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西班牙比斯凯亚公司用于处理高附加值超薄热轧带钢的新酸洗线

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钢铁 2004年第9期39卷 43-44页

作者： D.sylvain J.A.Conde 奥钢联克莱西姆公司奥钢联Cosim公司

薄规格热轧带钢的生产需要专门的酸洗线以确保高附加值的热轧产品能够与各种冷轧材料相竞争。介绍奥钢联为西班牙比斯凯亚公司提供的超薄热带酸洗线的先进特点。

关键词：超薄热带高附加值酸洗线

Biological effect of human serum collected before and after oral intake of Pygeum africanum on various benign prostate cell cultures

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Asian Journal of Andrology 2012年第3期14卷 499-504,I0010页

作者： Stephane Larre Philippe Camparo Eva Comperat Delphine Boulbes Mohammed Haddoum sylvain Baulande Pascal Soularue Pierre Costa Olivier Cussenot Nuffield Department of Surgical Science University of Oxford Oxford OX3 9DU UK ER2 UMPC CeRePP Paris 75000 France Department of Pathology Val de Grace Hospital Paris 75000 France Department of Pathology La Pitie Salpetriere Hospital Paris 75000 France Laboratoire Solvay Pharma Paris 75000 France partnerChip Genople Evry 91000 France Department of Urology CHU Caremeau NTmes 30000 France

Pygeum africanum （Tadenan） is a popular phytotherapeutic agent used in the treatment of symptomatic benign prostatic hyperplasia. The active compounds of the drug have not been identified, and determining the plasma concentration of the drug is, therefore, not possible. Because there are conflicting results on the efficacy of this drug, we aimed to investigate its effect on prostate cell growth in vitro using human serum collected before and after Pygeum africanum intake. We used primary and organotypic cultures of human prostatic stromal myofibroblast cell line WPMY and prostatic epithelial cell line PNT2. We also used fresh benign prostatic tissue. The serum of a treated man induced decreases in the proliferation of primary cells, organotypic cells and WPMY cells but not PNT2 cells. We also analysed the effect of treated serum on the gene expression profile of WPMY cells. The transcriptome analysis revealed an upregulation of genes involved in multiple tumour suppression pathways and a downregulation of genes involved in inflammation and oxidative-stress pathways. The oral intake of Pygeum africanum resulted in serum levels of active substances that were sufficient to inhibit the proliferation of cultured myofibroblasts prostatic cells. This inhibition was associated with changes in the transcriptome. Asian Journal of Andrology（2012） 14, 499-504; doi：lO.1038/aja.2011.132; published online 26 December 2011

关键词： benign prostatic hyperplasia organotypic culture primary culture PNT2 Pygeum africanum transcriptome WPMY

Left Eigenvector of a Stochastic Matrix

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Advances in Pure Mathematics 2011年第4期1卷 105-117页

作者： sylvain Lavalle′e 不详

We determine the left eigenvector of a stochastic matrix M associated to the eigenvalue 1 in the commutative and the noncommutative cases. In the commutative case, we see that the eigenvector associated to the eigenvalue 0 is (N1,Nn) , where Ni is the i–th iprincipal minor of N=M–In , where In is the identity matrix of dimension n. In the noncommutative case, this eigenvector is (P1-1,Pn-1) , where Pi is the sum in Q《αij》 of the corresponding labels of nonempty paths starting from i and not passing through i in the complete directed graph associated to M .

关键词： Generic Stochastic Noncommutative Matrix Commutative Matrix Left Eigenvector Associated To The Eigenvalue 1 Skew Field Automata

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THEY TESTED THE CAR

汽车自驾游 2013年第3期 22-27页

作者： sylvain REISSER 张菁(翻译)

每三辆售出的汽车中，就有一辆被女性消费者购买。喜欢小巧轻便款式的她们在挑选的时候却遇到了许多困难。来自欧洲的5位女记者体验了5种多功能的汽车，以下是她们的个人感受。

关键词：汽车产品介绍设计方案购车者

Impact of human sequences in variable domains of therapeutic antibodies on the location of CD4 T-cell epitopes

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Cellular & Molecular Immunology 2020年第6期17卷 656-658页

