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Advanced-glycation end-products axis:A contributor to the risk of severe illness from COVID-19 in diabetes patients

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World Journal of Diabetes 2021年第5期12卷 590-602页

作者： Armando Rojas Cristian Lindner ileana gonzàlez Miguel Angel Morales Biomedical Research Labs Medicine FacultyCatholic University of MauleTalca 3460000Chile Medicine Faculty Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products(RAGE)in orchestrating a plethora of proinflammatory cellular responses leading to many of the complications and end-organ damages reported in patients with diabetes mellitus(DM).During the coronavirus disease 2019(COVID-19)pandemic,many clinical reports have pointed out that DM increases the risk of COVID-19 complications,hospitalization requirements,as well as the overall severe acute respiratory syndrome coronavirus 2 case-fatality *** the present review,we intend to focus on how the basal activation state of the RAGE axis in common preexisting conditions in DM patients such as endothelial dysfunction and hyperglycemia-related prothrombotic phenotype,as well as the contribution of RAGE signaling in lung inflammation,may then lead to the increased mortality risk of COVID-19 in these ***,the crosstalk between the RAGE axis with either another severe acute respiratory syndrome coronavirus 2 receptor molecule different of angiotensin-converting enzyme 2 or the renin-angiotensin system imbalance produced by viral infection,as well as the role of this multi-ligand receptor on the obesity-associated lowgrade inflammation in the higher risk for severe illness reported in diabetes patients with COVID-19,are also discussed.

关键词： COVID-19 Diabetes mellitus Advanced glycation Alarmins Advancedglycation end-products axis Inflammation

Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

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World Journal of Gastroenterology 2023年第6期29卷 997-1010页

作者： Armando Rojas Cristian Lindner Iván Schneider ileana gonzález Miguel Angel Morales Biomedical Research Laboratories Medicine FacultyCatholic University of MauleTalca 34600000Chile Medicine Faculty Catholic University of MauleTalca 34600000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products(RAGE)axis activation in the development of neoplasms,including gastric cancer(GC).This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu,not only by supporting phenotypic changes favoring growth and dissemination of tumor cells,but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori *** the present review,we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and ***,the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed.

关键词： Gastric cancer Advanced glycation end-products Receptor of advanced glycation end-products Alarmins Helicobacter pylori Chronic inflammation

Receptor of advanced glycation end-products axis and gallbladder cancer:A forgotten connection that we should reconsider

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World Journal of Gastroenterology 2022年第39期28卷 5679-5690页

作者： Armando Rojas Cristian Lindner Iván Schneider ileana gonzàlez Miguel Angel Morales Biomedical Research Laboratories Catholic University of MauleTalca 34600000MauleChile Medicine Faculty Catholic University of MauleTalca 34600000MauleChile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000SantiagoChile

Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder *** this regard,data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products(RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu,thus supporting tumor growth and *** are formed in biological systems or foods,and food-derived AGEs,also known as dietary AGEs are known to contribute to the systemic pool of *** they bind to RAGE,the activation of multiple and crucial signaling pathways are triggered,thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and *** the present review,we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer,and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.

关键词： Gallbladder cancer Advanced glycation end-products Receptor of advanced glycation end-products Chronic inflammation Nutrition

Helicobacter Pylori Infection and Lung Cancer： New Insights and Future Challenges

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中国肺癌杂志 2018年第9期21卷 658-662页

作者： ileana gonzAlez Paulina ARAYA Armando ROJAS Biomedical Research Laboratories Medicine Faculty Catholic University of Maule Talca Chile

Helicobacter pylori(H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori has very high rates of infection in human populations, and it is estimated that over 50% of the world population is infected. Recently, certain extra-gastric manifestations, linked to H. pylori infection, have been widely investigated. Noteworthy, a growing body of evidences supports an association between H. pylori infection with lung cancer. The present review intend to highlight not only the most recent evidences supporting this association, but also some missed points, which must be considered to validate this emerging association.

关键词：幽门螺杆菌慢性胃炎治疗方法临床分析

RAGE in Cancer Lung： the End of a Long and Winding Road is in Sight

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中国肺癌杂志 2018年第9期21卷 655-657页

作者： Armando ROJAS ileana gonzAlez Paulina ARAYA Biomedical Research Laboratories Medicine Faculty Catholic University of Maule Talca Chile

Introduction The receptor of advanced glycation end-products (RAGE),is a type I single-pass transmembrane protein, member of the multi-ligand immunoglobulin superfamily molecule, which was discovered in 1992, on accou... 详细信息

关键词：糖基化终产物受体肿瘤医学研究

Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1997-2012页

作者： Armando Rojas Cristian Lindner Iván Schneider ileana gonzàlez Hernan Araya Erik Morales Milibeth Gómez Nelson Urdaneta Paulina Araya Miguel Angel Morales Biomedical Research Lab. Medicine FacultyCatholic University of MauleTalca 34600000Chile Department of Clinical Sciences Medicine FacultyCatholic University of MauleTalca 34600000Chile Servicio de Oncología Hospital Regional de TalcaTalca 34600000Chile Servicio de Anatomía Patologica Hospital Regional de TalcaTalca 34600000Chile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus(DM)as a risk factor associated with increased cancer incidence and mortality in many human neoplasms,including gastric cancer(GC).DM is considered a systemic inflammatory disease and therefore,this inflammatory status may have profound effects on the tumor microenvironment(TME),particularly by driving many molecular mechanisms to generate a more aggressive *** is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix(ECM),leading to an increased ECM ***,DM can alter many cellular signaling mechanisms and thus favoring tumor growth,invasion,and metastatic potential,as well as key elements in regulating cellular functions and cross-talks,such as the microRNAs network,the production,and cargo of exosomes,the metabolism of cell stroma and resistance to *** the present review,we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC.

