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Dosage and utilization of dexamethasone in the management of COVID-19: A critical review

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World Journal of Virology 2024年第3期13卷 107-114页

作者： imran Sethi Asim Shaikh Musa Sethi Hira Khalid Chohan Sheraz Younus Syed A Khan Salim Surani Department of Critical Care Medicine Marion General HospitalMarionIN 46952United States Department of Medicine Aga Khan UniversityKarachi 74200SindhPakistan Department of Medicine Eman SchoolFishersIN 46038United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Hospital Medicine Franciscan HealthIndianapolisIN 46237United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States

BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory ***,a synthetic glucocorticoid,exerts its anti-inflammatory effects by inhibiting the transcription of pro-inflammatory genes and suppressing the activity of various immune *** mechanism has implications for mitigating the cytokine storm observed in severe COVID-19 *** on in the pandemic,the Recovery Collaborative working group showed a mortality benefit of using dexamethasone in decreasing mortality in patients with COVID-19 requiring respiratory ***,the optimal dosage of corticosteroids remains *** studies that compare different doses of dexamethasone in COVID-19 exist,but the results are *** To review the latest evidence regarding dosage,safety,and efficacy of dexamethasone in severe *** We followed preferred reporting items for systematic reviews and meta-analysis guidelines.A detailed literature search was conducted across PubMed,Google Scholar,and Medline to include publications up to March *** keywords included“COVID-19”“SARS-CoV-2”“dexamethasone”“corticosteroid”“steroid”and“glucocorticoid”-along with their *** employed the Cochrane Risk of Bias Tool and the Newcastle-Ottawa scale to evaluate the integrity and potential of bias in the included studies.A meta-analysis was conducted using a random-effects model,assessing pooled odds ratios and mean differences,with heterogeneity gauged by the I2 statistic and theχ^(2) *** No statistical differences were found in 28-day all-cause mortality[pooled odds ratio(OR)=1.109,95%CI:0.918-1.340],60-day all-cause mortality(OR=0.873,95%CI:0.744-1.024;I2=47.29%),mean length of hospital stay(mean difference=-0.08 days,95%CI:-0.001 to 0.161)and adverse events(OR=0.877,95%CI:0.707-1.087).CONCLUSION Differing doses of corticosteroids have no clinical implication

关键词： COVID-19 Steroids Corticosteroids Steroid dosage Critical care Corona virus

参附注射液对脓毒症患者血清胃蛋白酶原Ⅰ、Ⅱ和胃泌素17的影响:单中心随机对照实验

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中华急诊医学杂志 2024年第9期33卷 1281-1285页

作者：张苏明张尧尧王博 Salwa M.imran 刘艳存柴艳芬天津医科大学总医院急诊医学科天津300052 徐州医科大学附属医院重症医学科徐州221000

目的探讨参附注射液对脓毒症患者血清胃蛋白酶原(pepsinogen,PG)Ⅰ,PGⅡ和胃泌素17(gastrin 17,G17)的影响。方法本研究为单中心随机对照临床试验,选取2021年6至2022年12月收治于徐州医科大学附属医院重症医学科的脓毒症合并急性胃肠损... 详细信息

