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sIRT3-mediated inhibition of Fos through histone H3 deacetylation prevents cardiac fibrosis and inflammation

signal Transduction and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palomer Msilvia román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera Department of Pharmacology Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Biomedicine IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBCNatal-Barcelona Center for Maternal–Fetal and Neonatal Medicine(Hospital Clínic and Hospital sant Joan de Deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genomic Programming of Betacells Laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain section of Epigenomics and Disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK servicio de Cirugía Cardiovascular Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain Departamento de Fisiología y Farmacología Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain Department of Radiation oncology Columbia UniversityNew YorkNYUSA

sirtuin 3(sIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative *** of sIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac *** this study,we investigated the role of sIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of sIRT3 and human cardiac AC16 ***3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of *** with this,sIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of Fos and the DNA-binding activity of ***,we demonstrated that sIRT3 inhibits Fos transcription through specific histone H3 lysine K27 deacetylation at its *** findings highlight an important function of sIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the Fos/AP-1 *** fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to sIRT3 as a potential target for treating these diseases.

关键词： sIRT3 inflammation cardiac

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改变一切的方程

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新发现 2020年第9期 86-90页

作者： román Ikonicoff 竹叶(编译) 不详

“这一切始于纪堯姆·德里翁(Guillaume Drion)进行白鼠实验后提出的一组建模神经元的方程。”那是在2010年代初,人工神经网络和深度学习的研究尚未呈现暴发式增长。“纪尧姆想要知道这组方程能否在人工神经网络研究中发挥‘某种作用’... 详细信息

“这一切始于纪堯姆·德里翁(Guillaume Drion)进行白鼠实验后提出的一组建模神经元的方程。”那是在2010年代初,人工神经网络和深度学习的研究尚未呈现暴发式增长。“纪尧姆想要知道这组方程能否在人工神经网络研究中发挥‘某种作用’。这也是我在2018年加人他的实验室的原因。”尼古拉·韦科文(Nicolas Vecoven)回顾道,这位年轻的工程师目前正在比利时列日大学的德里翁实验室准备自己的博士论文。

关键词：深度学习人工神经网络博士论文尼古拉纪尧姆实验室神经元工程师

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Ximenia americana: Chemical and spectral studies of Extracts of seeds. Analysis of Trimethylsilyl Derivatives by Gas Chromatography and Mass spectrometry

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American Journal of Analytical Chemistry 2016年第2期7卷 192-202页

作者： romézio Alves Carvalho da silva Telma Leda Gomes de Lemos Daniele Alves Ferreira Francisco José Queiroz Monte Programa de Pós-Graduacao em Química Department of Organic Chemistry e Inorganic Federal University of Ceará Fortaleza Brazil

Among the numerous botanical species found in the Brazilian plant biome, Ximenia americana is widespread in the Northeast of Brazil, especially in the state of Ceará, where it is known as bush plum. Its bark, leaves and roots are used in popular medicine for the treatment of skin infections, hemorrhoids, stomach ulcers, gastric pain, among others. In this work, hexane and ethanolic extracts of X. americana seeds were subjected to silylation reactions followed by analysis of the silylated derivatives by gas chromatography-mass spectrometry (GC/Ms). In the hexane extract, 18 substances were identified, where the most abundant and most important components were the octadec-9-enoic (38.14%), (9Z,12Z)-octadec-9,12-dienoic (18.83%), Ethanedioic (8.21%) and (Z,Z,Z)-9,12,15-octadecatrienoic (7.22%) acids. From the ethanol extract 18 substances were also identified having D-sucrose (29.36%), L-sorbose (9.19%), syllo-Inositol (8.34%) and D-Glucose (7.45%) as the main components. In addition, the presence of a steroid in hexane extract and triterpenes in ethanol extract was recorded. The constituents were identified using chromatographic and spectrometric methods, especially gas chromatography-mass spectrometry. To our knowledge, this is the first study of this nature from the oil of the X. american seeds.

关键词： Ximenia americana seeds TMs Carbohydrates Derivatives GC/Ms

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Frontiers In Electronics (With Cd-rom) - Proceedings of The Wofe-04

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丛书名： selected Topics In Electronics And systems

2006年

作者： Michael s shur Yoshi Nishi

ISBN: (数字)9789812773081

ISBN: (纸本)9789812568847

Frontiers in Electronics reports on the most recent developments and future trends in the electronics and photonics industry. The issues address CMos, soI and wide band gap semiconductor technology, terahertz technology, and bioelectronics, providing a unique interdisciplinary overview of the key emerging *** volume accurately reflects the recent research and development trends: from pure research to research and development; and its contributors are leading experts in microelectronics, nanoelectronics, and nanophotonics from academia, industry, and government agencies.

