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Natural Variation in OsPRR37 Regulates Heading Date and Contributes to Rice Cultivation at a Wide Range of Latitudes

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Molecular Plant 2013年第6期6卷 1877-1888页

作者： Bon-Hyuk Koo Soo-Cheul Yoo Joon-Woo Park Choon-Tak Kwon Byoung-Doo lee Gynheung An Zhanying Zhang linjie Li Zichao Li Nam-Chon Paek Department of Plant Science Plant Genomics and Breeding Institute and Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul 151-921 Korea Department of Plant Systems Biotech and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea Key Lab of Crop Heterosis and Utilization of Ministry of Education and Beijing Key Lab of Crop Genetic Improvement China Agriculture UniversityBeijing 100193 China Institute of Green Bio Science and Technology Seoul National University Pyeongchang 232-916 Korea

Heading date and photoperiod sensitivity are fundamental traits that determine rice adaptation to a wide range of geographic environments. By quantitative trait locus （QTL） mapping and candidate gene analysis using whole- genome re-sequencing, we found that Oryza sativa Pseudo-Response Regulator37 （OsPRR37; hereafter PRR37） is respon- sible for the Early heading7-2 （EH7-2）/Heading date2 （Hd2） QTL which was identified from a cross of late-heading rice ＇Milyang23 （M23）＇ and early-heading rice ＇H143＇. H143 contains a missense mutation of an invariantly conserved amino acid in the CCT （CONSTANS, CO-like, and TOC1） domain of PRR37 protein. In the world rice collection, different types of nonfunctional PRR37 alleles were found in many European and Asian rice cultivars. Notably, the japonica varieties harboring nonfunctional alleles of both Ghd7/Hd4 and PRR37/Hd2 flower extremely early under natural long-day condi- tions, and are adapted to the northernmost regions of rice cultivation, up to 53~ N latitude. Genetic analysis revealed that the effects of PRR37 and Ghd7 alleles on heading date are additive, and PRR37 down-regulates Hd3a expression to suppress flowering under long-day conditions. Our results demonstrate that natural variations in PRR37/Hd2 and GhdT/ Hd4 have contributed to the expansion of rice cultivation to temperate and cooler regions.

关键词： rice heading date quantitative trait locus natural variation Ghd7 OsPRR37.

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Selective Growth of ZnO Nanorods on SiO2/Si Substrates Using a Graphene Buffer Layer

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Nano Research 2011年第5期4卷 440-447页

作者： Won Mook Choi Kyung-Sik Shin Hyo Sug lee Dukhyun Choi Kihong Kim Hyeon-Jin Shin Seon-Mi Yoon Jae-Young Choi Sang-Woo Kim Samsung Advanced Institute of Technology Giheung Yongin Gyeonggi 446-712 Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan （SKKU） Advanced Institute of Nanotechnology （SAINT） Center for Human Interface Nanotechnology （HINT） Sungkyunkwan University Suwon 440-746 Republic of Korea Department of Mechanical Engineering Kyung Hee University Yongin Gyeonggi 446-701 Republic of Korea

为用在一个低温度答案过程的 graphene 缓冲区层的 SiO2/Si 底层上的 ZnO nanorods 的选择生长的有希望的策略被描述。ZnO nanorods 的高密度在一个大区域上被种，大多数 ZnO nanorods 在 graphene 上是垂直地排列得好的。而且， graphe... 详细信息

为用在一个低温度答案过程的 graphene 缓冲区层的 SiO2/Si 底层上的 ZnO nanorods 的选择生长的有希望的策略被描述。ZnO nanorods 的高密度在一个大区域上被种，大多数 ZnO nanorods 在 graphene 上是垂直地排列得好的。而且， graphene 上的 ZnO nanorods 的选择生长被使用一个简单机械处理认识到，自从在 graphene 上形成的 ZnO nanorods 在原子水平上是机械地稳定的。这些结果被证明 ZnO-graphene 绑定有一个低 destabilization 精力的第一原则计算证实。另外，与 graphene 缓冲区层在 SiO2/Si 上种的 ZnO nanorods 比在赤裸的 SiO2/Si 上种的 ZnO nanorods 有更好光的性质，这被发现。nanostructured ZnO-graphene 材料在未来有有希望的应用灵活电子、光的设备。

关键词： SiO2/Si 氧化锌纳米棒选择性生长石墨材料缓冲层 Si衬底机械处理光学设备

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Berberine inhibits inflammatory activation of rat brain microglia

