检索结果-南通市图书馆

Economic evaluation of the hepatitis C elimination strategy in Greece in the era of affordable direct-acting antivirals

引用

World Journal of Gastroenterology 2019年第11期25卷 1327-1340页

作者： ilias gountas Vana Sypsa George Papatheodoridis Kyriakos Souliotis Kostas Athanasakis Homie Razavi Angelos Hatzakis Department of Hygiene Epidemiology and Medical StatisticsMedical SchoolNational and Kapodistrian University of Athens Hellenic Scientific Society for the Study of AIDS and Sexually Transmitted Diseases Department of Gastroenterology Medical SchoolNational and Kapodistrian University of AthensLaiko General Hospital Faculty of Social and Political Sciences University of Peloponnese Department of Health Economics National School of Public Health Center for Disease Analysis

BACKGROUND Hepatitis C virus(HCV) is a leading cause of worldwide liver-related morbidity and mortality. The World Health Organization released an integrated strategy targeting HCV-elimination by 2030. This study aims to estimate the required interventions to achieve elimination using updated information for direct-acting antiviral(DAA) treatment coverage, to compute the total costs(including indirect/societal costs) of the strategy and to identify whether the elimination strategy is cost-effective/cost-saving in *** To estimate the required interventions and subsequent costs to achieve HCV elimination in *** A previously validated mathematical model was adapted to the Greek HCVinfected population to compare the outcomes of DAA treatment without the additional implementation of awareness or screening campaigns versus an HCV elimination strategy, which includes a sufficient number of treated patients. We estimated the total costs(direct and indirect costs), the disability-adjusted life years and the incremental cost-effectiveness ratio using two different price *** Without the implementation of awareness or screening campaigns,approximately 20000 patients would be diagnosed and treated with DAAs by2030. This strategy would result in a 19.6% increase in HCV-related mortality in2030 compared to 2015. To achieve the elimination goal, 90000 patients need to be treated by 2030. Under the elimination scenario, viremic cases would decrease by78.8% in 2030 compared to 2015. The cumulative direct costs to eliminate the disease would range from 2.1-2.3 billion euros(€) by 2030, while the indirect costs would be €1.1 billion. The total elimination cost in Greece would range from €3.2-3.4 billion by 2030. The cost per averted disability-adjusted life year is estimated between €10100 and €13380, indicating that the elimination strategy is very costeffective. Furthermore, HCV elimination strategy would save €560-895 million *** Without

关键词： Hepatitis C elimination Cost effectiveness Cost of elimination Indirect costs Projections Mathematical modelling Awareness and screening programs World Health Organization targets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Planning the hepatitis C virus elimination in Cyprus:A modeling study

引用

World Journal of Gastroenterology 2021年第31期27卷 5219-5231页

作者： ilias gountas Ioanna Yiasemi Evi Kyprianou Christos Mina Chrysanthos Georgiou Petros Katsioloudes Andri Kouroufexi Anna Demetriou Elena Xenofontos Georgios Nikolopoulos Medical School University of CyprusNicosia 1678Cyprus Cyprus Monitoring Centre Cyprus National Addictions AuthorityNicosia 1678Cyprus Nicosia General Hospital Nicosia 1678Cyprus Evangelistria Medical Centre Nicosia 1678Cyprus Ministry of Health Pharmaceutical ServicesNicosia 1678Cyprus Ministry of Health Health Monitoring UnitNicosia 1678Cyprus Department of Internal Medicine Limassol General HospitalLimassol 4131Cyprus

BACKGROUND Hepatitis C virus(HCV)infection is a major global public health *** the Republic of Cyprus,the estimated prevalence of chronic hepatitis C(CHC)among the general population is 0.6%,while the CHC prevalence among people who inject drugs(PWID)is estimated at 46%.Direct-acting antivirals that can eliminate HCV are not yet widely available in the Republic of ***,when direct-acting antivirals become available,a long-term strategic plan to guide elimination efforts will be needed to maximize the effect of *** To determine the programmatic targets to eliminate HCV in the Republic of *** A dynamic,stochastic,individual-based model of HCV transmission,disease progression,and cascade of care was calibrated to data from *** model stratifies the population into the infected general population and the PWID population.A variety of test,prevention,and treatment strategies concerning the general population,PWID,or both were *** time horizon of the analysis was until *** Under the status quo scenario,the model predicted that 75(95%confidence interval(CI):60,91)and 575(95%CI:535,615)liver-related deaths and new infections would occur by 2034,*** an expanded treatment program,without screening interventions,would cause modest outcomes regarding CHC prevalence(16.6%reduction in 2034 compared to 2020)and liverrelated deaths(10 deaths would be prevented compared to the status quo scenario by 2034).Implementing a test and treat strategy among the general population but without any intervention in the PWID population would suffice to meet the mortality target but not the incidence *** achieve HCV elimination in Cyprus,3080(95%CI:3000,3200)HCV patients need to be diagnosed and treated by 2034(2680 from the general population and 400 from PWID),and harm reduction coverage among PWID should be increased by 3%per year(from 25%in 2020 to 67%in 2034).CONCLUSION Elimination of HCV is a demanding pub

关键词： Mathematical modelling Projections Hepatitis C virus elimination Directacting antivirals Screening campaigns

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：