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Use of proton pump inhibitors in general practice

World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第3期8卷 180-185页

作者： Cesare Tosetti ilaria Nanni Health Agency of Bologna 40046 Alto Reno TermeItaly

To evaluate the characteristics of the prescription of the proton pump inhibitor drugs (PPI) and the adherence to the indications of the guidelines regulating the reimbursement limitations set forth by the Italian Drug Agency. METHODSThirty general practitioners (GP) participated in the study, providing data on more than 40000 patients in total. The population was divided into non occasional users of PPI drugs (PPI users) and non-users (PPI non-users) based on evidence of a prescription of at least 3 packs of PPIs in the last 90 d before analysis. The data provided allowed an assessment of compliance with the requirements of eligibility for PPI reimbursement according to the Italian Drug Agency rules, in order to obtain subpopulations which complied or not with the rules. RESULTSSix thousand three hundred and twenty-two patients were found to be PPI users, accounting for 14.9% of the patient population. PPI users were more frequently female, older and more frequently diagnosed with gastroesophageal reflux disease, gastric or duodenal ulcers, arthropathy, heart disease and cancer than the rest of the population. PPI users had more frequently received prescriptions for non-steroidal ant-inflammatory drugs (NSAIDS), acetylsalicylic acid (ASA), oral anticoagulant therapy (OAT) and systemic steroids. PPI reimbursement resulted applicable to 69.3% of the PPI users, but a potential for reimbursement of PPI prescriptions was identified in the non PPI users for the treatment of peptic or reflux disease (8.5%) and for the protection of gastric damage caused by NSAIDS (6.1%). Patients who are potentially eligible for reimbursement are older, diagnosed with arthropathy and heart disease more frequently and most commonly receive NSAID and ASA prescriptions compared with PPI users who do not satisfy eligibility requirements. Patients in whom it was not possible to identify conditions related to prescription suitability were more frequently associated with use of OAT. CONCLUSIONA

关键词： Proton pump inhibitors Appropriateness General practice Gastroprotection Peptic disease

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Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis

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World Journal of Hepatology 2019年第6期11卷 489-512页

作者： Daniela Campion ilaria Giovo Paola Ponzo Giorgio M Saracco Federico Balzola Carlo Alessandria Division of Gastroenterology and Hepatology Città della Salute e della Scienza di Torino Hospital University of Turin

Hepatic encephalopathy(HE)is a common and serious neuropsychiatric complication of cirrhosis,acute liver failure,and porto-systemic *** largely contributes to the morbidity of patients with liver disease,severely affecting the quality of life of both patients and their relatives and being associated with poor *** presentation is largely variable,manifesting with a broad spectrum of cognitive abnormalities ranging from subtle cognitive impairment to *** pathogenesis of HE is complex and has historically been linked with ***,in the last years,it has become evident that the interplay of multiple actors,such as intestinal dysbiosis,gut hyperpermeability,and neuroinflammation,is of crucial importance in its ***,HE can be considered a result of a dysregulated gut-liverbrain axis function,where cognitive impairment can be reversed or prevented by the beneficial effects induced by“gut-centric”therapies,such as non-absorbable disaccharides,non-absorbable antibiotics,probiotics,prebiotics,and fecal microbiota *** this context dietary modifications,by modulating the intestinal milieu,can also provide significant benefit to cirrhotic patients with *** review will provide a comprehensive insight into the mechanisms responsible for gut-liver-brain axis dysregulation leading to HE in ***,it will explore the currently available therapies and the most promising future treatments for the management of patients with HE,with a special focus on the dietary approach.

关键词： Cirrhosis Hepatic encephalopathy Diet therapy Gut microbiota Leaky gut Hyperammonemia Prebiotics Probiotics Gluten-casein free diet Gut microbiota transplantation

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Diet in neurogenic bowel management:A viewpoint on spinal cord injury

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World Journal of Gastroenterology 2020年第20期26卷 2479-2497页

作者： Marco Bernardi Anna Lucia Fedullo Elisabetta Bernardi Diego Munzi ilaria Peluso Jonathan Myers Florigio Romano Lista Tommaso Sciarra Department of Physiology and Pharmacology"V.Erspamer" Sapienza University of RomeRome 00185Italy Italian Paralympic Committee Rome 00191Italy Federazione Italiana Pallacanestro In Carrozzina(FIPIC) Rome 00188Italy Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity of Bari"Aldo Moro"Bari 70121Italy Joint Veteran Center Scientific DepartmentArmy Medical CenterRome 00184Italy Research Centre for Food and Nutrition Council for Agricultural Research and Economics(CREA-AN)Rome 00178Italy VA Palo Alto Health Care System and Stanford University Cardiology DivisionPalo AltoCA 94025United States Scientific Department Army Medical CenterRome 00184Italy