作者： sylvain Meunier Moustafa Hamze Anette Karle Marie de Bourayne Abdelaziz Gdoura Sebastian Spindeldreher Bernard Maillère CEA-Saclay Institut Frederic JoliotSIMOPROUniversitéParis-Saclay91191 Gif sur YvetteFrance Novartis Pharma AG BaselSwitzerland Present address:Integrated Biologix GmbH BaselSwitzerland

The clinical efficacy of therapeutic antibodies is recognized in many indications,explaining their rapid rise in the worldwide drug ***,therapeutic antibodies can be immunogenic by inducing a specific immune response characterized by the production of anti-drug antibodies(ADAs).ADAs can potentially increase the clearance of therapeutic antibodies,decrease their therapeutic effects1 and induce hypersensitivity *** humans are thought to be tolerant to their own proteins,sequences of the therapeutic antibodies have been humanized or human antibodies have been directly generated by technologies using human ***,human(ized)antibodies exhibit highly variable levels of immunogenicity,1,2 illustrating the poor understanding of the role of sequence humanization in mitigating the immunogenicity of therapeutic *** lines of evidence highlight the role of CD4 T lymphocytes during the initiation of an ADA response,3 but few T-cell epitopes of marketed therapeutic antibodies have been described to date.

关键词： therapeutic antibodies clinical

Synthesis of(±)-phthalascidin 622

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Science China Chemistry 2010年第9期53卷 1888-1898页

作者： CHRISTIAN R.Razafindrabe sylvain Aubry BENJAMIN Bourdon MARTA Andriantsiferana STEPHANE Pellet-Rostaing MARC Lemaire Laboratoire de Chimie des Produits Naturels et Biotechnologie(LPNB) Université d'Antananarivo17 Cité Mahatazana-Ampandrianomby101 Antananarivo ICBMS Institut de Chimie et Biochimie Moléculaires et SupramoléculairesCNRSUMR5246Laboratoire de Catalyse et Synthèse Organique ICSM institut de Chimie Séparative de MarcouleCNRS/CEA/UM2/ENSCMUMR 5257Laboratoire de Tri Ionique par des Systèmes Moléculaires auto-assemblés

A synthesis of functionalized phenolic α-amino-alcohols(±)-8 and(±)-16 as synthetic precursors of the catechol tetrahydroisoquinoline structure of phthalascidin 650 was disclosed.(±)-8 was prepared in 5 steps from the commercially available *** from 3-methyl catechol 5,8 steps gave rise to the synthesis of phenolic α-amino-alcohol(±)-16 in 27% overall *** synthetic strategy involved the elaboration of fully functionalized aromatic aldehyde 13 and its transformation into a phenolic α-amino-alcohol(±)-16,through a Knoevenagel condensation,simultaneous reduction of nitroketene and ester functions,and hydrogenolysis of the benzyl protecting *** pentacycle(±)-4 was obtained after 4 additional *** Pictet-Spengler cyclisation between the phenolic α-amino-alcohol(±)-16 and the N-protected α-amino-aldehyde 4 allowed to obtain(1,3')-bis-tetrahydroisoquinoline 17 with N-methylated and N-Fmoc *** last step was a Swern oxidation allowing the expected intramolecular condensation.

关键词： phthalascidin ecteinascidin (1 3’)-bis-tetrahydroisoquinoline Pictet-Spengler Bishler-Napieralsky

Ice-templated porous tungsten and tungsten carbide inspired by natural wood

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Journal of Materials Science & Technology 2020年第10期42卷 187-197页

作者： Yuan Zhang Guoqi Tan Da Jiao Jian Zhang Shaogang Wang Feng Liu Zengqian Liu Longchao Zhuo Zhefeng Zhang sylvain Deville Robert O.Ritchie Laboratory of Fatigue and Fracture for Materials Institute of Metal Research.Chinese Academy of SciencesShenyang 110016China School of Mechanical Engineering Liaoning Shihua UniversityFushun 113001China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Xi'an University of TechnologyXi'an710048China Laboratoire De Synthese Et Fonctionnalisation Des Ceramiques UMR3080 CNRS/Saint-Gobain CREESaint-Gobain Research ProvenceCavaillon 84306France Department ofMateriab Science and Engineering University of California BerkeleyBerkeleyCA 94720USA

