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Nomograms for predicting pathological response to neoadjuvant treatments in patients with rectal cancer

World Journal of Gastroenterology 2019年第1期25卷 118-137页

作者： Dong-Lin Ren Juan Li Hui-Chuan Yu Shao-Yong Peng Wei-Da Lin Xiao-Lin Wang Roshan ara Ghoorun Yan-Xin Luo Department of Colorectal and Anal Surgery Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat-sen University Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat-sen University Department of Colorectal Surgery Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat-sen University

BACKGROUND In recent decades, neoadjuvant therapy(NT) has been the standardized treatment for locally advanced rectal cancer(LARC). Approximately 8%-35% of patients with LARC who received NT were reported to have achieved a complete pathological response(pCR). If the pathological response(PR) can be accurately predicted, these patients may not need surgery. In addition, no response after NT implies that the tumor is destructive, resistant to both chemotherapy and radiotherapy, and prone to having a high metastatic potential. Therefore,developing accurate models to predict PR has great clinical significance and can help achieve individualized treatment in LARC *** To establish nomograms for predicting PR to different NT regimens based on pretreatment parameters for patients with *** Rectal cancer patients were identified from the database of The Sixth Affiliated Hospital, Sun yat-sen University from January 2012 to December 2016. Logistic regression and nomograms were developed to predict the probability of pCR and good downstaging to ypT0-2N0M0(ypTNM 0-I), respectively, based on pretreatment parameters for all LARC patients. Nomograms were also developed for three NT regimens(capecitabine/deGramont-RT, mFOLFOX6, and m FOLFOX6-RT) to predict pCR *** Four hundred and three patients were included in this study; 72(17.9%) had pCR at the final pathology report, and 177(43.9%) achieved good downstaging to ypT0-2N0M0(ypTNM 0-I). The nomogram for predicting pCR probability showed that NT regimens, tumor differentiation, mesorectal fascia(MRF) status,and tumor length significantly influenced pCR probability. When predicting the probability of good downstaging, tumor differentiation, MRF status, and clinical T stage were the significant factors. Nomograms were developed based on NT regimens. For the capecitabine/de Gramont-RT group, the multivariate analysis showed that the neutrophil-lymphocyte ratio(NLR) was the only significant factor, thu

关键词： Neoadjuvant therapy Locally advanced rectal cancer Nomogram Prediction of pathological response Complete pathological response Good downstaging

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盆腔和肛周的增生性毛根鞘瘤与其他实体瘤相鉴别：一项临床病理学和放射学回顾性研究

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消化肿瘤杂志（电子版） 2019年第3期11卷 195-200页

作者： Roshan ara Ghoorun 刘智敏赵严冬熊斐饶雄辉任东林中山大学附属第六医院结直肠外科广东广州510275 中山大学附属第六医院病理科广东广州510275 中山大学附属第六医院放射科广东广州510275 中山大学附属第八医院胃肠外科广东深圳518033

目的盆腔增生性毛根鞘瘤(PTT)经常被误诊为其他疾病,导致多次手术,增加病人痛苦。在此,我们致力于探究PTT的临床病理表现和放射学特征以帮助诊断。方法本研究仅纳入2011年9月至2018年12月间诊断为PTT的患者,回顾了其病变的临床病理特点... 详细信息

目的盆腔增生性毛根鞘瘤(PTT)经常被误诊为其他疾病,导致多次手术,增加病人痛苦。在此,我们致力于探究PTT的临床病理表现和放射学特征以帮助诊断。方法本研究仅纳入2011年9月至2018年12月间诊断为PTT的患者,回顾了其病变的临床病理特点和磁共振资料。结果4位患者为良性PTT,4位患者为恶性PTT(MPTT)。病变通常潜伏数年,然后突然扩速发展。MPTT患者年龄偏小(P=0.12)。从MRI上看,良性PTT表现为实性囊肿,而MPTT表现为广泛的瘘道。纳入患者广泛局部切除术后,切缘阴性,且无局部复发或转移。从病理学来看,PTT表现为分叶状,无边缘浸润,可伴有毛鞘角化特点,而MPTT存在延伸到周围真皮的明显的非典型鳞状细胞,并伴有软骨基质反应。结论临床医生可根据肿块明显且突然的进行性生长特点考虑为PTT,并应根据病变形态判断病变是否恶变。广泛的局部切除可得到一个良好的效果。

