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Three-dimensional label-free morphology of CD8+T cells as a sepsis biomarker

Light(Science & Applications) 2023年第12期12卷 2565-2576页

作者： MinDong Sung Jong Hyun Kim Hyun-Seok Min Sooyoung Jang JaeSeong Hong Bo Kyu Choi JuHye shin Kyung Soo Chung Yu Rang Park Division of Pulmonary and Critical Care Medicine Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Tomocube Inc155 Sinseong-roShinsung-dongYuseong-guDaejeonRepublic of Korea

Sepsis is a dysregulated immune response to infection that leads to organ dysfunction and is associated with a high incidence and mortality *** lack of reliable biomarkers for diagnosing and prognosis of sepsis is a major challenge in its *** aimed to investigate the potential of three-dimensional label-free CD8+T cell morphology as a biomarker for *** study included three-time points in the sepsis recovery cohort(N=8)and healthy controls(N=20).Morphological features and spatial distribution within cells were compared among the patients'*** developed a deep learning model to predict the diagnosis and prognosis of sepsis using the internal cell *** between the morphological features and clinical indices were *** morphological features and spatial distribution differed significantly between patients with sepsis and healthy controls and between the survival and non-survival *** model for predicting the diagnosis and prognosis of sepsis showed an area under the receiver operating characteristic curve of nearly 100%with only a few cells,and a strong correlation between the morphological features and clinical indices was *** study highlights the potential of three-dimensional label-free CD8+T cell morphology as a promising biomarker for *** approach is rapid,requires a minimum amount of blood samples,and has the potential to provide valuable information for the early diagnosis and prognosis of sepsis.

关键词： sepsis diagnosis Morphological

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Comparison of Antioxidant Properties of Water and Ethanol Extracts Obtained from Dried Boxthorn (<i>Lycium chinensis</i>) Fruit

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Food and Nutrition Sciences 2012年第9期3卷 1307-1320页

作者： Joo-shin Kim Department of Convergence Industry Public Health Program The Seoul Venture University Kangnam-Gu Seoul Republic of Korea

Antioxidant activities of W and E extracts obtained from dried boxthorn (Lycium chinensis) fruit were measured based on DPPH radical scavenging and reducing powers, and their relationships with total phenolics, flavonoid content, and antioxidant activity were investigated. A linear correlation among antioxidant activity, total phenolics, and flavonoid content was observed in concentration-dependent mode. Both extracts showed > 95% DPPH radical-scavenging activity and the higher reducing power of 3200 ppm at the same concentration. The antioxidant potential of both extracts were compared with those of commercial antioxidants such as BHA, BHT, TBHQ, ferulic acid, and α-tocopherol using H2O2 scavenging activity, inhibition of linoleic acid peroxidation, inhibition of hemolysis of rat erythrocyte induced by peroxyl radicals, and inhibition of Fe2+-induced lipid peroxidation using rat brain tissue. In the H2O2 scavenging activity, E extract showed a comparable significant antioxidant power, comparable to commercial antioxidants, and no signifi-cant difference (P > 0.05) was found between W and E extracts on inhibition of the linoleic acid peroxidation. Whereas W extract exhibited a significant power in the hemolysis of rat erythrocytes, none was observed in E extract. In the Fe-induced lipid peroxidation using rat brain tissue, no significant difference (P > 0.05) was found between both ex-tracts, showing a comparable activity with those of synthetic antioxidants. Both W and E extracts of dried boxthorn (Lycium chinensis) fruit may have a potential as natural antioxidants to replace synthetic antioxidants.

关键词： Antioxidant Activity Dried Boxthorn Fruit Extract Phenolics Radical Scavenging Lipid Peroxidation

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Korea＇s Future Policy Recommendation for the Promotion of Eco-Friendly Vehicles in Metropolitan Area

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Journal of Energy and Power Engineering 2017年第6期11卷 385-392页

作者： Won Shik shin Graduate School of Knowledge Based Technology and Ener~ Korea Polytechnic University 237 Sangidaehak-ro Siheung-siGyeonggi-do 15073 Korea President of Korea Association for Natural Gas Vehicles (KANGV) 2nd Floor KOGAS 340 Gonghang-daero Gangseo-gu Seoul07647 Korea

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Highly efficient and stable solid-state fiber dye-sensitized solar cells with Ag-decorated SiO_(2) nanoparticles

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Nano Research 2021年第8期14卷 2728-2734页

作者： Jae Ho Kim Seok-Ju Yoo Daseul Lee Jin Woo Choi Sang-Cheol Han Tae In Ryu Hyung Woo Lee Myunghun shin Myungkwan Song Materials Center for Energy Convergence Korea Institute of Materials Science(KIMS)797Changwon-daeroSungsan-guChangwonGyeongsangnam-do51508Republic of Korea CEN Nano.Co.Ltd. Nano Convergence CenterMuan-roBuduk-myeonMiryang-siGyeongsangnam-do50404Republic of Korea Accident Coordination and Training Division National Institute of Chemical Safety(NICS)90Gajeongbuk-roYuseong-guDaejeon34114Republic of Korea Department of Nanoenergy Engineering and Research Center of Energy Convergence Technology Pusan National UniversityBusandaehak-ro 63-2Geumjeong-guBusan 46241Republic of Korea School of Electronics and Information Engineering Korea Aerospace University Goyang-cityGyeonggi-do10540Republic of Korea

