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建筑实践 2012年第1期 62-63页

作者：张游 Valérie Tholl les m/Design Studio

les m已经为Pompidou-metz中心的儿童工作坊设计出了一个柔软鲜艳的世界,一种"巨大的"、柔软而温暖的"枕头",也可以说是充满了房间的五颜六色的安全城堡。将一些简单的垫子放在一个游戏区或小屋里,这个柔软的结构化的环

关键词：枕头 Design 房间工作坊儿童 Studio

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采用数字图像分析评估银屑病的炎症浸润程度

世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 32-33页

作者： Goedkoop A.Y De rie m.A Teunissen m.B.m 李政霄 Department of Dermatology Academic Medical Center University of Amsterdam P.O. Box 22660 1100 DDAmsterdam Netherlands

Traditionally the evaluation of the cellular infiltrate and protein expression in skin tissue sections is done by manual quantification. However, for reliable evaluation of histology in the development of new anti-psoriatic treatments there is a need for a more time-efficient and reproducible method. To test the use of digital image analysis (DIA) in this situation we compared the assessment of immunohistochemically stained skin sections with themore traditionalmanual quantification (mQ) and semiquantitative analysis (SQA). The number of CD3+T cells and the expression of E-selectin were evaluated in stained paired skin biopsie s from 11 patients with chronic plaque psoriasis before and after initiation of anti-psoriasis therapy. We observed significant correlations between mQ and DIA for the number of T cells (epiderm is: r=0.88, P ≤0.01, dermis r=0.87, P ≤0.01). Both DIA and mQ were equally eff ective in detecting reductions of T-cell numbers in active-treated patients. m Q took 20 h, compared to 6 h for *** also observed significant correlations b etween SQA and DIA for the expression of E-selectin (r=0.88, P ≤0.01), althoug h DIA was more sensitive than SQA to detect (early) changes. SQA took 10 h, comp ared to 4 h for DIA. In conclusion, the quantification of the inflammatory infil trate in psoriatic lesional skin by DIA generated similar results as mQ and SQA in a reliable, reproducible and higher time efficient fashion.

关键词：银屑病炎症浸润数字图像分析内皮细胞选择素活检标本组织切片重复操作半定量分析

Differential sumolation of the two major PmL sumolation sites by SUmO-1 and SUmO-2

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Differential sumolation of the two major PML sumolation site...

Prevalence and Study of the Clonality of Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Strains in Neonatology at the University Hospitals of Abidjan by the Pulsed Field Gel Electrophoresis and the Quantitative Antibiogram

第二届全国“跨学科蛋白质研究”学术讨论会

作者：雷鸣 Valérie LALlemAND-BREITENBACH marco TRAmIER matéCOPPEY Hugues de TH CNRS UPR 9051 Laboratoire associé N°11 du comité de Paris de la ligue contre le canceraffilié àl’université Paris Ⅶ.Höpital St.Louis 1 av.C.Vellefaux 75475 PARIS CEDEX 10 France Institut JACQUES mONOD I’université Paris Ⅶ CNRS UPR 9051 Laboratoire associé N°11 du comité de Paris de la ligue contre le canceraffilié à l’université Paris Ⅶ.Höpital St.Louis 1 av.C.Vellefaux 75475 PARIS CEDEX 10 France

PmL is the organizer of PmL Nuclear Bodies (NBs) and recruits onto these sub-nuclear structures a striking variety of very diverse proteins,several of which are implicated in *** may be conjugated bythe small-ubiquitin-like proteins SUmO-1/2/3 and PmL conjugation is required for the recruitment of the other NB-associated *** targets 3 specific lysine residues:K65 within the RING finger,K490 within the nuclear localization signal and K160 in the B box. Conjugation of K160 is greatly enhanced by AsO,controls recruitment of partner proteins,including the 11S proteasome complex,and is required for AsO-induced PmL ***,we show that SUmO-1,but not SUmO- 2,triggers the nuclear import of *** addition,PmL colocalised with SUmO-1 only in the nucleus,while SUmO-2 colocalisation was also observed in the ***,K160 was preferentially modified by SUmO-2,the K490 site only enabled colocalization with *** experiments show that AsO predominantly induces SUmO-2 modification of PmL PmL sumolation is induced in S phase,but abrogated in m and,accordingly,AsO-induced PmL sumolation was impeded in ***,differential modifications by SUmO-1 and SUmO-2/3 of the PmL sumolation sites K490 and K160 modulate properties of PmL,including its nucleo/cytoplasmic localisation.

