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Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： Amal George Kurian Rajendra K.Singh Varsha Sagar jung‑Hwan lee Hae‑Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji lee Dae-Geun Song Jae Woo jung Haesong lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu jung Weon lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea,2010-2018

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World Journal of Gastroenterology 2024年第9期30卷 1154-1163页

作者： Seulji Kim Hyun jung lee Seung Woo lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Department of Internal Medicine Korea Institute of Radiological and Medical SciencesSeoul 01812South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Inflammatory bowel disease(IBD)was previously regarded as a Western disease;however,its incidence is increasing in the *** epidemiology of IBD in Asia differs significantly from the patterns in the *** To comprehensively investigate the epidemiology of IBD in South Korea,inclu-ding its incidence,prevalence,medication trends,and *** We analyzed claims data from the Health Insurance Review and Assessment Service and Rare and Intractable Diseases(RIDs),operated by the National Health Insurance Service of South *** with IBD were identified based on the International Classification of Diseases,Tenth Revision,and RID diagnostic codes for Crohn’s disease(CD)and ulcerative colitis(UC)from 2010 to *** In total,14498 and 31409 patients were newly diagnosed with CD and UC,respectively,between 2010 and *** annual average incidence of CD was 3.11 cases per 105 person-years,and that of UC was 6.74 cases per 10^(5) *** 2014,the incidence rate of CD has been stable,while that of UC has steadily increased,shifting the peak age group from 50-year-olds in 2010 to 20-year-olds in *** CD and UC prevalence increased consistently over the study period;the use of 5-aminosali-cylates and corticosteroids gradually decreased,while that of immunomodulators and biologics steadily increased in both CD and *** clinical outcomes of IBD,such as hospitalization and surgery,decreased during the study *** The CD incidence has been stable since 2014,but that of UC has increased with a shift to a younger age at peak incidence between 2010 and *** clinical outcomes improved over time,with increased use of immunomodu-lators and biologics.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Incidence Prevalence

Next High Performance and Low Power Flash Memory Package Structure

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Journal of Computer Science & Technology 2007年第4期22卷 515-520页

作者： jung-Hoon lee ERI Control Instrumentation EngineeringGyeongSang National UniversityJinju660-701Korea

In general, NAND flash memory has advantages in low power consumption, storage capacity, and fast erase/write performance in contrast to NOR flash. But, main drawback of the NAND flash memory is the slow access time for random read operations. Therefore, we proposed the new NAND flash memory package for overcoming this major drawback. We present a high performance and low power NAND flash memory system with a dual cache memory. The proposed NAND flash package consists of two parts, i.e., an NAND flash memory module, and a dual cache module. The new NAND flash memory system can achieve dramatically higher performance and lower power consumption compared with any conventionM NAND-type flash memory module. Our results show that the proposed system can reduce about 78% of write operations into the flash memory cell and about 70% of read operations from the flash memory cell by using only additional 3KB cache space. This value represents high potential to achieve low power consumption and high performance gain.

关键词： flash memory NAND-type NOR-type memory localities buffer or cache memory

Topic Modeling Based Warning Prioritization from Change Sets of Software Repository

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Journal of Computer Science & Technology 2020年第6期35卷 1461-1479页

作者： jung-Been lee Taek lee Hoh Peter In College of Informatics Korea UniversitySeoul 02841Korea College of Knowledge-Based Services Engineering Sungshin UniversitySeoul 02844Korea

Many existing warning prioritization techniques seek to reorder the static analysis warnings such that true positives are provided first. However, excessive amount of time is required therein to investigate and fix prioritized warnings because some are not actually true positives or are irrelevant to the code context and topic. In this paper, we propose a warning prioritization technique that reflects various latent topics from bug-related code blocks. Our main aim is to build a prioritization model that comprises separate warning priorities depending on the topic of the change sets to identify the number of true positive warnings. For the performance evaluation of the proposed model, we employ a performance metric called warning detection rate, widely used in many warning prioritization studies, and compare the proposed model with other competitive techniques. Additionally, the effectiveness of our model is verified via the application of our technique to eight industrial projects of a real global company.

关键词： automated static analysis topic modeling warning prioritization

Densification simulation of compacted Al powders using multi-particle finite element method

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中国有色金属学会会刊：英文版 2009年第B9期19卷 68-75页

作者： Kyung-Hun lee jung-Min lee Byung-Min KIM School of Mechanical Engineering Pu san National University

The powder compaction simulations were performed to demonstrate deformation behavior of particles and estimate the effect of different punch speeds and particle diameters on the relative density of powder by a multi-particle finite element model(MPFEM). Individual particle discretized with a finite element mesh allows for a full description of the contact mechanics. In order to verify the reliability of compaction simulation by MPFEM, the compaction tests of porous aluminum with average particle size of 20 μm and 3 μm were performed at different ram speeds of 5, 15, 30 and 60 mm/min by MTS servo-hydraulic tester. The results show that the slow ram speed is of great advantage for powder densification in low compaction force due to sufficient particle rearrangement and compaction force increases with decrease in average particle size of aluminum.

