检索结果-南通市图书馆

Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2018年第2期34卷 312-320页

作者： Sugai Liang Roberto vega Xiangzhen Kong Wei Deng Qiang Wang Xiaohong Ma Mingli Li Xun Hu Andrew J.Greenshaw Russell Greiner Tao Li Mental Health Centre West China Hospital Sichuan University Huaxi Brain Research Centre West China Hospital Sichuan University Department of Computing Science University of Alberta Language and Genetics Department Max Planck Institute for Psycholinguistics Huaxi Biobank West China Hospital Sichuan University Department of Psychiatry University of Alberta

Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder(MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia(FES), 125 with MDD, and 237 demographically-matched healthy controls(HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests. The graphical LASSO model was trained with aone-vs-one scenario to learn the conditional independent structure of neurocognitive features of each group. Participants in the holdout dataset were classified into different groups with the highest likelihood. A partial correlation matrix was transformed from the graphical model to further explore the neurocognitive graph for each group. The classification approach identified the diagnostic class for individuals with an average accuracy of 73.41% for FES vs HC, 67.07% for MDD vs HC, and 59.48% for FES vs MDD. Both of the neurocognitive graphs for FES and MDD had more connections and higher node centrality than those for HC. The neurocognitive graph for FES was less sparse and had more connections than that for ***, neurocognitive graphs based on cognitive features are promising for describing endophenotypes that may discriminate schizophrenia from depression.

关键词： Schizophrenia Major depressive disorder Neurocognition Neurocognitive graph Graphical LASSO

Increase of Lignin Reactivity by Means of Depolymerization and Hydroxymethylation for Its Use in Synthetic Wood Elaboration

在线全文

学校读者我要写书评

暂无评论

Journal of Chemistry and Chemical Engineering 2012年第2期6卷 124-137页

作者： Alvaro Jimenez Marco vega Bibiana Gordillo Department of Chemistry Science and Education Faculty University Distrital Francisco Jose of Caldas Bogota 111931 Colombia

Lignin was extracted from peat by Sosa Method. In order to increase its chemical activity, it is necessary to make a structural modification by hydroxymethylation so it can be used in preparation of synthetic wood. Depolymerization was made by two methods：（1） reaction oflignin with NaOH 2%; （2） exposition oflignin to UV beam for 6, 12, 24, 36, 48 and 60 hours. The best depolimerization result was with exposition of lignin to UV by 12 hours since phenylpropanoic structure with higher number of free positions （unoccupied carbons） in C3 and C5 of its aromatic ring was obtained. It is known by Mannich Reaction and determination of phenolic OH by UV analysis. Later, its reactivity was increased by hydroxymethylation process by means of reaction of depolymerizated product with formaldehyde and later with glyoxal since it is less toxic. The modified product was mixed with six different kinds of resins （phenol-formaldehyde, urea-formaldehyde, melamine-formaldehyde, Glyoxal-formaldehyde, urea-formaldehyde and melamine-formaldehyde） to obtain a better mechanical characteristic as a synthetic wood. The best result was the one with melamine-formaldehyde. Finally, this product was mixed with testa rice so final product showed a great hardness and a shinny and smooth appearance.

关键词： Depolymerization hydroxymethylation lignin peat.

Fungal endophytes in green coffee seeds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

菌物学报 2008年第1期27卷 75-84页

作者： Femando E. vega Francisco POSADA M. Catherine AIME Stephen W. PETERSON Stephen A. REHNER Sustainable Perennial Crops Laboratory U. S. Department of Agriculture Agricultural Research Service Building 011A BARC-W Beltsville Maryland 20705 USA Centro Nacional de lnvestigaciones de Cafe CENICAFE Chinchina Caldas Colombia Department of Plant Pathology and Crop Physiology Louisiana State University AgCenter 302 Life Sciences Bldg. Baton Rouge LA 70803 USA Microbial Genomics and Bioprocessing Research Unit National Center for Agricultural Utilization Research U. S. Department of Agriculture Agricultural Research Service 1815 N. University St. Peoria IL 61604 USA Systematic Mycology and Microbiology Laboratory U. S. Department of Agriculture Agricultural Research Service Building 011A BARC-W Beltsville Maryland20705 USA

Green coffee seeds from Colombia, Guatemala, India, Kenya, Papua New Guinea, Puerto Rico and Vietnam were sampled for the presence of fungal endophytes. Stions of surface sterilized seeds were plated on yeast malt agar, and fungal growth was isolated for subsequent DNA extraction and sequencing. Several fungal genera were isolated, including Acremonium, Aspergillus, Eurotium, Fusarium, Gibberella, Penicillium, Pseudozyma and an undescribed clavicipitaceous species. The biological activities that these fungi might be playing in coffee seeds remain unknown, but in other plants some of the genera isolated have been reported to protect against plant pathogens.

