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Nano-Micro Letters 2022年第7期14卷 118-139页

作者： Jae seob lee Rakesh Saroha Jung Sang Cho Department of Engineering Chemistry Chungbuk National UniversityCheongjuChungbuk 361-763Republic of Korea

Metal–organic framework-templated nitrogen-doped graphitic carbon(NGC)and polydopaminederived carbon(PDA-derived C)-double coated one-dimensional CoSe_(2) nanorods supported highly porous threedimensional microspheres are introduced as anodes for excellent Na-ion batteries,particularly with long-lived cycle under carbonate-based electrolyte *** microspheres uniformly composed of ZIF-67 polyhedrons and polystyrene nanobeads(φ=40 nm)are synthesized using the facile spray pyrolysis technique,followed by the selenization process(P-CoSe_(2)@NGC NR).Further,the PDA-derived C-coated microspheres are obtained using a solution-based coating approach and the subsequent carbonization process(P-CoSe_(2)@PDA-C NR).The rational synthesis approach benefited from the synergistic effects of dual carbon coating,resulting in a highly conductive and porous nanostructure that could facilitate rapid diffusion of charge species along with efficient electrolyte infiltration and effectively channelize the volume ***,the prepared nanostructure exhibits extraordinary electrochemical performance,particularly the ultra-long cycle life *** instance,the advanced anode has a discharge capacity of 291(1000th cycle,average capacity decay of 0.017%)and 142 mAh g^(-1)(5000th cycle,average capacity decay of 0.011%)at a current density of 0.5 and 2.0 A g^(-1),respectively.

关键词： Spray pyrolysis Sodium-ion batteries Cobalt selenide nanorods Porous microspheres Dual carbon coating

Potentiating activity of rhein in targeting of resistance genes in methicillin-resistant Staphylococcus aureus

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 14-18页

作者： Ryong Gong Dae Young lee Jae Won lee Doo Jin Choi Geum-Soog Kim Sang Hyuk lee Young-seob lee Department of Herbal Crop Research National Institute of Horticultural & Herbal Science Rural Development Administration

Objective: To investigate the synergistic effect between rhein(RHE) and oxacillin against Staphylococcus aureus(MRSA) at the gene level. Method: A minimum inhibitory concentration and checkerboard dilution test were conducted to evaluate antibacterial activity. Reverse transcriptase polymerase chain reaction was conducted to investigate the gene expressions. Results: RHE exhibited a minimum inhibitory concentration of 62.5-250.0 μg/mL against various MRSA strains and the reference strain, respectively. As revealed by the checkerboard assay, a combination of RHE and oxacillin exhibited synergistic or partially synergistic effects against MRSA strains. RHE decreased the expressions of mecA/blaZ in a dose-dependent manner. RHE also decreased the expressions of the regulator genes mecI/blaI and mecR1/blaR1. Conclusions: We suggest that RHE affects the activity of mecR1/blaR1, which is located in the cell membrane of MRSA and results in the suppression of mecA/mecI/mecR1 and blaZ/blaI/blaR1 gene expressions.

关键词： Antimicrobials Mechanism of action Staphylococcus aureus Polymerase chain reaction

Bilateral superficial cervical plexus block for parathyroidectomy during pregnancy:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4153-4160页

作者： Jun-Young Chung Yo seob lee Seung Yeon Pyeon Sang-Ah Han Hyub Huh Department of Anesthesiology and Pain Medicine Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoul 05278South Korea Department of Obstetrics&Gynecology Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoul 05278South Korea Department of Surgery Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoul 05278South Korea

BACKGROUND Primary hyperparathyroidism(PHPT)is the most common cause of pregnancyrelated *** can cause maternal and fetal complications in pregnant *** anesthesia for non-obstetric surgery in pregnant women is associated with maternal hazards and concerns regarding long-term neonatal neurocognitive *** removal of the lesion in mid-pregnancy is currently the primary treatment option for pregnant patients with ***,the blood calcium concentration at which surgery should be considered remains under discussion due to the risk of *** SUMMARY A 31-year-old nulliparous woman at 11 wk of gestation was admitted to our hospital for *** patient had a history of intrauterine fetal death with unknown etiology at 16 wk of gestation 1 year *** blood test results showed that the serum calcium level was elevated to 12.9 mg/dL,and the parathyroid hormone level was elevated to 157 pg/*** a neck ultrasound,it revealed a 0.8 cm×1.5 cm sized oval,hypoechoic mass in the upper posterior of the left thyroid gland,which was compatible with parathyroid *** cervical plexus block(SCPB)for parathyroidectomy was *** surgery,the obstetrician checked the status of the fetus,and there were no abnormal *** then her calcium level returned to normal values after one week of surgery and a healthy male neonate of 2910 g was delivered vaginally at 38 wk of *** Our case suggests that SCPB can be an anesthetic option for parathyroidectomy during the first trimester of pregnancy.

