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在初始PSA和Gleason评分较高的前列腺癌病人中前列腺活检术后分期MRI对T3疾病的预测力会降低

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Asian Journal of Andrology 2011年第3期13卷 487-493,515页

作者： Young Hwii Ko Deuk Jae Sung Sung gu kang Seok Ho kang Jeong gu Lee Je Jong Kim Jun Cheon Department of Urology Korea University School of Medicine Seoul Korea Department of Radiology Korea University School of Medicine Seoul Korea

为提高预测囊外扩展（ECE）和精囊浸润（SVI）的准确性，我们评估了影响MRI（磁共振成像）预测的变量，并估计了这些变量对术前MRI分期和病理结果之间准确性的影响。121名行机器手前列腺癌根治术（RALP）的局限性或局限性晚期前列腺癌... 详细信息

为提高预测囊外扩展（ECE）和精囊浸润（SVI）的准确性，我们评估了影响MRI（磁共振成像）预测的变量，并估计了这些变量对术前MRI分期和病理结果之间准确性的影响。121名行机器手前列腺癌根治术（RALP）的局限性或局限性晚期前列腺癌病人，经直肠活检后，所有入选病人都接受了MRI的检查进行分期诊断。经过RALP后，只有43．8％（53／121）的病人与MRI的预测分期相匹配。与在ECE预测中的匹配组相比，非匹配组的初始前列腺特异抗原（PSA）明显高于匹配组（非匹配组12．8ng mL-1，匹配组8．1ng mL-1，P=0．048）．在对SVI的预测中，非匹配组中，初始PSA8．1w．17．3ng mL-1，P=0．009和穿刺活检Gleason评分6．5w．7．6，P=-0．035均显著高于匹配组。如果把10ng mL-1和20ng mL-1的PSA水平作为临床临界值，预测ECE时，对于PSA水平高于20ng mL-1的病人，MRJ准确性会下降（75．6％，64．5％，37．5％，P=0．01）；对这组病人预测SVI时，MRI的准确性也会明显下降（91．5％，77．4％，37．5％，P〈0．01）。如果把Gleason评分为7分作为临床临界值，对Gleason评分高于7分的病人，预测SvI时MRI的准确性也会显著下降（93．9％，82．1％，62．9％，P=0．01）。因此，对于这些患者，为了获得前列腺癌根治术过程中的切缘阴性，能提供大量信息的是手术发现而不是活检后的MRI图像，暗示在前列腺活检以前进行MRI检查在临床上更有优势。

关键词：磁共振成像肿瘤分期前列腺肿瘤

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检察监督介入行政性失信惩戒的困境与路径

湘潭大学学报（哲学社会科学版） 2023年第6期47卷 81-87页

作者：顾敏康宋阳湘潭大学信用风险管理学院湖南湘潭411105

检察监督介入行政性失信惩戒是践行新时代监督理念的内在要求,能够有效解决行政性失信惩戒中行政执法不规范和过惩失当等现实问题。检察监督介入行政性失信惩戒不乏法律和政策的支撑。为消解社会公众对检察机关“越俎代庖”的顾虑,须对... 详细信息

检察监督介入行政性失信惩戒是践行新时代监督理念的内在要求,能够有效解决行政性失信惩戒中行政执法不规范和过惩失当等现实问题。检察监督介入行政性失信惩戒不乏法律和政策的支撑。为消解社会公众对检察机关“越俎代庖”的顾虑,须对检察机关的监督对象和范围进行限定。在检察监督程序中,需建立案件线索来源渠道和研判机制以规范受理程序;明确检察建议为主的多元化监督方式、推进类案监督方式以规范处理机制;构建监督效果的反馈机制、跟进机制和协作机制以保障监督的效力。

关键词：行政性失信惩戒检察机关法律监督

新安江-千岛湖生态补偿试验区乡村人居环境质量时空分异及影响机制

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生态与农村环境学报 2023年第1期39卷 29-40页

作者：董冬罗毅王丽宸邰宇顾康康安徽建筑大学建筑与规划学院安徽合肥230022 安徽省国土空间规划与生态研究院安徽合肥230022

作为全国首个跨省流域横向生态补偿试点,新安江流域生态补偿已经过3轮试点,并进入新安江-千岛湖生态补偿试验区建设阶段。生态补偿政策已经拓展到乡村生态环境保护与治理、产业结构调整、村民就业与生活水平等领域,直接影响乡村人居环... 详细信息