The aim of this review is to offer dietary advice for individuals with spinal cord injury(SCI)and neurogenic bowel *** this in mind,we consider health conditions that are dependent on the level of lesion including skeletal muscle atrophy,autonomic dysreflexia and neurogenic *** addition,SCI is often associated with a sedentary lifestyle,which increases risk for osteoporosis and diseases associated with chronic low-grade inflammation,including cardiovascular and chronic kidney *** Mediterranean diet,along with exercise and dietary supplements,has been suggested as an anti-inflammatory intervention in individuals with ***,individuals with chronic SCI have a daily intake of whole fruit,vegetables and whole grains lower than the recommended dietary allowance for the general *** studies have reported an increase in neurogenic bowel dysfunction symptoms after high fiber intake;therefore,this finding could explain the low consumption of plant *** consumption of fibre induces dysbiosis,which is associated with bothendotoxemia and *** can be reduced by exercise and diet in individuals with ***,to summarize our viewpoint,we developed a Mediterranean diet-based diet and exercise pyramid to integrate nutritional recommendations and exercise *** guidelines come from previously suggested recommendations for military veterans with disabilities and individuals with SCI,chronic kidney diseases,chronic pain and irritable bowel *** also considered the recent exercise guidelines and position stands for adults with SCI to improve muscle strength,flexibility and cardiorespiratory fitness and to obtain cardiometabolic ***,dietary advice for Paralympic athletes is suggested.

关键词： Neurogenic bowel dysfunction Body composition Mediterranean diet Food–drug interactions Microbiota Paralympic athletes

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Training for Tourism Companies Staff Against Human Trafficking

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Chinese Business Review 2012年第9期11卷 839-848页

作者： Lucia Varra ilaria Prisco University of Florence FlorenceItaly

Human trafficking, involving mostly women and children, is closely related to the tourism businesses, because traffickers use often through their complicity, which including various companies： airports, trains, hotels, etc.. This work1 aims to analyze the effectiveness of training as a tool for monitoring and preventing this crime. After data and information collecting on the issue of human trafficking and links with the tourism industry, we analyzed the main training toolkits provided by organizations which deal with the prevention and monitoring of this phenomenon, two questionnaires were built and sent： the first questionnaire was sent to 136 organizations that are training for the staff of tourism companies; it aims to detect the educational needs that the organizations want to satisfy, the educational target, teaching techniques, and the results obtained with the training; the second questionnaire was sent to 495 companies who participating in the courses, explores the motivations, the educational objectives, and results related to the training received. Through this work, the authors only present the first results obtained during the first phase, involving the point of view of seven organizations offering training courses. The answers provided by the companies show that the learning targets have been fully achieved, in particular with regard to raising awareness on the issue. Still, some gaps with regard to the support that the training may offer in the development of new attitudes and skills to prevent and monitor the phenomenon. The course contents and teaching techniques used appear to be consistent with the objectives. All of the organizations interviewed carried out the evaluation of the course learning demonstrate how companies training participants are satisfied with the results, especially in terms of knowledge and skills to contribute to the prevention of an increasing phenomenon, while less significant are the advantages about the decrease of concret

关键词： human trafficking social development stafftraining sustainable tourism

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Black soldier fly defatted meal as a dietary protein source for broiler chickens:Effects on growth performance,blood traits,gut morphology and histological features

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Journal of Animal Science and Biotechnology 2018年第4期9卷 891-900页

作者： Sihem Dabbou Francesco Gai ilaria Biasato Maria Teresa Capucchio Elena Biasibetti Daniela Dezzutto Marco Meneguz Iveta Plachà Laura Gasco Achille Schiavone Department of Veterinary Science University of TurinLargo Paolo Braccini 210095 GrugliascoItaly Institute of Science of Food Production National Research CouncilLargo Paolo Braccini 210095 GrugliascoItaly Veterinary Medical Research Institute for Piemonte Liguria and Valle d’AostaVia Bologna 14810154 TurinItaly Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 GrugliascoItaly Institute of Animal Physiology Centre of BioscienceSlovak Academy of SciencesSoltesovej 4-6040 01 KosiceSlovak Republic Institute of Interdisciplinary Research on Sustainability University of TurinVia Accademia Albertina 1310100 TurinItaly

