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Anti-atherosclerotic activity of root bark of Premna integrifolia *** high fat diet induced atherosclerosis model rats

Journal of Pharmaceutical Analysis 2017年第2期7卷 123-128页

作者： Chitra Subramani Arivukkodi Rajakkannu Arunadevi Rathinam Sudesh Gaidhani ilavarasan raju Dhiman Vaidya Kartar Singh Department of Biochemistry Captain Srinivasa Murthy Regional Ayurveda Drug Development InstituteCentral Council for Research in Ayurvedic SciencesM/o AYUSHGovt.of IndiaA.A.Hospital CampusArumbakkamChennai 600106India Department of Pharmacology Captain Srinivasa Murthy Regional Ayurveda Drug Development InstituteCentral Council for Research in Ayurvedic SciencesM/o AYUSHGovt.of IndiaA.A.Hospital CampusArumbakkamChennai 600106India Ayurveda Captain Srinivasa Murthy Regional Ayurveda Drug Development InstituteCentral Council for Research in Ayurvedic SciencesM/o AYUSHGovt.of IndiaA.A.Hospital Campus ArumbakkamChennai 600106India

Premna integrifolia Linn. is a medicinal plant used in ＂Dhasamula＂ drug preparation of Ayurvedic systems of medicine in the treatment of various ailments like bronchitis, dyspepsia, liver disorders, piles, constipation,hyperlipidemia and fever. The anti-atherosclerotic activity of hydroalcoholic extract（HAE） of root bark of *** was evaluated in high fat diet induced atherosclerosis rats. Sixty Wistar rats were divided into six groups： the first group served as control, the second group was fed with high fat diet and the other three groups were fed with high fat diet along with various concentrations of HAE and the last group was treated with atorvastatin for 30 days. Lipid and lipoprotein profile, atherogenic index, and cardiac markers and histopathological evaluation of aorta were determined in high fat diet induced atherosclerosis rats. HAE of *** produced a significant and dose-dependent anti-atherosclerotic activity in terms of reduction in lipids and lipoprotein profile, atherogenic index, HMG-Co A reductase activity, marker enzymes such as lactate dehydrogenase（LDH）, creatine phosphokinase（CPK）, aspartate transaminase（AST）, alanine transaminase（ALT） and alkaline phosphatase（ALP）, alteration in collagen and calcium contents, mild mineralization and focal rupture of intima and media of aorta was noticed in treated groups as compared to the control. The results suggested that anti-atherosclerotic activity of HAE of P. integrifolia Linn. was due to its modulatory activity on metabolic pathway of lipid. The results contribute to the validation of the traditional use of Agnimantha in high fat diet induced atherosclerosis rats.

关键词： P.integrifolia HMG-CoA reductase Atherogenic index Biomarkers Atherosclerosis

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Identification and quantitative estimation of Emodin in Rhei Emodi *** and the relevant polyherbal ayurvedic formulation

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Asian Journal of Traditional Medicines 2021年第6期16卷 351-366页

作者： Ajay Kumar Meena R.ilavarasan Arjun Singh Lavkush Sharma Amit Dixit N.Srikanth Regional Ayurveda Research Institute AamkhoGwalior 474009India Captain Srinivasa Murthy Central Ayurveda Research Institute Chennai 600106India Central Ayurveda Research Institute Kolkata 700091India Central Council for Research in Ayurvedic Sciences Ministry of AYUSHGovernment of IndiaNew Delhi 110058India

The present study explored quality control of plant drug and polyherbal formulation using HPTLC and HPLC *** study combined qualitative analysis of Emodin and Rhein biomarker compound in Rhei Emodi *** extract and polyherbal formulation extract by HPTLC method with quantitative estimation of Emodin by HPLC method,aiming to help in accurate identification of Emodin and Rhein in plant materials,polyherbal *** study also checked adulteration,with the purpose of improving bio-efficacy of ayurvedic *** the samples showed characteristic peaks of Emodin at same retention time as that of standard *** to the HPTLC fingerprinting results,the Rf values of Rhein reference standard at 0.42 and Emodin at 0.62 were observed in test solution of Rhei emodi *** extract and polyherbal formulation extract and both were found *** quantitative evaluation of Emodin present in the polyherbal formulation and Rhei emodi *** extracts were 0.0177% and 0.3106% respectively.

关键词： Rhei emodi Emodin Rhein Standardization HPTLC HPLC and quantification

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