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玻璃体术后视网膜吲哚青绿染料残留

世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 59-59页

作者： Na.a.ura.H. Ha.a.a.a.K. imaizumi a. 程燕 Depa.tment of Ophtha.mology University of the Ryukyus Faculty of Medicine 207 Uehara Nishiharacho Okinawa 903- 0125 Japan

Ba.KGROUND a.D OBJECTIVE: To investiga.e the dura.ion of postopera.ive persistence of indocya.ine green (ICG) dye used during vitreous surgery. Pa.IENTS a.D METHODS: Thirty-three pa.ients (34 eyes) underwentma.ula. surgery with remova. of the interna. limiting membra.e (ILM)-or epiretina. membra.e using ICG dye to sta.n the membra.e for better visua.iza.ion. Infra.ed fundus photogra.hswere ta.en postopera.ively until infra.ed fluorescence ha. completely disa.pea.ed. The time for residua. ICG dye to fa.e from the retina.wa. studied for eyes with full-thickness ma.ula. hole, epiretina. membra.e, a.d ma.ula. edema.for compa.ison. RESULTS: Persistent ICG dye wa. prima.ily observed a. sites where ma.ula. hole wa. present, sites of norma. ILM tha. ha. not been removed, a.d the optic disc. ICG dye fa.ed a. a. a.era.e of 7.3 months for pa.ients with ma.ula. hole a.d 3.4 months for pa.ients with other ma.ula. disea.es (Pa.ula. surgery ca. persist in the ma.ula. region for up to 7 months following surgery, a.d seems to rema.n for a.longer period of time in ca.es with ma.ula. hole tha. in ca.es with other disea.es. Ca.tion is required rega.ding light exposure by postopera.ive fundus exa.ina.ions, da.light, a.d other na.ura. light.

关键词：玻璃体手术吲哚青绿黄斑裂孔黄斑水肿眼底检查摄影检查黄斑区残留时间持续时间谨慎对待

Field observa.ions of debris-flow initia.ion processes on sediment deposits in a.previous deep-sea.ed la.dslide site

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Journa. of Mounta.n Science 2016年第2期13卷 213-222页

作者： Fumitoshi imaizumi Sa.oshi TSUCHIYa.Okihiro OHSa.A Depa.tment of Environment a.d Forest Resources Science Faculty of AgricultureShizuoka University

a.though informa.ion rega.ding the initia.ion processes of debris flows is importa.t for the development of mitiga.ion mea.ures,field da.a.rega.ding these processes a.e *** conducted field observa.ions of debris-flow initia.ion processes in the upper Ichinosa.a.ca.chment of the Ohya.la.dslide,centra. *** 19 June 2012,our videoca.era.monitoring systems recorded the moment of debris-flow initia.ion on cha.nel deposits(nine surges) a.d ta.us slopes(eight surges).The initia.ion mecha.isms of these surges were cla.sified into three types by a.a.yzing the video ima.es: erosion by the surfa.e flow,movement of deposits a. a.ma.s,a.d upwa.d development of the fluid *** first type wa. a.socia.ed with the progress of surfa.e flow from the upper strea. on unsa.ura.ed cha.nel *** second type wa. likely ca.sed by a. increa.e in the pore wa.er pressure a.socia.ed with the rising in the groundwa.er level in cha.nel deposits;a.continuous wa.er supply from the upper strea. by the surfa.e flow might ha.e induced this *** third type wa. a.socia.ed with cha.ges in the downstrea. topogra.hy ca.sed by *** flow velocity of most surges wa. less tha. 3 m s^(-1) a.d they usua.ly stopped within 100 m from the initia.ion *** with a.unda.t pore fluid ha. a.higher flow velocity(a.out 3- 5 m s^(-1)) a.d could tra.el for a.onger *** observa.ions indica.e tha. the surfa.e flow pla.s a. importa.t role in the initia.ion of debris flows on cha.nel deposits a.d ta.us slopes.

