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Axonal growth inhibitors and their receptors in spinal cord injury:from biology to clinical translation

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Neural Regeneration Research 2023年第12期18卷 2573-2581页

作者： sílvia sousa Chambel Célia Duarte Cruz Experimental Biology Unit Department of BiomedicineFaculty of Medicine of PortoUniversity of PortoPortoPortugal Translational NeuroUrology Instituto de Investigação e Inovação em Saúde-i3S and IBMCUniversidade do PortoPortoPortugal

Axonal growth inhibitors are released during traumatic injuries to the adult mammalian central nervous system, including after spinal cord injury. These molecules accumulate at the injury site and form a highly inhibitory environment for axonal regeneration. Among these inhibitory molecules, myelinassociated inhibitors, including neurite outgrowth inhibitor A, oligodendrocyte myelin glycoprotein, myelin-associated glycoprotein, chondroitin sulfate proteoglycans and repulsive guidance molecule A are of particular importance. Due to their inhibitory nature, they represent exciting molecular targets to study axonal inhibition and regeneration after central injuries. These molecules are mainly produced by neurons, oligodendrocytes, and astrocytes within the scar and in its immediate vicinity. They exert their effects by binding to specific receptors, localized in the membranes of neurons. Receptors for these inhibitory cues include Nogo receptor 1, leucine-rich repeat, and Ig domain containing 1 and p75 neurotrophin receptor/tumor necrosis factor receptor superfamily member 19(that form a receptor complex that binds all myelin-associated inhibitors), and also paired immunoglobulin-like receptor B. Chondroitin sulfate proteoglycans and repulsive guidance molecule A bind to Nogo receptor 1, Nogo receptor 3, receptor protein tyrosine phosphatase σ and leucocyte common antigen related phosphatase, and neogenin, respectively. Once activated, these receptors initiate downstream signaling pathways, the most common amongst them being the Rho A/ROCK signaling pathway. These signaling cascades result in actin depolymerization, neurite outgrowth inhibition, and failure to regenerate after spinal cord injury. Currently, there are no approved pharmacological treatments to overcome spinal cord injuries other than physical rehabilitation and management of the array of symptoms brought on by spinal cord injuries. However, several novel therapies aiming to modulate these inhibitory prot

关键词： chondroitin sulphate proteoglycans collapsin response mediator protein 2 inhibitory molecules leucine-rich repeat and Ig domain containing 1 leucocyte common antigen related myelin-associated glycoprotein neurite outgrowth inhibitor A Nogo receptor 1 Nogo receptor 3 oligodendrocyte myelin glycoprotein p75 neurotrophin receptor Plexin A2 Ras homolog family member A/Rho-associated protein kinase receptor protein tyrosine phosphataseσ repulsive guidance molecule A spinal cord injury tumour necrosis factor receptor superfamily member 19

Genotype-environment interaction in Cordia trichotoma(Vell.)Arrá*** *** in two different soil conditions

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Journal of Forestry Research 2022年第1期33卷 309-319页

作者： Wanderley dos santos Bruno Marchetti de souza Daniele Fernanda Zulian Gilberto Terra Ribeiro Alves João Bosco Vasconcellos Gomes Mário Luiz Teixeira de Moraes Valderês Aparecida de sousa Ananda Virginia de Aguiar Faculdade de Engenharia de Ilha solteira Universidade Estadual Paulista“Júlio Mesquita Filho”Ilha Solteira 15385-000Brazil sucupira Agroflorestas Fazenda SucupiraValença 45400-000Brazil EMBRAPA Florestas Empresa Brasileira de Pesquisa AgropecuáriaColombo 83411-000Brazil

Investment in silvicultural techniques is noticeably lacking,especially in breeding programs for non-conventional wood *** genotype×environment interaction(G×E)is essential to the development of breeding ***,this study aimed to estimate genetic diversity of and the effects of G×E interaction on two progeny tests of Cordia trichotoma,including the estimation of genetic gain and genetic diversity after *** the experiment,30 progenies of *** were tested at two sites with differing soil *** at breast height(1.30 m above soil surface,dbh-cm),total height,diameter at 30 cm from the soil,first branch height,and survival were all monitored for four *** deviance,best linear unbiased estimator,and harmonic mean of relative performance of genetic values(MHPRVG)were all calculated to predict breeding values,estimate genetic parameters,and analyze *** quantified traits varied significantly among progenies by soil type,with greatest variation recorded for genetic *** of the progenies led to predictions of genetic gain,ranging from 7.73 to 15.45%,for dbh at four years of *** calculated decrease in genetic diversity after selection showed that this parameter should be monitored in subsequent breeding cycles.G×E was low for all *** best-performing progenies proved most stable and best adapted to the different environmental conditions tested.

