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Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)and their oxidation-sensitive polymersomes

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Chinese Chemical Letters 2020年第7期31卷 1931-1935页

作者： Yangwei Deng Hui Chen Xinfeng Tao sylvain Trepout Jun Ling Min-Hui Li Chimie ParisTech PSL University ParisCNRSInstitut de Recherche de Chimie ParisParis 75005France MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Institut Curie Inserm US43University Paris SaclayOrsay Cedex 91405France Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Amphiphilic block copolymers poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)(PEGb-PMeSPG)were synthesized via ring-opening polymerization of N-3-(methylthio)propyl glycine Nthiocarboxyanhydride(MeSPG-NTA)initiated by amino-terminated *** self-assemblies of three PEG-b-PMeSPG copolymers with different PMeSPG block lengths were first prepared by nanoprecipitation method using THF and DMF,respectively,as the organic solvent,and their morphologies were studied by Cryo-EM and *** prepare polymersomes loaded with glucose oxidase(GOx),double emulsion method followed by extrusion treatment was *** oxidation-responsive disruption of polymersomes was achieved upon the introduction of glucose because of the oxidants generated insitu by GOx/glucose.

关键词： Polypeptoid Self-assembly Polymersome Oxidation-responsive Glucose oxidase

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

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分子细胞生物学报:英文版 2011年第5期3卷 301-308页

作者： Mohamed Abu-Farha sylvain Lanouette Fred Elisma Veronique Tremblay Jeffery Butson Daniel Figeys Jean-Francois Couture Ottawa Institute of Systems Biology Department of BiochemistryMicrobiology and ImmunologyUniversity of Ottawa451 Smyth RoadRoger-Guindon HallOttawaONK1H8M5Canada Biochemistry and Molecular Biology Unit Dasman Diabetes InstituteDasman 15462Kuwait

The SMYD(SET and MYND domain)family of lysine methyltransferases(KMTs)plays pivotal roles in various cellular processes,including gene expression regulation and DNA damage *** identified as genuine histone methyltransferases,specific members of this family have recently been shown to methylate non-histone proteins such as p53,VEGFR,and the retinoblastoma tumor suppressor(pRb).To gain further functional insights into this family of KMTs,we generated the protein interaction network for three different human SMYD proteins(SMYD2,SMYD3,and SMYD5).Characterization of each SMYD protein network revealed that they associate with both shared and unique sets of *** those,we found that HSP90 and several of its co-chaperones interact specifically with the tetratrico peptide repeat(TPR)-containing SMYD2 and ***,using proteomic and biochemical techniques,we provide evidence that SMYD2 methylates K209 and K615 on HSP90 nucleotide-binding and dimerization domains,*** addition,we found that each methylation site displays unique reactivity in regard to the presence of HSP90 co-chaperones,pH,and demethylation by the lysine amine oxidase LSD1,suggesting that alternative mechanisms control HSP90 methylation by ***,this study highlights the ability of SMYD proteins to form unique protein complexes that may underlie their various biological functions and the SMYD2-mediated methylation of the key molecular chaperone HSP90.

关键词： SMYD proteins HSP90 lysine methylation SET domain histone methylation

Prognostic value of chemotherapy-induced hematological toxicity in metastatic colorectal cancer patients

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World Journal of Gastroenterology 2014年第6期20卷 1565-1573页

作者： Laurie Rambach Aurelie Bertaut Julie Vincent Veronique Lorgis sylvain Ladoire Francois Ghiringhelli Department of Medical Oncology Centre Georges-Fran ois Leclerc Biostatistics and Epidemiological Unit EA4184 Centre Georges-Fran ois Leclerc Institut National de la Santé et de la Recherche Médicale (INSERM) CRI-866 Faculty of Medicine School of Medicine University of Burgundy

AIM: To establish whether chemotherapy-induced neutropenia is predictive of better outcome in patients with metastatic colorectal cancer (mCRC).

关键词： Colorectal cancer Metastasis Prognostic factor Neutropenia Chemotherapy

Use of Large-Eddy Simulation for the bed shear stress estimation over a dune

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International Journal of Sediment Research 2021年第6期36卷 687-695页

作者： Adrien Bourgoin sylvain S.Guillou Jér?me Thiébot Riadh Ata Normandy University University of Caen Normandy Normandy University University of Caen Normand

Environmental flows are generally characterized by complex bed morphology and high current *** configurations favor the formation of vortex structures that strongly affect hydrody-namics and sediment transport. Large-Eddy Simulation(LES) enables investigation of the dynam-ics of the largest turbulence scales and, thanks to enhanced calculation resources, has now become applicable for simulating environmental flows. In this paper, a LES approach is developed in a CFD code(TELEMAC-3 D),which was originally developed to simulate free surface flows using RANS methods. The present developments involve implementing subgrid models, boundary con-ditions and numerical schemes suitable for LES. The LES version of TELEMAC-3 D was validated by comparing results on the model with experimental data for flow past a cylinder. Then, the model was applied to a test case representing flow over dunes. After validating the hydrodynamics, the model was used to assess the bottom shear stress,using both a RANS and a LES approach. Com-parison highlighted the potential contribution of LES to investigating the hydrodynamic forces acting on the bottom.