关键词： Bilateral superficial cervical plexus block Hypercalcemia Parathyroid adenoma Parathyroidectomy Pregnancy Case report

Effects of aqueous extract from red Liriope platyphylla on phthalic-anhydride-induced atopic dermatitis in Interleukin-4/Luciferase/Consensus non-coding sequence-1 transgenic mice evaluated in terms of luciferase signal and general phenotype biomarkers

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Journal of Traditional Chinese Medicine 2017年第4期37卷 475-485页

作者： Moon Hwa Kwak Ji Eun Kim Jun Go Hong Joo Son Hee seob lee Jin Tae Hong Dae Youn Hwang College of Natural Resources and Life Science/Life and Industry Convergence Research Institute Pusan National UniversityMiryang 627-706South of Korea College of Human Ecology Pusan National UniversityBusan 609-735south of Korea College of Pharmacy and Medical Research Center Chungbuk National UniversityChungju 361-763south of Korea College of Pharmacology Chungbuk National UniversityChungju 361-763south of Korea

OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phthalic anhydride(PA) treated Interleukin-4(IL-4)/Luc/Consensus non-coding sequence-1(CNS-1) transgenic(Tg) mice following treatment with aqueous extract of RLP(AEt RLP) for4 ***: Alterations in AD phenotypes were measured in IL-4/Luc/CNS-1 Tg mice following treatment with AEt RLP using inflammation parameter analysis, bioluminescence imaging analysis, histological analysis, reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and Western blot ***: RLP contained high concentrations of total phenolic compounds, total flavonoid compounds and 5-HNE related to AD therapy. The Luc signal was only detected in the abdominal region and the submandibular lymph node(SL), mesenteric lymph node(ML), thymus and pancreas of the PA treated group. This signal was significantly decreased by 28%-73% throughout the body and in the four organs in PA + AEt RLP treated group. Furthermore, the lymph node weight, immunoglobulin E concentration and dermal thickness were decreased by 37%-67% in the PA + AEt RLP treated ***: Our findings suggest that the therapeutic effect of AEt RLP on PA induced AD could be successfully quantified by comparison of Luc signals and AD phenotype markers in IL-4/Luc/CNS-1Tg mice, and that the Luc signal was as sensitive as the general AD phenotypes, enabling detection of effects without euthanasia.

关键词： Dermatitis, Atopic Liriope plant Interleukin-4 Luciferases Mice, transgenic Phthalic anhydrides Immunoglobulin E

Stochasticity dominates assembly processes of soil nematode metacommunities on three Asian mountains

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Pedosphere 2023年第2期33卷 331-342页

作者： Shuqi ZOU Jonathan ADAMS Zhi YU Nan LI Dorsaf KERFAHI Binu TRIPATHI Changbae lee Teng YANG Itumeleng MOROENYANE Xing CHEN Jinsoo KIM Hyun Jeong KWAK Matthew Chidozie OGWU Sang-seob lee Ke DONG Department of Integrative Biotechnology Sungkyunkwan University300 Chuncheon-DongSuwon 16419(Korea) School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210008(China) Key laboratory of Ministry of Education for Environment Change and Resources Use in Beibu Gulf Guangxi Key Laboratory of Earth Surface Processes and Intelligent SimulationNanning Normal University175 East Mingxiu RoadNanning 530001(China) School of Natural Sciences Department of Biological SciencesKeimyung UniversityDaegu 42601(Korea) Korea Polar Research Institute Incheon 21990(Korea) Department of Forestry Environment and SystemsKookmin UniversitySeoul 02707(Korea) State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences71 East Beijing RoadNanjing 210008(China) Institut National Recherche Scientifique Institut Armand-Frappier SantéBiotechnologie531 Boulevard des PrairiesLaval H7V1B7(Canada) College of Life Science and Technology Guangxi University100 Daxue RoadNanning 530004(China) Department of Biological Sciences Kyonggi University154-42 Gwanggyosan-roYeongtong-guSuwon-siGyeonggi-do 16227(Korea) School of Biological Sciences Seoul National University1 Gwanak-roSeoul 08826(Korea)