Background: The present study has evaluated the effects of different inclusion levels of a partially defatted black soldier fly(Hermetia illucens L.; HI) larva meal on the growth performance, blood parameters and gut morphology of broiler chickens. A total of 256 male broiler chickens(Ross 308) were reared from d 1 to d 35 and assigned to4 dietary treatments(8 replicates/treatment and 8 birds/replicate). HI larva meal was included at increasing levels(0, 5%, 10% and 15%; HI0, HI5, HI10 and HI15, respectively) in isonitrogenous and isoenergetic diets formulated for 3 feeding phases: starter(1–10 d), growing(10–24 d) and finisher(24–35 d). Two birds per pen were slaughtered at d 35 and morphometric investigations and histopathological alterations were ***: The live weight(LW) showed linear and quadratic responses to increasing HI larva meal(maximum for HI10 group). Average daily gain(ADG) showed a linear and quadratic responses to HI meal(maximum for HI10 group) during starter and growing periods. A linear decrease was observed for ADG during the finisher period. The daily feed intake(DFI) showed a linear and quadratic effect during the starter period(maximum for HI10 group).Linear and quadratic responses were observed for the feed conversion ratio(FCR) in the growing period and for the whole period of the experiment. The FCR showed a linear response in the finisher period(maximum for HI15).No significant effects were observed for the blood and serum parameters, except for the phosphorus concentration,which showed linear and quadratic responses as well as glutathione peroxidase(GPx) activity, the latter of which showed a linear response. The HI15 birds showed a lower villus height, a higher crypt depth and a lower villus height-to-crypt depth ratio than the other ***: Increasing levels of dietary HI meal inclusion in male broiler chickens may improve the LW and DFI during the starter period, but may also negatively affect the FCR and gut m

关键词： Broiler chickens Defatted insect meal Gut morphology Hermetia illucens Performance

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Processes of Adaptation and Creation of a Territorial Governance： The Experience of the Cities of Benevento and Salerno （Campania Region, Italy）~

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Sociology Study 2012年第11期2卷 819-833页

作者： Massimiliano Bencardino ilaria Greco University of Salerno Italy University of Sannio Italy

This paper presents some considerations about the definition and role of ＂medium-sized cities＂ in the processes of urban governance of the Italian regional systems, in line with the objectives of European programming 2007-2013. Beginning from some theoretical considerations, the research objective is to delineate the features of the ＂new urban geography＂ of Campania region as it has been formed on the base of the social and economic processes that in the last 30 years have modified the regional urban system in the widest context of Mezzogiorno. To such aim, the paper is articulated in two parts： the first one in which the fundamental passages are re-called in the processes of development of Italian urban areas that have carried to new paradigms object of theoretical approaches still in course of definition, and the second one in which such processes are considered regarding the model of urban development of Campania, on which the research is concentrated. Specifically, the paper presents the case of two ＂middle cities＂ in the Campania region： Benevento and Salerno, which play a particularly important role in the design and development of a ＂regional network of medium-sized cities＂.

关键词： Urban areas polycentrism territorial governance regional development

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Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer

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World Journal of Gastroenterology 2020年第20期26卷 2657-2668页

作者： Davide Ippolito Silvia Girolama Drago Anna Pecorelli Cesare Maino Giulia Querques ilaria Mariani Cammillo Talei Franzesi Sandro Sironi Department of Diagnostic Radiology H.S.Gerardo MonzaSan Gerardo HospitalUniversity of Milano-BicoccaMonza 20900Italy Department of Diagnostic Radiology Papa Giovanni XXIII HospitalUniversity of Milano-BicoccaBergamo 20110Italy

BACKGROUND The management of rectal cancer patients is mainly based on the use of the magnetic resonance imaging(MRI)technique as a diagnostic tool for both staging and *** treatment,to date,the evaluation of complete response is based on the histopathology assessment by using different tumor regression grade(TRG)features(e.g.,Dworak or Mandard classifications).While from the radiological point of view,the main attention for the prediction of a complete response after chemotherapy treatment focuses on MRI and the potential role of diffusion-weighted images and perfusion imaging represented by dynamiccontrast enhanced *** main aim is to find a reliable tool to predict tumor response in comparison to histopathologic *** To investigate the value of dynamic contrast-enhanced perfusion-MRI parameters in the evaluation of the healthy rectal wall and tumor response to chemo-radiation therapy in patients with local advanced rectal cancer with histopathologic *** Twenty-eight patients with biopsy-proven rectal adenocarcinoma who underwent a dynamic contrast-enhanced MR study performed on a 1.5 T MRI system(Achieva,Philips),before(MR1)and after chemoradiation therapy(MR2),were enrolled in this *** protocol included T1 gadolinium enhanced THRIVE sequences acquired on axial planes.A dedicated workstation was used to generate color permeability *** of interest was manually drawn on tumor tissue and normal rectal wall,hence the following parameters were calculated and statistically analyzed:Relative arterial enhancement(RAE),relative venous enhancement(RVE),relative late enhancement(RLE),maximum enhancement(ME),time to peak and area under the curve(AUC).Perfusion parameters were related to pathologic TRG(Mandard’s criteria;TRG1=complete regression,TRG5=no regression).RESULTS Ten tumors(36%)showed complete or subtotal regression(TRG1-2)at histology and classified as responders;18 tumors(64%)were classified as non-responders(TR