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Neural Regeneration Research 2010年第18期5卷 1384-1390页

作者： Kyong Nyon Nam Jae-Hong Kim Hoon-Ji Jung Jung-Mi Park Sang-Kwan Moon Young-Suk Kim Sun Yeou Kim Eunjoo H. lee Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University Department of Cardiovascular & Neurologic Diseases (Stroke Center) Hospital of Oriental MedicineKyung Hee University

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Berberine, the effective ingredient of Coptidis Rhizoma and Cortex Phellodendti, has a wide range of pharmacological functions, including anti-inflammatory, anti-atherosclerotic and anti-cancer effects. The neuroprotective potential of berberine has previously been demonstrated. The present study aimed to examine whether berberine could repress microglial activation and can be considered a potential therapeutic candidate to target neurodegenerative diseases. Primary microglial cells and BV2 microglial cells were cultured and stimulated with bacterial lipopolysaccharide （LPS）. Berberine chloride was treated prior to LPS or simultaneously with LPS stimulation. Results revealed that berberine was effective at inhibiting nitric oxide release from primary microglial cells when cells were exposed to the compound prior to LPS or simultaneously with LPS. It also reduced the LPS-stimulated production of tumor necrosis factor-α, interleukin-1β, prostaglandin E2, and intracellular reactive oxygen species and nuclear factor-kappa activation. Additionally, berberine reduced nitric oxide release from microglia stimulated with interferon-γ and amyloid β. These results suggest that berberine provides neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.

关键词： brain inflammation berberine interleukin-1β microglia nuclear factor-kappa nitric oxide prostaglandin tumor necrosis factor-a

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表面改性钛膜和原始钛膜对大鼠颅骨缺损模型引导骨再生的比较研究

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中国口腔医学继续教育杂志 2018年第1期21卷 9-17页

作者： Thuy-Duong Thi Nguyen So-hee Moon Tae-Ju Oh Jung-Jin Seok Min-Ho lee Tae-Sung Bae 蓝凯文滕伟不详广东省中山大学光华口腔医学院·附属口腔医院广东省广州市越秀区陵园西路56号510000

研究目的：本研究的目的是评价经过阳极氧化、循环预矿化、加热处理钛膜（APHTM）的生物活性，采用组织学分析和显微CT扫描（Micro-CT）比较APHTM和未处理钛膜（NTTM）的引导骨再生能力。材料与方法：制备APHTM样品并浸泡于模拟体液中2... 详细信息

研究目的：本研究的目的是评价经过阳极氧化、循环预矿化、加热处理钛膜（APHTM）的生物活性，采用组织学分析和显微CT扫描（Micro-CT）比较APHTM和未处理钛膜（NTTM）的引导骨再生能力。材料与方法：制备APHTM样品并浸泡于模拟体液中2天，然后用场发射扫描电子显微镜观察，接着用X射线能谱分析钙和磷酸盐的沉淀情况。体内实验中，在大鼠颅骨构造临界尺寸缺损（直径8mm）．用APHTM或NTTM覆盖处理（每一组n=14）。在2周和4周后活检进行组织学检查（n=3）。将骨荧光标记物在第3周（茜素红）和第5周（钙黄绿素）分别注射入每组三只大鼠，在第7周进行组织学分析，第8周进行Micro-CT扫描（n=5）。结果：APHTM具有较高的生物活性．于模拟体液浸泡2天后．APHTM表面特征性地遍布致密的纳米片状晶体、钙磷浓度增加。在2周和4周，APHTM组显示新生骨紧密贴附于膜上．而NTTM样品组在膜和新生骨之间形成结缔组织间隔。在荧光分析中也发现了同样的规律。Micro-CT分析显示．APHTM组较NTTM组骨量低，但骨矿化密度更高（P〈005）。结论：结果表明，用APH处理钛膜可促进膜与新成骨之间紧密贴合，从而提高骨再生结构的稳定性。还需要进一步体内和体外实验验证该结论。

关键词：引导骨再生骨缺损模型钛膜 Micro-CT扫描大鼠表面改性扫描电子显微镜观察 X射线能谱分析

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Performance and Effectiveness of UniFET^TM II MOSFET in HID Lamp Ballast

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Journal of Energy and Power Engineering 2012年第12期6卷 2001-2009页