Nematodes play an important role in ecosystems;however,very little is known about their assembly processes and the factors influencing *** studied nematode communities in bulk soils from three Asian mountain ecosystems to determine the assembly processes of free-living nematode metacommunities and their driving *** each mountain,elevations span a range of climatic conditions with the potential to reveal assembly processes that predominate across multiple biomes.A phylogenetic null modeling framework was used to analyze 18S rRNA gene amplicons to quantify various assembly *** found that phylogenetic turnover between nematode communities on all mountains was dominated by stochastic processes,with“undominated processes”being the most predominant stochastic *** has a significant impact on the relative importance of deterministic and stochastic processes.A variety of climatic and edaphic variables significantly influenced the variations in community assembly processes with elevation,even though their impacts were not consistent between the ***,our results indicate that free-living nematode metacommunities in a wide range of environments are largely structured by stochastic processes rather than by niche-based deterministic processes,suggesting that metacommunities of soil free-living nematodes may respond to climate change in a largely unpredictable way.

关键词： climate change ecological drift elevation gradient environmental stress stochastic process

Potentiating activity of luteolin on membrane permeabilizing agent and ATPase inhibitor against methicillin-resistant Staphylococcus aureus

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 16-19页

作者： Dae-Ki Joung Young-seob lee Sin-Hee Han Sang-Won lee Seon-Woo Cha Su-Hyun Mun Ryong Kong Ok-Hwa Kang Ho-Jun Song Dong-Won Shin Dong-Yeul Kwon Department of Oriental Pharmacy College of Pharmacy and Wonkwang-Oriental Medicines Research Institute.Wonkwang University Department of Herbal Crop Research National Institute of Horticultural & Herbal ScienceRDA BK21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University Department of Oriental Medicine Resources Sunchon National University

Objective:To investigate the mechanism of antibacterial activity of luteoiin(LUT) against methicillin-resistant Staphylococcus aureus(MRSA).Methods:The mechanism of anti-MRSA activity of LUT was analyzed by the viability assay in membrane permeabilizing agent ATPase inhibitors,and peptidoglycan(PGN) derived from Staphylococcus aureus(***).Also,transmission electron microscopy was used to monitor survival characteristics and changes in *** ***:Compared to the LUT alone,the optical density of suspensions treated with the combination of 125 μg/mL Tris and 230 μg/mL DCCD were reduced to 60%and 46%,***(15.6 μg/mL) gradually impeded the activity of LUT,and PGN(62.5 μg/mL) completely blocked the activity of LUT on ***:Increased susceptibility to LUT with me Tris and DCCD combinations is evident in all tested MRSA *** results indicate LUT synergy in increasing cytoplasmic membrane permeability and inhibiting *** PGN directly blocks the antibacterial activity of LUT,suggesting the direct binding of LUT with *** findings may be validated for the development of antibacterial agent for low MRSA resistance.

关键词： Iuteolin Methicillin-resistant Staphylococcus aureus Membrane permeabilizing agent ATPase inhibitor Peptidoglycan

Revolutionizing Non-Invasive Biomarker Discoveries: The Power of Methylation Screening Analysis in Cell-Free DNA Liquid Biopsy

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Open Journal of Genetics 2023年第1期13卷 48-74页

作者： Min seob lee Na Young Min Hyuk Jung Kwon Yonjung Kim Isaac Kise lee Eone Diagnomics Genome Center (EDGC) Incheon South Korea NGENI Foundation California USA Incheon National University (INU) Incheon South Korea