关键词： Electronics

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Effect of sustainable Land Management Practices on the soil Erodibility at the Plateau of Abomey (Centre of Benin)

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open Journal of soil science 2022年第7期12卷 323-337页

作者： Kouelo Alladassi Félix Medezo Arnaud Akplo Tobi Moriaque Houenou saïdi Avakoudjo Julien Agodo Lambert Dotonhoue Coffi Fulgence Gbèwommindéa sogbegnon Ahowanou rom.o Amadji Firmin Zoundji Mahougnon Carmelle Charlotte Houngnandan Pascal Djedje Mélanie Laboratory of soil Microbiology and Microbial Ecology Faculty of Agronomic Sciences University of Abomey-Calavi (LMSEM/FSA/UAC) Abomey-Calavi Benin Laboratory of Applied Ecology Faculty of Agronomic Sciences University of Abomey-Calavi (LEA/FSA/UAC) Abomey-Calavi Benin soil Protection and Rehabilitation Project to Improve Food security (ProsoL/GIZ) Parakou Benin sol Consult Africa (solCA) Abomey Benin Laboratory of Plant Horticultural and Forestry Sciences National University of Agriculture (LSVHF/UNA) Kétou Benin

The soils of Benin in general and those of the department of Zou, in particular, are highly degraded. This study aimed to evaluate the effectiveness of sustainable land management practices on soil erodibility in two villages in the Plateau of Abomey. soil samples were collected on plots under sustainable Land Management (sLM) measures (direct seeding, maize residue management and soybean-cereal rotation) and on their adjacent control. The soil samples were prepared and analyzed in laboratory to determine variables such as soil permeability, organic matter content, and particle size. soil erodibility was determined as proposed by Wischmeier & smith. The effect of sLM practices was significant (0.02) on soil permeability. on plots under sLM measurements, soil permeability is higher with an average of 93.97 mm/h at Folly and 82.43 mm/h at Hanagbo. sLM measurements significantly (0.04) added organic matter to the soil. The average organic matter of the plots under sLM measures in Folly varies from 0.73% to 1.39% while it varies from 0.49% to 0.73% in the control plots. In Hanagbo, the average organic matter of the plots under sLM measures varies from 1.86% to 2.48% against 1.41% to 1.66% for the control plots. Regarding soil erodibility, it was found that the influence of sLM measures is significant in both villages. In villages, direct seeding and maize residue management significantly (0.008) reduced soil erodibility compared to their adjacent controls, while the soybean-cereal rotation measure increased soil erodibility compared to plot witnesses. The average soil erodibility of plots under sLM measures varies by 0.21 t⋅h/Mj⋅mm at 0.38 t⋅h/Mj⋅mm in the village of Hanagbo and 0.25 t⋅h/Mj⋅mm at 0.38 t⋅h/Mj⋅mm in the village of Folly. It varies from 0.24 t⋅h/Mj⋅mm at 0.28 t⋅h/Mj⋅mm for the control plots at Hanagbo and 0.31 t⋅h/Mj⋅mm at 0.37 t⋅h/Mj⋅mm in Folly. These practices can therefore

关键词： Water Erosion Cropping systems sustainable Land Uses soil Erodibility Centre of Benin

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CoRUs热风炉技术——一生一次的抉择

CORUS热风炉技术——一生一次的抉择

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2001中国钢铁年会

作者： rom stokman 高斌 Egenolf van stein Callenfels Ruud Boonacker Danieli Corus

现在已成功开发高风温热风炉,这种热风炉即使经历多次的冷却与再升温也无需大修和维护,满负荷工作寿命可达20～30年。然而,老式设计的热风炉会逐渐显示性能降低、压力损失提高、局部危险扩大,需要彻底的全面修理;这些都是计划大修和性... 详细信息

现在已成功开发高风温热风炉,这种热风炉即使经历多次的冷却与再升温也无需大修和维护,满负荷工作寿命可达20～30年。然而,老式设计的热风炉会逐渐显示性能降低、压力损失提高、局部危险扩大,需要彻底的全面修理;这些都是计划大修和性能升级的充分理由。煤或燃料的大喷吹需要高风温,如果接受这种观点,提高设计风温、增加加热能力以及提升热风炉的设计观念,使热风炉适应另一个20～30年的寿命就十分有吸引力。对近期内需要优化热风系统的高炉工作者,本文阐述了一些具有典型意义的可能性和选择机会。

关键词：高风温热风炉长寿成熟设计

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红玉苹果和它的杂交后代

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国外农学(果树) 1988年第4期 33-34页

作者： rom R.C. 过国南

红玉是从'可口香'苹果的自然实生苗中选出的,具有典型的苹果优良风味,是由Rick在美国纽约州阿尔斯特县的伍德托克附近发现的,最初一度称为'新可口香'和'阿尔斯特实生'。 1926年,Buel首次发表文章介绍该品系,1829年定名为红玉。此后,红... 详细信息

红玉是从'可口香'苹果的自然实生苗中选出的,具有典型的苹果优良风味,是由Rick在美国纽约州阿尔斯特县的伍德托克附近发现的,最初一度称为'新可口香'和'阿尔斯特实生'。 1926年,Buel首次发表文章介绍该品系,1829年定名为红玉。此后,红玉苹果在美国及其他国家的苹果生产中得到了较大的发展。到本世纪初,红

