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Helicobacter Pylori Infection and Lung Cancer： New Insights and Future Challenges

中国肺癌杂志 2018年第9期21卷 658-662页

作者： ileana gonzalez Paulina ARAYA Armando ROJAS Biomedical Research Laboratories Medicine Faculty Catholic University of Maule Talca Chile

Helicobacter pylori(H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori has very high rates of infection in human populations, and it is estimated that over 50% of the world population is infected. Recently, certain extra-gastric manifestations, linked to H. pylori infection, have been widely investigated. Noteworthy, a growing body of evidences supports an association between H. pylori infection with lung cancer. The present review intend to highlight not only the most recent evidences supporting this association, but also some missed points, which must be considered to validate this emerging association.

关键词：幽门螺杆菌慢性胃炎治疗方法临床分析

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RAGE in Cancer Lung： the End of a Long and Winding Road is in Sight

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中国肺癌杂志 2018年第9期21卷 655-657页

作者： Armando ROJAS ileana gonzalez Paulina ARAYA Biomedical Research Laboratories Medicine Faculty Catholic University of Maule Talca Chile

Introduction The receptor of advanced glycation end-products (RAGE),is a type I single-pass transmembrane protein, member of the multi-ligand immunoglobulin superfamily molecule, which was discovered in 1992, on accou... 详细信息

关键词：糖基化终产物受体肿瘤医学研究

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Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases:A dangerous liaison?

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World Journal of Gastroenterology 2021年第19期27卷 2270-2280页

作者： Armando Rojas Ivan Schneider Cristian Lindner ileana gonzalez Miguel Angel Morales Medicine Faculty Catholic University of MauleTalca 3634000Chile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling evidence supports the crucial role of the receptor for advanced glycation end-products(RAGE)axis activation in many clinical entities.Since the beginning of the coronavirus disease 2019 pandemic,there is an increasing concern about the risk and handling of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in inflammatory gastrointestinal disorders,such as inflammatory bowel diseases(IBD).However,clinical data raised during pandemic suggests that IBD patients do not have an increased risk of contracting SARS-CoV-2 infection or develop a more severe course of infection.In the present review,we intend to highlight how two potentially important contributors to the inflammatory response to SARS-CoV-2 infection in IBD patients,the RAGE axis activation as well as the cross-talk with the renin-angiotensin system,are dampened by the high expression of soluble forms of both RAGE and the angiotensin-converting enzyme(ACE)2.The soluble form of RAGE functions as a decoy for its ligands,and soluble ACE2 seems to be an additionally attenuating contributor to RAGE axis activation,particularly by avoiding the transactivation of the RAGE axis that can be produced by the virus-mediated imbalance of the ACE/angiotensin II/angiotensin II receptor type 1 pathway.

关键词： COVID-19 Inflammatory bowel diseases Advanced glycation Angiotensinconverting enzyme 2 Alarmins Receptor for advanced glycation end-products Receptor for advanced glycation end-products axis Inflammation

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