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中国菌物学会第五届会员代表大会暨2011年学术年会

作者： in-sop shim Hyun-Jung PARK Hyun Soo shim Yong Ho AHN Kyung Soo KIM Kum Ju PARK Woong Ki CHOI Jung Il KANG Tae Seok KIM Ik Hyun YEO Jin Su KIM Hyo-Cheol HA Acupuncture and Meridian Science Research Center Kyung Hee UniversitySeoul 130-701Korea

The present study examined the effects of Tremella fuciformis(TF) on the learning and memory function and the neural activity in rats with TMT-induced memory *** rats were administered saline or TF(TF 25,50,100mg/kg,p.o.) daily for 21 *** cognitive improving efficacy of TF on the amnesic rats, which was induced by TMT,was investigated by assessing the Morris water maze test and by performing acetylchoine transferase(ChAT) and cAMP responsive element binding protein(CREB) immunohistochemistry. In order to confirm the underlying mechanisms of the memory enhancing effects of TF,we assessed the neurite outgrowth of PC12 *** also administered 18F-Fluorodeoxyglucose and performed a PET/CT scan of the frontal lobe. The rats with TMT injection showed impaired learning and memory of the tasks and treatment with TF produced a significant improvement of the escape latency to find the platform in the Morris water maze at the 2 day compared to that of the control group(after the 2 day,p<0.05).In the retention test,the TF50 group showed increased time spent around the platform compared to that of the control group(p<0.05).Consistent with the behavioral data,TF50 mg/kg significantly alleviated the loss of ChAT-ir neurons in the hippocampus compared to that of the control group(p<0.001).Treatment with TF significantly increased the CREB positive neurons in the hippocampal CA1 area as compared to that of the control *** addition,TF treatment(50mg/kg) increased the glucose uptake approximately sevenfold in the frontal lobe(p<0.001) and it significantly promoted neurite outgrowth of the PC 12 cells(p<0.01),as compared to that of the controls. These results suggest that TF may be useful for improving the cognitive function via regulation of cholinergic marker enzyme activity and neural activity.

关键词： Trimethyltin(TMT) Choline Acetyltransferase(ChAT) Tremella fuciformis(TF) PC12

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基于PageRank,HITS和SALSA算法的学术论文评价

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情报杂志 2015年第6期34卷 48-54页

作者：苏成 Hee-sop KIM 中国科学技术信息研究所情报方法研究中心北京100038 韩国庆北大学图书馆与信息科学系

科技论文评价对于科研工作者的评价以及相关科研管理工作至关重要。利用PageRank、HITS和SALSA算法进行了"图书馆与信息科学"领域的论文排序实验,比较了不同算法排序列表前100共同论文数和Spearman相关系数,讨论了不同算法特性对排序结... 详细信息

科技论文评价对于科研工作者的评价以及相关科研管理工作至关重要。利用PageRank、HITS和SALSA算法进行了"图书馆与信息科学"领域的论文排序实验,比较了不同算法排序列表前100共同论文数和Spearman相关系数,讨论了不同算法特性对排序结果的影响,最后讨论了不同算法的优缺点、适用范围。

关键词： PageRank HITS SALSA学术论文评价

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High Prevalence of Genetic Alterations in Infantile-Onset Cardiomyopathy

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Congenital Heart Disease 2021年第4期16卷 397-410页

作者： Junsung Park Go Hun Seo Yena Lee Yunha Choi Minji Kang Hyo-Sang Do Young-Hwue Kim Jeong Jin Yu Ellen Ai-Rhan Kim Euiseok Jung Byong sop Lee Jae Suk Baek Beom Hee Lee Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea billion Inc.SeoulKorea Genome Research Center for Birth Defects and Genetic Diseases Asan Institute for Life SciencesAsan Medical CenterSeoulKorea Division of Cardiology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Division of Neonatology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Medical Genetics Center Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulKorea

