndromes

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Journal of Geriatric Cardiology 2019年第2期16卷 103-113页

作者： Roberta De Rosa Federico Piscione Gennaro galasso Stefano De Servi Stefano Savonitto Department of Medicine Surgery and DentistrySchola Medica SalemitanaUniversity of SalernoItaly IRCCS Multimedica Sesto San Giovanni(MI)Italy Cardiovascular Department Alessandro Manzoni HospitalLeccoItaly

With population ageing and rise of life expectancy,a progressively increasing proportion of patients presenting with an acute coronary syndrome(ACS)are older adults,including those at extreme chronological *** amounts of data,including randomized clinical trials,have shown that the benefits of an early revascularization are maintained also at very old age,resulting in improved outcome after an acute coronary *** the contrary,the optimal antiplatelet therapy(APT)remains unclear in these patients,because of both safety and efficacy ***,age-related multiple organ dysfunction and high prevalence of comorbidities may on the one hand reduce the therapeutic effects of administered drugs;on the other hand,it leads to increased vulnerability to drug toxicity and side ***,management of APT is particularly challenging in elderly patients because of higher risk of both ischemic and bleeding *** aim of the present paper is to review the current evidence,gaps in knowledge and ongoing research regarding APT in the setting of an ACS in elderly and very elderly patients,and in those with significant comorbidities including chronic kidney disease,diabetes mellitus and frailty.

关键词： Acute coronary syndrome Antiplatelet therapy The elderly

A Likert Scale-Based Model for Benchmarking Operational Capacity,Organizational Resilience,and Disaster Risk Reduction

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International Journal of Disaster Risk Science 2020年第3期11卷 404-409页

作者： Gianluca Pescaroli Omar Velazquez Irasema Alcántara-Ayala Carmine galasso Patty Kostkova David Alexander Institute for Risk and Disaster Reduction University College London(UCL)London WC1E 6BTUK Institute of Geography National Autonomous University of Mexico(UNAM)Mexico CityMexico Department of Civil Environmental and Geomatic EngineeringUniversity College London(UCL)London WC1E 6BTUK

Likert scales are a common methodological tool for data collection used in quantitative or mixed-method approaches in multiple *** are often employed in surveys or questionnaires,for benchmarking answers in the fields of disaster risk reduction,business continuity management,and organizational ***,both scholars and practitioners may lack a simple scale of reference to assure consistency across disciplinary *** article introduces a simple-to-use rating tool that can be used for benchmarking responses in questionnaires,for example,for assessing disaster risk reduction,gaps in operational capacity,and organizational *** aim,in particular,to support applications in contexts in which the target groups,due to cultural,social,or political reasons,may be unsuitable for in-depth analyses that use,for example,scales from 1 to 7 or from 1 to *** methodology is derived from the needs emerged in our recent fieldwork on interdisciplinary projects and from dialogue with the stakeholders *** output is a replicable scale from 0 to 3 presented in a table that includes category labels with qualitative attributes and descriptive equivalents to be used in the formulation of model *** include examples of levels of resilience,capacity,and *** are connected to other tools that could be used for in-depth *** advantage of our Likert scale-based response model is that it can be applied in a wide variety of disciplines,from social science to engineering.

关键词： Assessment Disaster risk reduction Interdisciplinary Likert scale Questionnaires Scales

Minimum platelet count threshold before invasive procedures in cirrhosis:Evolution of the guidelines

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 127-141页

作者： Marco Biolato Federica Vitale Tiziano galasso Antonio Gasbarrini Antonio Grieco Department of Medical and Surgical Sciences CEMADFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Internal Medicine Catholic University of Sacred HeartRome 00168Italy

Cirrhotic patients with severe thrombocytopenia are at increased risk of bleeding during invasive *** need for preprocedural prophylaxis aimed at reducing the risk of bleeding in cirrhotic patients with thrombocytopenia who undergo scheduled procedures is assessed via the platelet count;however,establishing a minimum threshold considered safe is challenging.A platelet count≥50000/μL is a frequent target,but levels vary by provider,procedure,and specific *** the years,this value has changed several times according to the different guidelines proposed in the *** to the latest guidelines,many procedures can be performed at any level of platelet count,which should not necessarily be checked before the *** this review,we aim to investigate and describe how the guidelines have evolved in recent years in the evaluation of the minimum platelet count threshold required to perform different invasive procedures,according to their bleeding risk.

关键词： Liver disease Thrombocytopenia Avatrombopag Lusutrombopag Transfusion

Breast cancer stem cells: The role of sex steroid receptors

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World Journal of Stem Cells 2019年第9期11卷 594-603页

作者： Pia Giovannelli Marzia Di Donato Giovanni galasso Erika Di Zazzo Nicola Medici Antonio Bilancio Antimo Migliaccio Gabriella Castoria Department of Precision Medicine University of Campania "L.Vanvitelli"

Breast cancer(BC)is the most common cancer among women,and current available therapies often have high success ***,BC might acquire drug resistance and sometimes *** knowledge about the most aggressive forms of BC points to the role of specific cells with stem properties located within BC,the so-called“BC stem cells”(BCSCs).The role of BCSCs in cancer formation,growth,invasiveness,therapy resistance and tumor recurrence is becoming increasingly *** growth and metastatic properties of BCSCs are regulated by different pathways,which are only partially *** steroid receptors(SSRs),which are involved in BC etiology and progression,promote BCSC proliferation,dedifferentiation and ***,in the literature,there is incomplete information about their ***,there are contrasting conclusions about the expression and role of the classical BC hormonal biomarkers,such as estrogen receptor alpha(ERα),together with scant,albeit promising information concerning ER beta(ERβ)and androgen receptor(AR)properties that control different transduction pathways in *** this review,we will discuss the role that SRs expressed in BCSCs play to BC progression and recurrence and how these findings have opened new therapeutic possibilities.

关键词： Breast cancer Steroids Sex steroid receptors Cancer stem cells Therapeutic implications