关键词： Debris flow Initia.ion zone Field monitoring Ohya.la.dslide

Ba.kground disea.es a.d the number of previous intra.itrea. a.libercept injections on immedia.e intra.cula. pressure increa.e a.d vitreous reflux ra.e in pha.ic eyes

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Interna.iona. Journa. of Ophtha.mology(English edition) 2024年第3期17卷 545-550页

作者： Tetsuya.Muto Shigeki Ma.hida.Shinichiro imaizumi Depa.tment of Ophtha.mology Dokkyo Medical University Saitama Medical CenterKoshigaya 343-8555Japan imaizumi Eye Hospita. Koriyama 963-8877Japan Fukushima.Medica. University Fukushima 960-1295Japan

●a.M:To eva.ua.e the effect of ba.kground disea.es a.d number of previous intra.itrea. a.libercept injections(IVa.s)on immedia.e intra.cula. pressure(IOP)increa.e a.d vitreous reflux(VR)ra.e a.d to eva.ua.e the correla.ion of both a.e a.d a.ia. length with immedia.e IOP increa.e a.d VR ra.e.●METHODS:This study included 105 pa.ients with cystoid ma.ula. edema.seconda.y to retina. vein occlusion,35 pa.ients with dia.etic ma.ula. edema.69 pa.ients with neova.cula. a.e-rela.ed ma.ula. degenera.ion(na.D),a.d 12 pa.ients with myopic choroida. neova.cula.iza.ion,which underwent first-time *** correla.ion of immedia.e IOP increa.e a.d VR ra.es with the four ba.kground disea.es wa. ***,the correla.ion of a.e with immedia.e IOP increa.e a.d VR ra.e a. well a. correla.ion of a.ia. length with immedia.e IOP increa.e a.d VR ra.e were ***,54 pa.ients with na.D were trea.ed with IVa.>10 times(multiple IVa.s).Moreover,the correla.ion of immedia.e IOP increa.e a.d VR ra.es with first-time a.d multiple IVa.s in na.D wa. determined.●RESULTS:The immedia.e IOP increa.e(P=0.16)a.d VR ra.es(P=0.50)were a.most simila. a.ong the four ba.kground *** immedia.e postinjection IOP a.d a.e,VR ra.e a.d a.e,immedia.e postinjection IOP a.d a.ia. length,or VR ra.e a.d a.ia. length were not correla.ed in the four ba.kground *** immedia.e IOP increa.e(P=0.66)a.d VR ra.es(P=0.28)did not significa.tly differ between first-time a.d multiple IVa.s in na.D.●CONCLUSION:Ba.kground disea.es a.d number of previous IVa.s ha.e no effect on immedia.e IOP increa.e a.d VR ***,a.e a.d a.ia. length ha.e no correla.ion on immedia.e IOP increa.e a.d VR ra.e.

关键词： a.libercept intra.cula. pressure vitreous reflux intra.itrea. injection

Photoperiodic flowering in a.a.idopsis:Multila.ered regula.ory mecha.isms of CONSTa.S a.d the florigen FLOWERING LOCUS T

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Pla.t Communica.ions 2023年第3期4卷 47-65页

作者： Hiroshi Ta.a.i a.drew K.Hempton Ta.a.o imaizumi Depa.tment of Biology University of WashingtonSeattleWA 98195-1800USA Center for Gene Resea.ch Nagoya UniversityNagoya 464-8602Japan

The timing of flowering a.fects the success of sexua. *** developmenta. event a.so determines crop yield,bioma.s,a.d ***,this mecha.ism ha. been ta.geted for improvement a.ong with crop *** underlying mecha.isms of flowering a.e highly conserved in *** to these mecha.isms is how environmenta. a.d endogenous conditions control tra.scriptiona. regula.ion of the FLOWERING LOCUS T(FT)gene,which initia.es flora. development under long-da. conditions in *** the identifica.ion of FT a. florigen,efforts ha.e been ma.e to understa.d the regula.ory mecha.isms of FT *** ma.y tra.scriptiona. regula.ors ha.e been shown to directly influence FT,the question of how they coordina.ely control the spa.iotempora. expression pa.terns of FT still requires further *** FT regula.ors,CONSTa.S(CO)is the prima.y one whose protein sta.ility is tightly controlled by phosphoryla.ion a.d ubiquitina.ion/protea.ome-media.ed *** a.dition,va.ious CO intera.tion pa.tners,some of them previously identified a. FT tra.scriptiona. regula.ors,positively or nega.ively modula.e CO protein *** FT promoter possesses severa. tra.scriptiona. regula.ory"blocks,"highly conserved regions a.ong Bra.sica.ea. *** tra.scription fa.tors bind to specific blocks a.d a.fect FT expression,often ca.sing topologica. cha.ges in FT chroma.in structure,such a. the forma.ion of DNa.*** discuss the current understa.ding of the regula.ion of FT expression ma.nly in a.a.idopsis a.d propose future directions rela.ed to this topic.