关键词： Effective population number Native species Productivity stability and adaptability Tree improvement

Plastic effects on marine and freshwater environments

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Water Biology and security 2024年第1期3卷 23-27页

作者： Fabiula Danielli Bastos de sousa Technology Development Center Universidade Federal de PelotasRua Gomes Carneiro196010-610PelotasRSBrazil

In the 1930s,plastic items started to acquire *** then,they have overcome many barriers and are now important to many facets of ***-consumer plastic,however,is an environmental problem of increasing *** and freshwater environments are being impaired by plastic pollution,which is mostly the result of improper post-use plastic *** I review recent literature on plastic effects to marine and freshwater environments,based on a scopus ***'keywords were analyzed and *** depicted microplastics as a global concern for the environment,animals,and human health,and was identified as a primary research focus and emerging topic concerning plastic effects on marine and freshwater *** foremost research gap is the lack of clear connections between the effects of plastic on human health,animal health,and the *** pollution and its consequences on marine and freshwater environments are attributed primarily to human activity.

关键词： Bibliometric analysis Bibliometric mapping Microplastics Pollution

Evolution of process capability in a manufacturing process

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Journal of Management Analytics 2018年第2期5卷 95-115页

作者： sérgio sousa Nuno Rodrigues Eusébio Nunesa ALGORITMI Research Center University of Minho–DPSCampus de GualtarBragaPortugal Production and systems Department University of MinhoCampus de GualtarBragaPortugal

Before mass production of individual components industries may assess its capability to produce it according to *** capability assessment is a common requirement in the automotive *** work shows a case study,providing an in-depth analysis,on a critical component and finds evidence of process degradation over two years of production,quantified through capability *** pre-production,it was concluded that the process was capable and,thus,no statistical process control was done during its *** the months no defective units were detected but then its level began to increase and it was apparent that process variability had increased and the process was no longer *** improvement activities were developed using known quality tools and *** work shows how the control plan initially defined became obsolete and discusses the need to periodically review quality control mechanisms.

关键词： basic quality tools capability index measurement system analysis process improvement quality control quality planning statistical process control

High-throughput phenotyping of two plant-size traits of Eucalyptus species using neural networks

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Journal of Forestry Research 2022年第2期33卷 591-599页

作者： Marcus Vinicius Vieira Borges Janielle de Oliveira Garcia Tays silva Batista Alexsandra Nogueira Martins silva Fabio Henrique Rojo Baio Carlos Antônio da silva Junior Gileno Brito de Azevedo Glauce Taís de Oliveira sousa Azevedo Larissa Pereira Ribeiro Teodoro Paulo Eduardo Teodoro Federal University of Mato Grosso Do sul(UFMs) Chapadão Do SulMato Grosso Do Sul 79560000Brazil Department of Geography State University of Mato Grosso(UNEMAT)SinopMato Grosso 78555000Brazil

In forest modeling to estimate the volume of wood,artificial intelligence has been shown to be quite effi-cient,especially using artificial neural networks(ANNs).Here we tested whether diameter at breast height(DBH)and the total plant height(Ht)of eucalyptus can be pre-dicted at the stand level using spectral bands measured by an unmanned aerial vehicle(UAV)multispectral sensor and vegetation *** do so,using the data obtained by the UAV as input variables,we tested different configurations(number of hidden layers and number of neurons in each layer)of ANNs for predicting DBH and Ht at stand level for different Eucalyptus *** experimental design was randomized blocks with four replicates,with 20 trees in each experimental *** treatments comprised five Eucalyptus species(***,***,***,***-dis,and ***)and Corymbria *** and Ht for each plot at the stand level were measured seven times in separate overflights by the UAV,so that the multispectral sensor could obtain spectral bands to calculate vegetation indices(VIs).ANNs were then constructed using spectral bands and VIs as input layers,in addition to the categorical variable (species), to predict DBH and Ht at the stand level simultaneously. This report represents one of the first appli-cations of high-throughput phenotyping for plant size traits in Eucalyptus species. In general, ANNs containing three hidden layers gave better statistical performance (higher esti-mated r, lower estimated root mean squared error-RMsE) due to their greater capacity for self-learning. Among these ANNs, the best contained eight neurons in the first layer, seven in the second, and five in the third (8 − 7 − 5). The results reported here reveal the potential of using the gener-ated models to perform accurate forest inventories based on spectral bands and VIs obtained with a UAV multispectral sensor and ANNs, reducing labor and time.

关键词： Computational intelligence Diameter at breast height Forest inventory Remote sensing Vegetation indices

The initial stages of Li_(2)O_(2) formation during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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Journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Daniela M.Josepetti Bianca P.sousa simone A.J.Rodrigues Renato G.Freitas Gustavo Doubek Advanced Energy storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Department of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy density of lithium-ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contamination,metallic lithium reactivity,and complex discharge and charge reactions are the main issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good performance of secondary batteries',but the partial knowledge of its mechanisms,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Raman experiments and electrochemical impedance spectroscopy(EIs)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic formation of the discharge product signal(Li_(2)O_(2))was observed with operando Raman,indicating a first-order reaction and enabling an analysis by a microkinetic *** solution mechanism in the evaluated system was ascribed for an equivalent circuit with three time *** the time constant for the anode interface reveals to remain relatively constant after the first discharge,its surface seemed to be more *** model indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology here described thus offers a way of directly probing changes in surface chemistry evolution during cycling from a device through EIs analysis.