Fiber-shaped dye-sensitized solar cells(FDSSCs)represent promising futuristic flexible or wearable power sources,owing to their simple fabrication process,light weight,weavability,and *** with strategies on changing the properties of semiconductor materials,the effects of incorporating silver-embedded SiO_(2) nanoparticles(Ag@SiO_(2)NPs)on the photoanodes of solid-state FDSSCs(SS-FDSSCs)are *** power conversion efficiency(PCE)of SS-FDSSCs with Ag@SiO_(2) NPs reaches 5.38%,which is comparable to the reference(3.98%).The PCEs remain at 95%between-16.9 and 91.7℃,indicating the operational stability of SS-FDSSCs within this temperature *** fabricated SS-FDSSCs,whose radii were 2 mm,maintains more than 90%of their efficiency over 500 bending cycles and 10 washing cycles.

关键词： dye-sensitized solar cells fiber-shaped solar cells SiO_(2)nanoparticles plasmonic effect solid-state electrolyte

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Gain Flattening Filter for Hybrid Sb-Doped EDFA Using All-Fiber Mach-Zehnder Interferometers

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光学学报 2003年第S1期23卷 27-28页

作者： Manjung Han Youngeun Im Woojin shin Uh-Chan Ryu K. Oh Department of Information and Communications K-JIST 1 Oryong-dong Puk-gu Kwangju 500-712 Republic of KoreaDepartment of Information and Communications K-JIST 1 Oryong-dong Puk-gu Kwangju 500-712 Republic of KoreaDepartment of Information and Communications K-JIST 1 Oryong-dong Puk-gu Kwangju 500-712 Republic of KoreaDepartment of Information and Communications K-JIST 1 Oryong-dong Puk-gu Kwangju 500-712 Republic of KoreaDepartment of Information and Communications K-JIST 1 Oryong-dong Puk-gu Kwangju 500-712 Republic of Korea

We demonstrate a novel gain-flattening filter based on all fiber Mach-Zehnder interferometers for Sb-doped silica hybrid EDFA. A gain flatness of better than 0.9dB has been achieved for three concatenated filters in C... 详细信息

关键词： EDFA in In of for Gain Flattening Filter for Hybrid Sb-Doped EDFA Using All-Fiber Mach-Zehnder Interferometers Sb

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Portal vein stenting as a significant risk factor for biliary stricture in adult living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 480-486页

作者： Min-Ho shin Deok-Bog Moon Sung-Gyu Lee shin Hwang Ki-Hun Kim Chul-Soo Ahn Tae-Yong Ha Gi-Won Song Dong-Hwan Jung Gil-Chun Park Young-In Yun Wan-Jun Kim Woo-Hyoung Kang Seok-Hwan Kim Gi-Young Ko Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 0lympic-ro 43 gilSongpa-guSeoul 05505Korea Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine88 0lympic-ro 43 gilSongpa-guSeoul 05505Korea

BACKGROUND: Although perioperative portal vein (PV) stent implantation is an effective treatment for steno-occlusive disease in adult living donor liver transplantation (LDLT) re-cipients, we experienced high incidence of biliary anastomotic strictures (BAS) after PV stenting. In this study, we sought to clarify the relation between BAS and PV stenting and to suggest the possible mechanism of BAS and measures to reduce its in-cidence. METHODS: We retrospectively analyzed 44 LDLT recipients who underwent PV stent implantation across the line of PV anastomosis regardless of the location of steno-occlusion (stent group) and their matched controls (non-stented LDLT recipients, n=131). RESULTS: The incidence of BAS was higher in patients in the stent group than that in the control group (43.2% vs 17.6%, P=0.001). Cumulative 6-month and 1-, 2- and 5-year BAS rates were 31.8%, 34.1%, 41.4% and 43.2%, respectively, in the stent group and 13.0%, 13.8%, 16.1% and 17.8%, respectively, in the control group (P=0.001). Multivariate analysis revealed that PV stenting was an independent risk factor for BAS. CONCLUSIONS: Although PV stent implantation is a reliable treatment modality for steno-occlusive PV in adult LDLT recipients, innovative methods to prevent the PV stent from crossing the line of PV anastomosis may be necessary to reduce the incidence of postoperative BAS.

