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Epidemiological, Clinical and Follow-Up Data in a Series of Thirteen Renal Insufficiencies Complicating Sarcoidosis

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Open Journal of Clinical Diagnostics 2015年第2期5卷 50-53页

作者： Madiha Mahfoudhi imen Gorsane Amel Gaieb Battikh Sami Turki Hayet Kaaroud Rym Goucha Fathi Ben Hamida Taieb Ben Abdallah Internal Medicine A Department Charles Nicolle HospitalTunisTunisia Research Unit of Kidney Diseases(LR00SP01) Charles Nicolle HospitalTunisTunisia

The sarcoidosis is a systemic granulomatosis affecting most frequently the lungs and the mediastinum. An acute renal failure reveals exceptionally this disease. It’s a retrospective study implicating 13 cases of sarcoidosis complicated of acute renal failure. The aim of this study is to determine epidemiological, clinical, biological and histological profile in these cases and the interest of considering sarcoidosis diagnosis in case of unexplained renal failure. Extra-renal complications, therapeutic modalities and the outcome were determined in all patients. Our series involved 13 women with an average age of 41 years. Biological investigations showed an abnormal normocalcemia in 8 cases, a hypercalcemia in 5 cases, a hypercalciuria in 11 cases and polyclonal hypergammaglobulinemia in 7 cases. An acute renal failure was found in all patients with a median creatinin of 540 umol/L. The renal echography was normal in all patients. The kidney biopsy performed in all patients showed tubulo-interstitial nephritis. The extra-renal signs were: pulmonary interstitial syndrome in 5 cases, a sicca syndrome in 4 cases, mediastinal lymphadenopathy in 2 cases, a lymphocytic alveolitis in 3 cases, an anterior granulomatous uveitis in 3 cases and a polyarthritis in 6 cases. Six patients benefited from hemodialysis. The treatment consisted of corticosteroid in all cases. The follow up was marked by complete resolution of clinical and biological signs. The diagnosis of renal sarcoidosis should be made rapidly in order to avoid end stage renal failure.

关键词： Sarcoidosis Acute Renal Failure Interstitial Nephritis Granuloma

Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's

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World Journal of Gastroenterology 2015年第35期21卷 10150-10158页

作者： Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah Immunology Research Laboratory of Kidney Transplantation and Immunopathology Laboratoire de Recherche Laboratory of Immunology Charles Nicolle Hospital

AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) ***: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy ***: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population.

关键词： Hepatitis C virus Hemodialysis Natural evolution C

Interstitial Lung Diseases Associated with Connective Tissue Pathologies: Radiologic Features

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Open Journal of Respiratory Diseases 2019年第4期9卷 112-122页

作者： Houda Gharsalli Monia Attia Sawssen Hantous-Zannad imen Sahnoun Sonia Maalej Leila Douik El Gharbi Henda Neji Khaoula Ben Miled-Mrad Department of Pulmonology Abderrahmane Mami Hospital Ariana Tunisia University of Tunis El Manar Tunis Tunisia Department of Radiology Abderrahmane Mami Hospital Ariana Tunisia

Introduction: The high resolution computed tomography (HRCT) is an important part in the diagnostic approach of interstitial lung disease (ILD) associated with connective tissue diseases (CTD) by providing detailed information on the elementary lesion and the radiological pattern of ILD. Aim: to point out the role of HRCT in the diagnosis of ILD associated with CTD (ILD-CTD). Methods: A Retrospective descriptive study was conducted between 2008 and 2017. Data of 24 patients presenting ILD-CTD were collected. A review of HRCT was performed by a radiologist without knowledge of the CTD. Results: Predominant elementary lesion of ILD associated with dermatomyositis (9 cases) was ground glass opacity (n = 9) followed by consolidation (n = 6). Non Specific Interstitial Pneumonia (NSIP) was the most reported pattern (5 cases). Ground glass opacity was also the predominant elementary lesion for the 2 cases of scleroderma and in Sjögren’s syndrome (4 cases/5). NSIP was the predominant radiological presentation in these two CTD. Lymphoid interstitial pneumonia revealed Sjögren’s syndrome in one case. In rheumatoid arthritis (6 cases), the elementary HRCT lesions were irregular interlobular septal thickening (n = 4) and honeycombing (n = 4) consistent with Usual Interstitial Pneumonia (UIP) in 2 cases. Similarly UIP has been described for the 2 patients with lupus and mixed connective tissue disease. Conclusion: HRCT plays an important role in the management of ILD-CTD. Description of the HRCT elementary lesions and the radiological pattern of ILD can be helpful for CTD’s diagnosis.

关键词： Interstitial Lung Diseases Connective Tissue Diseases Computed Tomography Imaging Diagnosis

Can Twitter Sentiment Gives the Weather of the Financial Markets?

