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Artemisia vulgaris Induces Tumor-selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos santos Zamarioli Michele Rosana Maia santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine pereira soraya s smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo Js pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and sKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,sKBR-3 and K562 cells(Ps was reduced compared to HEAV-exposed fibroblasts(Ps with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(Pse of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(Pse mainly from lysosomes in K562 cells(Psed the number of non-viable cells treated with HEAV(Psions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

Antimicrobial and synergistic effects of lemongrass and geranium essential oils against streptococcus mutans,staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de Lima Thaís Cristine pereira Lara steffany de Carvalho Letícia Ferreira dos santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon schoenanthus and Pelargonium graveolens essential oils against streptococcus mutans,staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).REsULTs *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei staphylococcus aureus streptococcus mutans

Cooperative Localization and Tracking in Distributed Robot-sensor Networks

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Tsinghua science and Technology 2005年第1期10卷 91-101页

作者：张帆 Guilherme s.pereira Vijay Kumar General Robotics Automation sensing and Perception Laboratory University of Pennsylvania Philadelphia PA USA

This paper addresses the problem of real-time position and orientation estimation of networked mobile robots in two-dimensional Euclidean space with simultaneous tracking of a rigid unknown object based on exteroceptive sensory information extracted from distributed vision systems. The sufficient and necessary conditions for team localization are proposed. A localization and object tracking approach based on statistical operators and graph searching algorithms is presented for a team of robots localized with het- erogeneous sensors. The approach was implemented in an experimental platform consisting of car-like mobile robots equipped with omnidirectional video cameras and IEEE 802.11b wireless networking. The experimental results validate the approach.

关键词： cooperative localization multi-robot formation distributed sensor network sensor data fusion

Molecule-based kinetic modeling by Monte Carlo methods for heavy petroleum conversion

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science China Chemistry 2013年第11期56卷 1608-1622页

作者： de OLIVEIRA Luís pereira VERsTRAETE Jan J. KOLB Max IFP Energies nouvelles Rond-point de l'échangeur de Solaize-BP 369360 SolaizeFrance Laboratoire de Chimie cole Normale Supérieure69364 Lyon Cedex 07France

A methodology for kinetic modeling of conversion processes is *** proposed approach allows to overcome the lack of molecular detail of the petroleum fractions and to simulate the reactions of the process by means of a two-step *** the first step,a synthetic mixture of molecules representing the feedstock is generated via a molecular reconstruction method,termed sR-REM molecular *** the second step,a kinetic Monte Carlo method,termed stochastic simulation algorithm(ssA),is used to simulate the effect of the conversion reactions on the mixture of *** resulting methodology is applied to the Athabasca vacuum residue *** adequate molecular representation of the vacuum residue is obtained using the sR-REM *** reaction simulations present a good agreement with the laboratory data for Athabasca vacuum residue *** addition,the proposed methodology provides the molecular detail of the vacuum residue conversion throughout the reactions simulations.

关键词： Monte-Carlo molecular reconstruction kinetic modeling stochastic simulation algorithm vacuum residue hydrocracking

Tunable super-structured Fiber Bragg Gratings with Perfect sequences Based on m-sequence

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Journal of Electronic science and Technology 2017年第4期15卷 358-363页

作者： Joao s.pereira Marco P.M.Ferreira Marko Gasparovic Instituto de Telecomunicacoes Lisboa 1049-001 Portugal Institute Polytechnic of Leiria Leiria 2411-901 Portugal Centro de Investigaao em Informaica e Comunicacoes Institute Polytechnic of Leiria Leiria 2411-901Portugal

Recently, a tunable fiber Bragg grating(FBG) was developed by using stress-responsive colloidal crystals. In this paper, we have simulated the application of these nanoparticles into the super-structured fiber Bragg grating(ssFBG) written with perfect sequences derived from a short maximal-length sequence. A tunable ssFBG will be available to overcome the prohibitive temperature variation of the optical codecs. Nevertheless,we presented a method to implement coherent time spreading optical code-division multiple-access(OCDMA) where a unique code(or perfect sequence) can be reused and mixed with different wavelengths to obtain a tunable wavelength-division multiplexing(WDM)system. In order to maximize the binary throughput, we have selected a unique short maximal-length sequence composed of 7 chips that can be tuned with 7 different optical wavelengths. We found thousands of different tunable combinations that presented power contrast ratios(P/C) higher than 12 dB. When a WDM-OCDMA system used 2 different combinations simultaneously, the perfect binary detection with error correction codes was achieved successfully. The tunable ssFBG with colloidal crystals will be a simple and good alternative choice for fiber-to-the-home(FTTH) communications.

