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Pulmonary arterial hypertension related to human immunodeficiency virus infection:A case series

World journal of Cardiology 2014年第6期6卷 495-501页

作者： inês araújo Cristina Enjuanes-Grau Carmen Jimenez Lopez-Guarch Dariusz Narankiewicz Maria J Ruiz-Cano Teresa Velazquez-Martin Juan Delgado Pilar Escribano 3~(rd) Medicine Department S?o Francisco Xavier HospitalCHLO1449-005 LisboaPortugal Cardiology Department University Hospital of Canarias38320 La LagunaTenerifeSpain Teresa Velazquez-Martin Juan DelgadoPilar EscribanoPulmonary Hypertension UnitUniversity Hospital of 12 de Octubre28041 MadridSpain Internal Medicine Department Carlos Haya Hospital29010 MálagaSpain Pulmonary Hypertension Unit University Hospital of 12 de Octubre28041 MadridSpain

AIM: To present 18 new cases of human immunodeficiency virus(HIV)-related pulmonary arterial hypertension(PAH) with presenting features,treatment options and follow-up ***: This is a single-centre,retrospective,observational study that used prospectively collected data,conducted during a 14-year period on HIV-related PAH patients who were referred to a pulmonary hy-pertension unit. All patients infected with HIV were consecutively admitted for an initial evaluation of PAH during the study period and included in our study. Right heart catheterisation was used for the diagnosis of PAH. specific PAH treatment was started according to the physician's judgment and the recommendations for idiopathic PAH. The data collected included demographic characteristics,parameters related to both HIV infection and PAH and disease ***: Eighteen patients were included. Intravenous drug use was the major risk factor for HIV infection. Risk factors for PAH,other than HIV infection,were present in 55.5% patients. The elapsed time between HIV infection and PAH diagnoses was 12.2 ± 6.9 years. At PAH diagnosis,94.1% patients had a CD4 cell count > 200 cells/μL. Highly active antiretroviral therapy(present in 47.1% patients) was associated with an accelerated onset of PAH. survival rates were 93.8%,92.9% and 85.7% at one,two and three years,respectively. Concerning specific therapy,33.3% of the patients were started on a prostacyclin analogue,and the rest were on oral drugs,mainly phosphodiesterase-5 inhibitors. During the follow-up period,specific therapy was de-escalated to oral drugs in all of the living ***: The survival rates of HIV-related PAH patients were higher,most likely due to new aggressive specific therapy. The majority of patients were on oral specific therapy and clinically stable. Moreover,sildenafil appears to be a safe therapy for less severe HIVrelated PAH.

关键词： Human immunodeficiency virus infection Pulmonary arterial hypertension Treatment

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Appropriate search techniques to estimate Weibull function parameters in a Pinus ***

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journal of Forestry Research 2021年第6期32卷 2423-2435页

作者： Lais Almeida araujo Rafael Menali Oliveira Mario Dobner Jr Carolina souza Jarochinskie silva Lucas Rezende Gomide Department of Forest sciences Federal University of LavrasLavrasMinas GeraisBrazil Department of Agriculture Biodiversity and ForestsFederal University of Santa CatarinaCuritibanosSanta CatarinaBrazil

The Weibull function,a continuous probability distribution,is widely used for diameter distribution modelling,in which parameter estimation performance is affected by stand attributes and fitting *** Weibull cumulative distribution function is nonlinear,and classical fitting methods may provide a not optimal *** the use of artificial intelligence by metaheuristics is reasonable for this optimisation ***,aimed and compared(1)the metaheuristics genetic algorithm and simulated annealing performance over the moment and percentile methods;(2)the hybrid strategy merging the metaheuristics tested and the percentile method and,(3)the metaheuristics fitness functions under basal area and density errors.A long-term experiment in a Pinus taeda stand subjected to crown thinning was *** to our findings,all methods have a similar performance,independent of the thinning regimes and *** pattern of the estimated parameters tends to be acceptable,as b increases over time and c increases after ***,our findings suggest that methods based on metaheuristics have a higher precision than classical methods for estimating Weibull *** to the classification test,the methods that involved simulated annealing stood *** hybrid method involving this metaheuristic also stood out,with accurate *** methods showed the poorest performance,and we therefore suggest the use of simulated annealing due to its faster processing time and high-quality solution.