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Advances in microbiology 2024年第9期14卷 416-429页

作者： Valérie m’Bengue Gbonon Sidjè Arlette Afran Stanislas Assohoun Egomli Djeda Franck Arnaud Gnahoré Aboubakar Sylla N’Golo David Coulibaly Nathalie Guessennd Assanvo Simon-Pierre N’Guetta mireille Dosso Antibiotics Natural Substances and Anti-Infectious Resistance Surveillance Unit Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire molecular Genetics Platform Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Genetics and Species Improvement Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire mechanics and Computer Sciences Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire Biology and Health Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire molecular Biology Platform Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire

Background: ESBL-producing strains of Klebsiella pneumoniae, one of the main causes of nosocomial and hospital-acquired infections, are commonly associated with therapeutic impasses. Surveillance of these multidrug-resistant pathogens is a crucial tool for controlling and preventing infections. This surveillance involves the use of appropriate molecular and phenotypic typing techniques. The choice of techniques is based on criteria such as discriminatory power, intra- and inter-laboratory reproducibility, epidemiological concordance, ease of use and cost. The aim of our study was to identify clusters of Extended-Spectrum Beta-Lactamase-producing Klebsiella pneumoniae (ESBL-K. pneumoniae) strains circulating in neonatology using quantitative antibiogram (QA) and Pulsed Field Gel Electrophoresis (PFGE). materials and methods: This cross-sectional study included 55 K. pneumoniae strains isolated from a total of 513 samples. These various samples are taken from newborns, healthcare personnel, and the environment. K. pneumoniae identification followed standard bacteriological procedures and was confirmed using the Vitek® 2 (biom.rieux). The detection of the ESBL phenotype was performed using the synergy test. QA and PFGE were used to identify clonal relationships between the various strains isolated. Concordance between these two methods was assessed by calculating Cohen’s KAPPA coefficient and Simpson’s diversity index. Results: Among the 55 K. pneumoniae strains included in this study, 58.2% (32/55) were found to be Extended-Spectrum Beta-Lactamase (ESBL) producers. most of these strains were isolated from neonatal samples (blood samples and rectal swabs). The quantitative antibiogram method applied to 28 out of the 32 ESBL-producing strains revealed that the isolates were grouped into 5 clusters. Pulsed Field Gel Electrophoresis performed on a total of 16 ESBL-producing strains showed the existence of four profiles. A perfect concordance was observed between the two m

关键词： Resistance-Clone-Klebsiella pneumoniae-Pulsed Field Gel Electrophoresis-Quantitative Antibiogram

Ferroelectric solid solutions with perovskite- and columbite-type components: From structures formation to domain and hysteresis phenomena

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Journal of Advanced Dielectrics 2023年第2期13卷 13-23页

作者： m.O.moysa V.Yu.Topolov K.P.Andryushin A.V.Nagaenko L.A.Shilkina m.V.Il’ina O.I.Soboleva S.Sahoo L.A.Reznichenko Research Institute of Physics Southern Federal University194 Stachki Avenue Rostov-on-Don 344090Russia Department of Physics Southern Federal University5 Zorge Street Rostov-on-Don 344090Russia Institute of High Technologies and Piezotechnics Southern Federal University 10 Milchakov StreetRostov-on-Don 344090Russia Institute of Nanotechnologies Electronics and Equipment Engineering Southern Federal UniversityTaganrog 347922Russia Research Laboratory of Functional Nanomaterials Technology Southern Federal University Taganrog 347922Russia

The paper reports results on the complex study on ferroelectric ceramics that represent solid solutions containing components with a perovskite-type or columbite-type *** solutions of a three-component(1−x−y)NaNbO_(3)−xKNbO_(3)−yCdNb_(2)O_(6) system are manufactured at x=0.05-0.20 and y=*** structures in ceramic grains are *** consistency between experimental and calculated results is examined for coexisting phases split into non-180°domains(mechanical twins)in the solid solution with x=0.15.A correlation between the internal structure(crystal,domain,granular,and defect)and fundamental electromechanical and polarization properties is stated for the studied three-component solid solutions.

关键词： Ferroelectric materials KNN elastic matching crystal structure domain structure electrophysical properties.

