检索结果-南通市图书馆

Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment

引用

World Journal of Gastroenterology 2014年第2期20卷 486-497页

作者： Girolamo Ranieri ilaria Marech Vito Lorusso Veronica Goffredo Angelo Paradiso Domenico Ribatti Cosmo Damiano Gadaleta Interventional Radiology Unit with Integrated Section of Translational Medical Oncology National Cancer Research CentreCancer Institute "Giovanni Paolo Ⅱ"70124 BariItaly Medical Oncology Unit National Cancer Research CentreCancer Institute "Giovanni Paolo Ⅱ"70124 BariItaly Medical Oncology with Experimental Unit National Cancer Research CentreCancer Institute "Giovanni Paolo Ⅱ"70124 BariItaly Department of Basic Medical Sciences Neurosciences and Sensory OrgansSection of Human Anatomy and HistologyUniversity of Bari70124 BariItaly

Hepatocellular carcinoma(HCC)is the fifth most common cause of cancer in the *** to Barcelona Clinic Liver Cancer modified criteria,patients with early stage disease are candidate to radiofrequency ablation(RFA),while patients with intermediate stage HCC are usually treated by transarterial chemoembolization(TACE).TACE and RFA induce a transient devascularisation effect followed by strong neoangiogenic *** fact,after these procedures,it has been demonstrated an up-regulation of pro-angiogenic and growth factors such as vascular endothelial growth factor-A,which might contribute to accelerated progression in patients with incomplete *** studies have demonstrated that MAP-kinase and AKT pathways,in addition to neo-angiogenesis,have an important role in the development of *** advanced HCC,anti-angiogenic therapy and tyrosine kinases inhibitors showed potential clinical ***,a number of clinical studies are ongoing testing these agents in combination with TACE or *** this paper,we have reviewed the most recent preclinical and clinical results of such trials.

关键词： Hepatocellular carcinoma Molecular targeting agents Angiogenesis Chemoembolization therapeutic Radiofrequency treatment Sorafenib

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosomes of adult human fibroblasts cultured on 3D silk fibroin nonwovens intensely stimulate neoangiogenesis

引用

Burns & Trauma 2021年第1期9卷 488-506页

作者： Peng Hu Anna Chiarini Jun Wu Giuliano Freddi Kaiyu Nie Ubaldo Armato ilaria Dal Prà Human Histology&Embryology Section Department of SurgeryDentistryPaediatrics&GynaecologyUniversity of Verona Medical SchoolStrada Le Grazie 8I-37134VeronaVenetiaItaly Department of Burns&Plastic Surgery The Affiliated Hospital of ZunYi Medical University149 Dalian RoadZunYi City563003 Guizhou ProvinceChina Department of Burns and Plastic Surgery Second People’s HospitalUniversity of Shenzhen3002 Sungang West RoadFutian DistrictShenzhen518000Guangdong ProvinceChina Silk Biomaterials S.r.l. Via Cavour 2I-22074LomazzoLombardyItaly

Background:Bombyx mori silk fibroin is a biomacromolecule that allows the assembly of scaffolds for tissue engineering and regeneration purposes due to its cellular adhesiveness,high biocompatibility and low *** work showed that two types of 3D silk fibroin nonwovens(3D-SFnws)implanted into mouse subcutaneous tissue were promptly vascularized via undefined molecular *** present study used nontumorigenic adult human dermal fibroblasts(HDFs)adhering to a third type of 3D-SFnws to assess whether HDFs release exosomes whose contents promote ***:Electron microscopy imaging and physical tests defined the features of the novel carded/hydroentangled *** were cultured on 3D-SFnws and polystyrene plates in an exosome-depleted *** amounts and D-glucose consumption revealed the growth and metabolic activities of HDFs on ***9-expressing total exosome fractions were from conditioned media of 3D-SFnws and 2D polystyrene plates HDF *** growth factors(AGFs)in equal amounts of the two groups of exosomal proteins were analysed via doubleantibody arrays.A tube formation assay using human dermal microvascular endothelial cells(HDMVECs)was used to evaluate the exosomes’angiogenic ***:The novel features of the 3D-SFnws met the biomechanical requirements typical of human soft *** experimental day 15,3D-SFnws-adhering HDFs had increased 4.5-fold in numbers and metabolized 5.4-fold more D-glucose than at day 3 in *** to polystyrene-stuck HDFs,exosomes from 3D-SFnws-adhering HDFs carried significantly higher amounts of AGFs,such as interleukin(IL)-1α,IL-4 and IL-8;angiopoietin-1 and angiopoietin-2;angiopoietin-1 receptor(or Tie-2);growth-regulated oncogene(GRO)-α,GRO-βand GRO-γ;matrix metalloproteinase-1;tissue inhibitor metalloproteinase-1;and urokinase-type plasminogen activator surface receptor,but lesser amounts of anti-angiogenic tissue inhibitor metalloproteinase-2 and