作为全国首个跨省流域横向生态补偿试点,新安江流域生态补偿已经过3轮试点,并进入新安江-千岛湖生态补偿试验区建设阶段。生态补偿政策已经拓展到乡村生态环境保护与治理、产业结构调整、村民就业与生活水平等领域,直接影响乡村人居环境质量。科学开展乡村人居环境质量时空分异及影响机制研究对促进生态补偿机制优化具有重要意义,因此,选择2011—2019年新安江-千岛湖生态补偿试验区10个县(区、市)相关数据,采用熵权TOPSIS法和时空地理加权回归模型,对乡村人居环境质量进行综合评价。结果表明:(1)研究期新安江-千岛湖生态补偿试验区乡村人居环境综合质量以及乡村生态环境和乡村生活环境子系统质量总体呈上升趋势,而乡村生产环境呈现下降趋势。(2)新安江-千岛湖生态补偿试验区乡村人居环境质量呈现东西高、中部低的空间分布特征。(3)生态环境因素是研究区环境质量时空分异的主导因素,生产与生活因素是内在驱动因素,政策因素是外部直接因素。其中,生态补偿指数、新安江流域水质、乡村人均农林牧渔业总产值、乡村人均可支配收入、乡村医疗设施水平和乡村低保人数比例是驱动新安江-千岛湖生态补偿试验区乡村人居环境质量上升的主要影响因子,且影响力随着时间推移呈上升趋势。

关键词：乡村人居环境时空分异熵权TOPSIS 时空地理加权回归模型新安江-千岛湖生态补偿试验区

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论行政性失信惩戒中“履职需要”之界定

湘潭大学学报（哲学社会科学版） 2023年第2期47卷 57-63页

作者：顾敏康周灿湘潭大学信用风险管理学院湖南湘潭411105

“裁量型惩戒”是行政惩戒制度的重要组成部分,且其实施须以“履职需要”为依据。囿于立法和行政执法对“履职需要”概念界定的缺失,使得“裁量型惩戒”的实施规则不明,进而导致其错误或肆意实施之乱象,且其实施的合法性审查亦受阻碍。... 详细信息

“裁量型惩戒”是行政惩戒制度的重要组成部分,且其实施须以“履职需要”为依据。囿于立法和行政执法对“履职需要”概念界定的缺失,使得“裁量型惩戒”的实施规则不明,进而导致其错误或肆意实施之乱象,且其实施的合法性审查亦受阻碍。鉴于回应个案事实、尊重惩戒部门独立履职地位和顺应惩戒制度实践情况之需要,“履职需要”之界定应以行政执法界定为基础,即先由惩戒部门对“履职需要”进行明确说明,在听取被惩戒人意见后最终形成对“履职需要”的界定结果,以防止界定过程中的偏见。而“履职需要”的界定过程应当即时书面记载,便于司法部门以界定结论为基础,对“裁量型惩戒”的合法性进行过程性审查。

关键词：裁量型惩戒履职需要界定

Effective Analysis by Arrangement of Multi-Baffle at Weir Downstream

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Engineering（科研） 2016年第12期8卷 872-882页

作者： Joon-gu kang River Experiment Center Korea Institute of Civil Engineering and Building Technology Andong Korea

The purpose of the study is to analyze the reduction effects of multi-baffle installed for improving the scour issue of weir downstream and the study reviewed the flow reduction effect for the location of the battle and the reduction effect associated with the baffle installation. We carried out nine cases of experiments and analyzed reduction effects through the flow rate comparison for the arrangement type of the cases. As the result of the experiment, the maximum flow rate in the weir downstream of the case 1, which has no baffle installation, is measured at 2.068 m/s due to multidirectional flow and crossing waves, and channel walls had whirlpool generation on the left and right with fast discharge flow. The maximum water level showed lower water level than when the battle was installed as there is no flow resistance. The maximum stream velocity in the weir downstream from cases 2 to 9 installed with a baffle demonstrated reduction in the maximum stream velocity than before the battle was installed and showed an increased tendency than before the baffle was installed as the maximum water level is affected by flow resistance. As the result of the comparison of the reduction effect by installing the baffle, the V type of the case 6 demonstrated the best reduction effect.

