检索结果-南通市图书馆

Combined Transcriptomics and metabolomics of Arabidopsis thaliana Seedlings Exposed to Exogenous GABA Suggest Its Role in Plants Is Predominantly metabolic

引用

molecular Plant 2014年第6期7卷 1065-1068页

作者： Albert Batushansky menny Kirma Nicole Grillich David Toubiana Phuong Anh Pham ilse balbo.hillel fro.m Gad Galili Alisdair R. Fernie Aaron Fait The Jacob Blaustein Institutes for Desert Research Ben-Gurion University of the Negev84990 Sede Boqer Campus Israel Department of Plant Science Weizmann Institute of Science 76100 Rehovot Israel max-Planck Institute of molecular Plant Physiology Am Mühlenberg 114476 Potsdam-Golm Germany Department of molecular Biology and Ecology of Plants Faculty of Life Sciences Tel Aviv University 69978 Tel Aviv Israel

Dear Editor, y-Aminobutyric acid （GABA） is a non-protein amino acid （AA） metabolized via the GABA shunt; a three-enzyme pathway that includes glutamate decarboxylase （GAD）, GABA transaminases （GABA-T）, and succinic semialdehyde dehydrogenase （SSADH）（Bown and Shelp, 1997; Bouch~ and fro.m, 2004）. The majority of work on GABA, to date, has focused on its role as an inhibitory neurotransmitter in mammals. In plants, however, due to its intermediate posi- tion between carbon （C） and nitrogen （N）, the metabolism of GABA has been suggested as a modulator of C-N balance （Fair et al., 2008）. In addition, the numerous observations of a rapid accumulation of GABA in response to （a）biotic stresses has prompted different hypotheses to be postu- lated on its role including a regulator of cytosolic pH and a herbivore deterrent （Bouche and fro.m, 2004; Roberts, 2007）. Additionally, a signaling role has been hypothesized in plants, though evidence remains elusive and the debate on the dual function of GABA as a signaling molecule and as a metabolite in plants remains ongoing. In the present work, we report changes in the metabolite and transcript profiles in Arabidopsis seedlings exposed to exogenous GABA. Liquid-grown seedlings were cultured under C and N limitation to reveal a possible role of GABA as either C or N substrate and to ascertain its influence on transcriptional programs.

关键词： GABA 代谢物拟南芥外源性转录组植物幼苗 γ-氨基丁酸

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

引用

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

引用

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Affinely Prime Dynamical Systems(Dedicated to Professor Haim Brezis on the occasion of his 70th birthday)

引用

Chinese Annals of mathematics,Series B 2017年第2期38卷 413-424页

作者： hillel FURSTENBERG Eli GLASNER Benjamin WEISS Institute of mathematics Hebrew University of JerusalemJerusalemIsrae1 Department of mathematics Tel Aviv UniversityTel AvivIsrael.

This paper deals with representations of groups by "affine" automorphisms of compact, convex spaces, with special focus on "irreducible" representations: equivalently"minimal" actions. When the group in question is P SL(2, R), the authors exhibit a oneone correspondence between bounded harmonic functions on the upper half-plane and a certain class of irreducible representations. This analysis shows that, surprisingly, all these representations are equivalent. In fact, it is found that all irreducible affine representations of this group are equivalent. The key to this is a property called "linear Stone-Weierstrass"for group actions on compact spaces. If it holds for the "universal strongly proximal space"of the group(to be defined), then the induced action on the space of probability measures on this space is the unique irreducible affine representation of the group.

关键词： Irreducible affine dynamical systems Affinely prime Strong proximality mbius transformations Harmonic functions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

引用

Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Search for microglia-specific peptides:advances in the discovery toolbox

引用

Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

引用

Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient network immunization under limited knowledge

引用

National Science Review 2021年第1期8卷 127-134页

作者： Yangyang Liu hillel Sanhedrai Gao Gao Dong Louis m.Shekhtman Fan Wang Sergey V.Buldyrev Shlomo Havlin Department of Systems Science National University of Defense Technology Department of Physics Bar-Ilan University Faculty of Science Jiangsu University Network Science Institute Northeastern University Department of Physics Yeshiva University

Targeted immunization of centralized nodes in large-scale networks has attracted significant ***, in real-world scenarios, knowledge and observations of the network may be limited, thereby precluding a full assessment of the optimal nodes to immunize（or quarantine） in order to avoid epidemic spreading such as that of the current coronavirus disease（COVID-19） epidemic. Here, we study a novel immunization strategy where only n nodes are observed at a time and the most central among these n nodes is immunized. This process can globally immunize a network. We find that even for small n（≈10） there is significant improvement in the immunization（quarantine）, which is very close to the levels of immunization with full knowledge. We develop an analytical framework for our method and determine the critical percolation threshold p;and the size of the giant component P∞ for networks with arbitrary degree distributions P（k）. In the limit of n →∞ we recover prior work on targeted immunization, whereas for n = 1 we recover the known case of random immunization. Between these two extremes, we observe that, as n increases,p;increases quickly towards its optimal value under targeted immunization with complete information. In particular, we find a new general scaling relationship between |p;（∞）-p;（n）| and n as |p;（∞）-p;（n）| ～n;exp（-αn）. For scale-free（SF） networks, where P（k）～ k;, 2 from zero to nonzero when n increases from n = 1 to O（log N）(where N is the size of the network). Thus, for SF networks, having knowledge of ≈log N nodes and immunizing the most optimal among them can dramatically reduce epidemic spreading. We also demonstrate our limited knowledge immunization strategy on several real-world networks and confirm that in these real networks, p;increases significantly even for small n.

关键词： percolation complex networks network immunization critical phenomena

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

引用

Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Evaluation of Tire/Surfacing/Base Contact Stresses and Texture Depth

引用

International Journal of Transportation Science and Technology 2015年第1期4卷 107-118页

作者： W.J.vdm.Steyn m.ilse Department of Civil Engineering University of PretoriaLynnwood roadHatfield South Africa

Tire rolling resistance has a major impact on vehicle fuel *** resistance is the loss of energy due to the interaction between the tire and the pavement *** interaction is a complicated combination of stresses and strains which depend on both tire and pavement related *** include vehicle speed,vehicle weight,tire material and type,road camber,tire inflation pressure,pavement surfacing texture *** this paper the relationship between pavement surface texture depth and tire/surfacing contact stress and area is *** depth and tire/surfacing contact stress were measured for a range of tire inflation pressures on five different pavement *** the analysis the relationship between texture and the generated contact stresses as well as the contact stress between the surfacing and base layer are presented and discussed,and the anticipated effect of these relationships on the rolling resistance of vehicles on the surfacings,and subsequent vehicle fuel economy discussed.

关键词： texture inflation rolling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：