关键词： Silk fibroin Nonwovens Dermis Fibroblast Human endothelial cell Exosome Cytokine Chemokine Angiogenesis Regeneration Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: A case report and a review of literature

引用

World Journal of Gastroenterology 2006年第32期12卷 5234-5236页

作者： Chiara Riviello ilaria Tanini Greta Cipriani Pietro Pantaleo Carlo Nozzoli Alberto Poma Viligiardi Riccardo Andrea Valeri Second Division of General and Vascular Surgery Careggi Hospital FlorenceItaly Department of Internal Medicine Oncologic Day-Hospital University of Florence Italy Second Division of Internal Medicine Careggi Hospital FlorenceItaly

Renal cell carcinoma （RCC） is the most common renal tumor, accounting for 2%-3% of all malignancies. Though RCC is known to spread hematogenously, isolated RCC metastasis to the stomach is a rare event. In this article, we describe the clinical course of a patient who developed a pancreatic recurrence of RCC and 1 year later a gastric recurrence of RCC treated 10 years ago with a resection and interleukin-2 （IL-2）. Accumulating evidence indicates that metastatic involvement of the pancreas and stomach should be suspected in any patient with a history of RCC who presents with gastrointestinal symptoms even 10 years after RCC resection and immunotherapy.

关键词： Renal cell carcinoma Stomach metastasis Interleukin-2 treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of dietary Hermetia illucens meal inclusion on cecal microbiota and small intestinal mucin dynamics and infiltration with immune cells of weaned piglets

引用

Journal of Animal Science and Biotechnology 2020年第4期11卷 1089-1099页

作者： ilaria Biasato Ilario Ferrocino Elena Colombino Francesco Gai Achille Schiavone Luca Cocolin Valeria Vincenti Maria Teresa Capucchio Laura Gasco Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Department of Veterinary Sciences University of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Institute of Science of Food Production National Research CouncilLargo Paolo Braccini 210095 GrugliascoTOItaly.

Background: The constant interaction between diet and intestinal barrier has a crucial role in determining gut health in pigs. Hermetia illucens(HI) meal(that represents a promising, alternative feed ingredient for production animals) has recently been demonstrated to influence colonic microbiota, bacterial metabolite profile and mucosal immune status of pigs, but no data about modulation of gut mucin dynamics are currently available. The present study evaluated the effects of dietary HI meal inclusion on the small intestinal mucin composition of piglets, as well as providing insights into the cecal microbiota and the mucosal infiltration with immune ***: A total of 48 weaned piglets were randomly allotted to 3 dietary treatments(control diet [C] and 5% or10% HI meal inclusion [HI5 and HI10], with 4 replicate boxes/treatment and 4 animals/box) and slaughtered after61 days of trial(3 animals/box, 12 piglets/diet). The cecal microbiota assessment by 16 S r RNA amplicon based sequencing showed higher beta diversity in the piglets fed the HI-based diets than the C(P < 0.001). Furthermore,the HI-fed animals showed increased abundance of Blautia, Chlamydia, Coprococcus, Eubacterium, Prevotella,Roseburia, unclassified members of Ruminococcaceae, Ruminococcus and Staphylococcus when compared to the C group(FDR < 0.05). The gut of the piglets fed the HI-based diets showed greater neutral mucin percentage than the C(P < 0.05), with the intestinal neutral mucins of the HI-fed animals being also higher than the sialomucins and the sulfomucins found in the gut of the C group(P < 0.05). Furthermore, the piglets fed the HI-based diets displayed lower histological scores in the jejunum than the other gut segments(ileum [HI5] or ileum and duodenum [HI10], P < 0.05).Conclusions: Dietary HI meal utilization positively influenced the cecal microbiota and the small intestinal mucin dynamics of the piglets in terms of selection of potentially beneficial bacteria and preservatio

