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Application of a new reagent for analysis of oxygen presence in a lowcarbon steel wire rod

Journal of Iron and steel Research International 2021年第6期28卷 729-738页

作者： M.I.Dávila-Pérez H.J.vergara-Hernández O.vázquez-Gómez F.Reyes-Calderón E.López-Martínez J.M.salgado-López National Technology of Mexico/T.I.of Morelia Morelia 58120MichoacanMexico National Council for science and Technology CONACYT Mexico City 03940Mexico Isthmus University Santo Domingo TehuantepecOaxaca 70760Mexico Engineering and Industrial Development Center CIDEsI Santiago de Queretaro 76125QueretaroMexico

A microstructural analysis was performed to determine the presence of oxygen in a wire rod section of AIsI 1008 steel with a surface mechanical failure produced during wire *** failure zone was analyzed by comparison using three different attack reagents:alkaline sodium chromate(AsC),AsC with hydrogen peroxide and amyl alcohol,and a solution of nitric acid in ethyl *** reagents were applied in samples in the failure zone,showing different types of zones in regions with internal and superficial defects such as carbides,pores,cracks,deformation,and detachment zones,indicating the possible presence of *** areas identified were observed by means of an optical microscope and were correlated with the content of elements that were present in the region using a scanning electron microscope and a scattered X-ray energy spectrometer,which determined that the areas identified by chromate sodium correspond to regions with a high concentration of oxygen and slag-forming elements such as silicon,aluminum,and iron;this is associated with the presence of oxygen in the oxide *** was also observed that the AsC and the modified AsC solution with hydrogen peroxide and amyl alcohol could identify areas with a high presence of oxides,while the nitric acid solution only identified the steel *** modified AsC solution is an alternative to identify the presence of chemical variants of oxygen because the conventional formulation is unstable and has a too short shelf life,and therefore,its application must be carried out at the time of preparation.

关键词： Etching Alkaline sodium chromate Oxide presence Internal defect

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PHOTONIC CRYsTAL WAvEGUIDE BIOsENsOR

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Journal of Innovative Optical Health sciences 2013年第2期6卷 11-16页

作者： A.A.ZANIsHEvsKAYA A.v.MALININ v.v.TUCHIN YU.s.sKIBINA I.YU.sILOKHIN saratov state University 83 Astrakhanskaya str. Saratov 410012Russia sPE Nanostructured Glass Technology 101 50 let Oktjabrja ave.Saratov 410033Russia Institute of Precise Mechanics and Control ras 24 Rabochaya Str.Saratov 410028Russia University of OuluP.O.Box 4500Oulu FIN-90014Finland sPE Nanostructured Glass Technology 101 50 let Oktjabrja Ave.Saratov 410033Russia

The hollow core photonic crystal waveguide biosensor is designed and *** biosensor was tested in experiments for artificial sweetener identifcation in *** photonic crystal waveguide biosensor has a high sensitivity to the optical properties of liquids flling up the hollow *** compactness,good integration ability to different optical systems and compatibility for use in industrial settings make such biosensor very promnising for v arious biomedical applicat ions.

关键词： Biosensor hollow core photonic crystal fiber biomedical applications artificial sweetener food quality

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Effects of slight Plastic Deformation on Magnetic Properties and Giant Magnetoimpedance of FeCoCrsiB Amorphous Ribbons

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Chinese Physics Letters 2007年第5期24卷 1357-1360页