Comparative Study of Gut microbiota in Breast Cancer Patients versus Controls in Abidjan, Côte d’Ivoire

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Advances in microbiology 2024年第9期14卷 405-415页

作者： m’Bengue Gbonon Valérie Gnahore Djeda Franck Kouadio Kouamé Assohoun Stanislas Coulibaly Safiatou Diplo Flore Bernadette Sekongo mamadou Osseni Akandji Afran Sidje Arlette N’Guessan Jean-David Dosso mireille molecular Genetics Platform Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Laboratory of Biology and Health UFR Biosciences Flix Houphout Boigny University Abidjan Cte dIvoire Department of Environment and Health Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Bioinformatics & Computational Biology Group National Computing Center of Cte dIvoire Flix Houphout Boigny University Bingerville Cte dIvoire National Blood Transfusion Center Abidjan Cte dIvoire Oncology Department Treichville University Hospital Abidjan Cte dIvoire

Context: The gut microbiota represents a complex ecosystem encompassing all unicellular microorganisms residing in the digestive tract, primarily bacteria, fungi, archaea, and even viruses. The relationship between the host and the microbiota is symbiotic: bacteria benefit from a stable environment, while the host gains numerous capabilities in terms of digestion, metabolism, nutrition, and immunity. However, numerous studies suggest that the gut microbiota plays a crucial role in various non-communicable diseases, including obesity, chronic inflammatory bowel diseases, allergic and immune disorders, behavioral disorders, and even certain cancers. The objective of our study was to characterize the gut microbiota of a group of breast cancer patients by comparing it to that of control subjects in Côte d’Ivoire, using a metagenomic approach. method: A case-control study was conducted from may 2020 to September 2023. A total of 85 women (39 cases and 46 controls) were recruited, and stool samples were collected from both breast cancer patients and healthy women. Among these, ten (10) samples from patients and ten (10) samples from healthy women were randomly selected for the study of the gut microbiota. The gut microbiota was characterized by sequencing the V4 region of 16S rRNA using metagenomic NGS technology, and bioinformatic analysis was performed using the mothur pipeline. Results: In women with breast cancer, we observed a reduction in the relative abundance of the phyla Firmicutes and Bacteroidetes, as well as an increase in the phyla Actinobacteria and Verrucomicrobia. Additionally, their microbiota exhibited lower Chao1 and Sobs diversities compared to the control women (p molecular variance analysis (AmOVA) revealed a significant difference between the case and control groups (p major phyla within the gut microbiota of cases compared to healthy controls. It wil

关键词： Gut microbiota 16S metagenomic Sequencing Breast Cancer Dysbiosis

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评价导致斯洛文尼亚宫颈癌发病率升高的原因

世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 30-31页

作者： Smrkolj S. Rakar S. mo■ina A Er■en m. 赵巍 Unit of Gynecologic Pathology Dept. of Obstetrics and Gynecology Univ. Med. Ctr. Ljubljana S. Ljubljana Slovenia

Objective: In Slovenia the opportunistic cervical cancer (CC)screening programme has been performed within the regular gynaecological practice since 1960. The incidence rate 28.8/105 decreased to 16.1/105 in 1982, and increased to 23/105 in 1996. To explain the increased CC incidence the patientsscreening histories, occurrence of symptoms, and details of preventive measures were studied on the basis of medical records and questionnaire. Errors of cytological screening were analysed by reviewing previous smears. material: The answers obtained from 324 women, treated for CC in the period 1995-2000, were analysed in relation to age, stage and histology. The mean womens age was 46.76 ±13.07 (S.D.) years (range 23-85 years). After therapy, 271 patients were followedup by the end of January 2004, (mean followup time 80.3 ±20 S.D. months, range 29.7-110.3 months). Statistical analysis was performed using Chisquare test. Results: In 208 (80%) cases, CC was detected in stage 1, in 43 (17%) in stages 2A to 3B. Squamouscell carcinoma (192, 74.1%) was followed by adenocarcinoma (61, 23.5%) and (5, 1.9%) other malignancies. The screening interval ranged from 6 months to 4 years. Statistically significant differences existed between clinical and screening variables. CC was diagnosed in higher stages in women who were ignorant of the Pap test. Rescreened smears (n=126) showed 27.8%of false negative results. Conclusions: The reasons for high incidence of CC are poor performance of cytological screening, failures in gynecological examinations and diagnostic procedures, and the patientsnegligence of attending regular screening.

关键词：宫颈癌发病率细胞学筛查妇科查体检查和假阴性率恶性瘤鳞状细胞癌统计学显著性筛检预防措施

Conceptual design of irradiation device for silicon neutron transmutation doping around Es-Salam research reactor

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Nuclear Science and Techniques 2020年第4期31卷 69-78页

作者： m.Salhi B.mohammedi S.Laouar m.Dougdag m.Touiza m.Abbaci m.moughari Centre de Recherche Nucle′aire de Birine 17200 Ain OusseraAlgeria Institut Alge′rien de formation en Ge′nie Nucle′aire 16050 DrariaAlgerAlge′rie

Silicon neutron transmutation doping remains one of the most viable nuclear applications for research *** this kind of product involves an irradiation method capable of fulfilling the quality requirements of doping and alleviating the challenges related to the design and safety of the irradiation *** this paper,we propose an irradiation device prototype for neutron transmutation doping of silicon ingots with diameters of 2 to 3 *** on the Es-Salam research *** thermal hydraulic analysis of the proposed irradiation device was performed to determine the optimum conditions for *** effect of the mechanical vibrations induced by the circulation of coolant in the device was quantified via experimental measurements under different flow *** results show that the maximum temperature reached by the silicon ingots is below the temperature limit,effectively validating the design of the irradiation *** investigations are prospected to further optimize the design and the irradiation *** irradiation of silicon ingots with a large diameter will be considered.

