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Laboratory markers in ulcerative colitis: Current insights and future advances

World Journal of Gastrointestinal Pathophysiology 2015年第1期6卷 13-22页

作者： Michele Cioffi Antonella De Rosa Rosalba Serao ilaria picone Maria Teresa Vietri Department of Biochemistry Biophysics and General PathologySecond Medical School Naples

Ulcerative colitis(UC)and Crohn’s disease(CD)are the major forms of inflammatory bowel diseases(IBD)in *** some common features,these forms can be distinguished by different genetic predisposition,risk factors and clinical,endoscopic and histological *** aetiology of both CD and UC remains unknown,but several evidences suggest that CD and perhaps UC are due to an excessive immuneresponse directed against normal constituents of the intestinal bacterial *** sometimes invasive are routine for the diagnosis and care of patients with *** of UC is based on clinical symptoms combined with radiological and endoscopic *** employment of non-invasive biomarkers is *** biomarkers have the potential to avoid invasive diagnostic tests that may result in discomfort and potential *** ability to determine the type,severity,prognosis and response to therapy of UC,using biomarkers has long been a goal of clinical *** describe the biomarkers assessed in UC,with special reference to acute-phase proteins and serologic markers and thereafter,we describe the new biological markers and the biological markers could be developed in the future:(1)serum markers of acute phase response:The laboratory tests most used to measure the acute-phase proteins in clinical practice are the serum concentration of C-reactive protein and the erythrocyte sedimentation *** biomarkers of inflammation in UC include platelet count,leukocyte count,and serum albumin and serum orosomucoid concentrations;(2)serologic markers/antibodies:In the last decades serological and immunologic biomarkers have been studied extensively in immunology and have been used in clinical practice to detect specific *** UC,the presence of these antibodies can aid as surrogate markers for the aberrant host immune response;and(3)future biomarkers:The development of biomarkers in UC will be very important in the *** progress of

关键词： Inflammatory bowel diseases Ulcerative colitis Crohn’s disease Serologic markers Acute phase response

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