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Nitinol Stenting in Post-Traumatic Pseudo-Aneurysm of Internal Carotid Artery

Open Journal of Modern Neurosurgery 2012年第3期2卷 45-49页

作者： Or Cohen-inbar Yaaqov Amsalem Jean F. Soustiel 1Department of Neurosurgery Rambam Health Care Campus Technion Israel Institute of Technology Haifa Israel Department of Neurosurgery Rambam Health Care Campus Technion Israel Institute of Technology Haifa Israel Interventional Neuroradiology Unit Rambam Health Care Campus Haifa Israel

Background: A pseudoaneurysm of the internal carotid artery (ICA) at its cervicl part, is a rare and often lethal com-plication after cervical trauma. The treatment of choice is anticoagulation. Patients with a contraindication for anticoagulation or those who do not improve with standard treatment, warrant either a surgical repair or stent *** placement posses both short and long term risks such as immediate ischemic events, in-stent stenosis and stent breakage, thus the choice of stent type is critical. Advances in stent technology have made cervical stent placement a viable option. We report our experience with the LEO + (Balt Extrusion, Montmorency, France) nitinol flexible self expanding stent for post-traumatic ICA aneurysms. Methods: 5 patients suffering a post-traumatic cervical ICA pseudo-aneurysms refractory to standard treatment were treated with nitinol braided flexible self expanding stent. This stent has a shape memory and superelasticity virtues making it suitable. Diagnosis was made with CT angiography and confirmed by catheter angiography. All procedures were preformed under local anesthesia. Time between trauma and treatment ranged six days to over five years. Follow-up was performed by CT angiography or conventional angiography. Results: Five patients, having eight aneurysms were treated using 12 stents. In all cases, appropriate stent placement was achieved. No immediate or late complications, as well as no neurological sequele reported at 6 months. Radiological follow-up exams demonstrated complete pseudoaneurysm closure. Conclusion: Stent placement can be a safe and definitive treatment option for patients to conventional medical treatment.

关键词： Interventional Neuroradiology Angioplasty Stenting Nitinol Stent

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Ciliated hepatic foregut cyst with high intra-cystic carbohydrate antigen 19-9 level

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World Journal of Gastroenterology 2014年第43期20卷 16355-16358页

作者： Ziv Ben Ari Oranit Cohen-Ezra Jonathan Weidenfeld Tania Bradichevsky Ella Weitzman Uri Rimon Yael inbar Michal Amitai Barak Bar-Zachai Roni Eshkenazy Arie Ariche Daniel Azoulay Liver Disease Center Sheba Medical Center and Sackler School of MedicineTel Aviv University52621 Tel AvivIsrael Department of Pathology Sheba Medical Center and Sackler School of MedicineTel Aviv University52621 Tel AvivIsrael Department of Radiology Sheba Medical Center and Sackler School of MedicineTel Aviv University52621 Tel AvivIsrael Depatrment of Hepatobiliary Surgery Sheba Medical Center and Sackler School of MedicineTel Aviv University52621 Tel AvivIsrael

A ciliated hepatic foregut cyst (CHFC) is a rare foregut developmental malformation usually diagnosed in adulthood. Five percent of reported cases of CHFC transform into squamous cell carcinoma. We report the presentation, evaluation, and surgical management of a symptomatic 45-year-old male found to have a 6.2 cm CHFC. Contrast tomography-guided fine-needle aspiration demonstrated columnar, ciliated epithelium consistent with the histologic diagnosis of CHFC. The intracystic levels of carbohydrate antigen (CA) 19-9 and carcinoembryonic antigen (CEA) were extremely high (978118 U/mL and 973 μg/L, respectively). Histologically, the wall of the cyst showed characteristic pseudopapillae lined with a ciliated stratified columnar epithelium, underlying smooth muscle, an outer fibrous layer and no atypia. Immunohistochemistry for CA19-9 and CEA was positive. This is the first case report of a CHFC in which levels of CA 19-9 and CEA were measured. Our findings suggest that a large sized multilocular cyst and elevated cyst CA19-9 and CEA levels do not exclude a CHFC from consideration in the diagnosis. CHFCs should be included in the differential diagnosis of hepatic lesions. Accurate diagnosis of a CHFC is necessary given its potential for malignant transformation, and surgical excision is recommended.

