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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F u Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' uTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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Correction of failure in antenna array using matrix pencil technique

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Chinese Physics B 2017年第6期26卷 491-498页

作者： S u khan M k A Rahim Advanced RF & Microwave Research Group Department of Communication Engineering Faculty of Electrical Engineering Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia

In this paper a non-iterative technique is developed for the correction of faulty antenna array based on matrix pencil technique（MPT）. The failure of a sensor in antenna array can damage the radiation power pattern in terms of sidelobes level and nulls. In the developed technique, the radiation pattern of the array is sampled to form discrete power pattern information set. Then this information set can be arranged in the form of Hankel matrix（HM） and execute the sin.ular value decomposition（SVD）. By removing nonprincipal values, we obtain an optimum lower rank estimation of HM. This lower rank matrix corresponds to the corrected pattern. Then the proposed technique is employed to recover the weight excitation and position allocations from the estimated matrix. Numerical simulations confirm the efficiency of the proposed technique, which is compared with the available techniques in terms of sidelobes level and nulls.

关键词： array correction low rank estimation matrix pencil technique sin.ular value decomposition

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Synthesis of Nano-sized Barium Titanate Powder by Solid-state Reaction between Barium Carbonate and Titania

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Journal of Materials Science & Technology 2007年第5期23卷 655-658页

作者： u.Manzoor D.k.kim Department of Physics COMSATS Institute of Information TechnologyIslamabadPakistan Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonKorea

Size control of BaTiO3 in solid-state reaction between BaCO3 and TiO2 was demonstrated by varying the size of TiO2 and milling conditions of BaCO3. The smaller TiO2 particles had higher surface area, resulting in faster initial reaction. The mechanically milled BaCO3 particles accelerated the diffusion process and decreased the calcinations temperature. It can be deduced from the results that the size control is possible and nano-sized BaTiO3 particles with about 60 nm can be synthesized by using the conventional solid-state reaction between BaCO3 and TiO2.

关键词： Barium tltanate Mechanical milling Solid-state reaction Nano particles

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Saddle Point Criteria in Nonsmooth Semi-Infinite Minimax Fractional Programming Problems

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Journal of Systems Science & Complexity 2018年第2期31卷 446-462页

作者： MISHRA S k SINGH Yadvendra VERMA R u Department of Mathematics Banaras Hindu University Varanasi-221005 India. Department of Mathematics Texas State University USA

This paper considers a nonsmooth semi-infinite minimax fractional programming problem（SIMFP） involving locally Lipschitz invex functions. The authors establish necessary optimality conditions for SIMFP. The authors establish the relationship between an optimal solution of SIMFP and saddle point of scalar Lagrange function for SIMFP. Further, the authors study saddle point criteria of a vector Lagrange function defined for SIMFP.

关键词： Generalized convexity Lagrange function nonsmooth programming problems saddlepoint semi-infinite minimax fractional programming problems.

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Hybrid Active Contour Mammographic Mass Segmentation and Classification

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Computer Systems Science & Engineering 2022年第3期40卷 823-834页

作者： k.Yuvaraj u.S.Ragupathy Department of Electronics and Instrumentation Engineering Kongu Engineering College PerunduraiErode638060India

This research implements a novel segmentation of mammographic *** methods are proposed,namely,segmentation of mass based on iterative active contour,automatic region growing,and fully automatic mask selectionbased active contour *** the first method,iterative threshold is performed for manual cropped preprocessed image,and active contour is applied *** overcome manual cropping in the second method,an automatic seed selection followed by region growing is *** that the result is only a few images owing to over segmentation,the third method uses a fully automatic active *** of the segmentation techniques are compared with the manual markup by experts,specifically by taking the difference in their mean ***,the difference in the mean value of the third method is 1.0853,which indicates the closeness of the ***,the proposed method is compared with the existing fuzzy C means and level set *** automatic mass segmentation based on active contour technique results in segmentation with high *** using adaptive neuro fuzzy inference system,classification is done and results in a sensitivity of 94.73%,accuracy of 93.93%,and Mathew’s correlation coefficient(MCC)of 0.876.