作者： s. O. volchkov M. A. Cerdeira v. v. Gubernatorov E. I. Duhan A. P. Potapov v. A. Lukshina Ural state University Lenin Ave. 51 Yekaterinburg 620083 Russia Dpto. de Ffsica Universidad 'de Oviedo Avd. Calvo Sotelos/n 33007 Oviedo Spain Institute of Metal Physics Ural Branch of RAS Yekaterinburg 620041 Russia

slight plastic deformation of 0 to 1% by cold rolling is proposed as a treatment which may modify the responses of magnetoimpedance （MI） sensor with an amorphous ribbon used as a sensitive element. The dependence of the magnetic properties of melt spun Fe3Co67Cr3si15B12 amorphous ribbons and their MI responses in the initial state and after slight plastic deformation on the value of the deformation were comparatively analysed. The shape of the hysteresis loops shows a clear correlation with the value of the deformation. The variations of the total impedance, the real and the imaginary components, are measured for the current intensity of 1.s mA for the frequency of lO MHz. slight plastic deformation affects both real and imaginary components and allows a control of the shape of the MI curves in a small field in a range usually used in biomedical applications. The proposed deformation treatments can be useful for the construction of the MI sensitive elements with a new type of the responses.

关键词： IMPEDANCE sENsOR

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Alcoholic liver disease:Utility of animal models

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World Journal of Gastroenterology 2018年第45期24卷 5063-5075页

作者： Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa vázquez santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for Bioengineering(IBioE) School of EngineeringFaraday BuildingThe University of EdinburghEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Human Anatomy and Embryology Complutense University School of MedicineMadrid 28040Spain Instituto de Neurociencias Consejo Superior de Investigaciones CientíficasUniversidad Miguel HernándezSan Juan de Alicante 03550Spain Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain Department of Genetics Physiology and MicrobiologyFaculty of BiologyUniversidad ComplutenseMadrid 28040Spain Department of Internal Medicine Ⅲ University Hospital RWTH AachenAachen 52062Germany

Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.

关键词： steatohepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Reactive oxygen species

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Chemical behaviour of Al/Cu nanoparticles in water

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Progress in Natural science:Materials International 2015年第1期25卷 1-5页

作者： N.v.svarovskaya A.v.Berenda O.v.Bakina E.A.Glazkova A.s.Lozhkomoev E.G.Khorobraya v.v.Domashenko M.I.Lerner A.N.Fomenko Institute of strength Physics and Materials science Siberian Branch of the Russian Academy of Sciences (ISPMS SB RAS)2/4 pr.Akademichesky ave. Tomsk 634021 Russia National Research Tomsk state University (TsU) 36 Lenina ave. 634050 Tomsk Russia National Research Tomsk Polytechnic University (TPU) 30 Lenina ave. 634050 Tomsk Russia

Bimetallic Al/Cu nanoparticles with Al/Cu composition 10:90, 20:80, 40:60 were produced by method of simultaneous electrical explosion of metal pairs in the argon atmosphere. Nanopowders containing 20% and 40% (mass) of aluminum interacted with water at 40–70 ℃ and formed composite particles that were porous structures of nanopetal pseudoboehmite with nanosized copper-containing inclusions inside. Aluminum in nanopowder with Al/Cu composition 10:90 did not react with water, as far as it is in the phase of intermetallic compounds Сu Al2and С*** produced can be used as an active component of antibacterial agents.

关键词： Nanopowders Bimetallic nanoparticles Composite nanoparticles

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Experimentation on Tool Wear and surface Roughness in AIsI D2 steel Turning with WC Insert

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Modern Mechanical Engineering 2018年第3期8卷 204-220页

作者： N. López-Luiz O. jim.nez Alemán F. Alvarado Hernández M. Montoya Dávila v. H. Baltazar-Hernández Centro de Tecnología Avanzada CIATEQ Doctorado en Manufactura Avanzada Aguascalientes México Departamento de Ingeniería de Proyectos CUCEI Universidad de Guadalajara Zapopan Jal México Maestria en Ciencia e Ingeniería de los Materiales Universidad Autónoma de Zacatecas Zacatecas México