作者： Jae-Eul Yeon Won-Hwa lee Kyu-Min Cho hee-Jun Kim Consumer Power System Team High Voltage Power Conversion Industrial & Automotive Bucheon 420-711 Korea Department of Information and Communication Engineering Yuhan Univisity Bucheon 422-749 Korea School of Electrical and Computer Engineering Hanyang University Ansan 426-791 Korea

An advanced cell structure and lifetime control technology has enhanced on-resistance and reverse recovery performance of power MOSFET (metal oxide semiconductor field-effect transistor) simultaneously. This paper introduces a newly developed planar MOSFET-UniFETTM II MOSFET-with highly improved body diode characteristics, and presents its performance and effectiveness. UniFET II MOSFET is divided into normal FET(field effect transistor), FRFET (fast recovery field effect transistor), and Ultra FRFET MOSFETs according to the concentration of lifetime control, and their reverse recovery times are about 70%, 25%, and 15% of that of a conventional MOSFET, respectively. To verify the performance and effectiveness of the new MOSFET, an experiment using a 150 W HID (high intensity discharge) lamp ballast that includes a mixed frequency inverter was implemented. As a result, it was verified that two UniFET II MOSFETs can replace two conventional MOSFEs and four additional FRDs (fast recovery diodes) without MOSFET failure.

关键词：功率MOSFET HID灯恢复性能金属氧化物半导体场效应晶体管镇流器反向恢复时间 TM 快速恢复

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Electrolyte Effect on Ni/MgO-SiO2 Catalysts for Methane Steam Reforming in DIR-MCFC（摘要）

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华东理工大学学报（自然科学版） 2010年第6期36卷 861-861页

作者： LI Zhen-lan DEVIANTO Hary HAN Jong-hee YOON Sung Pil LIM Tae-Hoon lee Ho-In School of Chemical and Biological Engineering and Research Center for Energy Conversion and Storage Seoul National University Seoul 151-744 Korea Center for Fuel Cell Research Korea Institute of Science and Technology Seoul 136-791 Korea

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Comparison of selected inflammation-based prognostic markers in relapsed or refractory metastatic colorectal cancer patients

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World Journal of Gastroenterology 2015年第43期21卷 12410-12420页

作者： Anna Song Wankyu Eo Sookyung lee Department of Clinical Oncology College of Korean MedicineKyung Hee University Department of Medical Oncology College of MedicineKyung Hee University

AIM: To investigate the impact of systemic inflammationbased prognostic markers on overall survival in relapsed/refractory metastatic colorectal cancer(m CRC) patients. METHODS: To investigate prognostic markers in m CRC patients,this study was performed with patients who have experienced relapsed/refractory m CRC with standard chemotherapy or were inapplicable to conventional treatment modality because of poor performance status,age,or comorbidity. We reviewed the medical records of 177 m CRC patients managed with Korean Medicine(KM) treatment modality using an anticancer agent of Rhus verniciflua Stokes extract from June 2006 to April 2013. The clinicopathologic characteristics,laboratory test,the systemic inflammation markers including the modified Glasgow prognostic score(m GPS),neutrophil lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR),lymphocyte monocyte ratio(LMR),and prognostic nutritional index(PNI) were analyzed. The overall survival of patients was calculated with the Kaplan-Meier method and the statistical significance was compared using with the log-rank test. To compare the impact of systemic inflammation based markers,the hazard ratio(HR) of m GPS,NLR,PLR,LMR,and PNI for overall survival were evaluated with the Cox proportional hazards ***: The majority of m CRC patients had relapsed/refractory to standard chemotherapy; 128 patients(72.3%) had undergone more than second line chemotherapy,and the median time from diagnosis of m CRC to initiation of KM was 9.4 mo. The median overall survival of enrolled patients was 8.3 mo. On univariate analyses,the inflammation markers of higher m GPS(P 300(P = 0.004),LMR ≤ 3.4(P < 0.001),and PNI ≤ 45.3(P = 0.001) were significantly associated with decreased survival time. On stepwise multivariate proportional hazards model,m GPS at 2 vs 0(HR = 3.212,95%CI: 1.437-7.716,P = 0.004),and LMR ≤ 3.4(HR = 1.658,95%CI: 1.092-2.518,P = 0.018) as independent predictors assoc

