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Diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects

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World Journal of Clinical Cases 2022年第24期10卷 8450-8462页

作者： Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir Ismail Nurul iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha Department of Neurosciences School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia Department of Radiology School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia School of Computer Sciences Universiti Sains Malaysia11800 USMPenangMalaysia Department of Neurosciences Hospital Universiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia

Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of *** a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain *** relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in *** tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter ***,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical *** this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals.

关键词： Diffusion tensor imaging White matter Cerebral small vessel disease Pipeline processing Tractography

Cost-effectiveness of one-stage versus two-stage breast reconstruction in the United Kingdom

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Plastic and Aesthetic Research 2015年第1期2卷 320-325页

作者： Isabel Teo iman A.Azmy Department of Plastic Surgery St John’s Hospital at HowdenLivingstonWest Lothian EH546PPUK Department of Breast Surgery Chesterfield Royal Hospital-NHS Foundation TrustCalowChesterfieldDerbyshire S445BLUK

Aim:Permanent expanders allow for breast reconstruction as a single *** prostheses are more expensive than conventional tissue expanders,but this excess cost is markedly offset as only one operation is ***,if the revision rate is sufficiently high,then this effect is *** aim to compare costs of one-stage ***-stage reconstruction at a single center,taking into account explantation and unexpected admissions following ***:A retrospective review was carried out on all patients who underwent one-stage and two-stage reconstruction over a 5-year period by a single surgeon.A cost analysis was performed taking into account,explantation and additional ***:One hundred and forty-three one-stage and 45 two-stage procedures were *** explantation rate for one-stage procedures is 36%,at a mean of 12.9 months postimplantation,the majority of which were exchanged for silicone implants to improve ***(9%)of the two-stage procedures were explanted a mean of 18 months ***,one-stage reconstructions were significantly more expensive than the two-stage group(P=0.016).Conclusion:There are many benefits of one-stage breast ***,it does not appear to be cost-effective when additional admissions for explantation surgery are taken into account.

关键词： Breast reconstruction cost‑effectiveness latissimus dorsi flap McGhan^(TM)150 expander implant Natrelle^(TM)150 expander implant one‑stage breast reconstruction permanent tissue expanders

finding the optical properties of plasmonic structures by image processing using a combination of convolutional neural networks and recurrent neural networks

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Microsystems & Nanoengineering 2019年第1期5卷 398-405页

作者： iman Sajedian Jeonghyun Kim Junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Image processing can be used to extract meaningful optical results from ***,from images of plasmonic structures,we combined convolutional neural networks with recurrent neural networks to extract the absorption spectra of *** provide the data required for the model,we performed 100,000 simulations with similar setups and random *** designing this deep network,we created a model that can predict the absorption response of any structure with a similar *** used convolutional neural networks to collect spatial information from the images,and then,we used that data and recurrent neural networks to teach the model to predict the relationship between the spatial information and the absorption *** results show that this image processing method is accurate and can be used to replace time-and computationally-intensive numerical *** trained model can predict the optical results in less than a second without the need for a strong computing *** technique can be easily extended to cover different structures and extract any other optical properties.

关键词： optical networks neural

T6SS-5 and the cGAS-STING pathway in Burkholderia pseudomallei infection and immunity

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Asian Pacific Journal of Tropical Biomedicine 2023年第3期13卷 94-103页

作者： Noreafifah Semail Nik Mohd Noor Nik Zuraina Yasmin Khairani Muhammad Ismadi Nurul iman Mohamad Azian Harun Ismail Aziah Zakuan Zainy Deris Department of Medical Microbiology and Parasitology School of Medical SciencesUniversiti Sains Malaysia16150 Kubang KerianKelantanMalaysia School of Biology Faculty of Applied ScienceUniversiti Teknologi MaraShah Alam40450 SelangorMalaysia Institute for Research in Molecular Medicine Universiti Sains Malaysia16150 Kubang KerianKelantanMalaysia

Burkholderia pseudomallei is a causative agent of melioidosis that can infect humans and animals in endemic countries,specifically in Southeast Asia and tropical Australia.A fundamental component for the pathogenesis of Burkholderia pseudomallei is the capability of the bacterium to enter,survive,replicate,and cause disease in a host cell by inducing the host cell *** fusion results in multinucleated-giant cell formation,thus enabling the dissemination of Burkholderia pseudomallei *** reacts to Burkholderia pseudomallei infection by activating the cGAS-STING pathway and subsequently limiting host's aberrant cell division and cellular replication by inducing autophagic cell *** this review,we discuss the host-pathogen interactions between the typeⅥsecretion system 5(T6SS-5)of Burkholderia pseudomallei and human cGAS pathway in melioidosis *** T6SS-5 is a main virulent factor in Burkholderia pseudomallei and the c GAS pathway is vital for host immune response,elucidating their functions is important for better understanding the pathogenesis of Burkholderia pseudomallei.