目的探讨参附注射液对脓毒症患者血清胃蛋白酶原(pepsinogen,PG)Ⅰ,PGⅡ和胃泌素17(gastrin 17,G17)的影响。方法本研究为单中心随机对照临床试验,选取2021年6至2022年12月收治于徐州医科大学附属医院重症医学科的脓毒症合并急性胃肠损伤(acute gastrointestinal injury,AGI)患者,按照随机数字表将患者分为参附组和对照组。所有患者均根据指南给予脓毒症常规治疗,包括治疗原发病、液体复苏和对症治疗等,参附组在常规治疗同时加用参附注射液治疗,记录并比较两组患者治疗前以及治疗第3天和第7天的胃肠损伤指标(PGⅠ、PGⅡ、G17和AGI分级)、机械通气时间和住ICU时间。结果本研究纳入89例脓毒症合并AGI患者,分为参附组44例,对照组45例。治疗前,两组患者血清PGⅠ、PGⅡ和G17比较差异无统计学意义(均P>0.05)。治疗第3天,参附组血清PGⅠ低于对照组[(156.46±62.90)µg/L vs.(183.03±45.44)µg/L,P0.05)。治疗第7天,参附组血清PGⅠ、PGⅡ、G17低于对照组[(107.97±23.18)µg/L vs.(154.78±33.11)µg/L;(10.73±5.62)µg/L vs.(13.83±6.30)µg/L;(7.31±3.20)pmol/L vs.(9.29±3.92)pmol/L],差异均有统计学意义(均P<0.05)。与对照组比较,参附组AGI分级明显降低,机械通气时间和ICU住院时间均明显减少,均差异有统计学意义(均P<0.05)。结论参附注射液可以改善脓毒症AGI患者的血清胃功能,降低AGI分级,减少机械通气时间和ICU住院时间。

关键词：参附注射液脓毒症急性胃肠损伤血清胃功能

Machine Learning Empowered Security and Privacy Architecture for IoT Networks with the Integration of Blockchain

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Intelligent Automation & Soft Computing 2024年第2期39卷 353-379页

作者： Sohaib Latif M.Saad Bin Ilyas Azhar imran Hamad Ali Abosaq Abdulaziz Alzubaidi Vincent Karovic Jr. Department of Computer Science The University of ChenabGujrat50700Pakistan Department of Creative Technologies Air UniversityIslamabad42000Pakistan Computer Science Department College of Computer Science and Information SystemsNajran UniversityNajran66244Saudi Arabia Department of Computer Science Umm Alqura UniversityAlQunfudah28821Saudi Arabia Department of Information Systems Faculty of ManagementComenius University in BratislavaBratislava82005Slovakia

The Internet of Things(IoT)is growing rapidly and impacting almost every aspect of our lives,fromwearables and healthcare to security,traffic management,and fleet management *** has generated massive volumes of data and security,and data privacy risks are increasing with the advancement of technology and network *** access control solutions are inadequate for establishing access control in IoT systems to provide data protection owing to their vulnerability to single-point OF ***,conventional privacy preservation methods have high latency costs and overhead for resource-constrained *** machine learning approaches were also unable to detect denial-of-service(DoS)*** study introduced a novel decentralized and secure framework for blockchain *** avoid single-point OF failure,an accredited access control scheme is incorporated,combining blockchain with local peers to record each transaction and verify the signature to ***-based attribute-based cryptography is implemented to protect data storage privacy by generating threshold parameters,managing keys,and revoking users on the *** innovative contract-based DOS attack mitigation method is also incorporated to effectively validate devices with intelligent contracts as trusted or untrusted,preventing the server from becoming *** proposed framework effectively controls access,safeguards data privacy,and reduces the risk of *** results depict that the suggested framework outperforms the results in terms of accuracy,precision,sensitivity,recall,and F-measure at 96.9%,98.43%,98.8%,98.43%,and 98.4%,respectively.

关键词： Machine learning internet of things blockchain data privacy security Industry 4.0

Unraveling the therapeutic mechanisms of myristic acid and luteolin 7-rutinoside in oral cancer: insights from network pharmacology and molecular docking analysis

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Pharmacology Discovery 2024年第2期4卷 1-9页

作者： Ansari Vikhar Danish Ahmad Misba Ruhi Syed Ayaz Ali Qazi Yasar Mohd.Mukhtar Khan Subur W Khan Mohammed imran Anees Y.B.Chavan College of Pharmacy Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India Maulana Azad College Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India