关键词：咖啡种子内生真菌新记录

Irbesartan desmotropes:Solid-state characterization,thermodynamic study and dissolution properties

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2019年第5期9卷 339-346页

作者： Andrea Mariela Araya-Sibaja Carlos Eduardo Maduro de Campos Cinira Fandaruff Jose Roberto vega-Baudrit Teodolito Guillen-Giron Mirtha Navarro-Hoyos Silvia Lucía Cuffini Laboratorio Nacional de Nanotecnología LANOTEC-CeNAT-CONARE 1174-1200 Pavas San Jose Costa Rica Escuela de Ciencia e Ingeniería de los Materiales Tecnologico de Costa Rica Cartago 159-7050 Costa Rica Escuela de Química Universidad de Costa Rica San Pedro de Montes de Oca 2060 San Jose Costa Rica Programa de Pos-Graduacao em Física Universidade Federal de Santa Catarina Florianopolis Brazil Independent Researcher 06472-005 Barueri Sao Paulo Brazil Laboratorio de Investigacion y Tecnología de Polímeros POLIUNA Escuela de Química Universidad Nacional de Costa Rica Heredia 86-3000 Costa Rica Instituto de Ciencia e Tecnica Universidade Federal de Sao Paulo Sao Jose dos Campos Sao Paulo Brazil

Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2H-tautomer). Studies have reported that IBS is a polymorphic system and its forms A and B are related monotropically. These reports indicate form B as the most stable and less soluble form. Therefore, the goal of this contribution is to demonstrate through a complete solid-state characterization, thermodynamic study and dissolution properties that the IBS forms are desmotropes that are not related monotropically. However, the intention is also to call attention to the importance of conducting strict chemical and in solid-state quality controls on the IBS raw materials. Hence, powder X-ray diffraction (PXRD) and Raman spectroscopy (RS) at ambient and non-ambient conditions, differential scanning calorimetry (DSC), hot stage microscopy (HSM), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM) techniques were applied. Furthermore, intrinsic dissolution rate (IDR) and structural stability studies at 98% relative humidity (RH), 25℃ and 40 ℃ were conducted as well. The results show that in fact, form A is approximately four-fold more soluble than form B. In addition, both IBS forms are stable at ambient conditions. Nevertheless, structural and/or chemical instability was observed in form B at 40℃ and 98% RH. IBS has been confirmed as a desmotropic system rather than a polymorphic one. Consequently, forms A and B are not related monotropically.

关键词： Irbesartan Solid-state characterization Intrinsic dissolution rate Tautomerism Desmotropic forms

双峰分布颗粒体系的多角度动态光散射数据反演（英文）

在线全文

学校读者我要写书评

暂无评论

光子学报 2017年第2期46卷 121-132页

作者：徐敏申晋朱新军 THOMAS John C CLEMENTI Luis A vega Jorge R 山东理工大学电气与电子工程学院山东淄博255049 天津工业大学电气工程与自动化学院天津300387 Group Scientific Pty Ltd 23 Pine Lodge Crescent Institute of Technological Development for the Chemical Industry(INTEC UNL-CONICET)

采用多角度动态光散射和加权正则化反演方法,对4组模拟的双峰分布颗粒体系(100/600nm,200/600nm,300/600nm和350/600nm)分别选取1、3、6和10个散射角进行测量.粒度反演结果表明,采用加权正则化方法反演双峰颗粒体系的多角度动态光散射... 详细信息

采用多角度动态光散射和加权正则化反演方法,对4组模拟的双峰分布颗粒体系(100/600nm,200/600nm,300/600nm和350/600nm)分别选取1、3、6和10个散射角进行测量.粒度反演结果表明,采用加权正则化方法反演双峰颗粒体系的多角度动态光散射测量数据,可获得峰值位置比小于2∶1且含有大粒径(>350nm)颗粒的双峰颗粒粒度分布.采用标准聚苯乙烯乳胶颗粒进行实测的结果验证了这一结论.得到含大粒径颗粒的双峰粒度分布反演结果的原因在于,多角度动态光散射能提供更多的大粒径颗粒的粒度信息,加权正则化反演方法能减少测量数据中的噪声,因而多角度动态光散射测量数据的加权反演能实现峰值位置比小于2∶1且含有大粒径颗粒的双峰颗粒体系的测量.

