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SARS-CoV-2 spike variants differ in their allosteric responses to linoleic acid

Journal of Molecular Cell Biology 2023年第3期15卷 55-66页

作者： A.Sofia F.Oliveira Deborah K.Shoemark Andrew D.Davidson imre berger Christiane Schaffitzel Adrian J.Mulholland School of Chemistry Centre for Computational ChemistryUniversity of BristolBristol BS81TSUK School of Chemistry University of BristolBristol BS81TSUK School of Biochemistry University of BristolBristol BS81TDUK School of Cellular and Molecular Medicine University of BristolUniversity WalkBristol BS81TDUK School of Chemistry Max Planck Bristol Centre for Minimal BiologyBristol BS81TSUK

The SARS-CoV-2 spike protein contains a functionally important fatty acid(FA)binding site,which is also found in some other coronaviruses,***-CoV and *** occupancy of the FA site by linoleic acid(LA)reduces infectivity by‘locking’the spike in a less infectious ***,we use dynamical-nonequilibrium molecular dynamics(D-NEMD)simulations to compare the allosteric responses of spike variants to LA removal.D-NEMD simulations show that the FA site is coupled to other functional regions of the protein,*** receptor-binding motif(RBM),N-terminal domain(NTD),furin cleavage site,and regions surrounding the fusion peptide.D-NEMD simulations also identify the allosteric networks connecting the FA site to these functional *** comparison between the wild-type spike and four variants(Alpha,Delta,Delta plus,and Omicron BA.1)shows that the variants differ significantly in their responses to LA *** allosteric connections to the FA site on Alpha are generally similar to those on the wild-type protein,with the exception of the RBM and the S71–R78 region,which show a weaker link to the FA *** contrast,Omicron is the most different variant,exhibiting significant differences in the RBM,NTD,V622–L629,and furin cleavage *** differences in the allosteric modulation may be of functional relevance,potentially affecting transmissibility and *** comparison of the effects of LA on SARS-CoV-2 variants,including emerging variants,is warranted.

关键词： SARS-CoV-2 spike allosteric modulation D-NEMD simulations fatty acid binding site SARS-CoV-2 variants

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Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3211-3214页

作者： Elisa Avolio Prashant K.Srivastava Jiahui Ji Michele Carrabba Christopher T.W.Tsang Yue Gu Anita C.Thomas Kapil Gupta imre berger Costanza Emanueli Paolo Madeddu Bristol Medical School Translational Health SciencesUniversity of BristolBristolUK National Heart&Lung Institute Imperial CollegeLondonUK School of Biochemistry University of BristolBristolUK

Dear Editor,The Coronavirus disease 2019(COVID-19)pandemic has caused over 670 million cases and 6.7 million deaths worldwide,many of which are attributed to cardiovascular ***-induced endothelial damage,endothelial b... 详细信息

关键词： damage cardiovascular cardiac

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Vanishing torsion of parametric curves

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 593-595页

作者： JUHSZ imre Department of Descriptive Geometry University of MiskolcMiskolc-Egyetemváros H-3515Hungary

We consider the class of parametric curves that can be represented by combination of control points and basis func- tions. A control point is let vary while the rest is held fixed. It’s shown that the locus of the moving control point that yields points of zero torsion is the osculating plane of the corresponding discriminant curve at its point of the same parameter value. The special case is studied when the basis functions sum to one.

关键词： Parametric curve Torsion Discriminant curve

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Information schema constructs for defining warehouse databases of genotypes and phenotypes of system manifestation features

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 862-884页

作者： Shahab POURTALEBI imre HORVáTH Faculty of Industrial Design Engineering Delft University of Technology

Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. The novelty of this toolbox is that it uses system manifestation features(SMFs) for transdisciplinary modeling of these systems. The main challenges of implementation of the toolbox are functional design- and language-independent computational realization of the warehouses, and systematic development and management of the various evolving implements of SMFs(genotypes, phenotypes, and instances). Therefore, an information schema construct(ISC) based approach is proposed to create the schemata of the associated warehouse databases and the above-mentioned SMF implements. ISCs logically arrange the data contents of SMFs in a set of relational tables of varying semantics. In this article we present the ISCs necessary for creation of genotypes and phenotypes. They increase the efficiency of the database development process and make the data relationships transparent. Our follow-up research focuses on the elaboration of the SMF instances based system modeling methodology.