关键词： portal vein stenting biliary stricture living donor liver transplantation

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Role of human glioma stroma mesenchymal stem cells in human glioma

Role of human glioma stroma mesenchymal stem cells in human ...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Seok-gu Kang Hyun-Su Mok Hyun-Do shin Yoon-Kyung Park Na-Ri Park Youn Soo Lee YongKil Hong Department of Neurosurgery The Catholic University of Korea College of MedicineSeoul St.Mary's Hospital

Object We have proved that the existence of glioma stroma mesenchymal stem cells（GS-MSCs）,which are one of components of glioma ***-MSCs may represent non-neural stem cells that act as an important source of mesenchymal elements,particularly during the growth of *** tried to investigate the biological effect of GS-MSCs on glioma cancer stem cells（gCSCs）.We hypothesized that GS-MSCs increase the proliferation of *** We could isolate human GS-MSCs and human gCSCs from human glioma *** gCSCs were co-cultured with human *** vitro proliferation characteristics were evaluated between gCSCs alone and gCSCs co-cultured with *** also investigated the changes of gCSCs protein before and after GS-MSCs *** we created mouse orthotopic glioma xenograft with gCSCs and gCSCs after coculturing with *** analyzed the survival,tumor volume,vessel formation,and proliferation about mouse orthotopic glioma xenografts between two groups（gCSCs alone and gCSCs after co-culturing with GSMSCs） by immunofluorescent *** After gCSCs were co-cultured with GS-MSCs,proliferation activity of gCSCs increased 4 times more than gCSCs *** Akt pathway related protein expression was increased when gCSCs were co-cultured with *** co-culturing gCSCs with GS-MSCs,tumor volume,PCNA expression,and vessel density were increased and survival time was *** together,GS-MSCs change biological characteristics of gCSCs to become more aggressive *** Our results indicated that GS-MSCs are able to change biological characteristics of gCSCs to become more aggressive *** the first time,we have successfully proved the biological effect of human GSMSCs on human gCSCs in vitro and in ***-MSCs may represent non-neural stem cells that act as an important source of mesenchymal elements,particularly during the growth of gliomas.

关键词： glioma glioma cancer stem cells mesenchymal stem cells proliferation stroma cells survival

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Potentiation of antiglioma effect with combined temozolomide and interferon-β

Potentiation of antiglioma effect with combined temozolomide...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Jin-A Park Seung-Ho Yang Won-Il Joo Seok-gu Kang shin-Soo Jeun Dong-Sup Chung Yong-Kil Hong

＜正＞Temozolomide （TMZ） is a DNA methylating agent that has shown promising anti-tumor activity against high grade glioma. Interferon- β （IFN- β） is known to have antiproliferative and antiangiogenic activities. The aim of this study was to elucidate whether an antiglioma effect could be potentiated by the combination of TMZ and IFN-

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Preliminary experimental study of a supercritical CO2 power cycle test loop with a high-speed turbo-generator using R134a under similarity conditions

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Frontiers in Energy 2017年第4期11卷 452-460页

作者： Junhyun CHO Hyungki shin Jongjae CHO Young-Seok KANG Ho-Sang RA Chulwoo ROH Beomjoon LEE Gilbong LEE Byunghui KIM Young-Jin BAIK Thermal Energy System Laboratory Korea Institute of Energy Research 152 Gajeong-ro Yusung-gu Daejeon 34129 Republic of Korea Engine Component Research Team Korea Aerospace Research Institute (KARl) 169-84 Gwahak-ro Yusung-gu Daejeon 34133 Republic of Korea InGineers 21 Saman-ro 16 Beon-gil Gimhae-si Gyeongsangnam-do 621-220 Republic of Korea

Research on applying a supercritical carbon dioxide power cycle （S-CO2） to concentrating solar power （CSP） instead of a steam Rankine cycle or an air Brayton cycle has been recently conducted. An S-CO2 system is suitable for CSP owing to its compactness, higher efficiency, and dry-cooling capability. At the Korea Institute of Energy Research （KIER）, to implement an S-CO2 system, a 10 kWe class test loop with a turbine- alternator-compressor （TAC） using gas foil bearings was developed. A basic sub-kWe class test loop with a high- speed radial type turbo-generator and a test loop with a capability of tens of kWe with an axial type turbo- generator were then developed. To solve the technical bottleneck of S-CO2 turbomachinery, a partial admission nozzle and oil-lubrication bearings were used in the turbo- generators. To experience the closed-power cycle and develop an operational strategy of S-CO2 operated at high pressure, an organic Rankine cycle （ORC） operating test using a refrigerant as the working fluid was conducted owing to its operational capability at relatively low- pressure conditions of approximately 30 to 40 bar. By operating the sub-kWe class test loop using R134a as the working fluid instead of CO2, an average turbine power of 400 W was obtained.

关键词： supercritical CO2 power cycle turbomachin-ery compressor turbine

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A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

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Nano Research 2019年第12期12卷 3024-3030页

作者： Jin Sil Lee Youngmin Hwang Hyeryeon Oh Sunghyun Kim Jin-Hwa Kim Jeung-Hoon Lee Yong Chui shin Giyoong Tae Won II Choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

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