关键词： photoperiodic flowering a.a.idopsis tha.ia.a circa.ia. clock photoreceptor CONSTa.S FLOWERING LOCUS T

Mizoribine in the trea.ment of pedia.ric-onset glomerula. disea.e

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World Journa. of Pedia.rics 2015年第2期11卷 108-112页

作者： Hiroshi Ta.a.a.Ka.ushi Tsuruga.Ta.da.su imaizumi Depa.tment of School Hea.th Science Faculty of EducationHirosaki UniversityHirosaki 036-8560Japan Depa.tment of Pedia.rics Hirosaki University HospitalHirosaki 036-8563Japan Depa.tment of Va.ula. Biology Graduate School of MedicineHirosaki UniversityHirosaki 036-8562Japan

Ba.kground:Mizoribine(MZR)is a.selective inhibitor of inosine monophospha.e dehydrogena.e,a.key enzyme in the pa.hwa. responsible for de novo synthesis of gua.ine *** a. immunosuppressa.t,MZR ha. been used successfully without a.y serious a.verse effects in the trea.ment of rena. disea.es in children a. well a. *** its immunosuppressive effect,MZR ha. been reported to a.eliora.e tubulointerstitia. fibrosis in ra.s via.suppression of ma.ropha.e *** Sources:In this review,we summa.ize reported possible benefits of MZR in the trea.ment of pedia.ric-onset glomerula. ***:We recently observed tha. MZR itself selectively a.tenua.es the expression of monocyte chemoa.tra.ta.t protein-1 a. both the mRNa.a.d protein levels in huma. mesa.gia. *** MZR binds specifica.ly to 14-3-3 proteins a.d hea. shock protein 60,both of which a.e reportedly expressed in infla.ed glomeruli,MZR ma. bind directly to infla.ed glomerula. cells,thereby possibly preventing progressive da.a.e from glomerulonephritis through a.suppressive effect on a.tiva.ed ma.ropha.es a.d intrinsic rena. ***,it ha. recently been reported tha. MZR directly prevents podocyte injury through correction of the intra.ellula. energy ba.a.ce a.d nephrin biogenesis in cultured podocyte a.d ra. models,suggesting a.direct a.ti-proteinuric effect of ***:These beneficia. mecha.isms of a.tion of MZR a. well a. its immunosuppressive effect would wa.ra.t its use in the trea.ment of pedia.ric-onset glomerula. *** further studies rema.n to be done,we believe tha. MZR ma. be a. a.tra.tive trea.ment of choice for children with glomerula. disea.es from a.histologic a. well a. clinica. sta.dpoint.

关键词： ma.ropha.e infiltra.ion mesa.gia. cells mizoribine monocyte chemoa.tra.ta.t protein-1 podocytes

Frequent a.d prolonged nocturna. occupa.ion of port a.ea. by Ya.gtze finless porpoises (Neophoca.na.a.ia.orienta.is): Forced choice for feeding?

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Integra.ive Zoology 2015年第1期10卷 122-132页

作者： Zhita. Wa.G Tomona.i a.a.a.SU Zhiga.g MEI Lijun DONG Tomohito imaizumi Kexiong Wa.G Ding Wa.G The Key La.ora.ory of a.ua.ic Biodiversity a.d Conserva.ion of Chinese a.a.emy of Sciences Institute of Hydrobiology of the Chinese Academy of SciencesWuhanChina University of Chinese a.a.emy of Sciences BeijingChina Na.iona. Resea.ch Institute of Fisheries Engineering IbarakiJapan

During the Ya.gtze Freshwa.er Dolphin Expedition 2012,Ya.gtze finless porpoises(Neophoca.na.a.ia.orienta.is)were a.oustica.ly monitored in 9 port a.ea. a. *** 6566 min of nocturna. monitoring,porpoise sona. wa. detected for 488 min(7.43%of the tota. time).Of a.l 81 encounters,the longest echoloca.ion spa. obta.ned wa. 102.9 min,suggesting frequent a.d prolonged porpoise occupa.ion of the port a.ea..a.combined tota. of 2091 click tra.ns were recorded,with 129(6.2%)conta.ning minimum inter-click interva.s(ICIs)below 10 ms(termed a.buzz).Buzzes with a.decrea.e in ICIs a.d sea.ch a.d a.proa.h pha.es tha. resembled feeding echoloca.ion signa.s a.counted for 44.2%(N=52)of a.l *** with a. increa.e in ICIs,suggesting a.mirrored prey ca.ture pha.e,a.counted for 20.2%(N=26)a.d could reflect a.tempts to loca.e esca.ed prey beca.se they were followed by a.proa.h-pha.e feeding *** evidence of porpoises fleeing the proximity of vessels wa. *** recordings indica.ing clusters of porpoises feeding nea. the port a.ea. suggest a.forced choice for feeding due to the rela.ively higher prey a.a.la.ility in the port a.ea. compa.ed to other a.ea. in the Ya.gtze River tha. a.e proba.ly overfished.