Epigenetic changes of DNA, including methylation, have long been recognized as key indicators of various diseases, including aging, cancer, and neurological disorders. Biomarker discoveries based on distinct methylation patterns for both hypermethylation and hypomethylation lead the way in discovery of novel diagnosis and treatment targets. Many different approaches are present to detect the level of methylation in whole genome (whole genome bisulfite sequencing, microarray) as well as at specific loci (methylation specific PCR). Cell-free DNA (cf-DNA) found in body fluids like blood provides information about DNA methylation and serves as a less invasive approach for genetic screening. Cell-free DNA and methylation screening technologies, when combined, have the potential to transform the way we approach genetic screening and personalized therapy. These technologies can help enhance disease diagnostic accuracy and inform the development of targeted therapeutics by providing a non-invasive way for acquiring genomic information and identifying disease-associated methylation patterns. We highlight the clinical benefits of using cell-free DNA (cf-DNA) liquid biopsy analysis and available methylation screening technologies that have been crucial in identifying biomarkers for disease from patients using a non-invasive way. Powering such biomarker discoveries are various methods of cf-DNA methylation analysis such as Bisulfite Sequencing and most recently, Methylation-Specific Restriction Enzyme (MSRE-seq) Analysis, paving the way for novel epigenetic biomarker discoveries for more robust diagnosis such as early disease detection, prognosis, monitoring of disease progression and treatment response as well as discovery of novel drug targets.

关键词： Epigenetics Biomarkers Cell-Free DNA (cf-DNA) Methylation Liquid Biopsy Drug Target Methylation-Specific Restriction Enzyme (MSRE) Cancer Epigenetic Drugs Hypermethylation Hypomethylation

Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker Discovery

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Advances in Aging Research 2023年第2期12卷 11-38页

作者： Min seob lee Hyuk Jung Kwon Yonjung Kim Na Young Min So Young lee Isaac Kise lee Eone Diagnomics Genome Center (EDGC) Incheon South Korea Incheon National University (INU) Incheon South Korea

Background: Aging is a complex biological process that is associated with a decline in physiological functions and an increased risk of age-related diseases. Despite advances in molecular biology and genetics, the underlying mechanisms of aging remain largely unknown. Study: The identification of biomarkers of aging would provide a powerful tool for monitoring the effects of aging and for developing interventions to improve healthspan. Aging is associated with alterations in genetics, epigenetic marks, telomere shortening, cell senescence, and changes in the expression of genes involved in metabolism, inflammation, and DNA damage repair. Epigenetic changes, including modifications to DNA methylation and histone acetylation patterns, play a critical role in the aging process. As we age, these changes can lead to altered gene expression and contribute to the development of age-related diseases such as cancer, Alzheimer’s disease (AD) and cardiovascular disease (CVD). Conclusion: The discovery of aging biomarkers that are sensitive to these epigenetic changes has the potential to revolutionize our understanding of the aging process and inform the development of interventions to improve healthspan and extend lifespan.

关键词： Aging Biomarkers Epigenetics Methylation Geriatric Disease

Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim Moon-Won Yoo in seob lee Jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn Jeong Hoon lee Kee Wook Jung Do Hoon Kim Ho June Song Gin Hyug lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

Ultra-Fast Next Generation Human Genome Sequencing Data Processing Using DRAGEN<sup>TM</sup>Bio-IT Processor for Precision Medicine

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Open Journal of Genetics 2017年第1期7卷 9-19页

作者： Amit Goyal Hyuk Jung Kwon Kichan lee Reena Garg Seon Young Yun Yoon Hee Kim Sunghoon lee Min seob lee EONE-DIAGNOMICS Genome Center Co. Ltd. Inchon Korea

Slow speed of the Next-Generation sequencing data analysis, compared to the latest high throughput sequencers such as HiSeq X system, using the current industry standard genome analysis pipeline, has been the major factor of data backlog which limits the real-time use of genomic data for precision medicine. This study demonstrates the DRAGEN Bio-IT Processor as a potential candidate to remove the “Big Data Bottleneck”. DRAGENTM accomplished the variant calling, for ~40× coverage WGS data in as low as ~30 minutes using a single command, achieving the over 50-fold data analysis speed while maintaining the similar or better variant calling accuracy than the standard GATK Best Practices workflow. This systematic comparison provides the faster and efficient NGS data analysis alternative to NGS-based healthcare industries and research institutes to meet the requirement for precision medicine based healthcare.

关键词： NGS Data Analysis BWA-GATK DRAGEN Bio-IT Processor Genomics INDEL Mapping