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Tree-Based Index Overlay in Hybrid Peer-to-Peer Systems

Journal of Computer Science & Technology 2010年第2期25卷 313-329页

作者： insung kang SungJin Choi Member, IEEE SoonYoung Jung SangKeun Lee Computer Science and Engineering Department Korea University Seoul 136-713 Korea Corporate Center KT (Korea Telecom) Seoul 137-792 Korea Computer Science Education Department Korea University Seoul 136-701 Korea

Hybrid Peer-to-Peer （P2P） systems that construct overlay networks structured among superpeers have great potential in that they can give the benefits such as scalability, search speed and network traffic, taking advantages of superpeer-based and the structured P2P systems. In this article, we enhance keyword search in hybrid P2P systems by constructing a tree-based index overlay among directory nodes that maintain indices, according to the load and popularity of a keyword. The mathematical analysis shows that the keyword search based on semi-structured P2P overlay can improve the search performance, reducing the message traffic and maintenance costs.

关键词： tree-based index overlay keyword search fault-tolerance performance

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Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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Nano Research 2018年第5期11卷 2532-2543页

作者： Seong-Min Kim Seyeong Lee Dongyoon Kim Dong-Hee kang Kisuk Yang Seung-Woo Cho Jin Seok Lee insung S. Choi Kyungtae kang Myung-Han Yoon School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 61005 Republic of Korea Department of Biotechnology Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea Department of Chemistry Sookmyung Women's University Seoul 04310 Republic of Korea Center for Cell-Encapsulation Research Department of Chemistry KAIST Daejeon 34141 Republic of Korea Department of Applied Chemistry Kyung Hee University Yongin Gyeonggi 17104 Republic of Korea

In this study, we report that height-controlled vertically etched silicon nano- column arrays （vSNAs） induce strong growth cone-to-substrate coupling and accelerate in vitro neurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography- induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.

关键词： vertical silicon nanostructures metal-assisted chemical etching primary hippocampal neurons neurite outgrowth cytoskeletal dynamics

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