关键词： Irradiation device prototype Es-Salam research reactor NTD-Si Irradiation temperature CFD method

Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C

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World Journal of Gastroenterology 2012年第41期18卷 5879-5888页

作者： Akihito Tsubota Noritomo Shimada Hiroshi Abe Kai Yoshizawa rie Agata Yoko Yumoto makiko Ika Yoshihisa Namiki Keisuke Nagatsuma Hiroshi matsudaira Kiyotaka Fujise Norio Tada Yoshio Aizawa Institute of Clinical medicine and Research The Jikei University School of Medicine163-1 Kashiwa-shitaKashiwaChiba 277-8567Japan Division of Gastroenterology and Hepatology Kashiwa HospitalThe Jikei University School of Medicine163-1 Kashiwa-shitaKashiwaChiba 277-8567Japan Department of Gastroenterology Shinmatsudo Central General Hospital1-380 ShinmatsudoMatsudoChiba 270-0034Japan Division of Gastroenterology and Hepatology Katsushika Medical CenterThe Jikei University School of Medicine6-41-2 AotoKatsushika-kuTokyo 125-8506Japan

AIm： To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon plus ribavirin for chronic hepatitis C. mETHODS： Five hundred and sixty-one Japanese patients with hepatitis C virus genotype lb who had received combination treatment were enrolled and as- signed randomly to the derivation and confirmatory groups. Single nucleotide polymorphisms at or nearby ITPA were genotyped by real-time detection poly- merase chain reaction. Factors influencing significant anemia （hemoglobin concentration 〈 10.0 g/dL at week 4 of treatment） and significant hemoglobin decline （declining concentrations 〉 3.0 g/dL at week 4） were analyzed using multiple regression analyses. Prediction formulae were constructed by significantly independent factors. RESULTS： multivariate analysis for the derivation group identified four independent factors associated with significant hemoglobin decline： hemoglobin decline at week 2 [P = 3.29× 10^4, odds ratio （OR） = 7.54 （g/dL）], estimated glomerular filtration rate [P = 2.16× 10^4, OR = 0.962 （ml/min/1.73 m2）], rs1127354 （P = 5.75 × 10^4, OR = 10.94） and baseline hemoglobin [P = 7.86 × 10^4, OR = 1.50 （g/alL）]. Using the model constructed by these factors, positive and negative predictive values and predictive accuracy were 79.8%, 88.8% and 86.2%, respectively. For the confirmatory group, they were 83.3%, 91.0% and 88.3%. These factors were closely correlated with significant anemia. However, the model could not be constructed, because no patients with rs1127354 minor genotype CA/AA had significant anemia. CONCLUSION： Reliable formulae for predicting the likelihood of ribavirin-induced anemia were constructed. Such modeling may be useful in developing individual tailoring and optimization of ribavirin dosage.

关键词： Chronic hepatitis C virus infection Ribavi-rin Pegylated interferon Prediction model Hemolyticanemia Single nucleotide polymorphism

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漂浮在城市上空

现代装饰（家居） 2011年第11期 32-43页

作者： Greg Truen ina Fourie Adam Court Dook 肖俊 OKHA Interiors SAOTA-Stefan Antoni Olmesdahl Truen Architects

项目地址南非约翰内斯堡项目面积1000m^2Sandhurst Towers是位于南非约翰内斯堡桑顿的一处三层的顶楼公寓。公寓展现了21世纪城市生活的演变,表达了其独有的个性并体现了智能家居技术的发展,例如为此量身定制的照明设备以及自动化操作... 详细信息

项目地址南非约翰内斯堡项目面积1000m^2Sandhurst Towers是位于南非约翰内斯堡桑顿的一处三层的顶楼公寓。公寓展现了21世纪城市生活的演变,表达了其独有的个性并体现了智能家居技术的发展,例如为此量身定制的照明设备以及自动化操作系统等。"在我们计划将多种视觉概念呈递给业主之前,我们花费了大量时间讨论业主的生活运作模式;他们对于各种家居功能的需求;

关键词：项目地址智能家居项目面积照明设备居住需求世纪城市室内设计师自动化操作自然纹理异域风