关键词： Cyber-physical systems Software toolbox Pre-embodiment design System manifestation features(SMFs) Warehouses Database schemata SMF genotypes SMF phenotypes SMF instances Information schema constructs

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Ripoptosome:a novel IAP-regulated cell death-signalling platform

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Journal of Molecular Cell Biology 2011年第6期3卷 324-326页

作者： Gergely imre Sarit Larisch Krishnaraj Rajalingam Institute of Biochemistry II Goethe University School of MedicineTheodor-Stern-Kai 7D-60590 Frankfurt am MainGermany Cell Death Research Laboratory Department of BiologyFaculty of Natural SciencesUniversity of HaifaMulti-Purpose BuildingMount CarmelHaifa 31905Israel

Recent studies have revealed that cell death stimuli can trigger programmed necrosis,***-interacting serine–threonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and *** studies now describe a novel RIP1 containing∼2 MDa‘Ripoptosome’complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 ***,cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.

关键词： death endogenous Receptor

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LIQUID-LIQUID PHASE EQUILIBRIUM OF POLYMER SOLUTIONS AND POLYMER BLENDS UNDER POSITIVE AND NEGATIVE PRESSURE

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Chinese Journal of Polymer Science 2003年第2期21卷 241-250页

作者： Attila R.imre KFKI Atomic Energy Research Institute H-1525 Budapest POB 49 Hungary

In this paper we would like to give a brief review about the extensibility of the liquid-liquid locus into the negativepressure region. Negative pressure states are hardly explored; most researchers believe that the pressure scale ends at p = *** would like to show that this is not true, the p = 0 point is not a special point for liquids, it can be 'easily' crossed. We aregoing to give a few example, where the extension of liquid-liquid locus for polymer blends and solutions below p = 0 givesus some interesting results, like the merging of UCST and LCST branches in weakly interacting polymer solutions or thereason why most UCST blends exhibit pressure induced immiscibility. Also, we will see what happens with the immiscibilityisland of aqueous polymer solutions when -- reaching the critical molar mass -- it 'disappears'.

关键词： Pressure Negative pressure Polymer Solubility Phase transition

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Modeling of Reversibleγ/αTransformations of Low Carbon Steels in the Intercritical Temperature Range

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材料热处理学报 2004年第05B期25卷 702-705页

作者： Tamás RTl imre FELDE Hakan GR Budapest Polytechnic Budapest HungaryBay Zoltdn Institute for Materials Science and Technology Budapest HungaryMetallurgical and Materials Eng. Dept. Middle East Technical University Ankara Turkey

A phenomenological kinetic model has been developed for the prediction of non-isothermal reversible incomplete transformations in low-carbon hypoeutectoid steels. The theoretical basis of the proposed method has its origin in a possible extension of the traditional Austin-Rickett kinetic differential equation. To critically assess the applicability of the model, a number of experiments based on computer simulations have been performed to predict the austenite/ferrite proeutectoid transformation in the temperature range of Aei to Ae3 on plain carbon hypoeutectoid steels. A comparison with published experimental data has verified that the model developed is reasonable both quantitatively and with respect to well-established trends. Extension of the method of prediction appears promising when the non-isothermal reactions occurring during heat treatment (such as carbide precipitation and dissolution) can be assumed to proceed in a reversible manner.

