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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： seungmee Lee Yu-ra Jeon Changmin shin sun-Young Kwon sojin shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** sUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

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Position in the evolution of reproductive endocrine of amphioxus, Branchiostoma belcheri

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Chinese science Bulletin 1998年第3期43卷 177-185页

作者： FANG Yongqiang Third Institute of Oceanography, soa, Xiamen 361005, China Third Institute of Oceanography SOA Xiamen China

This review summarizes the recent discoveries of many authors who found that in amphioxus Hatschek’s pit is capable of synthesizing vertebrate gonadotropin_like substance, and that the content of gonadotropin_releasing hormone in the amphioxus’ body shows a positive correlation with the reproductive cycle, and that the sex steroid hormone exists in gonads. Exogenous hormones could promote gonadal development, maturation and reproductive activity in amphioxus. A possible implication might be that the reproductive activity in amphioxus is regulated by reproductive hormones like vertebrate, indicating the existence of primitive reproductive endocrine regulatory axis, brain vesicle_Hatschek’s pit_gonads axis, as compared with regulatory axis of vertebrate. It will provide a new line for establishing the position of reproductive endocrine evolution in lancelet.

关键词： amphioxus (lancelet) Hatschek’s pit reproductive endocrine evolution gonadotropin_releasing hormone gonadotropin sex steriod hormone.

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An Adaptive Classifier Based Approach for Crowd Anomaly Detection

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Computers, Materials & Continua 2022年第7期72卷 349-364页

作者： sofia Nishath P.s.Nithya Darisini school of Computer science and Engineering Vellore Institute of TechnologyChennai600127India

Crowd Anomaly Detection has become a challenge in intelligent video surveillance system and *** video surveillance systems make extensive use of data mining,machine learning and deep learning *** this paper a novel approach is proposed to identify abnormal occurrences in crowded situations using deep *** this approach,Adaptive GoogleNet Neural Network Classifier with Multi-Objective Whale Optimization Algorithm are applied to predict the abnormal video frames in the crowded *** use multiple instance learning(MIL)to dynamically develop a deep anomalous ranking *** technique predicts higher anomalous values for abnormal video frames by treating regular and irregular video bags and video *** use the multi-objective whale optimization algorithm to optimize the entire process and get the best *** performance parameters such as accuracy,precision,recall,and F-score are considered to evaluate the proposed technique using the Python simulation *** simulation results show that the proposed method performs better than the conventional methods on the public live video dataset.

关键词： Abnormal event detection adaptive GoogleNet neural network classifier multiple instance learning multi-objective whale optimization algorithm

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A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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Particuology 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta Filipe simões sérgio simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HsG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HsG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HsG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HsG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design scale-up

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Modern sea level changes of the Eastern China seas and their influences on coastal areas

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Journal of Environmental sciences 1992年第1期4卷 52-59页

作者： Liu ZhenxiaFirst Institute of Oceanography, soa, Qingdao 266003, China

The statistics of tidal gauging records showed that the mean sea level of the China seas has risen for 14 cm in past 100 years. The annual mean sea levels of the Eastern China seas have been rising at a speed of about 0.21 -0.23 cm/a since 1960. The annual mean sea levels of the Eastern China seas in 1989 were 1.45 cm higher than that in 1988 on *** sea level rise may cause the damage of the dynamical balance of the natural environments in the coastal area? and form or strengthen many coastal disasters, such as storm-tide catastrophic events, sea water invasion landward, soil salinization in coastal lowland and plains, and beach erosion retreat.

关键词： sea level: Eastern China seas coastal area.

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Alpha-1 antitrypsin deficiency and Pi^(*)Z allele as important co-factors in the development of liver fibrosis

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World Journal of Hepatology 2024年第8期16卷 1099-1110页

作者： Ana Isabel Ferreira Catarina Guimarães Vitor Macedo silva sofia Xavier Joana Magalhães JoséCotter Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Life and Health sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal Life and Health sciences Research Institute/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Pulmonology Hospital Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal

BACKGROUND Alpha-1 antitrypsin deficiency(AATD)is a codominant autosomal hereditary condition that predisposes patients to the development of lung and/or liver disease,and Pi*Z allele is the most clinically relevant *** To evaluate the impact of clinical parameters and AATD phenotypes,particularly the Pi*Z allele,in liver *** Cross-sectional cohort study including consecutive patients with AATD followed in Pulmonology or Hepatology *** Included 69 patients,49.3%had Pi*MZ phenotype and 10.1%Pi**** age≥55 years,age at diagnosis≥41 years and AAT at diagnosissease fibrosis score(NFs)not excluding advanced fibrosis[area under the curve(AUC)=0.840,Ps and age at diagnosis≥41 years predicted a fibrosis-4 index of moderate to advanced fibrosis(AUC=0.831,Ps with hypertension,type 2 diabetes mellitus(DM),dyslipidaemia,metabolic syndrome,and regular alcohol consumption were more likely to have a NFs not excluding advanced fibrosis(Ps with at least one Pi*Z allele and type 2 DM were 8 times more likely to have liver stiffness measurement≥7.1 kPa(P=0.040).CONCLUsION Risk factors for liver disease in AATD included an age≥50 years,age at diagnosis≥41 years,metabolic risk factors,regular alcohol consumption,at least one Pi*Z allele,and AAT value at diagnosissease screening in AATD patients to use in primary care,selecting those to be referred to Hepatology consultation.