关键词：红玉苹果美国美利坚合众国北美洲苹果品种澳洲青苹青森树体生长

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桃砧木现状的国际剖析

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国外农学(果树) 1983年第3期 1-6页

作者： rom R.C. 王宇霖

这篇报告是在国际间调查研究的基础上写成的。给作者提供材料的有世界上生产桃的25个国家中的40位科学工作者。根据各国提供的材料所写成的这篇报告正确地反映了各国是如何选择他们现今所用的桃的砧木的。作为桃的砧木首要的是,砧木接... 详细信息

这篇报告是在国际间调查研究的基础上写成的。给作者提供材料的有世界上生产桃的25个国家中的40位科学工作者。根据各国提供的材料所写成的这篇报告正确地反映了各国是如何选择他们现今所用的桃的砧木的。作为桃的砧木首要的是,砧木接穗之间必须具有良好的亲和力。除了利用桃的基因材料作为桃的

关键词：砧木台木嫁接材料无性繁殖系无性系法国法兰西共和国澳大利亚大洋洲栽培品种杂种杂交种扁桃芒果属抗线虫

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Vaccine against Dental Caries: An Update

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Advances in Microbiology 2014年第13期4卷 925-933页

作者： Diego romário da silva Andréa Cristina Barbosa da silva Robeci Macedo Filho Flaviana Dornela Verli sandra Aparecida Marinho Graduate Program in Dentistry Technology and Health State University of Paraiba UEPB Araruna Paraíba Brazil Department of Biological sciences Federal University of the Jequitinhonha and Mucuri Valleys UFVJM Diamantina Paraíba Brazil

Dental caries, the disease that causes tooth decay, is infectious, and the mutans streptococci bacteria have long been identified as the primary disease-causing agents. Caries vaccines showed promising results in experimental studies;however, it remains far the effective use in humans due to political-economic and ethical issues. Progress towards practical vaccine development requires evaluation of candidate vaccines in clinical trials. Promising strategies of passive immunization also require further clinical evaluation. The purpose of this chapter is to review the literature on the main research projects aimed at developing caries vaccines.

关键词： Caries Vaccine Immunology

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Alterations in fibrinolytic system proteins PAI-1,MMP-3,MMP-8,TIMP-1 and TIMP-2 in post-cholecystectomy bile duct injury

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Journal of Biomedical science and Engineering 2013年第8期6卷 58-67页

作者： Jose Manuel Hermosillo-sandoval Luis Miguel román-Pintos Adolfo Daniel Rodriguez-Carrizález Ernesto Germán Cardona-Munoz Fermin Paul Pacheco-Moisés Genaro Gabriel ortiz Alejandra Guillermina Miranda-Diaz Department of surgery Specialties Hospital of the National Occidental Medical CentreSocial Security Institute of Mexico(Departamento de CirugíaHospital de Especialidades del Centro Médico Nacional de OccidenteInstituto Mexicano del Seguro Social)GuadalajaraMéxico University Health sciences Centre University of Guadalajara(Centro Universitario de Ciencias de la SaludUniversidad de Guadalajara)GuadalajaraMéxico University Centre for Exact and Engineering sciences University of Guadalajara(Centro Universitario de Ciencias Exactas e IngenieríasUniversidad de Guadalajara)GuadalajaraMéxico Pathology and oxidative stress Laboratory Division of NeurosciencesOccidental Biomedical Research CentreSocial Security Institute of Mexico(Laboratorio de Estrés Oxidativo&PatologíaDivision de NeurocienciasCentro de Investigacion Biomédica de OccidenteInstituto Mexicano del Seguro Social)GuadalajaraMéxico

Introduction: In bile duct injuries (BDI), cholestasis and cholangitis can alter the fibrinolytic system by promoting an increase of extracellular matrix depositions which favor an imbalance between metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Materials and Methods: Levels of PAI-1, MMP-3, MMP-8, TIMP-1 and TIMP-2 in 35 patients with post-cholecystectomy BDI by complete biliary obstruction were measured and compared to a healthy control group. sirius red staining and immune staining for MMP-3 and MMP-8 were also undertaken in liver biopsies. Results: Levels of PAI-1, TIMP-1, TIMP-2 and MMP-8 were higher in BDI than healthy controls: 15 ± 2 ng/mL vs 7.1 ± 2 ng/mL (p 0.024);539 ± 64 ng/mL vs 256 ± 13 ng/mL (p p p 2 vs. 22865.7 ± 3865 μm2 in healthy controls (p 2 vs. 30744.2 ± 5810.2 μm2 (p 2 vs. 116337.9 ± 24803.3 μm2 (p 0.55). These results suggest an imbalance between fibrogenic/fibrinolytic protein levels. Interestingly, expression of the fibrinolytic protein MMP-8 was increased in serum and liver biopsies in BDI. Conclusion: We found an imbalance of profibrogenic molecules which promote extracellular matrix deposition. The over-expression of fibrinolytic proteins such as MMP-8 could limit liver fibrosis, preventing hepatic dysfunction in post-cholecystectomy BDI.

关键词： Cholecystectomy Bile Duct Injury(BDI) Plasminogen Activator Inhibitor Type 1(PAI-1) Tissue Inhibitors of Metalloproteinases(TIMP’s) Metalloproteinases(MMP’s)

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