关键词：奥氏体转变动力学低碳钢临界温度

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Investigating the influence of monosodium L-glutamate on brain responses via scalp-electroencephalogram(scalp-EEG)

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Food Science and Human Wellness 2022年第5期11卷 1233-1239页

作者： Ben Wu Xirui Zhou imre Blank Yuan Liu Department of Food Science&Technology School of Agriculture and BiologyShanghai Jiaotong UniversityShanghai 200240China Zhejiang Yiming Food Co. Ltd.Wenzhou 325400China

As the relevance between left and right brain neurons when transmitting electrical signals of umami taste is unknown,the aim of this work was to investigate responsive regions of the brain to the umami tastant monosodium glutamate(MSG)by using scalp-electroencephalogram(EEG)to identify the most responsive brain regions to *** concentrations of MSG(0.05,0.12,0.26 g/100 mL)were provided to participants for tasting while recoding their responsive reaction times and brain *** results indicated that the most responsive frequency to MSG was at 2 Hz,while the most responsive brain regions were T4 CzA2,F8 CzA2,and Fp2 ***,the sensitivity of the brain to MSG was significantly higher in the right brain *** study shows the potential of using EEG to investigate the relevance between different brains response to umami taste,which contributes to better understanding the mechanism of umami perception.

关键词： Umami Taste Monosodium glutamate Electroencephalogram Brain

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Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 152-175页

作者： Santiago RUIZ-ARENAS Zoltán RUSáK imre HORVáTH Ricardo MEJí-GUTIERREZ Faculty of Industrial Design Engineering Delft University of Technology Grupo de Investigación en Ingeniería de Diseno Universidad EAFIT

Malfunction or breakdown of certain mission critical systems(MCSs) may cause losses of life, damage the environments, and/or lead to high costs. Therefore, recognition of emerging failures and preventive maintenance are essential for reliable operation of MCSs. There is a practical approach for identifying and forecasting failures based on the indicators obtained from real life processes. We aim to develop means for performing active failure diagnosis and forecasting based on monitoring statistical changes of generic signal features in the specific operation modes of the system. In this paper, we present a new approach for identifying emerging failures based on their manifestations in system signals. Our approach benefits from the dynamic management of the system operation modes and from simultaneous processing and characterization of multiple heterogeneous signal sources. It improves the reliability of failure diagnosis and forecasting by investigating system performance in various operation modes, includes reasoning about failures and forming of failures using a failure indicator matrix which is composed of statistical deviation of signal characteristics between normal and failed operations, and implements a failure indicator concept that can be used as a plug and play failure diagnosis and failure forecasting feature of cyber-physical systems. We demonstrate that our method can automate failure diagnosis in the MCSs and lend the MCSs to the development of decision support systems for preventive maintenance.

关键词： Failure indicators Failure classification Failure detection and diagnosis Complex systems

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复杂技术系统中基础研究的初步分类(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第9期16卷 681-705页

作者： imre HORVáTH Faculty of Industrial Design Engineering Delft University of Technology2628 CE Delft the Netherlands

目的:对于复杂技术系统,给出不同研究领域的初步分类,并找出一些研究关注的问题。创新点:提出了一种推理方法,将复杂技术系统的研究领域分为三类。方法:1.对相关的学术刊物进行直觉探索;2.对领域和子领域研究给出基于证据的分类规范;3.... 详细信息

目的:对于复杂技术系统,给出不同研究领域的初步分类,并找出一些研究关注的问题。创新点:提出了一种推理方法,将复杂技术系统的研究领域分为三类。方法:1.对相关的学术刊物进行直觉探索;2.对领域和子领域研究给出基于证据的分类规范;3.对基于相关学术刊物的控制给出的分类进行提炼与验证。结论:复杂技术系统的研究领域分为三类,分别为:(1)智能化类,包括哲学、本体和认识论;(2)实现类,包括方法论和复杂技术系统的创建;(3)影响类,包括表现和价值学。

关键词：基础研究复杂技术系统初步分类研究范畴与领域

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