关键词： Alpha-1 antitrypsin deficiency Liver fibrosis Nonalcoholic fatty liver disease fibrosis score Fibrosis-4 index Liver stiffness measurement

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Distribution of growth hormone-like immunoreactive cells and somatostatin receptors in the nervous system and Hatschek's pit of amphioxus, Branchiostoma belcheri

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Progress in Natural science:Materials International 2006年第4期16卷 359-365页

作者： FANG Yongqiang and WENG Youzhu Third Institute of Oceanography, soa, Xiamen 361005, China [a]Third Institute of Oceanography Xiamen China

Using immunohistochemical method and double staining technique, the localization of growth hormone (GH) and somatostatin receptors in the nervous system and Hatschek’s pit of amphioxus has been investigated. The results showed that the growth hormone-like nerve cells and endocrine cells as well as three subtypes of somatostatin receptors exist in the nervous system and Hatschek s pit, and GH-like nerve cells and endocrine cells co-exist with three subtypes of somatostatin receptors in the brain vesicle and Hatschek s pit. It is suggested that a primitive control system of inhibitory growth hormone secretion in Hatschek s pit could have been developed in amphioxus, as in vertebrates. The present study provides new evidence for the endocrinology and the evolution of Hatschek’s pit.

关键词： amphioxus nervous system Hatschek’s pit growth hormone-like cell somatostatin receptor.

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An application of space-filling curves to improve results of turbulent aerodynamics modeling with convolutional neural networks

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Chinese Journal of Aeronautics 2024年第2期37卷 81-92页

作者： Mikhail PETROV sofia ZIMINA Moscow Institute of Physics&Technology Dolgoprudny 141701Russia

When carrying out calculations for turbulent flow simulation,one inevitably has to face the choice between accuracy and speed of *** order to simultaneously obtain both a computationally efficient and more accurate model,a surrogate model can be built on the basis of some fast special model and knowledge of previous calculations obtained by more accurate base models from various test bases or some results of serial *** objective of this work is to construct a surrogate model which allows to improve the accuracy of turbulent calculations obtained by a special model on unstructured *** this purpose,we use 1D Convolutional Neural Network(CNN)of the encoder-decoder architecture and reduce the problem to a single dimension by applying space-filling *** an approach would have the benefit of being applicable to solutions obtained on unstructured *** this work,a non-local approach is applied where entire flow fields obtained by the special and base models are used as input and ground truth output ***-Allmaras(sA)model and Near-wall Domain Decomposition(NDD)method for sA are taken as the base and special models *** efficiency and accuracy of the obtained surrogate model are demonstrated in a case of supersonic flow over a compression corner with different values for angleαand Reynolds number *** conducted an investigation into interpolation and extrapolation by Re and also into interpolation byα.

关键词： space-filling curves Convolutional neural network Domain decomposition Turbulent flows Unstructured mesh

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Cardiovascular rehabilitation in patients aged 70-year-old or older:benefits on functional capacity,physical activity and metabolic profile in younger *** patients

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Journal of Geriatric Cardiology 2020年第9期17卷 544-553页

作者： Marta Fontes-Oliveira Maria Trêpa Patrícia Rodrigues Preza Fernandes sandra Magalhães sofia Cabral Mário santos severo Torres Cardiology Department University Hospital Centre of PortoPortoPortugal Cardiac Rehabilitation Unit Cardiology DepartmentUniversity Hospital Centre of PortoPortoPortugal Pulmonary Vascular Disease Unit University Hospital Centre of PortoPortoPortugal

Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AMI)patients have been *** aim was to assess the impact of EBCR in³70-years-old *** post-AMI *** We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 *** evaluated changes in several outcomes based on pre-and post-CRP *** Of a total of 1607 patients,333(21%)were³*** the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(Ps showed a smaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in *** the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on *** As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.

关键词： Aging Cardiovascular prevention Exercise-based cardiac rehabilitation

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Flocculation and magnetically-assisted sedimentation of size-sorted beidellite platelets mixed with maghemite nanoparticles

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Nano Research 2020年第11期13卷 3001-3011页

作者： sofia Housni sébastien Abramson Jean-Michel Guigner Pierre Levitz Laurent Michot Laboratoire de PHysico-chimie des Electrolytes et Nanosystèmes InterfaciauX(PHENIX UMR 8234 Sorbonne Université-CNRS)Sorbonne UniversitéParis75252France Institut de Minéralogie de Physique des Matériaux et de Cosmochimie(IMPMC UMR 7590Sorbonne Université-IRD-CNRS-MNHN)Sorbonne UniversitéParis75252France

In this study,the flocculation and the subsequent decantation step of mixed suspensions of 10 nm-sizedγ-Fe_(2)O_(3) magnetic nanoparticles and 500 nm-sized beidellite clay platelets was *** work may find application in the field of water treatment,specifically the flocculation processes with magnetically assisted *** a short description of the preparation and characterization of the raw materials(nanoparticles and clays),the influence of several parameters(pH,concentrations of nanoparticles and clays etc.)on the amount of flocculated materials was examined,which gave information on the concentration ranges allowing a complete flocculation,together with a better understanding on the interactions between nanoparticles and clays responsible for *** optimal conditions for magnetically assisted settling were then determined by comparing for each sample sedimentation velocities under gravity and in the presence of a Nd-Fe-B ***,the complex multiscale structure of the flocs in water was explored,through the measurement of several bulk properties(zeta-potential and volume measurements,laser granulometry),while the organization of the materials at a microscopic scale was investigated by cryo-transmission electron microscopy(cryo-TEM)and small-angle X-ray scattering(sAXs).

关键词： magnetic separation nanoparticles clay flocculation decantation characterization

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