关键词： Forest management Diameters distribution Weibull function Genetic algorithm simulated annealing

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Chemical characterization UPLC-EsI-QToF-MsE,antibacterial and antibiofilm potential of sarcomphalus joazeiro(MART.)Hauenschild

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Food Bioscience 2022年第6期50卷 1249-1259页

作者： Nara J.s.araújo Ana Raquel P.silva Maria s.Costa Thiago s.Freitas josé M.Barbosa Filho Yedda M.L.s.Matos Maria Flaviana B.Morais-Braga Francisco N.Pereira Junior C.A.P.silva Erlânio O.souza Paulo R.V.Ribeiro Bruna Caroline Gonçalves Vasconcelos de Lacerda Edlane Martins de Andrade Henrique D.M.Coutinho Jacqueline C.Andrade-Pinheiro Programa de pós-graduação em Ciências da saúde Universidade Federal do CaririUFCADivino Salvador284CEP63180-000BarbalhaCEBrazil Programa de pós-graduação em Biotecnologia Universidade Estadual do CearáUECEAv.Dr Munguba1700CEP60714-903FortalezaCEBrazil Departamento de Química Biológica Universidade Regional do CaririURCACel Antônio Luis1161CEP63105-000CratoCEBrazil Laboratório de Tecnologia Farmacêutica Universidade Federal da ParaíbaUFPBCidade Universitária5009CEP58051-970João PessoaPBBrazil Laboratório de Bioensaios – LABIO Universidade Federal do Cariri – UFCAR.Olegário Emidio de Araujos/nCEP63260-000Brejo SantoCEBrazil Faculdade de Tecnologia do Cariri FATECAmália Xavier de OliveiroCEP63040-000Juazeiro do NorteCEBrazil Embrapa Agroindústria Tropical R.Pernambuco2270 - Pici60511-110FortalezaCEBrazil CECAPE College.Av.Padre Cícero 3917 - São JoséJuazeiro do NorteCE63024-015Brazil

The present study aims to demonstrate the chemical composition of the ethanolic extract of sarcomphalus joazeiro bark and to evaluate its antibacterial and antibiofilm *** that,the ethanolic extract of the stem bark was prepared,and chemical characterization was carried out in *** inhibitory concentration and antibiotic modification test were performed by the microdilution *** and antiformation assays were evaluated by the crystal violet *** the chemical characterization,the presence of 24 peaks was *** activity showed minimum inhibitory concentration≥2048μg/*** the evaluations of the potentiating activity,synergism was the most *** the formation analysis,it was observed that most strains showed moderate biofilm *** was concluded that saponin derivatives are the major secondary metabolites in the analyzed extract and that it presents relevant synergism with the antibiotics studied and a significant ability to inhibit bacterial biofilm formation.

关键词： Biofilm saponins synergism Inhibition

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Contributions on selective Waste Collection and Recycling Cooperatives in Municipalities in the state of são Paulo,Brazil

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journal of Environmental science and Engineering(B) 2022年第5期11卷 189-205页

作者： Clauciana schmidt Bueno de Moraes Larissa senden Carnicel Adriana Maria Nolasco Giulia Malaguti Braghini Marcolini Martires Cinthia Mara Vital Bonaretto Willian Leandro Henrique Pinto Bruna Ferrari Felipe Felipe josésasso Laís araújo de Paula são Paulo state University(UNEsP) São Paulo 13506-900Brazil school of Technology University of Campinas(UNICAMP)Limeira 13484-332Brazil University of são Paulo(UsP) 13.418-900.PiracicabaBrazil Fehily Timoney and Company D11 PXT0.DublinIreland

The collection and proper disposal of MsW(Municipal solid Waste)is one of the biggest challenges faced by Brazilian public *** recyclable waste represents about 33.6%of the gravimetric composition of MsW,with a tendency to increase in the next few years,due to the increasing consumption of processed products,with short life cycles and excess *** inadequate management of these residues results in a series of social,environmental and economic *** recent years,there has been a great advance in Brazilian laws,assigning responsibilities and regulating waste management in the country,optimizing the use of infrastructure and human and financial *** resources and insufficient infrastructure demand actions based on a lot of *** of the main limiting factors for the planning and development of public policies for the sector is the lack of reliable data and information on the generation and management of waste,that allow the creation of future scenarios and the definition of adequate strategies for minimization,valorization of waste and final disposal of waste that no longer can be ***,this work sought to analyze the current situation of selective waste collection and recycling cooperatives in 211 municipalities in the state of são Paulo,evaluating the issues and opportunities for the applicability of Law n.12,305/2010,Brazilian PNRs(in Portuguese)(National Policy of solid Waste)in the management of this waste in small,medium and large cities.A bibliographic research was carried out on the panorama of solid waste management in Brazil and in the state of são Paulo,as well as a contextualization on selective waste collection and recycling *** that,data from 211 municipalities taking part in the survey solid Waste Management—Municipalities of the state of são Paulo were analyzed,focusing on answers that correlated with the topics covered in this *** this work,questions were used in order to obt