关键词：增殖性毛根鞘瘤恶性增殖性毛根鞘瘤盆腔罕见实体瘤

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联合三氧化二砷序贯治疗急性早幼粒细胞白血病临床观察

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新医学 2004年第1期35卷 18-19页

作者：何易黄仁魏吴祥元林曲李旭东董敏林东军中山大学附属第三医院血液科 510630

目的:观察三氧化二砷(As2O3)序贯治疗急性早幼粒细胞白血病(acute promyelocvtic leuk-emia,APL,)的疗效。方法:8例初发APL患者经维A酸诱导缓解后,再予DA方案(柔红霉素、阿糖胞苷)、维A酸和As2O3序贯巩固强化治疗3年,观察持续缓解时问及... 详细信息

目的:观察三氧化二砷(As2O3)序贯治疗急性早幼粒细胞白血病(acute promyelocvtic leuk-emia,APL,)的疗效。方法:8例初发APL患者经维A酸诱导缓解后,再予DA方案(柔红霉素、阿糖胞苷)、维A酸和As2O3序贯巩固强化治疗3年,观察持续缓解时问及As2O3的不良反应。结果:8例中,7例随访4-42个月,1例失访。随访的7例均处于完全缓解中,中数缓解时间为17个月。随访超过24个月者3例,仍持续缓解,持续缓解时间最长者已达42个月。此疗法不良反应轻。结论:联合As2O3序贯治疗APL,疗效良好,有望延长APL患者的持续缓解时间及无病生存时间。

关键词：三氧化二砷序贯疗法联合治疗急性早幼粒细胞白血病维A酸

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原发性中枢神经系统淋巴瘤的影像学特点及治疗

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中国神经肿瘤杂志 2008年第3期6卷 202-206页

作者：刘巧丹谢传淼陈忠平夏忠军夏云飞华南肿瘤学国家重点实验室/中山大学肿瘤防治中心广东广州510060

原发性中枢神经系统淋巴瘤是一种比较罕见的结外原发非霍奇金淋巴瘤(NHL),其细胞来源多为弥漫大B淋巴细胞,淋巴细胞影像学表现为单发或多发的深部脑实质、脑室周围或脑膜等处的病变。其治疗尚无标准方案,目前多采用放化疗结合的综合治... 详细信息

原发性中枢神经系统淋巴瘤是一种比较罕见的结外原发非霍奇金淋巴瘤(NHL),其细胞来源多为弥漫大B淋巴细胞,淋巴细胞影像学表现为单发或多发的深部脑实质、脑室周围或脑膜等处的病变。其治疗尚无标准方案,目前多采用放化疗结合的综合治疗。化疗采用以大剂量MTX为主的方案,全脑放疗已被公认为治疗PCNSL的有效手段。但最佳的化疗方案组合、MTX最佳剂量及放疗剂量仍无定论。我们收治一例原发性中枢神经系统淋巴瘤,于外院行肿瘤切除术,术后予阿糖胞苷加大剂量MTX化疗6程后残留,现经多学科讨论后认为应予辅助放疗加替莫唑胺维持化疗。现患者已完成放疗,替莫唑胺维持化疗中。本文就此病例的影像特点及治疗进行讨论。

关键词：原发性中枢神经系统淋巴瘤影像学特点放射治疗化学治疗

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原发性中枢神经系统淋巴瘤临床治疗结果分析

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中国神经肿瘤杂志 2004年第1期2卷 5-8页

作者：黄慧强林旭滨李宇红夏中军蔡绮纯姜文奇中山大学肿瘤医院内科广东广州510060

原发性中枢神经系统淋巴瘤(PCNSL)是一种罕见的淋巴瘤,近数十年来发病率逐渐上升。由于部位特殊,现有淋巴瘤的预后因素和常规治疗方案不适用于PCNSL。PCNSL发病率低,目前尚无标准的预后因素和一线标准治疗方案,但随着临床治疗经验的不... 详细信息

原发性中枢神经系统淋巴瘤(PCNSL)是一种罕见的淋巴瘤,近数十年来发病率逐渐上升。由于部位特殊,现有淋巴瘤的预后因素和常规治疗方案不适用于PCNSL。PCNSL发病率低,目前尚无标准的预后因素和一线标准治疗方案,但随着临床治疗经验的不断积累,在治疗上已取得一定的共识,含大剂量MTX的全身化疗结合放疗使PCNSL中位生存期有较明显提高。本研究目的是了解PCNSL的临床特征和治疗结果,评价VM26/ara-C/HD-MTX方案加放疗治疗PCNSL的疗效与毒性,寻求有效简单的治疗方案。方法:回顾性分析1990～2003年我院13例PCNSL的临床资料。其中采用VM26/ara-C/HD-MTX加鞘注方案治疗5例***。结果:13例PCNSL,男性6例,女性7例,中位年龄47岁。病理类型83%为弥漫性B细胞性。1例单纯手术切除,12例综合治疗。中位随访15个月,死亡5例,尚未达到中位生存期。5例以VM26+HD-ara-C+HD-MTX加鞘内注射MTX+ara-C+DXM化疗,随后加全脑放疗,有效率100%,完全缓解(CR)率80%。Ⅲ-Ⅳ度血液学毒性占30%,感染占3%,未发现明显的神经毒性。结论:手术在PCNSL中起诊断作用,术后加化/放疗等综合治疗可延长生存期,VM26+HD-ara-C+HD-MTX方案近期疗效高,毒性可以接受,值得进一步研究。