Background and Method:The genetic cause of infantile-onset cardiomyopathy is rarely ***,we conducted whole exome sequencing(WES)and mitochondrial DNA(mtDNA)sequencing in eight patients with infantile-onset cardiomyopathy to identify genetic ***:Among these patients,two(25%)had dilated cardiomyopathy(DCMP),two(25%)had left ventricular non-compaction(LVNC),and four(50%)had hypertrophic cardiomyopathy(HCMP).Except four patients identified prenatally,the remaining patients presented at a median age of 85.5 *** identified genetic variants in a total of seven(87.5%)patients and mtDNA sequencing in the other ***1 and MYH7 variants were identified in the two patients with DCMP;MYH11 and MYLK2 variants in the two patients with LVNC;HRAS,BRAF,and MYH7 variants in three patients with HCMP;and MT-ND1 variant in one patient with HCMP having high blood lactic acid *** the eight variants,four were classified as pathogenic or likely-pathogenic according to the American College of Medical Genetics(ACMG)guidelines,and the remaining were identified as variants of unknown significance(VUSs).Three pathogenic mutations were de novo,whereas four(likely-pathogenic or VUSs)were inherited from a respective parent,excluding one variant where parental testing was unavailable,questioning whether these inherited variants are *** patients died before 3 months of ***:Genomic studies,such as WES with additional mtDNA sequencing,can identify a genetic variant in high proportions of patients with infantile-onset *** clinical implication of the parentally inherited variant needs to be assessed in a larger patient and family cohort with a longitudinal follow-up.

关键词： Cardiomyopathy whole exome sequencing infantile-onset

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Factors Affecting the Genetic Diagnostic Rate in Congenital Heart Disease

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Congenital Heart Disease 2022年第6期17卷 653-673页

作者： Jun Sung Park Go Hun Seo Yunha Choi Soojin Hwang Minji Kang Hyo-Sang Do Young-Hwue Kim Jeong Jin Yu Ellen Ai-Rhan Kim Euiseok Jung Byong sop Lee Jae Suk Baek Beom Hee Lee Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea 3 Billion Inc.SeoulKorea Genome Research Center for Birth Defects and Genetic Diseases Asan Institute for Life SciencesAsan Medical CenterSeoulKorea Division of Cardiology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Division of Neonatology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Medical Genetics Center Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulKorea

Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally,multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This studyinvestigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHDand the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromicCHD aged 0.05), betweenthe groups with and without a diagnostic variant. However, patients with ≥3 extracardiac phenotypes had a significantlyhigher likelihood of having a diagnostic variant than those with ≤2 (38.3% vs. 5.9%, odds ratio = 9.93,95% confidence interval = 1.21–81.44, P = 0.013). Conclusions: The number of extracardiac phenotypes is importantin predicting the possibility of genetic diagnosis. Physicians will be able to select patients with a high probabilityof genetic diagnosis and provide appropriate genetic counseling based on the results of this study.

关键词： Heart defects congenital whole-exome sequencing genetic testing phenotype

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Influence of Long-term Climate on Fatigue Life of Bridge Pier Concrete and a Reinforcement Method

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Hydro Science & Marine Engineering 2019年第1期1卷 2-8页

作者： Nam-Hyok Ri Kum-Hyok So Yong-sop Ri Zhiyao Ma Yong-Ae Kim Hui-Gwang Yun School of Architecture Tianjin UniversityTianjin300072China Faculty of Mechanics Engineering Kim Il Sung UniversityPyongyangDPR of Korea School of Civil Engineering Tianjin UniversityTianjin300072China Department of Resources Exploration Engineering Kim Chaek University of technologyPyongyangDPR of Korea

This paper quantitatively evaluated the fatigue life of concrete around the air-water boundary layer of bridge piers located in inland rivers,considering the long-term *** paper suggests a method to predict the low-cycle fatigue life by demonstrating a thermal-fluid-structural analysis of bridge pier concrete according to long-term climate such as temperature,velocity and pressure of air and water in the process of freezing and thawing in *** addition,it proposes a reinforcing method to increase the life of damaged piers and proves the feasibility of the proposed method with numerical comparison experiment.