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Journal on Big Data 2021年第4期3卷 155-173页

作者： imen Hamraoui Adel Boubaker International Finance Group Tunisia Faculty of Management and Economic Sciences of Tunis TunisiaEl Manar UniversityTunis CedexC.P.2092Tunisia

Finance 3.0 is still in its *** big data represents an unprecedented opportunity for *** massive increase in the volume of data generated by individuals every day on the Internet offers researchers the opportunity to approach the question of financial market predictability from a new *** this article,we study the relationship between a well-known Twitter micro-blogging platform and the Tunisian financial *** particular,we consider,over a 12-month period,Twitter volume and sentiment across the 22 stock companies that make up the Tunindex *** find a relatively weak Pearson correlation and Granger causality between the corresponding time series over the entire period.

关键词： Twitter investor sentiment tunisian financial market Twitter volume

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马乳和人乳中三酰基甘油分子组成的研究

中国畜牧兽医 2012年第5期39卷 247-247页

作者： imen Haddad 臧长江

奶油和无水乳脂肪产品的性质取决于三酰基甘油(TAGs)的分子组成,同时TAGs的分子组成也决定了乳脂肪的营养价值、加工特性和质构特性。本试验采用非水反相液相色谱法(NARP-HPLC)、电喷雾离子质谱法(ESI-MS3)和高温气相色谱法(GC)分析了... 详细信息

奶油和无水乳脂肪产品的性质取决于三酰基甘油(TAGs)的分子组成,同时TAGs的分子组成也决定了乳脂肪的营养价值、加工特性和质构特性。本试验采用非水反相液相色谱法(NARP-HPLC)、电喷雾离子质谱法(ESI-MS3)和高温气相色谱法(GC)分析了马乳和人乳中TAGs的组成。与人乳相比,马乳TAGs分子中脂肪酸组成非常复杂,两者在脂肪酸组成上差异显著,特别是在中链脂肪酸C8、C10和C12上差异较大。用CN表示碳原子数,马乳TAGs中CN36～CN46最为丰富,CN44的最大浓度达到15.3%,而在人乳TAGs中CN44～CN52占主导地位,CN52最大浓度达到30%。根据脂肪酸随机分布假说来预测TAGs分子中脂肪酸的分布,马乳中具有CN44的TAGs所对应的脂肪酸碳原子分布主要为C8/C18/C18、C12/C14/C18和C10/C16/C18。而在人乳中,含有C16/C18/C18脂肪酸分布的CN52在TAGs中所占的比例比随机计算值要高。

关键词：马乳人乳三酰基甘油非水反相液相色谱法气相色谱电喷雾离子质谱

Targeting Arab Markets:Is Cultural Context Irrelevant to Marketing in Libya?

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Management Studies 2021年第3期9卷 153-176页

作者： Izzudin Busnaina Faraj Almgatif imen Sdiri University of Benghazi BenghaziLibya Zintan University AlzintanLibya ISG Bizerte BanzartTunisia

Marketing experts have debated for more than two decades about the effect of nationality and culture on ***,most research on this issue was conducted in Western *** important question for marketers in the international arena,therefore,is whether the consumer’s responses(i.e.,sentiment and behavioural aspects)toward the global marketing programs in developing countries depend on *** a research representing a large sample of consumers and four different home appliances country-of-origin global operators in Libya,we explore the potential role of culture on consumers’responses toward foreign marketing *** indicate that although the foreign companies have a tendency to adopted standardisation perspective,this does not impact on consumers’responses in a single cultural context toward *** findings reveal that buying behavior was more a function of individual difference than of national cultural ***,our results suggest that for mainstream home appliances,segmenting on the basis of nationality is probably unnecessary and that a standardized approach would likely be successful across an increasingly relevant Arab world;and that continuing perceptions of Arab insularity are likely to be *** with the effectiveness of globally efficient marketing programs,local manufacturers would need to work hard to identify particular niche segments where a culturally-specific appeal might be more successful.

关键词： buyer’s characteristics consumer behaviour the Arab World marketing program home appliances

Clinical and Molecular Cytogenetic Study of 38 Williams-Beuren Syndrome Tunisian Patients

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Open Journal of Genetics 2014年第5期4卷 385-391页

作者： Ines Ouertani Myriam Chaabouni imen Chelly Lilia Kraoua Faouzi Maazoul Mediha Trabelsi Rym Meddeb Rafik Boussaada Hatem Azzouz Fatma Charfi Emira Ben Hamida Ahmed Meherzi Ridha Mrad Habiba Bouhamed-Chaabouni Service des Maladies Congénitales et Héréditaires H&#244pital Charles Nicolle Tunis Tunisie Service de Pédiatrie H&#244pital Régional de Bizerte Bizerte Tunisie Service de Cardiologie Pédiatrique H&#244pital la Rabta Tunis Tunisie Service de Pédiatrie H&#244pital la Rabta Tunis Tunisie Service de Pédopsychiatrie H&#244pital Razi La Mannouba Tunisie Service de Néonatologie H&#244pital Charles Nicolle Tunis Tunisie Service de Pédiatrie H&#244pital Mongi Slim La Marsa Tunisie

