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Development of cell mitogenic fusion protein consist of human epidermal growth factor and collagen binding domain of Vibrio mimicus metalloprotease

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Development of cell mitogenic fusion protein consist of huma...

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

The 12th Japan-China-Korea Joint Symposium on Enzyme Engineering

作者： Dong-Gyun Kim Bo-Hye Nam Hee Jeong kong Woo-Jin Kim Bong-Seok Kim Sang-Jun Lee in-soo kong Young-Ok Kim Biotechnology Research Division National Fisheries Research and Development Institute Department of Biotechnology Pukyong National University

＜正＞Introduction Among the human growth factors,epidermal growth factor（hEGF）consisted of 53 amino acids exhibited various effects on epidermal cell regeneration,stimulation of proliferation and migration of keratinocytes,promote formation of granulation tissues,and stimulates fibroblast motility,which are important in the process of wound *** these multifunctional activities,EGF was employed as

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

In situ cardiac regeneration by using neuropeptide substance P and IGF-1C peptide eluting heart patches

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Regenerative Biomaterials 2018年第5期5卷 303-316页

作者： Muhammad Shafiq Yue Zhang Dashuai Zhu Zongxian Zhao Dong-Hwee Kim soo Hyun Kim Deling kong Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)College of Life ScienceNankai UniversityTianjin 300071China Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and TechnologyCheongryangSeoul 130-650Republic of Korea Department of Chemistry Center for Tissue Engineering&Regenerative MedicinePakistan Institute of Engineering&Applied Sciences(PIEAS)NiloreIslamabad 45650Pakistan Department of Physiology&Pathophysiology Tianjin Medical UniversityTianjin 300070China KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Cardiovascular diseases cause huge socio-economic burden *** a mammalian myocardium has its own limited healing capability,scaffold materials capable of releasing stem cell recruiting/engrafting factors may facilitate the regeneration of the infarcted *** aim of this research was to develop cardiac patches capable of simultaneously eluting substance P(SP)and insulin-like growth factor-1C(IGF-1C)***/collagen type 1-based patches with or without SP and IGF-1C peptide were fabricated by co-electrospinning,which exhibited nanofibrous *** and IGF-1C/SP patches recruited significantly higher numbers of bone marrow-mesenchymal stem cells than that of the negative control and patch-only groups in *** developed patches were transplanted in an infarcted myocardium for up to 14 *** underwent left anterior descending artery ligation and received one of the following treatments:(i)sham,(ii)saline,(iii)patch-only,(iv)IGF-1C patch,(v)SP patch and(vi)IGF-1C/SP *** and IGF-1C/SP patch-treated groups exhibited better heart function and attenuated adverse cardiac remodeling than that of the saline,patch-only and individual peptide containing cardiac *** patch and IGF-1C/SP patch-treated groups also showed higher numbers of CD31-positive vessels and isolectin B4-positive capillaries than that of other ***-1C/SP-treated group also showed thicker left ventricular wall in comparison to the saline and patch-only ***,IGF-1C/SP patches recruited significantly higher numbers of CD29-positive cells and showed less numbers of Tunel-positive cells compared with the other *** data suggest that SP and IGF-1C peptides may act synergistically for in situ tissue repair.

关键词： cardiac patch stem cell recruitment myocardial infarction electrospinning

On Multifractal of Cantor Dust

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Acta Mathematica Sinica,English Series 2009年第7期25卷 1175-1182页

作者： In-soo BAEK Department of Mathematics Pusan University of Foreign Studies

We consider quasi-self-similar measures with respect to all real numbers on a Cantor dust. We define a local index function on the real numbers for each quasi-self-similar measure at each point in a Cantor dust, The value of the local index function at the real number zero for all the quasi-self-similar measures at each point is the weak local dimension of the point. We also define transformed measures of a quasi-self-similar measure which are closely related to the local index function. We compute the local dimensions of transformed measures of a quasi-self-similar measure to find the multifractal spectrum of the quasi-self-similar measure, Furthermore we give an essential example for the theorem of local dimension of transformed measure. In fact, our result is an ultimate generalization of that of a self- similar measure on a self-similar Cantor set. Furthermore the results also explain the recent results about weak local dimensions on a Cantor dust.

关键词： Cantor set Hansdorff dimension packing dimension quasi-self-similar measure local dimension

Design and optimization of a cavity-backed spiral antenna for use in 6-12 GHz band

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Journal of Central South University 2013年第7期20卷 1838-1843页

作者： Gyoo-soo Chae Joong-soo Lim Division of Information & Communication Engineering Baekseok University

The design and optimization of a self-complementary two-arm Archimedean spiral antenna backed by an absorptive cavity were presented. Parametric studies on the proposed antenna structure were carried out by using CST MWS. Simulation results show that the proper choice of spiral turns and cavity depth can miniaturize the dimensions of the cavity-backed spiral antenna presented here. According to simulation results, prototype antennas operating in the 6 12 GHz band are fabricated and the dimension of the proposed cavity-backed spiral antenna is 22 mm (diameter)×15 mm (height). The performance of the proposed antenna was measured and compared with the simulation results. It is shown that the experimental results are consistent with the theoretical predictions and the suggested antenna is good enough to adapt for various wideband applications.

