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Vanishing torsion of parametric curves

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 593-595页

作者： JUHSZ imre department of descriptive Geometry University of MiskolcMiskolc-Egyetemváros H-3515Hungary

We consider the class of parametric curves that can be represented by combination of control points and basis func- tions. A control point is let vary while the rest is held fixed. It’s shown that the locus of the moving control point that yields points of zero torsion is the osculating plane of the corresponding discriminant curve at its point of the same parameter value. The special case is studied when the basis functions sum to one.

关键词： Parametric curve Torsion discriminant curve

Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 152-175页

作者： Santiago RUIZ-ARENAS Zoltán RUSák imre HORVáTH Ricardo MEJí-GUTIERREZ Faculty of Industrial design Engineering Delft University of Technology Grupo de Investigación en Ingeniería de diseno Universidad EAFIT

Malfunction or breakdown of certain mission critical systems(MCSs) may cause losses of life, damage the environments, and/or lead to high costs. Therefore, recognition of emerging failures and preventive maintenance are essential for reliable operation of MCSs. There is a practical approach for identifying and forecasting failures based on the indicators obtained from real life processes. We aim to develop means for performing active failure diagnosis and forecasting based on monitoring statistical changes of generic signal features in the specific operation modes of the system. In this paper, we present a new approach for identifying emerging failures based on their manifestations in system signals. Our approach benefits from the dynamic management of the system operation modes and from simultaneous processing and characterization of multiple heterogeneous signal sources. It improves the reliability of failure diagnosis and forecasting by investigating system performance in various operation modes, includes reasoning about failures and forming of failures using a failure indicator matrix which is composed of statistical deviation of signal characteristics between normal and failed operations, and implements a failure indicator concept that can be used as a plug and play failure diagnosis and failure forecasting feature of cyber-physical systems. We demonstrate that our method can automate failure diagnosis in the MCSs and lend the MCSs to the development of decision support systems for preventive maintenance.

关键词： Failure indicators Failure classification Failure detection and diagnosis Complex systems

Information schema constructs for defining warehouse databases of genotypes and phenotypes of system manifestation features

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 862-884页

作者： Shahab POURTALEBI imre HORVáTH Faculty of Industrial design Engineering Delft University of Technology

Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. The novelty of this toolbox is that it uses system manifestation features(SMFs) for transdisciplinary modeling of these systems. The main challenges of implementation of the toolbox are functional design- and language-independent computational realization of the warehouses, and systematic development and management of the various evolving implements of SMFs(genotypes, phenotypes, and instances). Therefore, an information schema construct(ISC) based approach is proposed to create the schemata of the associated warehouse databases and the above-mentioned SMF implements. ISCs logically arrange the data contents of SMFs in a set of relational tables of varying semantics. In this article we present the ISCs necessary for creation of genotypes and phenotypes. They increase the efficiency of the database development process and make the data relationships transparent. Our follow-up research focuses on the elaboration of the SMF instances based system modeling methodology.

关键词： Cyber-physical systems Software toolbox Pre-embodiment design System manifestation features(SMFs) Warehouses database schemata SMF genotypes SMF phenotypes SMF instances Information schema constructs

Ripoptosome:a novel IAP-regulated cell death-signalling platform

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Journal of Molecular Cell Biology 2011年第6期3卷 324-326页

作者： Gergely imre Sarit Larisch krishnaraj Rajalingam Institute of Biochemistry II Goethe University School of MedicineTheodor-Stern-Kai 7D-60590 Frankfurt am MainGermany Cell death Research Laboratory Department of BiologyFaculty of Natural SciencesUniversity of HaifaMulti-Purpose BuildingMount CarmelHaifa 31905Israel

Recent studies have revealed that cell death stimuli can trigger programmed necrosis,***-interacting serine–threonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and *** studies now describe a novel RIP1 containing∼2 Mda‘Ripoptosome’complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 ***,cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.

关键词： death endogenous Receptor

SARS-CoV-2 spike variants differ in their allosteric responses to linoleic acid

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Journal of Molecular Cell Biology 2023年第3期15卷 55-66页

作者： A.Sofia F.Oliveira deborah k.Shoemark Andrew d.davidson imre Berger Christiane Schaffitzel Adrian J.Mulholland School of Chemistry Centre for Computational ChemistryUniversity of BristolBristol BS81TSUK School of Chemistry University of BristolBristol BS81TSUK School of Biochemistry University of BristolBristol BS81TDUK School of Cellular and Molecular Medicine University of BristolUniversity WalkBristol BS81TDUK School of Chemistry Max Planck Bristol Centre for Minimal BiologyBristol BS81TSUK

The SARS-CoV-2 spike protein contains a functionally important fatty acid(FA)binding site,which is also found in some other coronaviruses,***-CoV and *** occupancy of the FA site by linoleic acid(LA)reduces infectivity by‘locking’the spike in a less infectious ***,we use dynamical-nonequilibrium molecular dynamics(d-NEMd)simulations to compare the allosteric responses of spike variants to LA removal.d-NEMd simulations show that the FA site is coupled to other functional regions of the protein,*** receptor-binding motif(RBM),N-terminal domain(NTd),furin cleavage site,and regions surrounding the fusion peptide.d-NEMd simulations also identify the allosteric networks connecting the FA site to these functional *** comparison between the wild-type spike and four variants(Alpha,delta,delta plus,and Omicron BA.1)shows that the variants differ significantly in their responses to LA *** allosteric connections to the FA site on Alpha are generally similar to those on the wild-type protein,with the exception of the RBM and the S71–R78 region,which show a weaker link to the FA *** contrast,Omicron is the most different variant,exhibiting significant differences in the RBM,NTd,V622–L629,and furin cleavage *** differences in the allosteric modulation may be of functional relevance,potentially affecting transmissibility and *** comparison of the effects of LA on SARS-CoV-2 variants,including emerging variants,is warranted.