关键词：粉末压实粉末粒子多孔铝有限元法模拟致密化平均粒径有限元模型

Ultra-low concentration of total organic carbon in ultrapure water using ion-exchange resin embedding silanized magnetic nanoparticles

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Journal of Environmental Sciences 2020年第6期32卷 11-17页

作者： jung Joon lee Jihyeon Park Bo-Hyun Kim Sunjong lee Department of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419South Korea Korea Institute of Industrial Technology 89 Yangdaegiro-gilIpjang-myeonCheonan-si 31056South Korea

Regeneration of pure water is an important issue not only for the healthy life but also for the fine control of precise processes in various *** important issue in ultrahigh purified water is to reduce the amount of total organic carbon(TOC).Herein,we introduce a new approach to reduce the TOC using the surface silanized nanoparticles,in which the magnetic nanoparticles(mNPs)are silanized and then complexed with ion exchange resin(IER)*** Fe3O4 mNPs are surface modified by using high concentrated vinyltrimethoxysilane(VTMS)and then adhered on the surface of IER *** surface modified mNPs have a thick-shell of polysiloxane layer varying from 5 to 22 nm depending on the amount of VTMS used,which leads the significant increase of specific surface *** IER beads embedding VTMS-silanized mNPs achieves about 7μg/L of the TOC level in ultrapure water system,which is two orders less than 228μg/L of the feeding water and one order less than 96μg/L from the system using pristine IER *** result is mainly attributed to the polysiloxane layer forming broccoli-like surface structure and some part by the vinyl group of VTMS exposed to the amines in the water.

关键词： Total organic carbon Ultrapure water Magnetic nanoparticle Ion-exchange resin Hybrid structure

Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells

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Bone Research 2023年第2期11卷 354-367页

作者： Eun jung lee Kyoung Jin lee Seungpil jung Kyong Hwa Park Serk In Park Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoulRepublic of Korea The BK21 Graduate Program Department of Biomedical SciencesKorea University College of MedicineSeoulRepublic of Korea Division of Breast and Endocrine Surgery Department of SurgeryKorea University Anam HospitalSeoulRepublic of Korea Division of Oncology and Hematology Department of Internal MedicineKorea University Anam HospitalSeoulRepublic of Korea Vanderbilt Center for Bone Biology Vanderbilt University School of MedicineNashvilleTNUSA

Myeloid-derived suppressor cells(MDSCs)are bone marrow(BM)-derived immunosuppressive cells in the tumor microenvironment,but the mechanism of MDSC mobilization from the BM remains *** investigated how BM stromal cell activation by PTH1R contributes to MDSC ***1R activation by parathyroid hormone(PTH)or PTH-related peptide(PTHrP),a tumor-derived counterpart,mobilized monocytic(M-)MDSCs from murine BM without increasing immunosuppressive *** vitro cell-binding assays demonstrated thatα4β1 integrin and vascular cell adhesion molecule(VCAM)-1,expressed on M-MDSCs and osteoblasts,respectively,are key to M-MDSC binding to *** PTH1R activation,osteoblasts express VEGF-A and IL6,leading to Src family kinase phosphorylation in *** inhibitors suppressed PTHrP-induced MDSC mobilization,and Src activation in M-MDSCs upregulated two proteases,ADAM-17 and MMP7,leading to VCAM1 shedding and subsequent disruption of M-MDSC tethering to ***,our data provide the molecular mechanism of M-MDSC mobilization in the bones of tumor hosts.

关键词： MMP7 suppressor regulated

Study on wear behavior of plasma electrolytic oxidation coatings on aluminum alloy

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Rare Metals 2006年第Z2期25卷 141-145页

作者： KANG Suk-Bong lee jung-Moo Department of Materials Engineering Korean Institute of Machinery & Materials Gyeongnam 641831 Korea

Thick and hard ceramic coatings were fabricated on A356 aluminum alloy by using plasma electrolytic oxidation(PEO) technique. The microstructure and phase composition of the PEO coatings were examined by using SEM and XRD method. It is found that the PEO coatings are mainly composed of crystalline α-Al2O3 and mullite. The dry sliding wear test of PEO coatings were carried out on a ring-on-ring wear machine. Results shows that there is hardly no wear loss of polished PEO coatings while the wear rate of uncoated aluminum alloy is 4.3×10-5 mm3·(N·m)-1 at a speed of 0.52 m·s-1 and a load of 40 N.

关键词： aluminum alloy plasma electrolytic oxidation ceramic coating wear