关键词： Feature optimization hybrid active contour segmentation mass classification mass feature extraction medical image analysis

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Thermal Properties of Ni–Cr–Si–B–Fe Based Interlayer Material and Its Application in TLP Bonding of IN 718 Superalloy

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Acta Metallurgica Sinica(English Letters) 2020年第12期33卷 1666-1680页

作者： u.k.Tarai P.S.Robi Sukhomay Pal Department of Mechanical Engineering IIT GuwahatiGuwahati 781039India

A new Ni–Cr–Si–B–Fe fi ller material is prepared for transient liquid-phase(TLP)bonding of Inconel 718 superalloy by mechanical alloying *** melting temperature range of the fi ller material and its activation energy of melting are determined by diff erential scanning calorimetry *** activation energy and melting temperature of the alloy powder decrease with increasing milling *** 718 alloy was joined via TLP by using the newly developed fi ller *** eff ect of TLP bonding temperature and time on microstructural evolution and mechanical properties of the joint was *** distinct microstructural regions were observed in the bonding area:isothermal solidifi cation zone consisting of a single-phase solid solution,diff usion aff ected zone consisting of extensive diff usion-in.uced precipitates of metallic boride,and unaff ected base *** ultimate shear strength and microhardness of the TLP-bonded joint increase with bonding time and temperature.

关键词： Transient liquid-phase(TLP)bonding kissinger plot Mechanical alloying Inconel 718

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Study of nucleon-nucleon and alphanucleon elastic scattering by the Manning-Rosen potential

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Communications in Theoretical Physics 2020年第7期72卷 60-64页

作者： A k Behera J Bhoi u Laha B khirali Department of Physics National Institute of TechnologyJamshedpur831014India Department of Physics Veer Surendra Sai University of TechnologyBurla-768018OdishaIndia

Although often used in molecular dynamics,in this work the Manning-Rosen potential is parameterized to compute the scattering phase shifts for the nucleon-nucleon and the alphanucleon systems by exploiting the standard phase function *** obtain excellent agreement in phase shifts with the more sophisticated calculations up to partial waves l=2.

关键词： phase function method Manning-Rosen potential scattering phase shifts nucleon-nucleon and the alpha-nucleon systems

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Inter-relationship of Various Results in Analysis of （14.0 MeV／u） Pb＋Pb Reaction using Mica and CN-85 Track Detectors

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Chinese Physics Letters 2005年第1期22卷 69-71页

作者： F.N.khattak E.u.khan TabassumNasir J.J.Baluch F.u.khan u.W.C. GomalUniversityDeraIsmailKhanPakistan RadiationPhysicsDivision PINSTECHNiloreIslamabadPakistan DepartmentofPhysics GomalUniversityDeraIsmailKhanPakistan

Two detector materials mica and cellulose-nitrate(CN)-85 have been used to study (14.0MeV/u) Pb + Pb reaction. Events of different multiplicities were registered in mica and CN-85 detectors using the 2π-geometry technique of solid state nuclear track detection. After removing the target material from the detectors the damaged trails in the detectors were revealed as tracks by proper chemical etching. The irradiated area of each sample was scanned and events of different multiplicities were traced. The binary events were bifurcated into elastic and inelastic events. The elastic binary events and three prong events, observed in the reaction, have been used to search out coefficients Cμν in the presence of both the detectors, for the reaction under study. using these coefficients 3- and 4-prong events have been analysed. From the detailed analysis of the results of (14.0MeV/u) Pb+Pb reaction, obtained from mica and CN-85 track detectors we observed a great resemblance of results obtained from the two detectors. Combining the results of both the detectors, we report some important outcomes.