关键词： cavity-backed spiral antenna miniaturization balanced structure wideband balun

The inhibition effect of Chlorpromazine against the β-lactam resistance of MRSA

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 526-530页

作者： Ryong kong Ok-Hwa Kang Yun-soo Seo Su-Hyun Mun Tian Zhou Dong-Won Shin Dong-Yeul Kwon BK21 Plus Team Professional Graduate School of Oriental Medicine Wonkwang University Department of Oriental Pharmacy College of Pharmacy Wonkwang Oriental Medicines Research Institute Institute of Biotechnology Wonkwang University Department of Oriental Medicine Resources College of Bio Industry Science Sunchon National University

Objective:To investigate the gene related to β-lactam resistance and to confirm the mechanism about a synergy effect between CPZ and β-lactam ***:To measure antibacterial activity,we performed a minimum inhibitory concentration(MIC) and synergy *** electron microscopy(TEM) was used in morphological *** analyze gene expression,we conducted reverse transcriptase polymerase chain reaction(PCR).Results:We confirmed a synergy effect between CPZ and β-lactam ***,we observed that CPZ affect the cell envelope of MRS A by using *** the gene level,CPZ reduced the expression of resistance ***:Through this result,we hypothesize that a decrease of resistance factor expressions was caused by CPZ because it disrupts the activity of a sensor protein located in the cell membrane.

关键词： Chlorpromazine PBP2a β-lactamase mecA blaZ MRSA

Parameter estimation for building energy models using GRcGAN

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Building Simulation 2023年第4期16卷 629-639页

作者： Hansol Shin Cheol-soo Park Department of Architecture and Architectural Engineering College of EngineeringSeoul National UniversitySeoul08826R.O.Korea Institute of Construction and Environmental Engineering Institute of Engineering ResearchCollege of EngineeringSeoul National UniversitySeoul08826R.O.Korea

Parameter estimation methods can be classified into(1)manual(trial-and-error),(2)numerical optimization(optimization,sampling),(3)Bayesian inference(Bayes filter,Bayesian calibration),and(4)machine learning(generative model).Bayesian calibration has been widely used because it can capture stochastic nature of uncertain ***,the results of Bayesian calibration could be biased by(1)the prior distribution assumed by the expert’s subjective judgment;(2)the likelihood function that cannot always describe the true likelihood;and(3)the posterior distribution approximation method,such as the Markov Chain Monte Carlo,which requires significant computation *** overcome this,a new approach using a generator-regularized continuous conditional generative adversarial network(GRcGAN)is presented in this *** target parameters of the DOE reference building model were *** was trained to estimate uncertain parameters using simulated monthly electricity and gas *** can successfully estimate five uncertain parameters based on 1,000 training data *** proposed approach presents a potential for stochastic parameter estimation.

关键词： generative adversarial networks generative model parameter estimation inverse problem model calibration parameter uncertainty

Highly efficient reduction of aqueous Cr(VI) with novel ZnO/SnS nanocomposites through the piezoelectric effect

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Journal of Environmental Sciences 2022年第8期34卷 57-66页

作者： Hao Sun soo-Jin Park Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212South Korea

In this work, novel ZnO/SnS nanocomposites were successfully synthesized via a hydrothermal approach, which is developed for piezoelectric catalytic reduction of hexavalent chromium(Cr(VI)) in an aqueous solution. The constructed ZnO/SnS nanocomposites exhibited higher catalytic efficiency for Cr(VI) reduction under a mechanical force(e.g., ultrasonic vibration) compared to pristine ZnO and SnS. In particular, the ZnO/SnS(with 30 wt.% of SnS) heterojunctions revealed an optimal degradation activity among all the prepared samples, which completely removed the Cr(VI)(20 mg/L) solution within 35 min. Moreover, the piezoelectric catalytic activity of ZnO/SnS remained stable after four consecutive cycling experiments. The results of the morphology observations indicated that the SnS nanoparticles adhere to the surface of the ZnO nanorods. The improved piezoelectric catalytic performance of the ZnO/SnS heterojunctions can be attributed to the formation of an intimate interfacial between ZnO and SnS, which effectively inhibits the electron-hole recombination and speeds up the rate of charge transfer. The study reveals a new design of ZnO/SnS heterojunctions as a high-performance and eco-friendly piezoelectric catalyst and provides a promising strategy for addressing environmental problems and energy crises.

关键词： Cr(VI)reduction ZnO/SnS Piezoelectric effect

Areas vulnerable to natural disasters and damage estimation of infrastructure in Busan, Korea

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Journal of Central South University 2014年第4期21卷 1499-1507页

作者： JEON Sang-soo Department of Civil and Urban Engineering Inje University

Since the damages caused by disasters associated with climate anomalies and the diversification of the social structure increase every year, an efficient management system associated with a damage assessment of the areas vulnerable to disasters is demanded to prevent or mitigate the damages to infrastructure. The areas vulnerable to disasters in Busan, located at southeastern part of Korea, were estimated based on historical records of damages and a risk assessment of the infrastructure was performed to provide fundamental information prior to the establishment of the real-time monitoring system for infrastructure and establish disaster management system. The results are illustrated by using geographical information system(GIS) and provide the importance of the roadmap for comprehensive and specific strategy to manage natural disasters.

关键词： natural disaster damages risk assessment infrastructure disaster management system geographical information system