关键词： SARS-CoV-2 spike allosteric modulation d-NEMd simulations fatty acid binding site SARS-CoV-2 variants

LIQUId-LIQUId PHASE EQUILIBRIUM OF POLYMER SOLUTIONS ANd POLYMER BLENdS UNdER POSITIVE ANd NEGATIVE PRESSURE

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Chinese Journal of Polymer Science 2003年第2期21卷 241-250页

作者： Attila R.imre kFkI Atomic Energy Research Institute H-1525 Budapest POB 49 Hungary

In this paper we would like to give a brief review about the extensibility of the liquid-liquid locus into the negativepressure region. Negative pressure states are hardly explored; most researchers believe that the pressure scale ends at p = *** would like to show that this is not true, the p = 0 point is not a special point for liquids, it can be 'easily' crossed. We aregoing to give a few example, where the extension of liquid-liquid locus for polymer blends and solutions below p = 0 givesus some interesting results, like the merging of UCST and LCST branches in weakly interacting polymer solutions or thereason why most UCST blends exhibit pressure induced immiscibility. Also, we will see what happens with the immiscibilityisland of aqueous polymer solutions when -- reaching the critical molar mass -- it 'disappears'.

关键词： Pressure Negative pressure Polymer Solubility Phase transition

Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer

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World Journal of Gastroenterology 2017年第46期23卷 8109-8119页

作者： Ferenc Sipos Hajnal Székely imre dániel kis Zsolt Tulassay Gyorgyi Muzes 2nd department of Internal Medicine Semmelweis University Faculty of Medicine Semmelweis University Molecular Medicine Research Group Hungarian Academy of Sciences

Metabolic syndrome(Met S), as a chronic inflammatory disorder has a potential role in the development of inflammatory and cancerous complications of the colonic tissue. The interaction of dNA damage and inflammation is affected by the insulin-like growth factor 1 receptor(IGF1 R) signaling pathway. The IGF1 R pathway has been reported to regulate autophagy, as well, but sometimes through a bidirectional context. Targeting the IGF1 R-autophagy crosstalk could represent a promising strategy for the development of new antiinflammatory and anticancer therapies, and may help for subjects suffering from Met S who are at increased risk of colorectal cancer. However, therapeutic responses to targeted therapies are often shortlived, since a signaling crosstalk of IGF1 R with other receptor tyrosine kinases or autophagy exists, leading to acquired cellular resistance to therapy. From a pharmacological point of view, it is attractive to speculate that synergistic benefits could be achieved by inhibition of one of the key effectors of the IGF1 R pathway, in parallel with the pharmacological stimulation of the autophagy machinery, but cautiousness is also required, because pharmacologic IGF1 R modulation can initiate additional, sometimes unfavorable biologic effects.

关键词： Insulin-like growth factor IGF1R Autophagy Colitis Colorectal cancer Metabolic syndrome

Optimal design of the fillet weld fastening the wind turbine column

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China Welding 2024年第3期33卷 39-43页

作者： imre Timár István W.Árpád Mechanical Engineering department Faculty of EngineeringUniversity of PannoniaVeszprem H-8200Hungary Mechanical Engineering department Faculty of EngineeringUniversity of DebrecenDebrecen H-4032Hungary

This paper deals with the optimal design of the fillet weld of wind turbine column subjected to bending *** the premise of determined the force acting on the column,in order to further optimize the fillet weld,the minimum volume of corner seam was determined in the case of non-linear design *** constraints relate to the maximal stresses and fatigue of welding seam.A numerical solution to this problem is given by genetic optimization *** optimisation calculation result indicated that the active condition(constraint)was the stress from the static *** and meaningful information is provided for the engineering field.

关键词： fillet weld optimal design genetic algorithm static and dynamic load

Modeling of Reversibleγ/αTransformations of Low Carbon Steels in the Intercritical Temperature Range

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材料热处理学报 2004年第05B期25卷 702-705页

作者： Tamás RTl imre FELdE Hakan GR Budapest Polytechnic Budapest HungaryBay Zoltdn Institute for Materials Science and Technology Budapest HungaryMetallurgical and Materials Eng. Dept. Middle East Technical University Ankara Turkey

A phenomenological kinetic model has been developed for the prediction of non-isothermal reversible incomplete transformations in low-carbon hypoeutectoid steels. The theoretical basis of the proposed method has its origin in a possible extension of the traditional Austin-Rickett kinetic differential equation. To critically assess the applicability of the model, a number of experiments based on computer simulations have been performed to predict the austenite/ferrite proeutectoid transformation in the temperature range of Aei to Ae3 on plain carbon hypoeutectoid steels. A comparison with published experimental data has verified that the model developed is reasonable both quantitatively and with respect to well-established trends. Extension of the method of prediction appears promising when the non-isothermal reactions occurring during heat treatment (such as carbide precipitation and dissolution) can be assumed to proceed in a reversible manner.

关键词：奥氏体转变动力学低碳钢临界温度