关键词：动态光散射粒度分布加权约束正则化峰值位置比吉洪诺夫正则化

Basal Cell Carcinoma at Pediatric Age Gorlin-Goltz Syndrome Clinic Experience

在线全文

学校读者我要写书评

暂无评论

Journal of Life Sciences 2017年第4期11卷 185-190页

作者： Gonzalez Mufioz A. A Naveira Arrastia L Sotto Rodriguez S. I vega Gonzalez J. M. vega Gonzalez j. vega Gonzalez J. A. Pediatrics Health Care Center San Benito (Canary lslands Health Service (SCS) Santa Cruz de Tenerife 38200 Spain Family and Community Medicine (Institute of Legal Medicine S/C Tenerife) Santa Cruz de Tenerife 38320 Spain Family and Community Medicine Health Care Center Tacoronte (Canary Islands Health Service (SCS) Santa Cruz de Tenerife38350 Spain Legal Medicine and Forensic (Institute of Legal Medicine S/C Tenerife) Santa Cruz de Tenerife 38320 Spain Nurseat La laguna University Santa Cruz de Tenerife 383200 Spain University of Lleida Lleida 25001 Spain

The nevoid basal cell carcinoma syndrome is an autosomal dominant inherited disease, associated with PTCH gene mutation. Its presentation is polymorphous, being frequent to appear the clinical triad carcinomas basal cell, odontogenic cysts and skeletal abnormalities. Skin lesions are a very frequent reason for consultation in the paediatric age, being evaluated in most cases in primary care. Sometimes, patients need the intervention of other specialists to deep in a given area. The medical literature shows a fragmented view of the disease, possibly related to the low frequency of appearance of this syndrome, and by the need for intervention of not transversal knowledge specialist, which is why we feel interesting to evaluate the role of specialist who is developing the activity at primary care, with patients who require a multidisciplinary intervention.

关键词： Gorlin-Goltz syndrome basal cell carcinomas pediatric age.

Same day discharge after structural heart disease interventions in the era of the coronavirus-19 pandemic and beyond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2022年第5期14卷 271-281页

作者： Abdulaziz A Asbeutah Muhammad Junaid Fatima Hassan Jesus Avila vega Nephertiti Efeovbokhan Rami N Khouzam Uzoma N Ibebuogu Internal Medicine University of Tennessee Health Science CenterMemphisTN 38013United States Internal Medicine Forrest City Medical CenterForrest CityAR 72335United States Department of Cardiology NEA Baptist clinicJonesboroAR 72401United States Department of Medicine The University of Tennessee Health Science CenterMemphisTN 38104United States Department of Cardiology University of Tennessee Health Science CenterMemphisTN 38103United States

With recent advancements in imaging modalities and techniques and increased recognition of the long-term impact of several structural heart disease interventions,the number of procedures has significantly *** the increase in procedures,also comes an increase in *** view of this,efficient and cost-effective methods to facilitate and manage structural heart disease interventions are a ***-day discharge(SDD)after invasive cardiac procedures improves resource utilization and patient *** in appropriately selected patients has become the standard of care for some invasive cardiac procedures such as percutaneous coronary *** is not the case for the majority of structural heart *** the coronavirus disease 2019 pandemic,safely reducing the duration of time spent within the hospital to prevent unnecessary exposure to pathogens has become a *** light of this,it is prudent to assess the feasibility of SDD in several structural heart *** this review we highlight the feasibility of SDD in a carefully selected population,by reviewing and summarizing studies on SDD among patients undergoing left atrial appendage occlusion,patent foramen ovale/atrial septal defect closure,Mitra-clip,and trans-catheter aortic valve replacement procedures.

关键词： Mitra-clip Transcatheter aortic valve replacement Same-day discharge Atrial septal defect Coronavirus

Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第3期13卷 329-340页

作者： Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-vega M Isabel Lucena Liver Unit Gastroenterology Service "Virgen de la Victoria" University Hospital and School of Medicine Mlaga Spain Clinical Pharmacology Service "Virgen de la Victoria" University Hospital and School of Medicine Mlaga Spain

Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected.

关键词： Drug-induced hepatotoxicity Causality assessment Diagnostic algorithms Clinical scales

Micro,Meso and Macro Porous Materials on Medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomaterials and Nanobiotechnology 2015年第4期6卷 247-256页

作者： Victor Solano-Umana Jose Roberto vega-Baudrit Environmental Management Master Degree Senior Chemist Hologic Surgical ProductsDOCINADE Science PhD StudentSan JoseCosta Rica PhD National Nanotechnology Laboratory(LANOTEC-CeNAT-CONARE)San JoseCosta Rica

An enormous development is experimented on the porous materials. The porous was considered a defect on solid materials some years ago, but right now, this defect is an advantage, based on the properties obtained from a micro and mesoporous materials. Microporous, mesoporous and macroporous materials with an uniformed pore distribution offer new properties, such as absorption, adsorption, exchange separation, and catalysis of different compounds, also they can play different roles as hosts for a nanocomposite materials to modify or improve their properties. Today, the structural types of open framework porous compounds have rapidly increased by their unique structural properties, porous size window and accessible void space are critical factors on a medical application.

关键词： Microporous Mesoporous Macro Porous