关键词： Colorectal neoplasm Inflammation Modified Glasgow

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In-situ formation of MOF derived mesoporous Co3N/amorphous N-doped carbon nanocubes as an efficient electrocatalytic oxygen evolution reaction

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Nano Research 2019年第7期12卷 1605-1611页

作者： Bong Kyun Kang Seo Young Im Jooyoung lee Sung Hoon Kwag Seok Bin Kwon SintayehuNibret Tiruneh Min-Jun Kim Jung Ho Kim Woo Seok Yang Byungkwon Lim Dae Ho Yoon Nano Materials and Components Research Center Korea Electronics Technology InstituteSeongnam 463-816Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University Suwon 440-746Republic of Korea Advanced Materials & Processing Center Institute for Advanced Engineering (IAE)Yongin 175-28Republic of Korea Australian Institute for Innovative Materials (AIIM) University of WollongongSquires WayNorth Wollongong NSW 2500Australia Department of Advanced Materials Engineering for Information and Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do17104Republic of Korea

The suitable materials,metal nitrides,are a promising class of electrocatalyst materials for a highly efficient oxygen evolution reaction (OER) because they exhibit superior intrinsic conductivity and have higher sustainability than oxide-based *** our knowledge,for the first time,we report a designable synthesis of three-dimensional (3D) and mesoporous Co3N@ amorphous N-doped carbon (AN-C) nanocubes (NCs) with well-controlled open-framework structures via monodispersed Co3[Co(CN)6]2 Prussian blue analogue (PBA) NC precursors using in situ nitridation and calcination ***3N@AN-C NCs (2 h) demonstrate better OER activity with a remarkably low Tafel plot (69.6 mV-dec-1),low overpotential of 280 mV at a current density of 10 ***,excellent cycling stability in alkaline electrolytes was exhibited without morphological changes and voltage elevations,superior to most reported hierarchical structures of transition-metal nitride *** presented strategy for synergy effects of metal-organic frameworks (MOFs)-derived transition-metal nitrides-carbon hybrid nanostructures provides prospects for developing high-performance and advanced electrocatalyst materials.

关键词： transition-metal nitride metal organic framework mesoporous oxygen evaluation reaction alkaline water electrolysis

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Effect of the herbal medicine Danggui Sini plus Wuzhuyu Shengjiang Tang on erythrocyte deformability in normal subjects: a cross-over trial

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Journal of Traditional Chinese Medicine 2018年第5期38卷 769-772页

作者： JiEun lee Seung-Yeon Cho Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ki-Ho Cho Seungwon Kwon Department of Cardiology and Neurology College of Korean Medicine Kyung Hee University

OBJECTIVE: To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang(DSWST) has any transient effect on erythrocyte deformability in normal ***: A total of 25 subjects [mean age(27.8± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte ***: The elongation index increased significantly after 2 h(P = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant differenceobserved. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration,DSWST improved erythrocyte deformability significantly compared to water(P < 0.001).CONCLUSION: DSWST has a transient effect on erythrocyte deformability in normal subjects.

关键词： Erythrocyte deformability Peptide elongation factors Raynaud disease Coldness of hands and feet Cross-over studies Danggui Sini plus Wuzhuyu Shengjiang Tang

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Reactivation of tuberculosis in hepatocellular carcinoma treated with transcatheter arterial chemoembolization: A report of 3 cases

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World Journal of Radiology 2012年第5期4卷 236-240页

作者： Yun Jeung Kim Pyung Gohn Goh hee Seok Moon Eaum Seok lee Seok Hyun Kim Byung Seok lee Heon Young lee Division of Hepatology Department of Internal Medicine Chung-Nam National University Hospital 640 Daesa-Dong Jung-Gu Daejeon 301-721 South Korea

Pulmonary tuberculosis is an opportunistic infection that can be reactivated in immunocompromised conditions, for example, in malignancy or after liver transplantation. Hepatocellular carcinoma (HCC) has a high mortality rate because it is frequently diagnosed at an advanced stage. Although surgical resection is the established curative measure for HCC, it is only feasible for earlystage HCC. Transcatheter arterial chemoembolization (TACE) is the most common treatment modality for patients with unresectable HCC. However, repeated TACE sessions and, occasionally, the tumor itself can further impair the reserve hepatic function and immunity. We report 3 recent cases of HCC with reactivation of pulmonary tuberculosis after TACE.

关键词： Hepatocellular carcinoma Reactivation Transcatheter arterial chemoembolization Tuberculosis

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