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Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype

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Asian Journal of Andrology 2007年第1期9卷 108-115页

作者： Birsen Aydemir ilhan onaran Ali R. Kiziler Bulent Alici Mehmet C. Akyolcu Department of Biophysics Cerrahpasa Medical Faculty lstanbul University lstanbul 34098 Turkey Department of Medical Biology Cerrahpasa Medical Faculty lstanbul University lstanbul 34098 Turkey Department of Urology Cerrahpasa Medical Faculty lstanbul University lstanbul 34098 Turkey

Aim： To examine whether a relationship exists between glutathione S-transferase Mu-1 （GSTM1） gene polymorphism and the susceptibility of sperm and seminal plasma from patients with idiopathic infertility to oxidative stress. Methods： Fifty-two men with idiopathic infertility and 60 healthy fertile men were recruited to this study. GSTM1 gene polymorphism was determined by polymerase chain reaction （PCR） and both the infertile and control individuals were divided into GSTM1 null and GSTM1 positive groups according to their GSTM1 gene structure. We compared reactive oxygen species （ROS） generation, malondialdehyde （MDA）, protein carbonyls and glutathione （GSH） concentrations, and glutathione S-transferase （GST） activity in seminal plasma and spermatozoa from infertile patients and controls with respect to GSTM1 genotype. Results： Significantly higher levels of oxidative stress and damage markers were found in idiopathic infertile men with the GSTM1 null genotype compared with those with the GSTM1 positive genotype. There was no significant difference in genotype distribution for theGSTM1 variant between the idiopathic infertile subjects and fertile subjects. Patients with the GSTM1 null genotype also had lower sperm concentrations than those with GSTM1 positive genotype. Conclusion： Our results suggest that the susceptibility of sperm and seminal plasma to oxidative stress is significantly greater in idiopathic infertile men with the GSTM1 null genotype compared with those possessing the gene. Therefore, in patients with idiopathic infertility, GSTM1 polymorphism might be an important source of variation in susceptibility of spermatozoa to oxidative damage.

关键词： idiopathic infertility glutathione S-transferase Mu-1 GSTM1 polymorphism semen sperm oxidative stress

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Influence of CrN Coating on Electrochemical Behavior of Plasma Nitrided Pure Titanium in Bio-simulated Environment

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Journal of Bionic Engineering 2016年第1期13卷 150-155页

作者： ilhan Celik Department of Mechanical Engineering Gumushane University Gumushane 29100 Turkey

Titanium and its alloys are widely used as materials for bio-medical applications, such as implants. However, ions of the alloy can release to the body region and spread into the blood circulation. In this study, plasma nitriding and CrN coating techniques are used in order to overcome the problem of ion release. The objective of this study was to investigate the effects of plasma nitrided pure titanium on the structural properties and corrosion behaviors before and after CrN coating in Ringer＇s solution at 37℃. The structural properties were investigated using Scanning Electron Microscopy （SEM） and X-ray diffraction （XRD）. A diffusion layer and a compound layer composed of δ-TiN and ε-Ti2N phases were observed on the surface of nitrided pure titanium. Corrosion tests were made for the determination of electrochemical properties with the help of Potentio- stat/Galvanostat device. The results show that corrosion behaviors of untreated and treated samples have similar characteristic.

关键词： titanium corrosion CrN coating plasma nitriding duplex treatment

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Investigating the implications of technological innovations,financial inclusion,and renewable energy in diminishing ecological footprints levels in emerging economies

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Geoscience Frontiers 2023年第6期14卷 341-357页

作者： Najia Saqib ilhan Ozturk Muhammad Usman Department of Finance College of Business AdministrationPrince Sultan UniversityRiyadhSaudi Arabia College of Business Administration University of SharjahSharjahUAE Faculty of Economics Administrative and Social SciencesNisantasi UniversityIstanbulTurkey School of Economics and Management and Center for Industrial EconomicsWuhan UniversityWuhan430072China

The correlation between technological innovation,economic growth,renewable energy,and ecological footprint carries significant policy implications for environmental ***,financial inclusion can drastically affect the technology-climate nexus across different countries and its moderating impacts have received sufficient *** do this,this study examined how technological innovation,financial inclusion,economic growth,and renewable energy affected emerging economies’ecological footprint from 1990 to ***,this study also scrutinizes the moderating role of financial inclusion with other regressors on ecological *** account for structural shifts,disguised cointegration,and numerous breaks in panel regression,this study applies advanced panel estimation methods for empirical *** estimated outcomes exhibit that the influence of technical innovation,climate technologies,and renewable energy significantly reduces the ecological footprint ***,economic growth and financial inclusion significantly increase the ecological footprint levels in the emerging ***,the integration of innovative technology and renewable energy in emerging countries mitigates the adverse effects of financial inclusion by making it easier for creative technologies and reducing ecological *** results show that emerging countries’innovative technology and renewable energy sources should be integrated with financial inclusion to enable longterm mitigation of environmental damages and sustainable *** on these estimated findings,the research recommends that emerging economies should hasten technological innovations along with stronger financial development to curtail ecological concerns without hindering the pace of sustainable economic growth.