关键词： 16S rRNA Gut health Hermetia illucens L. Histology Insect meal Microbiota Mucin Pig

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Possible biological and translational significance of mast cells density in colorectal cancer

引用

World Journal of Gastroenterology 2014年第27期20卷 8910-8920页

作者： ilaria Marech Michele Ammendola Claudia Gadaleta Nicola Zizzo Caroline Oakley Cosmo Damiano Gadaleta Girolamo Ranieri Interventional Radiology Unit with Integrated Section of Translational Medical Oncology National Cancer Research Centre Istituto Tumori "Giovanni Paolo Ⅱ" 70124 BariItaly Department of Clinical Surgery University of Catanzaro "Magna Graecia" Medical School 88100 Catanzaro Italy Department of Pathology Veterinary Medical School University of Bari Valenzano 70010 Bari Italy

Mast cells (MCs), located ubiquitously near blood vessels, are descended from CD34+ hematopoietic stem cells. Initially, although their role has been well defined in hypersensitivity reactions, the discovery of their sharing in both innate and adaptive immunity has allowed to redefine their crucial interplay on the regulatory function between inflammatory and tumor cells through the release of mediators granule-associated (mainly tryptase and vascular endothelial growth factor). In particular, in several animal and human malignancies it has been well demonstrated that activated c-Kit receptor (c-KitR) and tryptase (an agonist of the proteinase-activated receptor-2) take pivotal part in tumor angiogenesis after the MCs activation, contributing to tumor cells invasion and metastasis. In this review, we focused on crucial MCs density (MCD) role in colorectal cancer (CRC) development and progression angiogenesis-mediated; then, we will analyze the principal studies that have focused on MCD as possible prognostic factor. Finally, we will consider a possible role of MCD as novel therapeutic target mainly by c-KitR tyrosine kinase inhibitors (imatinib, masitinib) and tryptase inhibitors (gabexate and nafamostat mesylate) with the aim to prevent CRC progression.

关键词： Tryptase Mast cell density Proteinase-activated receptor-2 c-Kit receptor Vascular endothelial growth factor Angiogenesis Colorectal cancer Tumor progression Tryptase inhibitors c-Kit receptor tyrosine kinase inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Black soldier fly and gut health in broiler chickens:insights into the relationship between cecal microbiota and intestinal mucin composition

引用

Journal of Animal Science and Biotechnology 2020年第3期11卷 841-852页

作者： ilaria Biasato Ilario Ferrocino Sihem Dabbou Rocchina Evangelista Francesco Gai Laura Gasco Luca Cocolin Maria Teresa Capucchio Achille Schiavone Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Department of Veterinary Sciences University of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Institute of Science of Food Production National Research CouncilLargo Paolo Braccini 210095 GrugliascoTOItaly

Background:The relationship between diet and intestinal microbiota and mucin composition appears to be fundamental for poultry gut *** effects of insect meal(whose role as alternative feed ingredient is now well recognized)on gut microbiota and mucin composition have recently been reported in Tenebrio molitor-fed free-range and broiler chickens,but no data are currently available for Hermetia illucens(HI)-fed *** present study evaluated the effects of dietary HI meal inclusion on cecal microbiota and intestinal mucin composition of broiler ***:A total of 256 male broiler chickens were allotted to 4 dietary treatments(control diet[C]and 5%,10%and 15%HI meal inclusion,with 8 replicate pens/treatment and 8 birds/pen)and slaughtered at 35 d of age(2 animals/pen,16 birds/diet).The cecal microbiota assessment by 16S rRNA amplicon based sequencing showed lower alpha diversity in HI15 chickens(Shannon,P<0.05)and higher beta diversity(Adonis and ANOSIM,P<0.001)in birds fed HI diets than ***,HI15 birds displayed significant increase of the relative abundance of Proteobacteria phylum(False Discovery Rate[FDR]<0.05)when compared to HI10.L-Ruminococcus(Ruminococcus from Lachnospiraceae family),Faecalibacterium,Blautia and Clostridium genera were found to be characteristic of HI5 cecal microbiota(FDR<0.05),while broiler chickens fed HI10 and HI15 diets were characterized(FDR<0.05)by Lactobacillus and Ruminococcus(HI10)and Bacteroides,Roseburia and Helicobacter genera(HI15).Periodic-acid Schiff,Alcian Blue pH 2.5 and high iron diamine staining on small and large intestine also demonstrated lower mucin staining intensity in the intestinal villi of HI10 and HI15 birds than C(P<0.05).Conclusions:Dietary HI meal utilization at low inclusion levels(i.e.,5%)positively influenced either the cecal microbiota or the gut mucin dynamics in terms of selection of potentially beneficial bacteria and increase in villi ***,high inclusion levels(in