关键词： Ciliated hepatic foregut cyst Carbohydrate antigen 19-9 Carcinoembryonic antigen Computed tomography-guided fine-needle aspiration Magnetic resonance imaging Squamous cell carcinoma

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A Novel Facial Cream Based on Skin Penetrable Hemp Oil Microparticles

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 165-178页

作者： Rachel Lubart inbar Yariv Dror Fixler Ayelet Rothstein Arie Gruzman Anat Lipovsky Department of Chemistry Bar Ilan University Ramat-Gan Israel Physics Department of Faculty of Exact Sciences Bar Ilan University Ramat-Gan Israel Faculty of Engineering Bar Ilan University Ramat-Gan Israel Institute of Nanotechnology and Advanced Materials Bar-Ilan University Ramat-Gan Israel Hava Zingboim Ltd. Ramat-Gan Israel

Objective: Hemp seed oil is perfect for most skin types;it moisturizes skin and protects it from inflammation, oxidation, and other causes of aging. The problem is that the Hemp oil-based products do not penetrate the skin;they remain on the skin’s surface. Recently researchers have been trying to prepare nano emulsions of hemp oil to facilitate its permeation to deep skin layers. In all techniques used today, surfactants are added to the emulsification process. These surfactants may cause unwanted skin side effects. In the present study, we prepare micronized Hemp (m-Hemp) without using any surfactants in the micronization process, thus avoiding the side effects associated with surfactant addition. Methods & Results: Particles size of m-Hemp was evaluated using electron microscopy. Various sizes of m-Hemp were found, the smallest being 100 nm in diameter. The antioxidation properties of m-Hemp were measured using the Electron Spin Resonance (ESR) technique and were found to be enhanced. Skin topography and morphology following a cream containing m-Hemp treatment were visualized by Optical Profilometry and ESEM respectively. The results show a marked improvement in skin topography in all measured parameters. In addition, human keratinocytes (HaCaT) were exposed to inflammatory conditions and were then treated using Hemp. As a result, one of the key inflammatory factors (IL-2) was significantly reduced after treatment with m-Hemp (p ≤ 0.0001). The skin penetration of the cream containing m-Hemp was tested on human skin using the IMOPE (Iterative Multi-plane Optical Property Extraction) system. The results indicate that m-Hemp penetrates both the stratum corneum and the deep epidermal layers towards the dermis. Conclusion: The new cream prepared with micronized Hemp shows significant anti-inflammatory and antioxidative effects and demonstrates the entrance of m-Hemp to the skin epidermal layer.

关键词： Hemp Microparticles Anti-Inflammatory Antioxidant Skin Penetration

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国际竹藤组织与联合国工业发展组织签署合作协议

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世界竹藤通讯 2021年第5期19卷 93-94页

作者： inbar inbar

(inbar网站新闻10月29日消息)2021年10月28日,国际竹藤组织与联合国工业发展组织签署合作伙伴关系协议,并举行线上签字仪式。国际竹藤组织董事会联合主席江泽慧、国际竹藤组织总干事穆秋姆,联合国工业发展组织总干事李勇出席签字仪式并... 详细信息

(inbar网站新闻10月29日消息)2021年10月28日,国际竹藤组织与联合国工业发展组织签署合作伙伴关系协议,并举行线上签字仪式。国际竹藤组织董事会联合主席江泽慧、国际竹藤组织总干事穆秋姆,联合国工业发展组织总干事李勇出席签字仪式并致辞。江泽慧说,国际竹藤组织和联合国工业发展组织有着坚实的合作基础,感谢联合国工业发展组织长期以来支持国际竹藤组织及全球竹藤事业发展。

关键词：国际竹藤组织联合国工业发展组织江泽慧董事会伙伴关系协议网站新闻竹藤签字仪式

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锡达玛竹屋埃塞俄比亚古老的人居符号

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生态文明世界 2019年第2期 64-73,7页

作者：李智勇(文/摄影) inbar(图) 不详

埃塞俄比亚是人类的重要起源地,人类祖母露西(Lucy)的故乡,也是非洲竹林资源分布最丰富的国家之一,如今已成为风靡全球的咖啡原产地。据国际竹藤组织(inbar)董事会现任董事、前埃塞俄比亚农业部国务部长盖塔宏先生介绍.