关键词： Environmental-related technology Financial inclusion Renewable energy Ecological footprints Emerging countries

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Dual Control Strategy for Grid-tied Battery Energy Storage Systems to Comply with Emerging Grid Codes and Fault Ride Through Requirements

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 977-988页

作者： Maxime Berger ilhan Kocar Evangelos Farantatos Aboutaleb Haddadi Department of Electrical Engineering Polytechnique MontréalMontréalCanada Electric Power Research Institute(EPRI) Palo AltoUSA

Battery energy storage systems(BESSs)need to comply with grid code and fault ride through(FRT)requirements during disturbances whether they are in charging or discharging *** literature has shown that constant charging current control of BESSs in charging mode can prevent BESSs from complying with emerging grid codes such as the German grid code under stringent unbalanced fault *** address this challenge,this paper proposes a new FRTactivated dual control strategy that consists of switching from constant battery current control to constant DC-link voltage control through a positive droop *** results show that the strategy ensures proper DC-link voltage and current management as well as adequate control of the positive-and negative-sequence active and reactive currents according to the grid code *** is also shown that the proposed FRT control strategy is tolerant to initial operating conditions of BESS plant,grid code requirements,and fault severity.

关键词： Battery energy storage system inverter-based resource fault ride through electromagnetic transient

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Analysis of EST-SSRs in silver birch(Betula pendula Roth.)

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Journal of Forestry Research 2016年第3期27卷 639-646页

作者： Ertugrul Filiz ilhan Dogan Ibrahim Ilker Ozyigit Department of Crop and Animal Production Cilimli Vocational SchoolDuzce University Department of Molecular Biology and Genetics Izmir Institute of Technology Department of Biology Faculty of ScienceRahatlayadururken Manas University Department of Biology Faculty of Science and ArtsMarmara University

Simple sequence repeats（SSRs） defined as sequence repeat units between 1 and 6 bp occur abundantly in both coding and non-coding regions in eukaryotic genomes and these repeats can affect gene expression. In this study, ESTs（expressed sequence tags） of Betula pendula（silver birch） were analyzed for in silico mining of ESTSSRs, protein annotation, open reading frames（ORFs）,designing primers, and identifying codon repetitions. In ***, the frequency of ESTs containing SSRs was 7.8 %with an average of 1SSR/4. 78 kb of EST sequences. A total of 188 SSRs was identified by using MISA software and dinucleotide SSR motifs（65.9 %） were found to be the most abundant type of repeat motif followed by tri-（27.1 %）,tetra-（4.8 %）, and penta-（2.2 %） motifs. Based on ORF analysis, 175 of 178 sequences were predicted as ORFs and the most frequent SSRs were detected in 50 UTR（58.43 %）,followed by in ORF（31.46 %） and in 30UTR（8.43 %）. 102 of 178 ESTs were annotated as ribosomal protein, transport protein, membrane protein, carrier protein, binding protein,and transferase protein. For a total of 102 SSRs（57.3 %）with significant matches, a set of 102 primers（100 %） with forward and reverse strands was designed by using Primer 3 software. Serine（Ser, 19.6 %） was predominant in putative encoded amino acids and most of amino acids showed nonpolar（35.3 %） nature. Our data provide resources for *** and can be useful for in silico comparative analyses of Betulaceae species, including SSR mining.

关键词： Silver birch (Betula pendula) Betulaceae -EST-SSR SSR mining In silico analysis

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Synthesis and spectral studies of macrocyclic Pb(Ⅱ),Zn(Ⅱ),Cd(Ⅱ)and La(Ⅲ) complexes derived from 1,4-bis(3-aminopropoxy)butane with metal nitrate and salicylaldehyde derivatives

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Chinese Chemical Letters 2009年第3期20卷 339-343页

作者： Salih ilhan Hamdi Temel Salih Pasa Department of Chemistry Faculty of Art and SciencesSiirt UniversitySiirtTurkey Department of Chemistry Faculty of EducationDicle UniversityDiyarbakirTurkey

Eight new macrocyclic complexes were synthesized by template reaction of 1,4-bis（3-aminopropoxy）butane with metal nitrate and 1,3-bis（2-formylphenyl）propane or 1,4-bis（2-formylphenyl）butane and their structures were proposed on the basis of elemental analysis, FTIR, UV-vis, molar conductivity measurements, ^1H NMR and mass spectra. The metals to ligand molar ratios of the complexes were found to be 1： 1. The complexes are 1：2 electrolytes for Pb（II）, Zn（II） and Cd（II） complexes and 1：3 electrolytes for La（III） as shown by their molar conductivities （Am） in DMSO at 10^-3 mol L^-1. Due to the existence of free ions in these complexes, such complexes are electrically conductive. The configurations of La（III） and Pb（II） were proposed to probably octahedral and Zn（II） and Cd（II） complexes were proposed to probably tetrahedral.