关键词： Burkholderia pseudomallei Melioidosis T6SS-5 c GAS-STING IfN-1

Circulating Levels of Hypoxia-regulating MicroRNAs in Systemic Lupus Erythematosus Patients with Hemolytic Anemia

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Current Medical Science 2022年第6期42卷 1231-1239页

作者： Amira M.Gamal-Eldeen Cinderella A.fahmy Bassem M.Raafat fayez Althobaiti iman H.Bassyouni Roba M.Talaat Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia High Altitude Research Center Prince Sultan Medical ComplexAl-HawiyahTaif UniversityTaif21944Saudi Arabia Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced SciencesNational Research CentreCairo12622Egypt Biochemistry Department National Research CentreCairo12622Egypt Radiological Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Rheumatology and Rehabilitation Faculty of MedicineCairo UniversityEl-Kasr El-Aini HospitalCairo12613Egypt Molecular Biology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)Sadat City UniversitySadat City32897Egypt

Objective MicroRNAs are fine regulators for gene expression during the post-transcriptional stage in many autoimmune ***(miR-210 and miR-21)play an important role in hypoxia and in inflammation-associated *** lupus erythematosus(SLE)is a chronic systemic autoimmune disease that would potentiate many pathological complications,including hemolytic *** study aimed to investigate the role of hypoxamiRs in SLE/hemolytic anemia *** This work was designed to analyze the circulating levels of↱the miR-210 and miR-21 expressions and hypoxia-inducible factor-1α(HIf-α)in SLE/hemolytic anemia *** activity was evaluated for all patients by SLE Disease Activity Index(SLEDAI).Clinical manifestations/complications and serological/hematological investigations were ***-αconcentration was assayed by ELISA and expression of miR-21 and miR-210 was analyzed by *** The results indicated that the fold change of the miR-210/miR-21 expressions in plasma was significantly elevated in SLE/hemolytic anemia patients.A strong positive correlation between the miR-210 and miR-21 expression levels was also *** the associated-disease complications,hypertension,arthritis,oral ulcers,and serositis were associated with a high circulating miR-210 expression,while the occurrence of renal disorders was associated with the increased miR-21 ***,the HIf-αlevel was remarkably elevated in SLE/hemolytic anemia patients.A high positive correlation was recorded between the HIf-αconcentration and miR-210/miR-21 expression *** occurrence of oral ulcers,arthritis,and hypertension was associated with the increased HIf-α*** the other hand,SLEDAI and white blood cell count were positively correlated with miR-21/*** erythrocyte sedimentation rate was positively correlated with *** The dysregulation of the circulating miR-210/miR-210/HIf-1αlevels in SLE/hemolytic anemia pat

关键词： circulating hypoxamiRs miR-210 and miR-21 hypoxia-inducing factor-1α hemolytic anemia systemic lupus erythematosus

碱性介质中(氢)氧化铜修饰电极电催化氧化蔗糖(英文)

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催化学报 2010年第11期31卷 1351-1357页

作者： Majid JAfARIAN Mehdi RASHVAND AVEI iman DANAEE fereydoon GOBAL Mohammad G.MAHJANI Department of Chemistry K.N.Toosi University of Technology Abadan faculty of Petroleum Engineering Petroleum University of Technology Department of Chemistry Sharif University of Technology

A stable copper(hydr)oxide-modified electrode was prepared in 0.5 mol/L NaOH solution by cyclic voltammetry in the range of -250 to 1 000 *** can be used for electrochemical studies in the range of -250 to 1000 mV without interfering peaks because there is no oxidation of *** an anodic potential sweep,the electro-oxidation of saccharose on Cu occurred by the formation of CuⅢ and this reaction also occurred in the early stages of the reversed cycle until it is stopped by the negative potentials.A mechanism based on the electro-chemical generation of CuⅢ active sites and their subsequent consumption by saccharose was proposed,and the rate law and kinetic parameters were *** charge transfer resistance from theoretical and impedance studies was used to verify the *** chronoamperometry regimes,the reaction followed Cottrellian *** transfer of up to 21 electrons was observed in further investigations of the electro-oxidation of saccharose on a(hydr)oxide Cu rotating disk electrode.

关键词： saccharose copper(hydr)oxide equivalent circuit electrocatalytic oxidation mechanism

反复使用抗生素患者结膜菌群的变化及耐药模式研究（英文）

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国际眼科杂志 2019年第11期19卷 1828-1833页

作者： Rania Abdelmonem Khattab Maha Abdelfattah iman fahmy 埃及开罗大学药学院微生物与免疫学系11562 眼科研究所微生物科埃及吉萨12556 眼科研究所眼科埃及吉萨12556

目的:观察和分析反复使用抗生素患者结膜菌群的变化。此外,确定这种反复暴露对结膜菌群抵抗模式的影响。方法:研究纳入40例眼科研究所视网膜科患者。所有受试者至少进行了连续4次、每月一次的玻璃体腔注射(IVI),其中一些患者根据需要延... 详细信息