Background: Williams-Beuren syndrome (WBS) is a rare multi-system genomic disorder, caused by 7q11.23 microdeletion with a prevalence of 1/7500 - 1/20,000 live births. Clinical phenotype includes typical facial dysmorphism (elfin face), mental retardation associated with a peculiar neuropsychological profile and congenital heart defects. Other signs are occasional like ocular, skeletal, renal and dental anomalies. Here in, we present 38 WBS Tunisian patients. Methods: All patients underwent a genetic consultation and in order to confirm the clinical diagnosis of WBS, fluorescent in situ hybridization (FISH) was applied on metaphase spreads using the dual color locus specific identifier WBS region probe (Vysis probe) that hybridized to the ELN and LIMK1 loci at 7q11.23 and to control loci D7S486 and D7S522 at 7q31. About 15 to 20 metaphases were analyzed for each case. Results: The mean age at diagnosis was 4 years and 4 months. All patients showed facial dysmorphism. 66% (23/35) have cardiovascular anomaly, peripheral pulmonary stenosis (10/35) is interestingly more frequent than the supravalvular aortic stenosis (7/35). Various degrees of mental retardation were present and a normal intelligence was found in three patients. The unique cognitive profile was found in all patients except one who had autistic disorders. Ocular anomalies (13/38) were less frequent than described, the skeletal anomalies too (12/38). Dental malformations were frequent (22/32). Idiopathic hypercalcemia was present in 50% of children less than one year (2/4). Conclusions: WBS was a rare disorder, cardinal signs (facial dysmorphism, mental retardation and cardiovascular defects) were found in our patients in the same proportions than described. The occasional clinical signs have proportion different of precedent reported like hypercalcemia, ocular and dental anomalies. The identification of the different clinical signs in WBS patients permits to establish a strategy of follow up.

关键词： Williams-Beuren Syndrome FISH Dysmorphism Cardiovascular Malformation

Combined surgical-orthodontic rehabilitation of cleidocranial dysplasia: 5 years follow-up

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World Journal of Clinical Cases 2015年第8期3卷 751-756页

作者： Emre?imen ?mür Dereci Ay?egül Mine Tüzüner-?ncül Duygu Yaz?c?o?lu Erhan?zdiler Asl??enol Nejat Bora Sayan Private Practice 34890 IstanbulTurkey Department of Oral and Maxillofacial Surgery Faculty of DentistryEskişehir Osmangazi University26480 EskişehirTurkey Department of Oral and Maxillofacial Surgery Faculty of DentistryAnkara University06500 AnkaraTurkey Private Practice 06500 AnkaraTurkey Department of Orthodontics Faculty of DentistryAnkara University06500 AnkaraTurkey

Cleidocranial dysplasia(CD) is an autosomal dominant syndrome which is characterized by several skeletal malformations such as non-closed fontanelles, skeletal abnormalities of the maxilla and mandible and absence of clavicles. Mid-facial hypoplasia and mandibular prognathism are mostly seen jaw abnormalities in CD. In this study, the combined orthodontic-surgical treatment of a patient with CD with class Ⅲ malocclusion and multiple unerupted primary and deciduous teeth is presented.

关键词： Cleidocranial dysplasia Marie-Sainton syndrome Forced eruption Prognathism Orthodontic extrusion

Direction of Arrival Estimation of RF Signals Using Five-Port Technology and High Resolution Method

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通讯和计算机（中英文版） 2012年第9期9卷 1051-1056页

作者： imen Sfar Lotfi Osman Ferid Harabi Ali Gharsallah Department of Physics Faculty of Sciences of TunisTunis El Manar University2092Tunisia

This paper presents a system based on five-port demodulator which measures DoA (directions-of-arrival) of radio frequency signals received on an antenna array in the azimuth plane. The receiver operating at 2.4 GHz is composed of four five-port demodulators connected to a ULA (uniform linear array) of four patch antennas. The DoA is estimated by measuring the phase difference of signals picked up by the elements of the array. Analytical and measurement results prove high integration, low-cost implementation and less sensibility to the phase and amplitude imbalances of the proposed demodulator. Moreover, the system presents good performance in terms of precision and resolution by using MUSIC (MUltipleSIgnal Classification) method in DoA estimation.

关键词： DOA估计 RF信号高清晰度技术解调器到达方向射频信号天线阵列