关键词： Hydraulic concrete Bridge pier Concrete depression failure Scour phenomenon Low-cycle fatigue life Long-term climate Thermal-structural analysis Fluid-structural analysis ANSYS

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Iron and Zinc Serum Levels in Young Adult Cameroonians after Supplementation in Poor Vitamin A and Controlled Diets

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Journal of Food Science and Engineering 2014年第4期4卷 184-195页

作者： Kana sop Marie Modestin Gouado Inocent Schweigert Florian Van Camp John Oberleas Donald AmvamZollo Paul Henri Tetanye Ekoe Department of Biochemistry Faculty of Science University of Douala Douala 24157 Cameroon Institute of Nutritional Science University of Potsdam Potsdam 114-115 D-14558 Germany Department of Food Safety and Food Quality University of Gent Ghent 653 B-9000 Belgium Food and Nutrition University of Lubbok Lubbock 79423 USA Department of Biochemistry University of Ngaoundere Ngaoundere 454 Cameroon Department of Paediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundd Yaounde 2036 Cameroon

Iron, zinc and vitamin A deficiencies co-exist in Cameroon in all age groups. However, natural sources of vitamin A are available and could be used to meet the need of the whole population in association with iron and zinc supplementation. This study aims at assessing the serum levels of zinc and iron after 11 days of supplementation. The study enrolled 26 men 08-33 years）, distributed into five groups. From the first day, they were supplemented with 20 mg of zinc and iron, taken each alone, both either together or at two different times. The five last days, participants were put on free vitamin A diets. Serums were obtained at day l, day 5 and day 11 for Zn and Fe levels determination by atomic absorption spectrophotometry. The highest serum iron and zinc concentrations were observed in groups either supplemented with zinc or with iron given alone. In those two groups, serum Zn concentrations increased from 0.69 μg/mL ±0.02μg/mL to 0.95 μg/mL ± 0.13 μg/mL （group 2）, from 0.48 μg/mL ± 0.06 μg/mL to 0.97 μg/mL ± 0.11 μg/mL （group 3）; and serum Fe concentrations from 1.49 μg/mL ± 0.54 μg/mL to 3.49 μg/mL ± 1.01 μg/mL （group 2）; and from 1.42 μg/mL ± 0.45 μg/mL to 3.41 μg/mL ± 0.81 μg/mL （group 3）, respectively. Supplementation with Fe or Zn alone increased both Fe and Zn serum levels of participants. Serum levels of iron and zinc when given together or at different time were not significantly different. Further studies on a larger population are necessary to confirm that supplementation with zinc or with iron alone could raise both zinc and iron levels in serum simultaneously.

关键词： Supplementation iron zinc young-adults Cameroon.

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Biodegradable zinc-iron alloys: Complex study of corrosion behavior,mechanical properties and hemocompatibility

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Progress in Natural Science:Materials International 2021年第2期31卷 279-287页

作者： Z.Orságová Králová R.Gorejová R.Orin?aková M.Petra?ková A.Orin?ak M.Kupková M.Hrubov?a?ková T.sop?ák M.Baláz? I.Maska?ová A.Kovalc?íková K.Kova? Department of Physical Chemistry Faculty of Science Pavol Jozef ?afa?rik University in Ko?ice Institute of Materials Research Slovak Academy of Sciences Institute of Geotechnics Slovak Academy of Sciences University of Veterinary Medicine and Pharmacy in Ko?ice Department of Animal Nutrition Dietetics and Animal Breeding

Zn-Fe alloys have been extensively investigated in this study with a view to their application as biodegradable bone implants. Biogenic element zinc is a very appropriate metal because of the ideal degradation rate compared to those of Mg and Fe. Studied alloys were made by compressing metallic powders in a content ratio of 100% Zn,Zn-1% Fe, Zn-2% Fe, Zn-5% Fe and Zn-10% Fe and sintering at 350°C for 1 h. Prepared samples were examined by optical microscopy, SEM and XRD. Corrosion behavior, mechanical testing and hemocompatibility were observed subsequently. The electrochemical performance of such materials was studied in the simulated body fluids. The enhanced corrosion rate was observed for all samples after iron addition due to the micro-galvanic effect between the pure Zn and Zn;Fe intermetallic phase. The corrosion rate of the Zn-5% Fe alloyed sample was more than 20-times higher（2.89 mmpy） compared to the pure Zn. However, alloying with more than 5 wt %of iron diminished the mechanical performance of the material. Therefore, the performed mechanical and hemocompatibility tests showed acceptable biocompatibility of zinc and Zn-1% Fe and Zn-2% Fe samples.