关键词： 16S rRNA Gut health Hermetia illucens L. Histochemistry Insect meal Microbiota Mucin Poultry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of organic-rich mineral debris revealed by rapid glacier retreat, Indren Glacier, European Alps

引用

Journal of Mountain Science 2021年第6期18卷 1521-1536页

作者： FREPPAZ Michele WILLIAMS Mark W. GABRIELI Jacopo GORRA Roberta MANIA ilaria ASCHER-JENULL Judith EGLI Markus CELI Luisella Department of Agriculture Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 Grugliasco(TO)Italy NatRisk Research Centre on Natural Risks in Mountain and Hilly Environments University of TurinLargo Paolo Braccini 210095 Grugliasco(TO)Italy Institute of Arctic and Alpine Research and Department of Geography University of Colorado at BoulderUCB 450BoulderCO 80309USA CNR-ISP(Consiglio Nazionale delle Ricerche Istituto di Scienze Polari)via Torino 15530172 Venezia-MestreItaly Institute of Microbiology University of InnsbruckTechnikerstraße 256020 InnsbruckAustria Department of Geography University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland

In the summer of 2003 and 2004, characterized by a rapid glacier retreat, a stony surface covered by well-structured organic-rich mineral debris was observed very close to the Indren glacier terminus(Monte Rosa Massif, NW Italy, 3100 m ASL), on an area covered by the glacier tongue till the year before. The origin and type of this organicrich material were investigated, in order to detect their characteristics, potential sources and fate within the foreland system. The deposits were dated using Carbon-14 and analyzed for the chemical characteristics of the organic component, the elemental composition of the mineral fraction and presence of microbial markers. The material, granular and dark in color, had a total organic carbon(TOC) content ranging between 17.4 ± 0.39 and 28.1 ± 0.63 g kg^(-1) dry weight(dw), significantly higher than the surrounding glacial till(~ 1.4 g kg^(-1) dw), although only 0.33% of it was in water soluble form. Microbial carbon(C) and nitrogen(N) accounted for 10.6% and 3.13% of TOC and total N, respectively. Dissolved nitrogen(N), mainly present as ammonium, represented 2.40% of the total N. The low aromatic component and large presence of nitrogen(N)-derived compounds suggested that most of the organic carbon(OC) in these organic-rich mineral deposits was derived from microbial cells, although the high average radiocarbon age of about 2900 years may also point to the contribution of aeolian depositions of anthropogenic or natural origin. Elemental composition and the crustal enrichment factor of trace elements in the mineral fraction of the aggregates corroborated the hypothesis that most part of the accumulated material derived from ice meltwater. Some indicators of the colonization of these deposits by microbial communities were also reported, from the abundance of DNA and phylogenetic markers, to the presence of bacterial taxa commonly able to thrive in similar habitats. All these elements suggested that such kind of deposits may have a p

关键词： Glacier foreland Dissolved organic carbon Organic matter q PCR Microbial community Trace elements

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surgical treatment of locally advanced anal cancer after male-to-female sex reassignment surgery