关键词： Optical code-division multiple-access(OCDMA) super-structured fiber Bragg grating(ssFBG) wavelength-division multiplexing OCDMA(WDM-OCDMA)

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气象数据缺测条件下参照腾发量的计算方法

水利学报 2001年第3期32卷 11-17页

作者：刘钰 L.s.pereira 中国水利水电科学研究院水利所北京100044 葡萄牙里斯本技术大学农学院农业工程系

利用河北雄县和望都两气象站的数据 ,对FAO推荐的气象数据缺测时参照腾发量的计算方法进行了检验和评价 ,分析了参照腾发量对各气象要素的敏感性。

关键词：参照腾发量彭曼-蒙特斯方程气象数据农作物

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考虑地面灌水技术制约的灌溉制度优化

农业工程学报 2003年第4期19卷 74-79页

作者：刘钰 L.s.pereira 中国水利水电科学研究院水利研究所北京100044 葡萄牙里斯本技术大学高等农学院农业工程系

制定作物灌溉制度不仅要考虑补充根层土壤水分以满足作物需求 ,还应考虑灌水方法对灌水量的限制。为研究我国华北地区地面灌溉条件下冬小麦 -夏玉米连作的节水灌溉制度 ,在河北省雄县进行了连续 3年不同灌水处理试验 ,用水量平衡模型 Is... 详细信息

制定作物灌溉制度不仅要考虑补充根层土壤水分以满足作物需求 ,还应考虑灌水方法对灌水量的限制。为研究我国华北地区地面灌溉条件下冬小麦 -夏玉米连作的节水灌溉制度 ,在河北省雄县进行了连续 3年不同灌水处理试验 ,用水量平衡模型 IsAREG对各处理进行数值模拟 ,从而验证了选定的模型和参数。采用该模型模拟了不同水文年冬小麦 -夏玉米连作的多种灌溉制度 ,对各方案的灌水次数、灌水量、降雨和灌溉水量损失以及作物产量等因素进行了对比 ,并对现行灌溉制度进行了评价。结果显示 :雄县现行灌溉定额大大超过了灌溉需水量 ,主要原因是地面灌水技术的制约 ,如田面不平、进地流量过小或畦块过大等 ,造成难以控制小水量灌溉。为研究既能满足作物基本需水要求 ,又使灌溉水量损失最小的最佳灌水定额 ,用模拟地面灌溉水流运动的 sRFR模型模拟不同生长阶段的灌溉 ,得到了每次灌溉时不同流量条件下的最小灌水量 ,以及灌水效率与灌水量的关系 ,据此提出了与灌水技术改进措施相结合的不同水文年的灌溉制度优化方案。

关键词：地面灌水技术灌溉制度模型验证方案选择

Ultrastructural analysis of the loss of desiccation tolerance in germinating Eremanthus erythropappus seeds

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Journal of Forestry Research 2019年第4期30卷 1331-1336页

作者： Rayana s.Martins Anderson C.José José Marcio R.Faria Wilson V.s.pereira Department of Forest sciences Federal University of Lavras(UFLA)

Eremanthus erythropappus(DC.)MacLeish is an important forest species native to the Brazilian savanna biome,an environment with well-defined rainy and dry *** seeds are desiccation tolerant,non-dormant and dispersed at the end of dry *** exposes them to the first sporadic rains that can trigger germination but the subsequent dry days can compromise survival of the newly germinated *** study evaluates if the damages caused by drying of germinating *** seeds,at the stage when they have lost desiccation tolerance,are *** percentage of normal seedlings was evaluated when seeds with different imbibition times were dried to their initial water content and then pre-humidified and *** tolerance was fully lost after 0.5 mm of hypocotyl-radicle protrusion(approximately 72 h)when the radicle had root hairs,a possible indicator of sensitivity to *** of cell contents and ultrastructural damage to the seeds subjected to drying were observed by electron scanning *** hairs disappeared after drying,reappearing after pre-humidification,possibly an attempt to increase the surface area of the radicle for water ***,the hypocotylradicle axis became darkened,probably by antioxidant system failure,causing seed death.

关键词： Candeia Drying Desiccation tolerant seeds Rehydration scanning electron microscopy

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对FAO推荐的作物系数计算方法的验证

农业工程学报 2000年第5期16卷 26-30页

作者：刘钰 L.s.pereira 中国水利水电科学研究院水利所葡萄牙里斯本技术大学农学院农业工程系

作物系数是计算作物需水量必不可少的参数。该文介绍了 FAO近期推荐的确定作物系数的 2种计算方法 ,一种是比较简单实用的分段单值平均法 ,另一种是比较复杂但相对准确的双值作物系数法。用河北省雄县灌溉试验站的冬小麦、夏玉米田间土... 详细信息

作物系数是计算作物需水量必不可少的参数。该文介绍了 FAO近期推荐的确定作物系数的 2种计算方法 ,一种是比较简单实用的分段单值平均法 ,另一种是比较复杂但相对准确的双值作物系数法。用河北省雄县灌溉试验站的冬小麦、夏玉米田间土壤水分观测资料计算作物实际腾发量 ,对上述 2种确定作物系数的方法进行了检验。计算的作物系数与雄县试验站的实测结果基本接近 ,从而初步证明了在缺少实测资料的情况下可以采用

关键词：作物系数计算方法水量平衡冬小麦夏玉米