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An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats

Neural Regeneration Research 2014年第14期9卷 1351-1357页

作者： Ji Yeong Kim Woo Joo Jeon Dong Hwee Kim Im Joo Rhyu young Hwan Kim inchan youn Jong Woong Park Department of Orthopedic Surgery Seoul Paik HospitalInje UniversitySeoulKorea Department of Orthopedic Surgery Korea UniversitySeoulKorea Department of Physical Medicine & Rehabilitation KoreaUniversitySeoulKorea Department of Anatomy Korea UniversitySeoulKorea Biomedical Research Center Korea Institute of Science and TechnologySeoulKorea

Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with plateletrich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.

关键词： nerve regeneration peripheral nerve injury sciatic nerve platelet-rich plasma in-side-out vein autografi myelinated axons axon diameter myelin sheath thickness histology sciaticnerve index neural regeneration

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Surface plasmon excitation in semitransparent inverted polymer photovoltaic devices and their applications as label-free optical sensors

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Light(Science & Applications) 2014年第1期3卷 5-12页

作者： Byoungchoo Park Soo Hong Yun Chan youn Cho young Chan Kim Jung Chul Shin Hong Goo Jeon Yoon Ho Huh inchan Hwang Ku youn Baik young In Lee Han Sup Uhm Guang Sup Cho Eun Ha Choi Department of Electrical and Biological Physics Kwangwoon UniversitySeoul 139-701Republic of Korea Department of Electronic Materials Engineering Kwangwoon UniversitySeoul 139-701Republic of Korea

Herein,we report on surface plasmon(SP)-sensitive semitransparent inverted polymer photovoltaic(PV)devices that are based on multilayered material systems consisting of poly(3-hexylthiophene):fullerene-derivative bulk-heterojunction PV layers and thin gold or silver *** demonstrate that these PV devices allow the simultaneous generation of both electrical power and SPs on their anodes for photoexcitation just above the optical absorption edge of the PV layers,resulting not only in attenuated total reflection,but also in attenuated photocurrent generation(APG)under the SP resonance(SPR)***,we also confirm that the biomolecular interaction of biotin–streptavidin on the PV devices can be precisely detected via apparent SPR angle shifts in the APG spectra,even without the need for complex attenuated total reflection *** highlight our view that APG measurements made using these PV devices show great potential for the development of future generations of compact and highly sensitive SPR-based optical sensors.

关键词： attenuated total reflection optical sensors photocurrent generation polymer photovoltaic devices surface plasmon

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