Background:The compound Luteolin-7-rutinoside(L7R)is a flavone derivative of luteolin,predominantly identified in plant species belonging to the families ***,Myristic acid is characterized by its structure as a 14-carbon,unsaturated fatty *** this investigation,we endeavor to elucidate the putative mechanisms underlying the therapeutic effects of Myristic Acid and Luteolin 7-rutinoside in the context of oral cancer treatment,employing network pharmacology coupled with molecular docking ***:The protein targets of Myristic Acid and Luteolin 7-rutinoside were identified through a search on the Swiss Target ***,a compound-target network was constructed using Cytoscape *** associated with OC were retrieved from the OMIM and GeneCards *** overlap between compound targets and OC-related targets was determined,and the resulting shared targets were subjected to protein-protein interaction(PPI)network analysis using the STRING ***,gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were conducted on the identified *** docking were performed to investigate the interactions between the core target and the active ***:The component target network comprises 103 nodes and 102 *** the proteins in the protein-protein interaction(PPI)network,those with higher degrees are TNF,PPARG,and *** through Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways indicates that the treatment of OC with Myristic Acid and Luteolin 7-rutinoside primarily involves the regulation of miRNA transcription and inflammatory *** identified signaling pathways include Pathways in cancer,PPAR signaling pathway,EGFR signaling pathway,and TNF signaling *** docking studies reveal that Luteolin 7-rutinoside and Myristic acid exhibit higher affinity towards TNF,PPARG,TP53,and ***:This study

关键词： myristic acid luteolin 7-rutinoside network pharmacology oral cancer molecular docking

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多维广义朗之万方程的解析精确解

曲阜师范大学学报(自然科学版) 2024年第04期 95-98页

作者： Mushtaq Rana imran 王春阳支世超赵曾轩鲁东大学物理与光电工程学院

采用拉普拉斯变换和矩阵运算相结合的方法解析求解了多维朗之万方程，并将所得结果与已有的二维解析研究进行了比较，验证了该方法的可行性和正确性，为将来在理论上使用多维朗之万方程研究复合核的形变等复杂随机问题奠定了基础.

关键词：矩阵拉普拉斯变换多维广义朗之万方程

On the Metric Dimension of Barycentric Subdivision of Cayley Graphs

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Acta Mathematicae Applicatae Sinica 2016年第4期32卷 1067-1072页

作者： Muhammad imran Department of Mathematics School of Natural Sciences National University of Sciences and Technology Sector H-12 Islamabad Pakistan

In a connected graph G, the distance d（u, v） denotes the distance between two vertices u and v of G. Let W = {w1, w2,……, wk} be an ordered set of vertices of G and let v be a vertex of G. The representation r（v1W） of v with respect to W is the k-tuple （d（v, w1）, d（v, w2）,…, d（v, wk））. The set W is called a resolving set or a locating set if every vertex of G is uniquely identified by its distances from the vertices of W, or equivalently, if distinct vertices of G have distinct representations with respect to W. A resolving set of minimum cardinality is called a metric basis for G and this cardinality is the metric dimension of G, denoted by β（G）. Metric dimension is a generalization of affine dimension to arbitrary metric spaces （provided a resolving set exists）. In this paper, we study the metric dimension of barycentric subdivision of Cayley graphs Cay （Zn Z2）. We prove that these subdivisions of Cayley graphs have constant metric dimension and only three vertices chosen appropriately suffice to resolve all the vertices of barycentric subdivision of Cayley graphs Cay （Zn Z2）.

关键词： metric dimension basis resolving set barycentric subdivision Cayley graph

Algebraic Characterization of SSC of Uni-Cyclic Multigraphs

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代数集刊:英文版 2023年第2期30卷 325-338页

作者： imran Ahmed Shahid Muhmood Department of Mathematics COMSATS University Islamabad Lahore CampusLahorePakistan

We introduce first the spanning simplicial complex(SSC)of a multigraph g,which gives a generalization of the SSC associated with a simple graph *** properties are discussed for the SSC of a family of uni-cyclic multigraphs U_(n)^(r),m with n edges including r multiple edges within and outside the cycle of length m,which are then used to compute the f-vector and Hilbert series of face ring k[△s(U_(n)^(r),m)]for the SSC △s(U_(n)^(r),m)(un,m).Moreover,we find the associated primes of the facet ideal I_(F)(△s(U_(n)^(r),m).Finally,we device a formula for homology groups of △s(U_(n)^(r),m) prove that the SsC of a family of uni-cyclic multigraphs is Cohen-Macaulay.