关键词： feeding beha.ior nocturna. pa.sive a.oustic monitoring port a.ea prey a.a.la.ility

Current sta.us of endoscopic retrogra.e chola.giopa.crea.ogra.hy in pa.ients with surgica.ly a.tered a.a.omy

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World Journa. of Ga.troenterology 2019年第26期25卷 3313-3333页

作者： Chonla.a.Krutsri Mitsuhiro Kida.Hiroshi Ya.a.chi Tomohisa.Iwa. Hiroshi imaizumi Wa.a.uro Koizumi Depa.tment of Surgery Faculty of MedicineRamathibodi HospitalMahidol UniversityBangkok 10400Thailand Depa.tment of Ga.troenterology Graduate School of MedicineKitasato University HospitalKanagawa 252-0375Japan

Endoscopic retrogra.e chola.giopa.crea.ogra.hy(ERCP)in pa.ients with surgica.ly a.tered a.a.omy must be performed by a.highly experienced *** cha.lenges a.e a.cessing the a.ferent limb in different types of reconstruction,ca.nula.ing a.pa.illa.with a.reverse orienta.ion,a.d performing thera.eutic interventions with uncommon endoscopic *** development of endoscopic techniques ha. led to higher success ra.es in this group of ***-a.sisted ERCP is the endoscopic procedure of choice for high success ra.es in short-limb reconstruction;however,these success ra.e is lower in long-limb *** a.sisted by endoscopic ultra.onogra.hy is now popula. beca.se it ca. be performed independent of the limb length;however,it must be performed by a.highly experienced a.d skilled *** deployment a.d sma.l stone remova. ca. be performed immedia.ely a.ter ERCP a.sisted by endoscopic ultra.onogra.hy,but the second session is needed for other difficult procedures such a. chola.gioscopy-guided electrohydra.lic ***-a.sisted ERCP ha. a. a.most 100%success ra.e in longlimb reconstruction beca.se of the use of a.conventiona. side-view duodenoscope,which is compa.ible with sta.da.d *** requires coopera.ion between the surgeon a.d endoscopist a.d is suita.le in urgent situa.ions requiring concomita.t *** review focuses on the a.va.ta.es,disa.va.ta.es,a.d outcomes of va.ious procedures tha. a.e suita.le in different situa.ions a.d reconstruction *** new techniques a.d their outcomes a.e a.so discussed.

关键词： Endoscopic retrogra.e chola.giopa.crea.ogra.hy Surgica.ly a.tered a.a.omy Endoscopic retrogra.e chola.giopa.crea.ogra.hy in Billroth II Endoscopic retrogra.e chola.giopa.crea.ogra.hy post-Whipple Endoscopic ultra.onogra.hy-guided endoscopic retrogra.e chola.giopa.crea.ogra.hy

Low tempera.ure-media.ed repression a.d fa.-red light-media.ed induction determine morning FLOWERING LOCUS T expression levels

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Journa. of Integra.ive Pla.t Biology 2024年第1期66卷 103-120页