关键词： Macrocyclic Schiff base Macrocyclic complexes Salicylaldehyde derivatives 1,4-Bis(3-aminopropoxy)butane

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Qualitative behavior of discrete-time Caputo-Fabrizio logistic model with Allee effect

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International Journal of Biomathematics 2024年第4期17卷 217-234页

作者： Hatice Karakaya Senol Kartal ilhan Oztirk Department of Mathematics Faculty of Science Erciyes UniversityKayseriTurkey Department of Science and Mathematics Education Faculty of Education Nevsehir Haci Bektas Veli University NevsehirTurkey Kapadokya University NevsehirTurkey

The aim of this paper is to investigate the dynamic behaviors of fractional-order logistic model with Allee effects in Caputo-Fabrizio *** of all,we apply the two-step Adams-Bashforth scheme to discretize the fractional-order logistic differential equation and obtain the two-dimensional discrete *** parametric conditions for local asymptotic stability of equilibrium points are obtained by Schur-Chon ***,we discuss the existence and direction for Neimark-Sacker bifurcations with the help of center manifold theorem and bifurcation *** simulations are provided to illustrate theoretical *** is observed that Allee effect plays an important role in stability *** Allee effect in population enhances the stability of the coexisting steady *** additional,the effect of fractional-order derivative on dynamic behavior of the system is also investigated.

关键词： Caputo-Fabrizio fractional derivative two-step Adams-Basforth method logistic differential equation Neimark-Sacker bifurcation Allee effect

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Large-signal modeling of three-phase dual active bridge converters for electromagnetic transient analysis in DC grids

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Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1684-1696页

作者： Maxime BERGER ilhan KOCAR Handy FORTIN-BLANCHETTE Carl LAVERTU Polytechnique Montreal MontrealCanada Bombardier Transportation St-Bruno-de-MontarvilleCanada Ecole de Technologie Superieure MontrealCanada

The three-phase dual active bridge(3 p-DAB)converter is widely considered in next-generation DC grid *** for traditional AC grids,the successful integration of power electronic converters in DC grids requires accurate time-domain system-level *** demonstrated in the existing literature,the development and efficient implementation of large-signal models of 3 pDAB converters are not *** this paper,a generalized average model is developed,which enables system-level simulation of DC grids with 3 p-DAB converters in electromagnetic transient type(EMT-type)*** proposed model is rigorously compared with alternative modeling techniques:ideal-model,switching-function and state-space *** is concluded that the generalized average model provides an optimal solution when accuracy of transient response,reduction in computation time,and wideband response factors are considered.

关键词： Three-phase dual active bridge(3p-DAB) Generalized averaging Large-signal analysis Electromagnetic transient DC–DC conversion

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Atherosclerosis and the role of immune cells

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World Journal of Clinical Cases 2015年第4期3卷 345-352页

作者： Fulya ilhan Sevgi Tas Kalkanli Department of Immunology Faculty of Medicine University of Firat Department of Immunology Faculty of Medicine University of Dicle

Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon(IFN)-α and β are generated upon the activation of tolllike receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immunecells in the atherosclerosis.

关键词： Atherosclerosis Inflammatory cytokines Pro-inflammatory mediators Immune cells Adhesion molecules

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An empirical investigation of financial development and ecological footprint in South Asia:Bridging the EKC and pollution haven hypotheses

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Geoscience Frontiers 2024年第4期15卷 427-436页

作者： ilhan Ozturk Sohail Farooq Muhammad Tariq Majeed Marinko Skare College of Business Administration University of SharjahSharjahUnited Arab Emirates Faculty of Economics Administrative and Social SciencesNisantasi UniversityIstanbulTurkey Hazara University Mansehra Pakistan School of Economics Quaid-i-Azam UniversityIslamabadPakistan Faculty of Economics and Tourism“Dr.Mijo Mirkovic ”Juraj Dobrila University of PulaPulaCroatia University of Economics and Human Sciences in Warsaw Poland

This research explores the dynamic relationships between ecological footprint,economic performance,financial development,energy usage,and foreign direct investment(FDI)in South Asian economies utilizing the panel data from 1971 to *** panel data analysis,conventional methods generally ignore the issues of cross-sectional dependency and the heterogenous nature of cross-sectional *** other concern with the existing research is that most of the studies ignore the significance of ecological footprint while evaluating financial development and FDI as sources of environmental *** longterm relationship among the indicators is tested utilizing the Westerlund cointegration *** findings support both environmental Kuznets curve and pollution haven hypotheses for South Asian ***,the empirical findings suggest that financial development increases environmental conservation while energy usage substantially disrupts the environment of the selected south Asian ***,the heterogeneous causality analysis reveals the causal relationships between the ***,overall results recommend that the South Asian economies need to boost economic growth without compromising the environment,decrease fossil fuel usage,enhance financial sector growth and incentivize environmentally friendly FDI to conserve the environment in the region.

关键词： Energy consumption Financial development Ecological footprint FDI South Asia

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