关键词： Diabetes mellitus Gastric cancer Tumor microenvironment Hyperglycemia Chronic inflammation

Differential Expression of Genes Related to Fruit Development and Capsaicinoids Synthesis in Habanero Pepper Plants Grown in Contrasting Soil Types

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 151-183页

作者： Eduardo Burgos-Valencia Federico García-Laynes ileana Echevarría-Machado Fatima Medina-Lara Miriam Monforte-gonzález JoséNarváez-Zapata Manuel Martínez-Estévez Unidad de Bioquímica y Biología Molecular de Plantas Centro de Investigación Científica de YucatánCalle 43#130Chuburnáde HidalgoMéridaYucatán97205México Instituto Politécnico Nacional-Centro de Biotecnología Genómica Blvd Del Maestro esq.Elias PiñaReynosaTamaulipas88710México

Habanero pepper(Capsicum chinense Jacq.)is a crop of economic relevance in the Peninsula of *** fruits have a high level of capsaicinoids compared to peppers grown in other regions of the world,which gives them industrial *** is an important factor that affects pepper development,nutritional quality,and capsaicinoid ***,the effect of soil type on fruit development and capsaicinoid metabolism has been little *** work aimed to compare the effect of soils with contrasting characteristics,black soil(BS)and red soil(RS),on the expression of genes related to the development of fruits,and capsaicinoid synthesis using a transcriptomic analysis of the habanero pepper *** growing in RS had bigger fruits and higher expression of genes related to floral development,fruit abscission,and softening which suggests that RS stimulates fruit development from early stages until maturation *** from plants growing in BS had enrichment in metabolic pathways related to growth,sugars,and ***,these fruits had higher capsaicinoid accumulation at 25 days post-anthesis,and higher expression of genes related to the branched-chain amino acids metabolism(ketol-acid reductisomerase KARI),pentose phosphate pathway and production of NADPH(glucose-6-phosphate-1-dehydrogenase G6PDH),and proteasome and vesicular traffic in cells(26S proteasome regulatory subunit T4 RPT4),which suggest that BS is better in the early stimulation of pathways related to the nutritional quality and capsaicinoid metabolism in the fruits.

关键词： Capsicum chinense jacq soil types plant growth environmental conditions fruit quality capsaicinoid metabolism transcriptome

Diabetes and cancer:Looking at the multiligand/RAGE axis

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World Journal of Diabetes 2011年第7期2卷 108-113页

作者： Armando Rojas ileana gonzález Erik Morales Ramón Pérez-Castro Jacqueline Romero Héctor Figueroa Biomedical Research Labs. Medicine FacultyCatholic University of Maule

The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many *** the association is not fully understood,current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms,including hyperinsulinemia,hyperglycemia and chronic *** this context,the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor *** high-light how RAGE,once activated,as it manifests itself in conditions such as diabetes or hyperglycemia,is able to continuously bring about an inflammatory milieu,thus supporting the contribution of chronic inflammation to the development of malignancies.

关键词： Diabetes Cancer Inflammation Receptor for advanced glycation end-products Malignant transformation

Meningeal cryptococcosis in a pancreas transplant recipient requiring grafectomy: A case report

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3032-3040页

作者： ileana Lulic Gorana Fingler Dinka Lulic Jadranka Pavicic Saric Danko Mikulic Tajana Filipec Kanizaj Eleonora Goluza Department of Anaesthesiology Intensive Care and Pain MedicineClinical Hospital MerkurZagreb 10000Croatia Immediate Medical Care Unit Saint James HospitalSliema SLM-1030Malta Department of Surgery Clinical Hospital MerkurZagreb 10000Croatia Department of Gastroenterology Clinical Hospital MerkurZagreb 10000Croatia Department of Anesthesiology Intensive Care Medicine and Pain TherapyUniversity Hospital Center ZagrebZagreb 10000Croatia

BACKGROUND Through continuous improvement in transplantation medicine,a wider range of solid organ transplant(SOT)recipients is considered suitable for complex *** advances in modern transplantation practice,transpiring invasive fungal infections pose a substantial threat for SOT *** our knowledge,cryptococcal infection confined amidst sole pancreas SOT recipients has not been described to *** of a multidisciplinary transplant team approach in the management of pancreas SOT recipients presenting with complex cryptococcal complications is fundamental in improving patient *** SUMMARY We present the case of a female pancreas transplant recipient,with confirmed meningeal cryptococcosis,referred to our institution for further evaluation and treatment from the Regional Center for Infectious *** admission,the patient was weaned from the protocolized immunosuppression therapy for two consecutive weeks,in addition to tapering systemic corticosteroid remedial *** novel multidisciplinary transplant team approach embodied exhaustive discussions of possible complex and diverse multiple organ system physiologic and pathologic challenges associated with distinct management strategies in pancreas transplant *** to the potentially devastating impact of invasive cryptococcosis in terms of morbidity and mortality,a definitive surgical intervention of pancreas transplant grafectomy was reinforced,as a pathway towards secure access to early meaningful expertise *** patient was discharged to the Regional Center for Infectious Diseases 2 mo after the admittance further advancing to a clinical *** The precision transplantation approach by tailoring complex medical interventions to individual needs proved indispensable in improving our patient’s outcomes.

关键词： Solid organ transplantation Pancreas transplantation Complications Meningeal cryptococcosis Management Grafectomy Case report