作者： Ha.eon Kim Hye Won Ka.g Da. Yeon Hwa.g Na.oung Lee a.a.e Kubota.Ta.a.o imaizumi Young Hun Song Depa.tment of a.ricultura. Biotechnology Seoul National UniversitySeoul 08826Korea Depa.tment of Biology Ajou UniversitySuwon 16499Korea Pla.t Genomics a.d Breeding Institute Seoul National UniversitySeoul 08826Korea Gra.ua.e School of Science a.d Technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Depa.tment of Biology University of WashingtonSeattleWA 98195USA Institute of a.ricultura. Life Sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the a.propria.e sea.on,pla.ts monitor light a.d tempera.ure cha.ges a.d a.ter downstrea. pa.hwa.s tha. regula.e florigen genes such a. a.a.idopsis(a.a.idopsis tha.ia.a.FLOWERING LOCUS T(FT).In a.a.idopsis,FT messenger RNa.levels pea. in the morning a.d evening under na.ura. long-da. conditions(LDs).However,the regula.ory mecha.isms governing morning FT induction rema.n poorly *** morning FT pea. is a.sent in typica. la.ora.ory LDs cha.a.terized by high red:fa.-red light(R:FR)ra.ios a.d consta.t ***,we demonstra.e tha. ZEITLUPE(ZTL)intera.ts with the FT repressors Ta.GET OF Ea.s(TOEs),thereby repressing morning FT expression in na.ura. *** LDs with simula.ed sunlight(R:FR=1.0)a.d da.ly tempera.ure cycles,which a.e na.ura. LD-mimicking environmenta. conditions,FT tra.script levels in the ztl muta.t were high specifica.ly in the morning,a.pa.tern tha. wa. mirrored in the toe1 toe2 double *** night-to-morning tempera.ures increa.ed the inhibitory effect of ZTL on morning FT expression by increa.ing ZTL protein levels ea.ly in the ***-red light countera.ted ZTL a.tivity by decrea.ing its a.unda.ce(possibly via.phytochrome a.phya.)while increa.ing GIGa.TEa.GI)levels a.d nega.ively a.fecting the forma.ion of the ZTL-GI complex in the ***,the phya.media.ed high-irra.ia.ce response a.d GI pla. pivota. roles in morning FT *** findings suggest tha. the delica.e ba.a.ce between low tempera.ure-media.ed ZTL a.tivity a.d the fa.-red light-media.ed functions of phya.a.d GI offers pla.ts flexibility in fine-tuning their flowering time by controlling FT expression in the morning.

关键词： fa.-red light FLOWERING LOCUS T flowering time GIGa.TEA low night-to-morning tempera.ure na.ura. long da.s phytochrome A red to fa.-red ra.io ZEITLUPE

Prognosis of meta.ta.ic splenic hilum lymph node in pa.ients with ga.tric ca.cer a.ter tota. ga.trectomy a.d splenectomy

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World Journa. of Hepa.ology 2010年第2期2卷 81-86页

作者： Keishiro a.ya.i Kikuo Kouhuji Motoshi Miya.i Ta.uya.imaizumi Junya.Kiza.i Ka.uo Shirouzu Depa.tment ofSurgery Kurume University School of MedicineFukuoka830-0011Japan

a.M:To cla.ify the significa.ce of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 pa.ients who ha. undergone tota. ga.trectomy with splenectomy,excluding non-cura.ive ca.es,resection of multiple ga.tric ca.cer, a.d those with remna.t stoma.h *** clinico-pa.hologica. fa.tors were eva.ua.ed for a.y independent contributions to No.10 LN meta.ta.is,usingχ 2 test. Significa.t fa.tors were extra.ted for further a.a.ysis, ca.ried out using a.logistic regression ***,lymph node meta.ta.is wa. eva.ua.ed for a.y independent contribution to No.10 LN meta.ta.is,using the sa.e *** cumula.ive surviva. ra.e wa. ca.cula.ed using the Ka.la.-Meier *** significa.ce of a.y difference between the surviva. curves wa. determined using the Cox-Ma.tel test,a.d a.y difference wa. considered significa.t a. the 5%level. RESULTS:From the va.ia.les considered to be potentia.ly a.socia.ed with No.10 LN meta.ta.is,a.e, depth,inva.ion of lymph vessel,N fa.tor,the numberof lymph node meta.ta.is,Sta.e,the number of sites, a.d loca.ion were found to differ significa.tly between those with meta.ta.is(the Positive Group)a.d those without(the Nega.ive Group).a.logistic regression a.a.ysis showed tha. the loca.iza.ion a.d Sta.e were significa.t pa.a.eters for No.10 LN *** wa. no ca.e loca.ed on the lesser curva.ure in the Posi-tive *** numbers of No.2,No.3,No.4sa.No. 4sb,No.4d,No.7,a.d No.11 LN meta.ta.is were ea.h found to differ significa.tly between the Positive Group a.d the Nega.ive Group.a.logistic regression a.a.ysis showed tha. No.4sa.No.4sb,a.d No.11 LN meta.ta.is were ea.h a.significa.t pa.a.eter for No.10 LN *** wa. no significa.t difference in surviva. curves between the Positive Group a.d the Nega.ive Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for ca.es which ha.e No.4sa.No. 4sb or No.11 LN ***,in ca.es where the tumor is loca.ed on th

关键词： Ga.tric ca.cer Lymph node meta.ta.is Lympha.enectomy,Splenectomy Tota. ga.trectomy