关键词： solid waste Brazilian National Policy of solid Waste solid waste management MsW recycling cooperatives

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Endoscopic ultrasound artificial intelligence-assisted for prediction of gastrointestinal stromal tumors diagnosis:A systematic review and meta-analysis

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World journal of Gastrointestinal Endoscopy 2023年第8期15卷 528-539页

作者： Rômulo sérgio araújo Gomes Guilherme Henrique Peixoto de Oliveira Diogo Turiani Hourneaux de Moura Ana Paula samy Tanaka Kotinda Carolina Ogawa Matsubayashi Bruno salomão Hirsch Matheus de Oliveira Veras joão Guilherme Ribeiro jordão sasso Roberto Paolo Trasolini Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura Department of Gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Division of Hepatology and Endoscopy Department of GastroenterologyHarvard Medical SchoolBrigham and Women’s HospitalBostonMA 02115United States

BACKGROUND subepithelial lesions(sELs)are gastrointestinal tumors with heterogeneous malignant *** ultrasonography(EUs)is the leading method for evaluation,but without histopathological analysis,precise differentiation of sEL risk is *** intelligence(AI)is a promising aid for the diagnosis of gastrointestinal lesions in the absence of *** To determine the diagnostic accuracy of AI-assisted EUs in diagnosing sELs,especially lesions originating from the muscularis propria *** Electronic databases including PubMed,EMBAsE,and Cochrane Library were *** of any sex and>18 years,with sELs assessed by EUs AIassisted,with previous histopathological diagnosis,and presented sufficient data values which were extracted to construct a 2×2 *** reference standard was *** primary outcome was the accuracy of AI for gastrointestinal stromal tumor(GIsT).secondary outcomes were AI-assisted EUs diagnosis for GIsT vs gastrointestinal leiomyoma(GIL),the diagnostic performance of experienced endoscopists for GIsT,and GIsT vs *** sensitivity,specificity,positive,and negative predictive values were *** corresponding summary receiver operating characteristic curve and post-test probability were also *** Eight retrospective studies with a total of 2355 patients and 44154 images were included in this *** AI-assisted EUs for GIsT diagnosis showed a sensitivity of 92%[95%confidence interval(CI):0.89-0.95;Pspecificity of 80%(95%CI:0.75-0.85;Psis of GIsT vs GIL by AI-assisted EUs,specificity was 90%(95%CI:0.88-0.95;P=0.02)and AUC of *** experienced endoscopists’values were sensitivity of 72%(95%CI:0.67-0.76;Pspecificity of 70%(95%CI:0.64-0.76;PsT vs GIL,the experts achieved a sensitivity of 73%(95%CI:0.65-0.80;P<0.01)and an AUC of ***

关键词： subepithelial lesions Ultrasound endoscopy Artificial intelligence

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn sua jo jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as strategy A. To compare the impacts of lignin upgrading and feedstock, strategy B, which co-produces tetrahydrofuran alone, and strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in strategy A. The market competitiveness of strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.strategy A was found to be the most favorable both economically（UsRDsCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

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Resolutive Results with Oral Corticosteroids for Patients with COVID-19 in Pulmonary Inflammatory Phase. successful Outpatient Experience during the Collapse of Belem Do Para Health system—Brazil