关键词：原发性中枢神经系统淋巴瘤临床治疗 PCNSL 化学治疗放射疗法神经系统毒性氨甲蝶呤肿瘤

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原发性中枢神经系统淋巴瘤的高剂量MTX化疗加放疗——附17例临床疗效分析

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中国神经肿瘤杂志 2004年第2期2卷 92-95页

作者：刘秀芳夏云飞黄慧强林旭滨张玉晶李勇中山大学肿瘤防治中心放疗科广东广州510060 中山大学肿瘤防治中心内科广东广州510060 中山大学肿瘤防治中心内科广东广州510060

背景和目的:原发性中枢神经系统淋巴瘤(Primary central nervous system lymphoma,PCNSL)是一种罕见的原发并局限于脑和脊髓的非霍奇金氏淋巴瘤,治疗上主要采用高剂量MTX(HD-MTX)为主的化疗及放射治疗。本文探讨HD-MTX为主的化疗及放疗... 详细信息

背景和目的:原发性中枢神经系统淋巴瘤(Primary central nervous system lymphoma,PCNSL)是一种罕见的原发并局限于脑和脊髓的非霍奇金氏淋巴瘤,治疗上主要采用高剂量MTX(HD-MTX)为主的化疗及放射治疗。本文探讨HD-MTX为主的化疗及放疗对PCNSL的疗效及毒性。方法:回顾性分析1991～2004年间我院收治的17例PCNSL患者的临床资料。其中,单纯CHOP方案化疗2例,含HD-MTX方案化疗12例,MTX/ara-C/DXM鞘内注射9例。13例患者接受放射治疗。其中,单纯全脑放疗2例,全脑+局部缩野照射8例,全中枢放疗2例;侵犯野照射1例。结果:随访时间最长120个月,中位随访时间24个月。死亡4例,2例死于肿瘤进展,1例死于复发,1例死于放化疗后感染。结论:含HD-MTX为主的化疗联合全脑照射是PCNSL治疗的主要模式,治疗毒性可以耐受。放疗在PCNSL治疗中的地位有待进一步研究。

关键词：原发性中枢神经系统淋巴瘤高剂量 MTX 化疗放疗

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Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study

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Portal Hypertension & Cirrhosis 2022年第1期1卷 7-14页

作者： Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineZhejiang Clinical Research Center of Hepatobiliary and Pancreatic DiseasesZhejiang Provincial Research Center for Diagnosis and Treatment of Heapatobiliary DiseasesZhejiang University Cancer CenterHangzhouZhejiangChina Department of Interventional Therapy National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Institute of Portal Hypertension Department of General SurgeryThe First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Anesthesiology and Operating Theater The First Hospital of Lanzhou UniversityLanzhouGansuChina Interventional Radiology Department The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Gastroenterology Ankara University School of MedicineAnkaraTurkey Department of Internal Medicine Istanbul Health and Technology University Medical SchoolIstanbulTurkey Department of General Surgery Key Laboratory of Biotherapy and Regenerative Medicine of Gansu ProvinceThe First Hospital of Lanzhou UniversityLanzhouGansuChina Nursing Department The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of General Surgery Donggang BranchFirst Hospital of Lanzhou UniversityLanzhouGansuChina The Diagnosis and Treatment Center of Endoscopy and Interventional Radiology Department of General SurgeryDonggang BranchFirst Hospital of Lanzhou UniversityLanzhouGansuChina Department of Interventional Radiology Lishui Central HospitalLishuiZhejiangChina Department of Hepatology and Gastroenterology of The Third Central Hospital of Tianjin TianjinChina Department of Radiology of The Third Central Hospital of Tianjin TianjinChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Hepatobiliar

Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver ***:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June *** related to the tolerance and acceptance of HVPG measurements were collected using descriptive ***:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement *** complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG *** these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,*** patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as ***:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure.

关键词： design hypertension multicenter study portal pressure prospective study questionnaire wedge

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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