关键词： Rectal neoplasm Chemotherapy Radiotherapy Tumor staging Treatment response Magnetic resonance imaging

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Hepatitis B and C virus reactivation in immunosuppressed patients with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第13期20卷 3516-3524页

作者： Stefano Sansone Maria Guarino Fabiana Castiglione Antonio Rispo Francesco Auriemma ilaria Loperto Matilde Rea Nicola Caporaso Filomena Morisco Gastroenterology Unit Department of Clinical Medicine and SurgeryUniversity of Naples "Federico II"80131 NaplesItaly

In recent years,a number of case reports and clinical studies have highlighted the risk of hepatitis B and C virus reactivation in patients with inflammatory bowel disease who are treated with immunosuppressive *** cases of viral hepatitis reactivation that have been reported are characterized by a wide range of clinical manifestations,from viremia without clinically relevant manifestations to fulminant life-threatening *** development and dissemination of biological immunosuppressive drugs have led to a significant increase in the number of reports of interest to physicians in a variety of clinical *** this topic,there have been a number of published guidelines and reviews that have collected the available evidence,providing recommendations on prophylactic and therapeutic strategies and methods for monitoring patients at ***,it should be noted that,to date,very few clinical studies have been published,and most of the recommendations have been borrowed from otherclinical *** published studies are mostly retrospective and are based on very heterogeneous populations,using different therapeutic and prophylactic regimens and obtaining conflicting ***,it seems clear that it is desirable to concentrate our efforts on prospective studies,not conducting further reviews of the literature in the continued absence of new evidence.

关键词： Inflammatory bowel disease Biological agents Hepatitis B virus reactivation Hepatitis C virus reactivation Prophylaxis

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Using Rapid Prototyping Data to Enhance a Knowledge-Based Framework for Product Redesign

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Intelligent Information Management 2010年第1期2卷 1-13页

作者： Stefano FILIPPI ilaria CRISTOFOLINI 不详

The particular characteristics of Rapid Prototyping technologies, both in terms of constrains and opportunities, often require the reconfiguration of the product model to obtain the best compliance with the product functionalities and performances. Within this field of research, a knowledge-based tool named Design GuideLines Collaborative Framework (DGLs-CF) was developed to support both the designers defining the product consistently with the manufacturing technologies and the manufacturers defining the building setup consistently with the product requirements. Present work is focused on enhancing the DGLs-CF knowledge base and on updating the DGLs-CF knowledge management by using the information gathered on some RP technologies. The added-value of this research is represented by an improvement in the Redesign/Reconfig- uration Package, the final result of the DGLs-CF adoption. This is a list of actions to be performed on the product model and on the process parameters to avoid the limitations of the technology and to exploit at best its opportunities.

关键词： rapid prototyping knowledge-based engineering product redesign collaborative engineering

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Interventional endoscopic ultrasound:Therapeutic capability and potential

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World Journal of Gastrointestinal Endoscopy 2009年第1期1卷 39-44页

作者： ilaria Tarantino Luca Barresi Gastroenterology and Endoscopy Department Medicine University of Pittsburgh Medical Center/Mediterranean Institute for transplantation and Specialized TherapiesPalermo 90127Italy

The linear echoendoscope,introduced in the 1990s,opened the era of interventional endoscopic ultrasound(IEUS).The linear echoendoscope enabled EUS guided Fine Needle Aspiration(EUS-FNA) allowing the path of the needle to be traced during the puncture *** EUS-FNA,other interventional procedures were introduced in clinical *** acquisition was the first EUS-guided interventional procedure and its higher diagnostic quality has undoubtedly been *** EUS-FNA,Celiac plexus neurolysis(CPN) and block(CPB),pancreatic pseudocyst drainage,abdominal and mediastinal collections/abscesses drainage,and in selected cases,pancreatic and biliary ductal system drainage,were introduced in clinical ***-guided fine needle injection with local delivery of antitumor agents is considered a promising *** have reviewed published data on EUS guided interventional procedures with the object of summarizing the diagnostic capability of endoscopic ultrasound and elaborates in detail its therapeutic capability and potential.

关键词： Endoscopic ultrasound Interventional endoscopic ultrasound Endoscopic ultrasound guided fine needle aspiration Endoscopic ultrasound-guided drainage Endoscopic ultrasound-fine need injection

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