关键词： Li-O_(2)battery Operando Raman analysis Equivalent circuit modeling Time-constant distribution

Drainage and Preliminary Risk of Flooding in an Urban Zone of Eastern Amazon

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Journal of Geoscience and Environment Protection 2023年第5期11卷 1-16页

作者： Taís silva sousa Clezio Júnior Teixeira Viegas Helenilza Ferreira Albuquerque Cunha Alan Cavalcanti da Cunha Graduate Program in Environmental sciences Federal University of Amapá Macapá Brazil Graduate Program in Tropical Biodiversity Federal University of Amapá Macapá Brazil Graduate Program in Biotechnology Federal University of Amapá Macapá Brazil

Drainage system is a poorly investigated basic sanitation and urban planning issue in the Amazon, which is often related to flooding processes and public health. The aim of the present research is to correlate Preliminary Risk of Flooding (PRF) to independent variables, based on the following methodology: 1) identifying and classifying risk areas by using the Geographic Information system (GIs) and 2) statistically correlating risk to sanitary and environmental variables. Results have shown that preliminary risk is correlated to, at least, seven sanitary and environmental variables, depending on flood influence area;and there are significant correlations observed in the rainy season interval [probability or significance (p) 0.05]. In conclusion, PRF is higher in the rainy season, but it is spatially influenced by the elevation of terrain, number of flooding points, drainage typology and Environmental salubrity Index (EsI) of neighborhoods, which directly affect the water quality in nearby groundwater wells (Total Coliforms, nitrate (NOsub>3sub>) and ammonia (NHsub>3sub>)). However, this influence can eventually significantly change in the dry season.

关键词： Drainage system Environmental salubrity Index Groundwater GIs

Dimensioning Urban Drainage systems in Housing subdivisions in the Amazon Using Different Hydrological Models

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Journal of Geoscience and Environment Protection 2023年第11期11卷 151-170页

作者： Caio Emanuel da silva Pacheco Taís silva sousa Elizandra Perez Araújo Alan Cavalcanti da Cunha Department of Exact and Technological sciences Federal University of Amapá Macapá Brazil Postgraduate Department Federal University of Amapá Macapá Brazil

Hydrological studies for sizing urban drainage systems in the Amazon have often been neglected and little investigated for rainwater projects. This research evaluated alternative hydrological models used in sizing urban drainage network projects in subdivisions with subsidized houses in the Amazonian region in Brazil. statistical tests of these models were performed for both original and alternative scenarios. The methodological steps we conducted as follows: 1) evaluate the dimensioning of infrastructure project networks, considering two case studies contemplated by the Calha Norte Program (CNP) in the state of Amapá;2) test the statistical significance of the dimensioning of network diameters (α sidering a) benchmark project (MD or M1) approved by the Ministry of Defense;b) determination of concentration time (Csub>tsub>) and rainfall intensity-duration-frequency (IDF) relationships, as well as estimating diameters using alternative models. The results indicated a significant influence on the diameters of the projected rainfall networks (p suggesting that alternative models predicted more unfavorable flow peaks than the original model. We conclude that the benchmarking model underestimated the diameter of the project compared to alternative models, which means the optimized Csub>tsub> parameter significantly impacts dimensioning estimates in rainwater projects in these Amazonian municipalities. This suggests that underestimated parameters in MD may cause inefficiency in the stormwater system projects in future similar scenarios.

关键词： Hydrological studies Concentration Time Calha Norte Program Amapá

Determination of critical state line(CsL)for silty-sandy iron ore tailings subjected to low-high confining pressures

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1684-1695页

作者： Nilo Cesar Consoli João Vítor de Azambuja Carvalho Alexia Cindy Wagner Hugo Carlos scheuermann Filho Inácio Carvalho Pedro Pazzoto Cacciari João Paulo de sousa silva Civil Engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil Exploration and Mineral Projects-Mineral Development Centre VALE S.A.Santa LuziaMG33040-900Brazil Department of Civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The disposal of filtered tailings in high dry stacks can induce particle breakage,changing the material's behaviour during the structure's *** grading changes influence material properties at the critical state,and this is not mature for intermediate artificial soils(tailings)in a broad range of confining *** this paper,it aims to describe the behaviour of iron ore tailings in a spectrum of confining pressures broader than the reported in previous studies.A series of consolidated drained(CD)triaxial tests was carried out with confining pressures ranging from 0.075 MPa to 120 *** results show that the amount of breakage plays an essential role in the response of iron ore *** existence of curved critical state line(CsL)in both specific volume(ν)-logarithm of mean effective stress(p′)and deviatoric stress(q)-mean effective stress(p′)planes,and different responses in the deviatoric stress-axial strain-volumetric strain curves were *** inverse s-shaped equation was proposed to represent the silty-sandy tailings'behaviour up to high pressures onν-lnp′*** proposed equation provides a basis for enhancing constitutive models and considers the evolution of the grading up to severe loading *** adjustment considered three regions with different responses associated with particle breakage at different pressure levels.

关键词： Tailings Iron ore tailings dry stacking silty-sandy material Critical state soil mechanics High confining pressures Particle breakage