The Taguchi method, based on an orthogonal arrangement (L9, 33), the vari-ance analysis, the signal-to-noise ratios and the response surface methodol-ogy have been used to optimize maximum flank wear (vBmax) and surface roughness (Ra) of the cutting tool when turning a hardened steel AIsI D2 (65 HRC) with PvD—TiAlN coated WC insert upon dry environment. By em-ploying regression models;cutting speed, cutting depth and feed rate, which optimize maximum flank wear and surface roughness were validated. Results of relation signal-to-noise ratios, showed that with cutting speed of 200 m/min, cutting depth of 0.2 mm and feed rate of 0.20 mm/rev, Ra is opti-mized. With cutting speed of 150 m/min, cutting depth of 0.4 mm and feed rate of 0.3 mm/rev, vBmax is optimized. Through the variance analysis it was concluded that the depth of cut was the main parameter that affected on the surface roughness;whereas, the feed rate was the most influential parameter on the flank wear. Confirmation test results showed that the Taguchi method was very successful in the optimization of machining parameters for mini-mum surface roughness and flank wear in the turning of the D2 steel.

关键词： Turning Taguchi Method Wear of Cutting Tool surface Roughness AIsI D2

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Could Low Hdl-Cholesterol Levels Be an Unvalued Predictor of Cancer Risk?: A Retrospective Case study

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International Journal of Clinical Medicine 2015年第12期6卷 984-992页

作者： Juan Antonio vílchez Natalia sancho-Rodríguez Ana Martínez-Ruiz Enrique Martínez-sánchez Francisco Ruiz-Espejo Isabel Tovar-Zapata Jose Antonio Noguera-velasco Clinical Analysis Department Virgen de la Arrixaca Clinic University Hospital Murcia Spain Cardiology Department Virgen de la Arrixaca Clinic University Hospital Murcia Spain Laboratorios Unilabs s. L. Murcia Spain

Background: The relationship between serum lipid profile levels and cancer risk remained uncertain. Recently, it had been reported a significant inverse association between high-density lipoprotein cholesterol (HDL) and the risk of incident cancer that was independent of low-density lipoprotein cholesterol (LDL), age or sex. Objective: The aim of our study was to evaluate the behavior of HDL in cancer patients and in healthy population. Methods: We created a retrospectively search strategy in the laboratory information system (LIs). We filtered and searched those patients with CEA within 5 - 20 ng/ml and any value of HDL and corroborated the presence of cancer (Group 1 (G1)) or not (Group 2 (G2)). Moreover, we searched a control group (patients in outpatient oncology clinic) to observe the values of HDL. Comparisons and statistical logistic regression models were applied to link the levels of this biomarkers and cancer risk. Results: We examined 852 valid patients, median age 62 (50 - 73) years. Within the search strategy group, G2 showed highest levels of HDL (54 (43 - 67) mg/dl) and lowest CEA levels (6.7 (5.7 - 8.4) ng/ml) comparing with G1: HDL (47 (37 - 60) mg/dl) and the CEA (7.9 (6.2 - 10.9) ng/ml);p p r2: 0.092;p p = 0.001)] and CEA [OR: 1.115 (1.060 - 1.174), (p s independent predictors of cancer. Conclusion: Our findings confirmed the inverse association of HDL levels between healthy populations and were diagnosed with cancer. Moreover, in a random population, patients with cancer presented lower HDL values compared to those without cancer. Therefore, it could demonstrate the possible positive predictive value of low HDL related to cancer risk.

关键词： High-Density Lipoprotein Cholesterol (HDL) Cancer Risk Lipid Profile Carcinoembryonic Antigen (CEA)

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Brassinosteroids and Plant Responses to Heavy Metal stress. An Overview

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Open Journal of Metal 2013年第2期3卷 34-41页

作者： Miriam Núnez vázquez Yanelis Reyes Guerrero Lisbel Martínez González Walfredo Torres de la Noval Department of Plant Physiology and Biochemistry National Institute of Agricultural SciencesSan Joséde las LajasCuba

soil contamination with heavy metals has become a world-wide problem, leading to the loss in agricultural productivity. Plants have a remarkable ability to take up and accumulate heavy metals from their external environment and it is well known that high levels of heavy metals affect different physiological and metabolic processes. Brassinosteroids are considered as the sixth class of plant hormones and they are essential for plant growth and development. These compounds are able of inducing abiotic stress tolerance in plants. In this paper, information about brassinosteroids and plant responses to heavy metal stress is reviewed.