关键词： Turbulence Environmental flows Large eddy simulations Bed shear stress

Extracellular vesicles:General features and usefulness in diagnosis and therapeutic management of colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1561-1598页

作者： Aurelien Mammes Jennifer Pasquier Olivier Mammes Marc Conti Richard Douard sylvain Loric INSERM UMR-938 Cancer Biology and Therapeutics UnitSaint-Antoine Research CenterSaint Antoine University HospitalParis 75012France UCBM Necker University HospitalParis 75015France Metabolism Research Unit Integracell SASLongjumeau 91160France Gastrointestinal Surgery Department Clinique BizetParis 75016France

In the world,among all type of cancers,colorectal cancer(CRC)is the third most commonly diagnosed in males and the second in *** most of cases,(RP1)patients’prognosis limitation with malignant tumors can be attributed to delayed diagnosis of the *** of patients with early-stage disease leads to more effective therapeutic ***,new screening methods and further innovative treatment approaches are mandatory as they may lead to an increase in progression-free and overall survival *** the last decade,the interest in extracellular vesicles(EVs)research has exponentially increased as EVs generation appears to be a universal feature of every cell that is strongly involved in many mechanisms of cell-cell communication either in physiological or pathological *** can cargo biomolecules,such as lipids,proteins,nucleic acids and generate transmission signal through the intercellular transfer of their *** this mechanism,tumor cells can recruit and modify the adjacent and systemic microenvironment to support further invasion and *** review intends to cover the most recent literature on the role of EVs production in colorectal normal and cancer *** attention is paid to the use of EVs for early CRC diagnosis,follow-up,and prognosis as EVs have come into the spotlight of research as a high potential source of‘liquid biopsies’.The use of EVs as new targets or nanovectors as drug delivery systems for CRC therapy is also summarized.

关键词： Extracellular vesicles Colorectal cancer Diagnostic Prognosis Vector Therapy

Nitric Oxide in Plants： Production and Cross-talk with Ca^2＋ Signaling

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Molecular Plant 2008年第2期1卷 218-228页

作者： Angelique Besson-Bard Cecile Courtois Adrien Gauthier Jennifer Dahan Grazyna Dobrowolska sylvain Jeandroz Alain Pugin David Wendehenne Unite Mixte de Recherche INRA 1088/CNRS 5184/Universite de Bourgogne Plante-Microbe-Environnement 17 rue Sully BP 86510 21065 Dijon cedex France Institute of Biochemistry and Biophysics Polish Academy of Sciences 02-106 Warsaw Poland Unite Mixte de Recherche UHP INRA 1136 Interactions Arbres/Micro-Organismes Universite Henry Poincare Nancy I BP 239 54506 Vandoeuvre cedex France

Nitric oxide （NO） is a diatomic gas that performs crucial functions in a wide array of physiological processes in animals. The past several years have revealed much about its roles in plants. It is well established that NO is synthesized from nitrite by nitrate reductase （NR） and via chemical pathways. There is increasing evidence for the occurrence of an alternative pathway in which NO production is catalysed from L-arginine by a so far non-identified enzyme. Contradictory results have been reported regarding the respective involvement of these enzymes in specific physiological conditions. Although much remains to be proved, we assume that these inconsistencies can be accounted for by the limited specificity of the pharmacological agents used to suppress NO synthesis but also by the reduced content of L-arginine as well as the inactivity of nitrate-permeable anion channels in nitrate reductase- and/or nitrate/nitrite-deficient plants. Another unre- solved issue concerns the molecular mechanisms underlying NO effects in plants. Here, we provide evidence that the second messenger Ca^2＋, as well as protein kinases including MAPK and SnRK2, are very plausible mediators of the NO signals. These findings open new perspectives about NO-based signaling in plants.

关键词： Nitric Oxide in Plants Production and Cross-talk Ca~(2+) Signaling

Western Tethyan Epeiric Ramp Setting in the Early Triassic： An Example from the Central Dinarides (Croatia)

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Journal of Earth Science 2018年第4期29卷 806-823页

作者： Dunja Aljinovic Micha Horacek Leopold Krystyn sylvain Richoz Tea Kolar-Jurkovsek Duje Smircic Bogdan Jurkovsek University of Zagreb Faculty of Mining Geology and Petroleum Engineering Pierottijeva 6 Zagreb 10000 Croatia BLT Wieselburg HBLFA Francisco-Josephinum Rottenhauserstr. 1 Wieselburg 3250 Austria Institute of Paleontology Vienna University A lthanstrafle 14 Vienna 1090 Austria Lund University Lithosphere and Biosphere science Solvegatan 12 Lund 22362 Sweden Geological Survey of Slovenia Dimiceva Ulica 14 Ljubljana 1000 Slovenia