引用

World Journal of Gastroenterology 2009年第23期15卷 2918-2919页

作者： Marco Caricato Fabio Ausania Giovanni Francesco Marangi ilaria Cipollone Gerardo Flammia Paolo Persichetti Lucio Trodella Roberto Coppola Department of General Surgery Campus Bio Medico University of Rome Rome 00139 Italy Plastic and Reconstructive Surgery Campus Bio Medico University of Rome Rome 00139 Italy Radiation Oncology Campus Bio Medico University of Rome Rome 00139 Italy

We present a case of a transsexual patient who underwent a partial pelvectomy and genital reconstruction for anal cancer after chemoradiation. This is the first case in literature reporting on the occurrence of anal cancer after male-to-female sex reassignment surgery. We describe the surgical approach presenting our technique to avoid postoperative complications and preserve the sexual reassignment.

关键词： Sex reassignment Pelvic surgery Analcancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mesenchymal stromal cells-exosomes:a promising cell-free therapeutic tool for wound healing and cutaneous regeneration

引用

Burns & Trauma 2019年第1期7卷 346-355页

作者： Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato ilaria Dal Prà Anna Chiarini Department of Burns&Plastic Surgery The Affiliated Hospital of ZunYi Medical UniversityDalian Road 149ZunYi City 563000Gui Zhou ProvinceChina Human Histology and Embryology Unit University of Verona Medical SchoolStrada Le Grazie 837134 VeronaItaly

Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types,growth factors,extracellular matrix(ECM),nerves,and blood *** stromal cells(MSCs)take part in all the skin wound healing stages playing active and beneficial roles in animal models and ***,which are among the key products MSCs release,mimic the effects of parental *** can shuttle various effector proteins,messenger RNA(mRNA)and microRNAs(miRNAs)to modulate the activity of recipient cells,playing important roles in wound ***,using exosomes avoids many risks associated with cell ***,as a novel type of cell-free therapy,MSC-exosome-mediated administration may be safer and more efficient than whole *** this review,we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous *** addition,we address the hypothesis of MSCs microenvironment extracellular vesicles(MSCs-MEVs)or MSCs microenvironment exosomes(MSCs-MExos)that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic *** review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration.

关键词： Cutaneous regeneration Mesenchymal stromal cell Exosomes Wound healing Microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of proton pump inhibitors in general practice

引用

World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第3期8卷 180-185页

作者： Cesare Tosetti ilaria Nanni Health Agency of Bologna 40046 Alto Reno TermeItaly

To evaluate the characteristics of the prescription of the proton pump inhibitor drugs (PPI) and the adherence to the indications of the guidelines regulating the reimbursement limitations set forth by the Italian Drug Agency. METHODSThirty general practitioners (GP) participated in the study, providing data on more than 40000 patients in total. The population was divided into non occasional users of PPI drugs (PPI users) and non-users (PPI non-users) based on evidence of a prescription of at least 3 packs of PPIs in the last 90 d before analysis. The data provided allowed an assessment of compliance with the requirements of eligibility for PPI reimbursement according to the Italian Drug Agency rules, in order to obtain subpopulations which complied or not with the rules. RESULTSSix thousand three hundred and twenty-two patients were found to be PPI users, accounting for 14.9% of the patient population. PPI users were more frequently female, older and more frequently diagnosed with gastroesophageal reflux disease, gastric or duodenal ulcers, arthropathy, heart disease and cancer than the rest of the population. PPI users had more frequently received prescriptions for non-steroidal ant-inflammatory drugs (NSAIDS), acetylsalicylic acid (ASA), oral anticoagulant therapy (OAT) and systemic steroids. PPI reimbursement resulted applicable to 69.3% of the PPI users, but a potential for reimbursement of PPI prescriptions was identified in the non PPI users for the treatment of peptic or reflux disease (8.5%) and for the protection of gastric damage caused by NSAIDS (6.1%). Patients who are potentially eligible for reimbursement are older, diagnosed with arthropathy and heart disease more frequently and most commonly receive NSAID and ASA prescriptions compared with PPI users who do not satisfy eligibility requirements. Patients in whom it was not possible to identify conditions related to prescription suitability were more frequently associated with use of OAT. CONCLUSIONA

关键词： Proton pump inhibitors Appropriateness General practice Gastroprotection Peptic disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：