关键词： Heavy Metal stress Brassinosteroids Tolerance

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Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway

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Cellular & Molecular Immunology 2017年第6期14卷 529-545页

作者： Rong Wang Aizhang Xu Xueying Zhang Jie Wu Andrew Freywald Jianqing Xu jim Xiang Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 school of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 shanghai Public Health Clinical Center Fudan University Shanghai 201508 China Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5

CD8＋ cytotoxic T lymphocyte （CTL） exhaustion is a chief issue for ineffective virus elimination in chronic infectious diseases. We generated novel ovalbumin （OvA）-specific OvA-Texo and HIv-specific Gag-Texo vaccines inducing therapeutic immunity. To assess their therapeutic effect in chronic infection, we developed a new chronic infection model by i.v. infecting C57BL/6 mice with the OvA-expressing adenovirus Advova. During chronic Advova infection, mouse CTLs were found to express the inhibitory molecules programmed cell-death protein-1 （PD-1） and lymphocyte-activation gene-3 （LAG-3） and to be functionally exhausted, showing a significant deficiency in T-cell proliferation, IFN-7 production and cytolytic effects. Naive CD8＋ T cells upregulated inhibitory PD-ligand 1 （PD-L1）, B- and T-lymphocyte attenuator and T-cell anergy-associated molecules （Grail and Itch） while down-regulating the proliferative response upon stimulation in mice with chronic infection. Remarkably, the OvA-Texo vaccine counteracted T-cell anergy and converted CTL exhaustion. The latter was associated with （i） the upregulation of a marker for CTL functionality, diacetylated histone-H3 （diAcH3）, （ii） a fourfold increase in CTLs, occurring independent of host DCs or CD4＋ T cells, and （iii） the restoration of CTL IFN-7 production and cytotoxicity. In vivo OvA-Texo-stimulated CTLs upregulated the activities of the mTORC1 pathway-related molecules Akt, s6, elF4E and T-bet, and treatment of the CTLs with an mTORC1 inhibitor, rapamycin, significantly reduced the OvA-Texo- induced increase in CTLs. Interestingly, OvA-Texo-mediated CD40L signaling played a critical role in the observed immunological effects. Importantly, the Gag-Texo vaccine induced Gag-specific therapeutic immunity in chronic infection. Therefore, this study should have a serious impact on the development of new therapeutic vaccines for human immunodeficiency virus （HIv-1） infection.

关键词： anti-CD40 Ab CD40L signaling chronic infection CTL exhaustion HIv Gag mTORC1 pathway T-cellanergy therapeutic T-cell vaccine

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Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

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Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Evgeniya v.Dolgova Oleg M.Andrushkevich Polina E.Kisaretova Anastasia s.Proskurina Genrikh s.Ritter Tatyana D.Dubatolova Margarita v.Romanenko Oleg s.Taranov Yaroslav R.Efremov Evgeniy L.Zavyalov Alexandr v.Romaschenko sergey v.Mishinov svetlana s.Kirikovich Evgeniy v.Levites Ekaterina A.Potter Alexandr A.Ostanin Elena R.Chernykh stanislav Yu.Roshchin Anatoliy v.Bervitskiy Galina I.Moysak Jamil A.Rzaev sergey s.Bogachev Institute of Cytology and Genetics sB ras Novosibirsk 630090Russia A.I.Evdokimov Moscow state University of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Novosibirsk state University Novosibirsk 630090Russia The state Research Center of virology and Biotechnology"vector" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia sklifosovsky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objective:Glioma is a highly invasive tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuvant therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CsCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CsCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in vitro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** sCID mice with developed subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Psplantation of U87 cells followed by surgical excision of the developed graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median survival of the mice twofold relative to the ***:The effectiveness of the Karanahan approach has been demonstrated both in vitro and in vivo in treating developed subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

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