In the central part of the External Dinarides in Plavno, Croatia, near Knin, a remarkably thick （927.5 m） Early Triassic depositional sequence was investigated. The Plavno sequence starts in the EarlyGriesbachian and ends with a continuous transition into the Anisian strata. A complete 13C isotope curve has been achieved and combined with conodonts, bivalves and ammonoids to establish and correlate stage and substage boundaries. The 613C curve is consistent with former studies. It displays a general increase from the Griesbachian to a prominent maximum beyond the ＋8%0 amplitude around the Dienerian-Smithian boundary （DSB）, followed by a steep and continuous decline to low, negative values in the Smithian. Around the Smithian-Spathian boundary （SSB） a steep rise to a second maximum occurred. It is followed by a saw-tooth shaped decline in the Spathian and a similar increase to a peak at the Spathian-Anisian boundary （SAB）. Sedimentologically, the Plavno sequence is interpreted as having been deposited on an extensive epeiric ramp under long-term transgressive conditions, sharing depositional characteristics of both the epeiric platform and the carbonate ramp. The entire Plavno sequence was deposited above the storm-wave base and was storm influenced. Three informal members are differentiated： 1） the dolostone member （Early Griesbachian）; 2） the silicielastic member （red-coloured shale, siltstone, sandstone with oolitic/bioclastie grainstone intercalations）, which can be further divided into lower, middle and upper intervals （Late Griesbachian, Dienerian and Smithian）; and 3） the mudstone member （grey lime mudstones, marls and calcisiltites with common ammonoids and gastropods- Spathian）. The Plavno sequence is compared with other western Tethyan sections. Observed differences stem from local controls on deposition in the overall shallow marine environment.

关键词： Early Triassic Dinarides epeiric ramp 6Z3C isotope curve litho- and biostratigraphy.

Assessment of compost and three biochars associated with Ailanthus altissima(Miller)Swingle for lead and arsenic stabilization in a post-mining Technosol

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Pedosphere 2021年第6期31卷 944-953页

作者： Ibrahim ALIDOU-ARZIKA Manhattan LEBRUN Florie MIARD Romain NANDILLON Gulriz BAYCU sylvain BOURGERIE Domenico MORABITO University of Orleans INRA USC1328LBLGC EA1207Orleans 45067(France) Division of Botany Department of BiologyFaculty of ScienceIstanbul UniversityIstanbul 34134(Turkey) Department of Bioscience and Territory University of MolisePesche 86090(Italy)

The elevated presence of metal(loid)s in the environment significantly impacts ecosystems and human health and is generally largely due to industrial and mining ***,in the current study,we investigated and proposed an environmentally friendly method(phytomanagement)aimed at reducing the negative impacts associated with metal(loid)pollution through the use of soil amendments(biochar and compost)to permit Ailanthus altissima growth on a highly contaminated mining Technosol,with arsenic(As)and lead(Pb)contents of 539.06 and 11453 mg kg^(-1),*** objective was to examine the impacts of three biochars and compost on i)the physicochemical characteristics of soil,ii)metal(loid)immobilization in soil,and iii)*** *** revealed that the application of biochar as a soil amendment improved soil conditions by increasing soil electrical conductivity,pH,and water-holding ***,concomitantly,we observed a large reduction(99%)in Pb mobility and availability following application of the hardwood biochar in combination with compost(HBCP).Thus,this combined soil amendment was most effective in promoting *** *** addition,the HBCP treatment prevented As translocation in the upper parts of plants,although soil pore water As concentration was not diminished by amendment application.

关键词： amendment metal(loid) mining soil phytomanagement soil pore water

The role of electrocardiographic imaging in patient selection for cardiac resynchronization therapy

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Journal of Geriatric Cardiology 2021年第10期18卷 836-843页

作者： Saer Abu-Alrub Marc Strik Peter Huntjens Michel Haïssaguerre Romain Eschalier Pierre Bordachar sylvain Ploux Cardiology Department Clermont University Hospital(CHU)Clermont-FerrandClermont-FerrandFrance Cardio-Thoracic Unit Bordeaux University Hospital(CHU)Pessac-BordeauxFrance IHU Liryc Electrophysiology and Heart Modeling InstituteFondation Bordeaux UniversitéPessac-BordeauxFrance Division of Cardiology Washington UniversitySt.LouisMissouriUSA

Cardiac resynchronization therapy(CRT)has been shown to improve symptoms,left ventricle(LV)performance and long-term survival in patients with heart failure with re-duced ejection fraction(HFrEF)and delayed ventricular activation.[1]CRT is currently recom-mended in symptomatic patients with LV ejection fraction of≤35%,and ventricular conduction dis-order manifested as left bundle branch block(LBBB)>149 ms,and should be considered in LBBB>129 ms or non-LBBB QRS duration>150 ms.

关键词： ventricular synchronization ventricle