关键词：亚的斯亚贝巴竹建筑埃塞俄比亚高地竹

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Cisplatin-Induced Posterior Reversible Encephalopathy Syndrome—Brief Report and Review of the Literature

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Journal of Behavioral and Brain Science 2012年第1期2卷 97-101页

作者： Limor Amit Irit Ben-Aharon Thomas Tichler Edna inbar Aaron Sulkes Salomon M. Stemmer Department of Radiology Rabin Medical Center Beilinson Campus Petah-Tiqva Israel Institute of Oncology Davidoff Center Rabin Medical Center Beilinson Campus Petah-Tiqva Israel The Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

Cisplatin is one of the most broadly used chemotherapeutic agents. Several central nervous system toxicities have been attributed to this agent, among which is a rare clinicoradiological condition referred to as posterior reversible leukoen-cephalopathy syndrome (PRES) or reversible posterior leukoencephalopathy syndrome (RPLS). PRES is characterized by subacute onset of headache, visual disturbances, confusion, seizures and rarely, coma. This usually reversible syn-drome was associated in the past mainly with hypertension. Several reports have associated the syndrome with several immunosuppressive and chemotherapeutic agents suggesting a disruption of the blood brain barrier due to direct damage to the endothelium and vasogenic edema. This syndrome is readily diagnosed with Computed Tomography (CT) or Magnetic resonance imaging (MRI) studies and quick withdrawal of the causative agent in conjunction with supportive care including rapid hypertension control and reduction of elevated intracranial pressure when needed, usually reverse the neurological symptoms with minimal or even no sequela within several days. In this brief report and review of the literature we describe two cases of PRES in two female patients that occurred a few days after receiving Cisplatin-based chemotherapy. We discuss the clinical presentation, diagnosis and treatment of this syndrome by reviewing the literature. The escalating number of clinical reports of PRES merit further studies of the mechanism of toxicity, appropriate treatment and awareness of physicians to this life threatening

关键词： PRES RPLS Encephalopathy Cisplatin Hypertension

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The Impact of Cane Supply on Rattan Trade in China

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Chinese Forestry Science and Technology 2003年第2期2卷 79-85页

作者： WU Junqi CHEN XuheInternational Network for Bamboo and Rattan (inbar). PO Box 100101-80Beijing 100101. P.R.China

Rattan-related products from China are popular and well known in international market, but China is facing shortage of rattan cane supply, and extinction of some rattan species. The big gap between demand and supply of rattan canes in China market is urgent to be bridged. This paper makes a brief introduction on rattan in the world and analyzes the rattan trade in China. The loss of habitats, overexploitation and inadequate replenishment of rattan result in a depleting resource and there are many challe...

关键词： rattan trade rattan canes

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Further Insights on the <i>Datura innoxia</i>Hyoscyamine 6<i>β</i>-Hydroxylase (DiH6H) Based on Biochemical Characterization and Molecular Modeling

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American Journal of Plant Sciences 2021年第1期12卷 53-70页

作者： Daniel Schlesinger Faris Salama Rachel Davidovich Rikanati Rotem Sertchook Ofir Tal Mosaab Yahyaa Adi Faigenboim Mwafaq Ibdah Moshe inbar Efraim Lewinsohn Department of Evolutionary & Environmental Biology University of Haifa Haifa Israel Department of Vegetable Crops Newe Ya’ar Research Center Agricultural Research Organization Ramat Yishay Israel Institute of Plant Sciences Agriculture Research Organization RishonLe Zion Israel Lilienblum 3 Gedera Israel Department of Vegetable Crops The Robert Smith Faculty of Agriculture The Hebrew University of Jerusalem Rehovot Israel

Hyoscyamine, anisodamine and scopolamine are tropane alkaloids present in some Solanaceae species and used in modern medicine. L-Hyoscyamine is hydroxylated to 6β-hydroxyhyoscyamine (anisodamine) and then epoxidated to scopolamine by the dual action of hyoscyamine 6β-hydroxylase (H6H), a 2-oxoglutarate dependent dioxygenase. A natural mutation in the Gly-220 residue to Cys was previously shown to be associated with the loss of function of H6H in Mandragora officinarum, preventing the accumulation of anisodamine and scopolamine in these plants. We show here that a deliberate Gly220Cys mutation in the Datura innoxia DiH6H protein caused a loss of both its enzymatic abilities and rendered it unable to hydroxylate L-hyoscyamine into anisodamine and to epoxidate anisodamine into scopolamine. By using protein modeling based on an available crystal structure of H6H from Datura metel, we show how the Cys220 residue causes a steric interference in the active site cavity impairing the interaction of both substrates, hyoscyamine and anisodamine with the active site of the protein. We also address the enantiomeric preference of DiH6H based on molecular modeling.

关键词： Hyoscyamine 6β Hydroxylase Datura innoxia. Mill. Solanaceae Scopolamine Hyoscyamine

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