关键词： simplicial complexes spanning trees Hilbert series vertex covers Betti numbers

Effect of kappa distribution on the damping rate of the obliquely propagating magnetosonic mode

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Plasma Science and Technology 2018年第3期20卷 43-48页

作者： imran Ali KHAN G MURTAZA Department of Physics G. C. University Lahore Katchery Road 54000 Lahore Pakistan

Data from spacecrafts suggest that space plasma has an abundance of suprathermal particles which are controlled by the spectral index κ when modeled on kappa particle velocity distribution. In this paper, considering homogeneous plasma, the effect of integer values of κ on the damping rate of an obliquely propagating magnetosonic（MS） wave is studied. The frequency of the MS wave is assumed to be less than ion cyclotron frequency, i.e.,iw（28）w. Under this assumption, the dispersion relation is investigated both numerically and analytically, and it is found that the real frequency of the wave is not a sensitive function of κ, but the imaginary part of the frequency is. It is also shown that for those values of κ where a large number of resonant particles participate in wave–particle interaction, the wave is heavily damped, as expected. The possible application of the results to the solar wind is discussed.

关键词： magnetosonic wave suprathermal plasma wave-particle interactions damping of wave

Removal of lead and cadmium ions by single and binary systems using phytogenic magnetic nanoparticles functionalized by 3-marcaptopropanic acid

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Chinese Journal of Chemical Engineering 2019年第4期27卷 949-964页

作者： imran Ali Changsheng Peng Iffat Naz College of Environmental Science and Engineering Ocean University of China Qingdao 266100 China The Key Lab of Marine Environmental Science and Ecology Ministry of Education Ocean University of China Qingdao 266100 China School of Environmental and Chemical Engineering Zhaoqing University Zhaoqing 526061 China Department of Biology. Qassim University Buraidah 51452 Kingdom of Saudi Arabia (KSA)

The present research study is focused on green fabrication of superparamagnetic Phytogenic Magnetic Nanoparticles(PMNPs), and then its surface functionalization with 3-Mercaptopropionic acid(3-MPA). The resulting material(i.e. 3-MPA@PMNPs) characterized by FTIR, powder XRD, SEM, TEM, EDX, VSM, BET and TGA techniques and then further employed for the investigation of the adsorptive removal of lead(Pb^2+) and cadmium(Cd^2+) ions from aqueous solutions in single and binary systems. The material showed fastest adsorptive rate(98.23%) for Pb^2+ and(96.5%) Cd2+within the contact time of 60 min at pH 6.5 in the single system. The experimental data were fitted well to Langmuir isotherm, indicated monolayer adsorption of both metal ions onto 3-MPA@PMNPs and an estimated comparable adsorptive capacity of 68.41 mg·g^-1(Pb2+) and 79.8 mg·g^-1(Cd2+) at p H 6.5. However, kinetic data agreed well with pseudo-second-order model, and indicated that the removal mainly supported chemisorption and/or ion-exchange mechanism. Thermodynamic parameters such asΔGo,ΔHo, and ΔSo, were-3259.20, 119.35 and 20.73 for Pb^2+, and-1491.10, 45.441 and 7.87 for Cd^2+ at temperature 298.15 K, confirmed that adsorption was endothermic, spontaneous and favorable. The material demonstrated higher selectivity of Pb2+ and its removal efficiency was(98.20 ± 0.3)% in binary system experiments. The material persisted performance up-to seven(07) consecutive treatment cycles without losing their stability and offered comparable fastest magnetic separation(35 s) from aqueous solutions. Therefore, it is recommended that the prepared material can be employed to remove toxic heavy metal ions from water/wastewaters and this "green" method can easily be implemented at large scale in low economy countries.

关键词： Green recipe Phytogenic magnetic nanoparticles Physical characterization of nanoparticles Lead and cadmium ions removal