关键词： Biodegradable materials Zinc Iron Alloy Corrosion behavior Hemocompatibility

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韩国学术期刊国际化状况研究

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编辑学报 2012年第6期24卷 609-612页

作者：苏成 Hee-sop KIM 潘云涛马峥袁军鹏郭红俞征鹿武夷山中国科学技术信息研究所情报方法研究中心北京100038 Department of Library&Information Science Kyungpook National UniversityDaegu702-701KOREA

从编委、稿源、语言、流通4个方面调查韩国学术期刊的国际化状况,考察NRF、KOFST、KISTI等机构促进学术期刊国际化的一些具体政策措施。研究结果表明:韩国学术期刊总的国际化水准还比较低,但编委国际化、流通国际化方面相对较好,医学期... 详细信息

从编委、稿源、语言、流通4个方面调查韩国学术期刊的国际化状况,考察NRF、KOFST、KISTI等机构促进学术期刊国际化的一些具体政策措施。研究结果表明:韩国学术期刊总的国际化水准还比较低,但编委国际化、流通国际化方面相对较好,医学期刊国际化水准相对较高;韩国基本形成了一个较为完备的促进学术期刊国际化的支持系统,其期刊国际化资助计划涵盖了期刊的投稿、审稿/编辑、发行、流通等全过程。根据韩国学术期刊国际化进程的经验教训,提出了中国学术期刊国际化路径的建议。

关键词：学术期刊国际化韩国 DOI OA

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部分区域约束下的交叉梯度多重地球物理数据联合反演

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地球物理学报 2016年第8期59卷 2979-2988页

作者：李桐林张镕哲朴英哲金钢燮金长鲜催邴敏吉林大学地球探测科学与技术学院金策工业综合大学资源探测工学系

交叉梯度联合反演方法通过对多种地球物理模型实现结构耦合,在岩石物性关系不确定的情况下,既能提高反演结果的可靠性,又能减少反演的多解性,还能减少不同方法解释结果之间的矛盾.当不同的模型观测数据覆盖范围不一致时,交叉梯度联合反... 详细信息

交叉梯度联合反演方法通过对多种地球物理模型实现结构耦合,在岩石物性关系不确定的情况下,既能提高反演结果的可靠性,又能减少反演的多解性,还能减少不同方法解释结果之间的矛盾.当不同的模型观测数据覆盖范围不一致时,交叉梯度联合反演通常需要取出重叠区域数据进行联合反演,并且建模时还要扩展一些模型范围.本文首先提出并实现了部分区域约束下的交叉梯度多重地球物理数据联合反演算法;接着进行了算法的模型试算;最后,我们将该反演算法用于本溪—集安深部地质调查重磁电综合地质地球物理解释中.结果表明:该算法不但能在重叠区域内很好地恢复结构相似的模型,而且在非重叠区域与重叠区域的边界处仍然可以得到平滑变化的模型;在本溪—集安10号剖面所获得的结构上相似的电阻率、密度及磁化率模型较好地反映了该区的深部地质结构,对于确定深部地质体的性质提供了有力的证据.

关键词：交叉梯度联合反演大地电磁测深初至波走时重磁法

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无人机在河流遥感中的应用最新进展

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电光系统 2019年第1期 51-63页

作者： Dong sop Rhee Young Do Kim Boosik Kang Dongsu Kim 刘中杰(译) 吴峰(审) 王玉婷(校) 不详

以前从生态、形态学和水力观点理解河流过程主要依赖有限的现场观测或基于卫星载遥感的稀疏空间和时间测量。随着无人机的出现以及传感器技术的进步,测量活动已发生革命性变化,江河观测已发生从局部向整体的根本性变化,从静态向动态转... 详细信息

以前从生态、形态学和水力观点理解河流过程主要依赖有限的现场观测或基于卫星载遥感的稀疏空间和时间测量。随着无人机的出现以及传感器技术的进步,测量活动已发生革命性变化,江河观测已发生从局部向整体的根本性变化,从静态向动态转变。无人机可以相对低的成本提供精细的空间和时间分辨率测量,与传统卫星或飞行员控制的机载系统相比,更适合窄江河和小湖泊过程分析。本文中,我们综合回顾并证明在河流环境及其它各种有关应用中无人机载遥感所获得的至关重要的成就。本文重点研究水滨植被、危险茂盛水藻、水中形态、水面倾斜、沉积物、河流流速、天灾,包括洪水测绘方面无人机载河流遥感。

关键词：无人机遥感河流江河激光雷达

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