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Health 2021年第8期13卷 830-838页

作者： Roberto s. Zeballos Luciana N. L. Cruz Vânia C. R. Brilhante Adriana V. Lima Carlliane L. L. P. Martins Karla N. A. Lima Michele C. G. L. Leão Belinete L. Cruz Alessandra B. Dysarz Paulo C. B. Lobato Erika s. Almeida Rute A. P. Costa Klevison C. araújo Augusto C. C. Almeida Leônidas B. D. Junior Kathia O. Harada Rita H. V. s. araújo Elaine X. Prestes Ivete M. s. souza Avany M. P. Pereira Antônio B. M. A. Rocha Iracema A. Estevão Fagnei I. C. Carvalho Paulo M. P. Melo Clinical Care Sao Paulo Brazil Instituto de Ciencias da saude Faculdade de Medicina Universidade Federal do Para Belem Brazil Fundacao Publica Estadual Hospital de Clinicas Gaspar Vianna Belem Brazil Hospital da Policia Militar do Para Belem Brazil Imunoclinic Belem Brazil Universidade Estadual do Para Fundacao Santa Casa de Misericordia do Para Belem Brazil Clinica Barros Cirurgia Plastica Belem Brazil secretaria de Estado de saude Publica Castanhal Brazil Centro de Tratamento Oncologico Belem Brazil sociedade Brasileira de Valorizaç ã o das sociedades Medicas—sOBEMED S&#227 o Paulo Brazil Clinica de Nutrologia Sao Luiz Brazil Hospital Nipo Brasileiro de Olhos Belem Brazil Centro de Ciencias Biologicas e da saude Universidade do Estado do Para Belem Brazil Hospital Regional do Baixo Amazonas Santarem Brazil Clinica Vallinoto secretaria de saude de Barcarena Barcarena Brazil Estrategia saude da Familia secretaria Municipal de saude de Ananindeua Centro Universitario do Estado do Para Belem Brazil A. M. P. Endocrinologia Belem Brazil Instituto Avertano Rocha Belem Brazil Departamento de Neurocirurgia Hospital Militar de Area De Sao Paulo Sao Paulo Brazil

In the face of new diseases, medicine needs to reinvent itself in order to contain and control epidemics, such as the one we have recently faced, COVID-19, a disease with a wide spectrum of clinical severity. A new moment has been established, since the application of well-known, effective and safe medications for other diseases, has shown high success rates in the treatment of COVID-19. Thereunto, studies with early intervention are needed, which can change the unfavorable outcome of patients. In this article, we report the successful experience using an oral strategy during the collapse of Belem (Para, Brazil) Health system. Two hundred and ten patients were diagnosed with respiratory failure due to COVID-19, with no option of hospital treatment due to lack of beds and resources. These patients were then started on therapeutic regimen consisting of 40 mg prednisolone, 40 mg enoxaparin and macrolides (500 mg clarithromycin, 500 mg axetylcefuroxime) associated and followed in outpatient facilities. Two hundred and eight patients had an excellent therapeutic response and there were only two fatalities. These results push research boundaries, valuing outpatient treatment with early use of prednisolone in the initial pulmonary phase, preventing severe COVID-19 pneumonitis. Adoption of the proposed treatment intends to reduce the need for hospitalization, as well as lethality, with social robust benefits and incalculable economic savings since involves the use of accessible, safe and not expensive medications.

关键词： COVID-19 Corticosteroids Pulmonary Inflammatory Phase Collapse Brazil

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Anti-angiogenic therapies for metastatic colorectal cancer:Current and future perspectives

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World journal of Gastroenterology 2013年第44期19卷 7955-7971页

作者： Inês Marques António araújo Ramon Andrade de Mello Faculty of Medicine University of Porto 4200-319 Porto Portugal Molecular Oncology Group Research CenterPortuguese Oncology Institute 4200-072 Porto Portugal Department of Medical Oncology Portuguese Oncology Institute 4200-072 Porto Portugal The Royal Marsden NHs Foundation Trust London SW3 6JJ United Kingdom

Colorectal cancer(CRC)is the fourth most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the United states,with about 142820 new cases and 50830 deaths expected in *** disease(mCRC)remains a challenge for oncologists worldwide due to its potential ***,chemotherapy regimens containing 5-fluorouracil,leucovorin,oxaliplatin and irinotecan combinations are a standard of care in the metastatic ***,biological therapies involving vascular endothelial growth factor and epidermal growth factor receptor pathways,such as bevacizumab and cetuximab,have emerged as good option for improving mCRC patient ***,aflibercept plus standard chemotherapy has also been approved in second line regimen for mCRC *** review will discuss novel biological drugs and their indications for mCRC patients and will bring future perspectives in this regard.

关键词： Colorectal cancer Bevacizumab Cetuximab Aflibercept FOLFOX FOLFIRI

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THE EFFECT OF MEMORY TERMs IN DIFFUsION PHENOMENA

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journal of Computational Mathematics 2006年第1期24卷 91-102页

作者： A. araújo J.A. Ferreira P. Oliveira Departamento de Matemática Universidade de Coimbra Portugal

In this paper the effect of integral memory terms in the behavior of diffusion phenomena is studied. The energy functional associated with different models is analyzed and stability inequalities are established. Approximation methods for the computation of the solution of the integro-differential equations are constructed. Numerical results are included.

关键词： Heat propagation Integro-differential equation Numerical approximation,splitting method

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui jo Anne stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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