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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 54-55页

作者： Ludvigsson j. Eylert M. ilonen j. O.Vaarala 沙焕臣 Department of Molecular and Clinical Medicine Faculty of Health SciencesLinkping UniversitySweden

*** study the effect of HLA DQ2,dietary history and development of coeliac disease(CD) on the induction of antibody response to wheat gliadin and cow’s milk,beta-lactoglobulin between 1 and 2.5 years of age in children who developed CD and in healthy *** and *** participating in a birth cohort study(the ABIS study) in Sweden were ***-nine children developed CD(cases) ,confirmed through biopsy,during follow-up until 2.5-5 years of age.A total of 181 healthy control children were matched for duration of exclusive breast-feeding,birth-weight,gender,maternal smoking and season of *** and IgA antigliadin and anti-beta-lactoglobulin antibodies were measured using enzyme immunoassay(EIA) .The effects of HLA-risk genotypes,DQ2 and DQ8,on CD were also *** who developed CD had higher IgG and IgA antigliadin and anti-beta-lactoglobulin antibody levels at 1 year of age than controls(all comparisons:p < 0.001) .Similar differences were seen between cases with as yet undiagnosed CD by 1 year of age and controls,and also when cases were compared with HLA-matched *** levels of IgG and IgA antibodies to beta-lactoglobu-lin(p = 0.003;p = 0.001) ,but not to gliadin,were found in treated cases versus controls at 2.5 years of ***-DQ2-positive healthy children had lower levels of IgG and IgA antigliadin antibodies than HLADQ2 negative controls at 1 year of age(p = 0.004;p = 0.012) .*** humoral response emerging not only to gliadin,but also to other food antigens seems to be primarily associated with *** induction of antibody response to wheat gliadin in healthy children with the HLA-DQ2 risk molecule could at least partly explain the genetic predisposition to gluten intolerance and CD.

关键词： HLA-DQ2 抗体形成乳糜泻谷蛋白体液免疫应答 β-乳球蛋白蛋白抗体组织学检查抗体反应

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