The structures of tungsten and tungsten carbide scaffolds play a key role in determining the properties of their infiltrated composites for multifunctional ***,it is challenging to construct and control the architectures by means of self-assembly in W/WC systems because of their large *** we present the development of unidirectionally porous architectures,with high porosities exceeding 65 vol.%,for W and WC scaffolds which in many respects reproduce the design motif of natural wood using a direct ice-templating *** was achieved by adjusting the viscosities of suspensions to retard sedimentation during *** processing,structural characteristics and mechanical properties of the resulting scaffolds were investigated with the correlations between them *** relationships were established to describe their strengths based on the mechanics of cellular solids by taking into account both inter-and intra-lamellar *** fracture mechanisms were also identified,especially in light of the *** study extends the effectiveness of the ice-templating technique for systems with large densities or particle *** further provides preforms for developing new natureinspired multifunctional materials,as represented by W/WC-Cu composites.

关键词： Ice-templating Tungsten Scaffolds Fracture mechanisms Bioinspired materials

Building a European geothermal information network using a distributed e-Infrastructure

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International Journal of Digital Earth 2016年第5期9卷 499-519页

作者： Eugenio Trumpy Gianpaolo Coro Adele Manzella Pasquale Pagano Donatella Castelli Philippe Calcagno Annamaria Nador Thorvaldur Bragasson sylvain Grellet Gunter Siddiqi aIstituto di Geoscienze e Georisorse(IGG) National Research Council of Italyvia Moruzzi 1PisaItaly Istituto di Scienza e Tecnologie dell’Informazione‘A.Faedo’(ISTI) National Research Council of Italyvia Moruzzi 1PisaItaly Bureau de Recherches Géologiques et Minières(BRGM) OrleansFrance Magyar Foldtaniès Geofizikai Intèzet(MFGI) BudapestHungary Orkustofnun(OS) ReykjavikIceland Swiss Federal Office of Energy(SFOE) BernSwitzerland

Geothermal data are published using different IT services,formats and content representations,and can refer to both regional and global scale *** stakeholders search for information with different aims.E-Infrastructures are collaborative platforms that address this diversity of aims and data *** this paper,we present a prototype for a European Geothermal Information Platform that uses INSPIRE recommendations and an e-Infrastructure(D4Science)to collect,aggregate and share data sets from different European data contributors,thus enabling stakeholders to retrieve and process a large amount of *** system merges segmented and national realities into one common *** demonstrate our approach by describing a platform that collects data from Italian,French,Hungarian,Swiss and Icelandic geothermal data providers.

关键词： Geothermal documents distributed data geothermal spatial data infrastructure e-Infrastructures D4Science hybrid data infrastructures

Encoding of local and global cues in domestic dogs’ spatial working memory

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Open Journal of Animal Sciences 2013年第3期3卷 1-11页

作者： sylvain Fiset Nathalie Malenfant Université de Moncton Campus d’Edmundston Edmundston Canada

The current study investigated whether domestic dogs encode local and/or global cues in spatial working memory. Seven dogs were trained to use a source of allocentric information (local and/or global cues) to locate an attractive object they saw move and disappear behind one of the three opaque boxes arrayed in front of them. To do so, after the disappearance of the target object and out of the dogs’ knowledge, all sources of allocentric information were simultaneously shifted to a new spatial position and the dogs were forced to follow a U-shaped pathway leading to the hiding box. Out of the seven dogs that were trained in the detour problem, only three dogs learned to use the cues that were moved from trial to trial. On tests, local (boxes and experimenter) and/or global cues (walls of the room) were systematically and drastically shifted to a new position in the testing chamber. Although they easily succeeded the control trials, the three dogs failed to use a specific source of allocentric information when local and global cues were put in conflict. In discussion, we explore several hypotheses to explain why dogs have difficulties to use allocentric cues to locate a hidden object in a detour problem and why they do not differentiate the local and global cues in this particular experimental setting.

关键词： Local and Global Cues Spatial Working Memory Domestic Dogs Allocentric and Egocentric Cues Object Permanence