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A minor emphasis on the outbreak of cutaneous leishmaniasis after devastating earthquakes in Turkey

亚太热带医药杂志：英文版 2023年第3期16卷 97-98页

作者： ilknur nihal ardic Nurittin ardic SabuncuoğluŞerefeddin Training and Research Hospital Emergency ServiceAmasyaTurkey Viagen Genetic Center Tissue Typing LaboratoryAnkaraTurkey

Leishmaniasis is a serious parasitic disease caused by Leishmania species transmitted by the bite of sandflies. This disease is also an important public health problem. Clinical manifestations can be classified as cutaneous, mucocutaneous, and visceral leishmaniasis, depending on the species of parasite and the host’s immune status. Although the cutaneous form is not fatal, it often causes disfiguring scars on the skin[1].

关键词： earthquakes minor problem.

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Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1390-1395页

作者： Emine Cinici nihal Cetin Bahadir Suleyman Durdu Altuner Oguzhan Yarali Hilal Balta ilknur Calik Levent Tumkaya Halis Suleyman Department of Ophthalmology Erzurum Region Education and Research Hospital Department of Pharmacology Faculty of MedicineErzincan University Department of Medical Genetics Goztepe Training and Research HospitalIstanbul Medeniyet University Department of Pathology Erzurum Region Education and Research Hospital Department of Histology and Embryology Faculty of MedicineRecep Tayyip Erdogan University

AIM： To compare the effects of thiamine pyrophosphate（TPP） and thiamine（TM） in oxidative optic neuropathy in rats induced by ethambutol.METHODS： The animals were divided into four groups：a control group（CG）,an ethambutol control（ETC） group,TM plus ethambutol group（TMG）,and TPP plus ethambutol group（TPPG）.One hour after intraperitoneal administration of TM 20 mg/kg to the TMG group and TPP 20 mg/kg to TPPG group,30 mg/kg ethambutol was given via gavage to all the groups but the CG.This procedure was repeated once daily for 90 d.After that period,all rats were exposed to high levels of anaesthesia in order to investigate the gene expression of malondialdehyde and glutathione in removed optic nerve tissue and histopathologically to examine these tissues. RESULTS： Malondialdehyde gene expression significantly increased,whereas glutathione gene expression significantly decreased in the ETC group compared to the CG.TM could not prevent the increase of malondialdehyde gene expression and the decrease of glutathione,while TPP significantly could suppress.Histopathologically,significant vacuolization in the opticnerve,single-cell necrosis in the glial cells,and a decrease in oligodendrocytes were observed in the ETC group.Vacuolization in the optic nerve,a decrease in oligodendrocytes and single-cell necrosis were found in the TMG group,while no pathological finding was observed in the TPPG group except for mild vacuolization.CONCLUSION： TPP protects the optic nerve against the ethambutol-induced toxicity but TM does not.TPP can be beneficial in prophilaxis of optic neuropathy in ethambutol therapy.

关键词： ethambutol gene expression optic neuropathy rat thiamine pyrophosphate

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