关键词： Multi-Baffle Weir Downstream Discharge Water Level Velocity

Biological and Functional Properties of Wedelolactone in Human Chronic Diseases

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 1-15页

作者： Ramachandran Vinyagam Pradeep Kumar Kyung Eun Lee Baojun Xu Muhammad Nurul Matin Sang gu kang Department of Biotechnology Institute of BiotechnologyCollege of Life and Applied ScienceYeungnam UniversityGyeongsanGyeongbuk38541Korea Department of Forestry North Eastern Regional Institute of Science and TechnologyNirjuli791109India Stemforce 313 Institute of Industrial TechnologyYeungnam UniversityGyeongsanGyeongbuk38541Korea Food Science and Technology Program Beijing Normal University-Hong Kong Baptist UniversityUnited International CollegeZhuhai519000China Department of Genetic Engineering and Biotechnology University of RajshahiRajshahi6205Bangladesh

Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders.Wedelolactone(WDL),a major bioactive compound in Eclipta prostrata L(Eclipta alba L),has been reported with potential benefits in human health against chronic diseases.However,a comprehensive study on WDL pharmacological benefits in various ailments,to the best of our knowledge,is not yet reported.Thereof,the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases,including cardiovascular,cancer,diabetes mellitus,liver disease,Alzheimer’s disease,and androgenetic alopecia.In this study,we collected all the relevant experimental information on WDL from Scientific databases such as PubMed,Web of Science,Science Direct,and Google Scholar.Conclusively,WDL is recognized as a key anti-oxidant with both specific regulator and inhibitor of major drug targetable proteins in human chronic diseases and disorders.Hence,WDL as a novel therapeutic bioactive molecule is advised to explore further for relevant pharmacological activities.

关键词： Wedelolactone Eclipta alba L Ecliptaprostrata L bioactivity bioavailability

Double-side fabrication process and millimeter waveresponse of intrinsic Josephson junctions

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Chinese Science Bulletin 2009年第5期54卷 873-876页

作者： WU JingBo YI DongChao gu ZhengHao kang Lin XU WeiWei CHEN Jian WU PeiHeng Research Institute of Superconductor Electronics Nanjing University Nanjing 210093 China

We adopted double-side fabrication process to prepare intrinsic Josephson junctions (IJJs) based on Bi2Sr2CaCu2O8+x (BSCCO) single crystals. Using crystal cleavage and double-side argon ion milling, we have successfully fabricated very uniform IJJs with the thickness of single crystal slice less than 200 nm. Using quasi-optical system, the response of the IJJs to millimeter wave radiation was studied. With applied magnetic field perpendicular to a-b plane, we have observed Shapiro steps under millimeter wave radiation, and the Josephson oscillation of each junction was phase-locking.

关键词：电磁波传播本征Josephson结双倍边制作过程毫米波

The progress in the verification of key technologies for floating structures near islands and reefs

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Journal of Hydrodynamics 2021年第1期33卷 1-12页

作者： You-sheng Wu Jun Ding Xue-kang gu Chun-yan Ji Xiong-bo Zheng guo-ping Zhou Dao-lin Xu Li Ma China Ship Scientific Research Center Wuxi 214082China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China Shanghai Merchant Ship Design and Research Institute Shanghai 201203China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266000China

In 2019 a Scientific Research&Demonstration Platform was deployed near islands and reefs in South China Sea by a joint research group of 7 institutes and universities in China.It is a simplified small model of a two-module semi-submersible-type VLFS.The test on site has continued for more than one and half years since then for long-term observations to validate the developed key technologies for design and behavior predictions of floating structures deployed near islands and reefs.An integrated information system was set up to continuously collect and inspect the data of the encountered waves,structure responses,connector forces,mooring line forces,anti-corrosion status of the platform,the performance efficiencies of a floating breakwater nearby and a wave energy converter attached on the breakwater.In this paper,the status of the on-site measurements and validations of the key technologies are briefly described.

关键词： near islands and reefs inhomogeneous wave environment multi-module floating structures VLFS floating breakwater wave responses hydroelastic analysis predictions on-site measurements validation verification

The least-square method in complex number domain

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Progress in Natural Science:Materials International 2006年第3期16卷 307-312页

作者： gu Xiangqian, kang Hongwen and CAO Hongxing (State Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China) State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Beijing 100081 China

The classical least-square method was extended from the real number into the complex number domain, which is called the complex least-square method. The mathematical derivation and its applications show that the complex least-square method is different from one that the real number and the imaginary number are separately calculated with the classical least-square, by which the actual least-square estimation cannot be obtained in practice. Applications of this new method to an arbitrarily given series and to the precipitation in rainy season at 160 meteorological stations in China mainland show advantages of this method over other conventional statistical models.

关键词： complex least square Fourier transformation forecast in rainy season.