目的:观察和分析反复使用抗生素患者结膜菌群的变化。此外,确定这种反复暴露对结膜菌群抵抗模式的影响。方法:研究纳入40例眼科研究所视网膜科患者。所有受试者至少进行了连续4次、每月一次的玻璃体腔注射(IVI),其中一些患者根据需要延长至6mo或1y。将患者随机分为3组,每组给予氧氟沙星、莫西沙星或头孢他啶任意一种抗生素。使用Kirby-Bauer扩散法对所有细菌进行药敏试验。结果:研究中,以表皮葡萄球菌(51.2%)为主,其次是金黄色葡萄球菌(14%),微球菌(12.8%)和其他凝固酶阴性葡萄球菌(CONS)占13%。结果显示,在4次随访中,与随机接受头孢他啶治疗的患者的基线培养相比,接受头孢他啶治疗的患者眼部表皮葡萄球菌的百分比有所增加。相比之下,与基线相比,金黄色葡萄球菌的百分比没有明显增加。在氟喹诺酮治疗眼中观察到表皮葡萄球菌的百分比从基线增加。与头孢他啶治疗组相比,氟喹诺酮治疗组的金黄色葡萄球菌百分比较基线升高。然而,随着新一代和老一代氟喹诺酮类药物的暴露,眼部菌群组成模式发生了变化。我们注意到,从基线开始,莫西沙星治疗组比氧氟沙星治疗组的表皮葡萄球菌增多。暴露于老一代和新一代氟喹诺酮类药物的金黄色葡萄球菌的模式没有差异。结论:反复使用眼用抗生素不仅会改变正常眼部菌群的组成,还会选择耐药菌株。

关键词：眼部菌群眼用抗生素表皮葡萄球菌耐药性

Diabetes Risk factor and Its Relationship to Increasing Coronavirus (COVID-19) Mortality Rate in United States in 2019-2022: An Epidemiological Study

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Open Journal of Epidemiology 2023年第2期13卷 128-143页

作者： Henry Zeidan iman Zeidan Laura Scholer-Bland College of Graduate & Professional Studies University of New England Portland USA McLaren Central Michigan Medical Center and Central Michigan University School of Medicine MT. Pleasant USA Georgia Institute of Technology Atlanta USA

As an effort to understand the effect of diabetes on the increasing rate of COVID-19 infection, we embarked upon a detailed statistical analysis of various datasets that include COVID-19 infection and mortality rate, diabetes and diseases that may contribute to the severity and risk factor of diabetes in individuals and this impact on COVID-19 and the mortality rate. These diseases include respiratory diseases, cardiovascular diseases, and obesity. Equally significant is the statistical analysis on ethnicity, age, and sex on COVID-19 infection as well as mortality rate. Their possible contributions to increasing the severity and risk factor of diabetes as a risk to mortality to individuals who have COVID-19. Objectives: The ultimate objectives of this investigation are as follow: 1) Is there a risk factor of diabetes on COVID-19 infection and increasing mortality rate? 2) To what extent do other disease conditions that include, obesity, heart failure, and respiratory diseases influence the severity and risk factor of diabetes on increasing COVID-19 infection and mortality rate? 3) To what extent does age, race, and gender increase the mortality of COVID-19 and increase the severity and risk factor of diabetes on COVID-19 mortality rate? 4) How and why COVID-19 virus increases the risk of diabetes in children? 5) Diabetes and COVID-19: Who is most at Risk? Lastly, understanding the misconception of COVID-19 and diabetes.

关键词： Middle East Respiratory Syndrome Coronavirus (MERS-COVID) Infection Risk factors Omicron Virus COVID-19 Risk on Children Interactions of Independent Variables Poisson Regression Linear Regression

Effects of GPU Structuring on Accelerated Schemes of LBM and Classical CfD for flow over a flat Plate

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Journal of Mathematics and System Science 2012年第2期2卷 126-132页

作者： Seyyed Mohammad iman Gohari Mohsen Ghadyani School of Mechanical Engineering VFE Research Institute University of Tehran Tehran 17446-73 785 lran Department of Mechanics Science and Research Branch Islamic Azad University Tehran 17446-73785 Iran

Current trends on CfD （Computational fluid Dynamics） along with high performance computing are moving towards using modem GPUs （Graphics Processing Units） in order to achieve substantial execution speedup. Consequently, it is definitely crucial to have some understanding about execution time of different computational methods and parallelization procedures. In this study, two GPU accelerated schemes namely LBM （Lattice Boltzmann Method） and SfV （Stream function-Vorticity） formulation are investigated and compared for simulation of flow over a fiat plate. The comparisons are based on solvers runtime and speedup and GPU type of structuring. On study the authors found that although the runtime for SfV formulation is less than LBM, LBM has greater potential to obtain higher speedup by using modern GPUs like NVIDIA GTX 480. In addition, a performance sensitivity is done to investigate for different GPU type of structures as a considerable parameter. The difference between GPU runtime in optimum and regular conditions indicates that using one-dimensional structuring can improve the GPU performance about 50 percent.

关键词： LBM GPU structuring stream function-vorticity flat plate