关键词： CN-85轨迹探测器高能物理学铅原子碰撞反应固态

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Analysis of docosanol using GC/MS:Method development,validation,and application to ex vivo human skin permeation studies

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Journal of Pharmaceutical Analysis 2022年第2期12卷 287-292页

作者： Vijay kumar Shankar Mei Wang Srinivas Ajjarapu Praveen kolimi Bharathi Avula Reena murthy Ikhlas khan Sathyanarayana Narasimha murthy Department of Pharmaceutics and Drug Delivery University of MississippiOxfordMS38677USA Natural Products utilization Research unit Agricultural Research ServiceU.S.Department of AgricultureOxfordMS38677USA National Center for Natural Products Research Research Institute of Pharmaceutical SciencesSchool of PharmacyUniversity of MississippiOxfordMS38677USA Topical Products Testing LLC OxfordMS38677USA

Docosanol is the only uS Food and Drug Administration(FDA)approved over-the-counter topical product for treating recurrent oral-facial herpes simplex *** analytical methods for docosanol are required to demonstrate the bioequivalence of docosanol topical products.A gas chromatography/selected ion monitoring mode mass spectrometry(GC/SIM-MS)method was developed and validated for docosanol determination in biological *** and isopropyl palmitate(internal standard)were separated on a high-polarity GC capillary column with(88%cyanopropy)aryl-polysiloxane employed as the stationary *** ions of m/z 83 and 256 were selected to monitor docosanol and isopropyl palmitate,respectively;the total run time was 20 *** GC/SIM-MS method was validated in accordance with uS FDA guidelines,and the results met the uS FDA acceptance *** docosanol calibration standards were linear in the 100-10000 ng/mL concentration range(R^(2)>0.994).The recoveries for docosanol from the receptor fluid and skin homogenates were>93.2%and>95.8%,*** validated method was successfully applied to analyze ex vivo human cadaver skin permeation *** applying Abreva®cream tube and Abreva®cream pump,the amount of docosanol that penetrated human cadaver skin at 48 h was 21.5±7.01 and 24.0±6.95 ng/mg,***,we concluded that the validated GC/SIM-MS was sensitive,specific,and suitable for quantifying docosanol as a quality control *** method can be used for routine analysis as a costeffective alternative to other techniques.

关键词： Docosanol Fatty alcohols Gas chromatography-mass spectrometry Topical formulation Skin permeation

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A Novel Segment White Matter Hyperintensities Approach for Detecting Alzheimer

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Computer Systems Science & Engineering 2023年第3期44卷 2715-2726页

作者： Antonitta Eileen Pious u.k.Sridevi Department of Science and Humanities Sri Krishna College of Engineering and TechnologyCoimbatore641008India Department of Applied Mathematics and Computational Sciences PSG College of TechnologyCoimbatore641008India

Segmentation has been an effective step that needs to be done before the classification or detection of an anomaly like Alzheimer’s on a brain *** helps detect pixels of the same intensity or volume and group them together as one class or region,where in that particular region of interest(ROI)can be concentrated on,rather than focusing on the entire *** this paper White Matter Hyperintensities(WMH)is taken as a strong biomarker that supports and determines the presence of Alzheimer’*** thefirst step a proper segmentation of the lesions has to be carried *** pointed out in various other research papers,when the WMH area is very small or in places like the Septum Pellucidum the detection of the lesion is hard *** overcome such problem areas a very optimized and accurate Threshold would be required to have a precise segmentation to detect the area of *** would help in proper detection and classification of the *** this paper an elaborate comparison of various thresholding techniques has been done for segmentation.A novel idea for detection of Alzheimer’s has been presented in this paper,which encompasses the effectiveness of an optimized and adaptive *** unet architecture has been taken as the baseline model with an adaptive kernel model embedded within the *** state-of-the-art technologies have been used with the dataset and a comparative study has been presented with the current architecture used in the *** lesion segmentation in narrow areas has accurately been detected compared to the other models and the number of false positives has been reduced to a great extent.

关键词： Alzheimer’s adaptive threshold deep learning segmentation

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