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Isoenergetic-practical and semi-purified diets for protein requirement determination in Hermetia illucens larvae:consequences on life history traits

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Journal of Animal Science and Biotechnology 2022年第3期13卷 897-906页

作者： Sara Bellezza Oddon ilaria Biasato Laura Gasco Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 210095 GrugliascoTOItaly

Background:Black soldier fly(BSF)is one of the most promising species for the intensive breeding of insects given its adaptability and its efficiency in the conversion of *** maximize the production and use waste as substrates,it is essential to determine the larvae nutritional *** study aims to evaluate the effects of5 practical,semi-purified and isoenergetic diets(PSPID)with increasing protein levels(10%,CP10;14%,CP14;16%,CP16;19%,CP19)on BSF life history traits.A total of 2000 six-day-old larvae were weighed and divided into groups of 100(4 replicates/treatment[PSPID and Gainesville diet(GA)used as environmental control]).In larva-prepupa stage,sampling was carried out on 30 individuals/replicate,while in prepupa-adult stage on ***:In the whole larval stage,the CP16 treatment performed better when compared to the other ***18 days old,the CP14 treatment showed a higher weight than the CP19(P<0.01),while the CP10 and CP16weights were *** the contrary,the CP10 prepupae weight was higher than the CP19(P<0.01).The CP10 and CP14 pupae performed better in terms of weight when compared to the others(P<0.01).The dietary treatments did not affect the adult *** sex significantly influenced both the exuvia weight,which was the greatest in females(P<0.001),and the fly lifespan,longest in males(P<0.05).Fly lifespan was also influenced by the interaction between treatment and sex,with the CP19 females showing a longer life than the others(P<0.05).Conclusions:In conclusion,the optimal protein level considering the whole larval stage is 16%on dry matter(DM).At 18 days old,looking at the size intended for the meal production,it can be considered 14%on *** result obtained on adult emergence in PSPID may not be attributable to the protein *** researches on macronutrients requirements determination have to be conducted to evaluate the substrates composition effects on BSF life history traits.

关键词： Hermetia illucens Life history traits Nutritional requirements Semi-purified

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Antagonizing amyloid-β/calcium-sensing receptor signaling in human astrocytes and neurons: a key to halt Alzheimer's disease progression?

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Neural Regeneration Research 2015年第2期10卷 213-218页

作者： ilaria Dal Prà Anna Chiarini Ubaldo Armato Histology & Embryology Section Department of Life & Reproduction Sciences University of Verona Medical School

Astrocytes＇ roles in late-onset Alzheimer＇s disease （LOAD） promotion are important, since they survive soluble or fibrillar amyloid-β peptides （Aβs） neurotoxic effects, undergo alterations of intracellular and intercellular Ca2＋ signaling and gliotransmitters release via the Aβ/a7-nAChR （αT-nicotinic acetylcholine receptor） signaling, and overproduce/oversecrete newly synthesized Aβ42 oligomers, NO, and VEGF-A via the Aβ/CaSR （calcium-sensing receptor） signaling. Recently, it was suggested that the NMDAR （N-methyl-D-aspartate receptor） inhibitor nitromemantine would block the synapse-destroying effects of Aβ/α7-nAChR signaling. Yet, this and the progressive extracellular accrual and spreading of Aβ42 oligomers would be stopped well upstream by NPS 2143, an allosteric CaSR antagonist （calcilytic）.

关键词： Alzheimer's disease amyloid-β astrocytes Ca2+ calcilytic calcium-sensing receptor nitromemantine NPS 2143 aT-nicotinic acetylcholine receptor

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Assessment of lead pollution in topsoils of a southern Italy area: Analysis of urban and peri-urban environment

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Journal of Environmental Sciences 2015年第7期27卷 179-187页

作者： ilaria Guagliardi Domenico Cicchella Rosanna De Rosa Gabriele Buttafuoco Department of Biology Ecology and Earth Sciences University of Calabria Department of Science and Technology University of Sannio National Research Council of Italy Institute for Agricultural and Forest Systems in the Mediterranean (ISAFOM)

Exposure to lead（Pb） may affect adversely human health. Mapping soil Pb contents is essential to obtain a quantitative estimate of potential risk of Pb contamination. The main aim of this paper was to determine the soil Pb concentrations in the urban and peri-urban area of Cosenza-Rende to map their spatial distribution and assess the probability that soil Pb concentration exceeds a critical threshold that might cause concern for human *** were collected at 149 locations from residual and non-residual topsoil in gardens,parks, flower-beds, and agricultural fields. Fine earth fraction of soil samples was analyzed by X-ray Fluorescence spectrometry. Stochastic images generated by the sequential Gaussian simulation were jointly combined to calculate the probability of exceeding the critical threshold that could be used to delineate the potentially risky areas. Results showed areas in which Pb concentration values were higher to the Italian regulatory values. These polluted areas were quite large and likely, they could create a significant health risk for human beings and vegetation in the near future. The results demonstrated that the proposed approach can be used to study soil contamination to produce geochemical maps,and identify hot-spot areas for soil Pb concentration.

关键词： Urban and peri-urban soils Geochemistry Lead Soil pollution Stochastic simulation

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Adolescent male genitalia dissatisfaction:a surgical perspective

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Asian Journal of Andrology 2022年第2期24卷 176-179页

作者： Nicola Zampieri ilaria Dando Francesco Saverio Camoglio Woman and Child Hospital Pediatric Surgical UnitUniversity of VeronaVerona 37100Italy Department of Neurosciences Biomedicine and Movement SciencesBiochemistry SectionUniversity of VeronaVerona 37100Italy

Genital dissatisfaction is well known in female and *** is known about male adolescents and their genital *** aim of this study was to investigate and report the role of surgery in male adolescents to improve the evaluation of their *** considered all patients treated for external genital pathology in the period of *** and exclusion criteria were *** underwent an evaluation test before and after *** the study period,137 patients were treated,and at the end of the study,98 cases were considered for *** most frequent pathologies were webbed penis and penile curvature.A postoperative score improvement was noted and patients with concealed penis and webbed penis showed a better postoperative *** was considered an important factor associated with a worse preoperative *** of the external genitalia is important in adolescents,and it is an understudied *** may be associated with a worse evaluation of one’s genital and should be clinically considered to avoid related social problems in ***,cosmetic genital surgery should be considered even in male adolescents.

关键词： adolescent esthetic genital dissatisfaction surgery

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Cellular and molecular mechanisms of intestinal fibrosis

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World Journal of Gastroenterology 2012年第28期18卷 3635-3661页

作者： Silvia Speca ilaria Giusti Florian Rieder Giovanni Latella Gastroenterology Unit Department of Internal Medicine and Public Health University of L'Aquila 67100 L'Aquila Italy Department of Gastroenterology and Hepatology Lerner Research Institute Cleveland Clinic Foundation Cleveland OH 73051 United States

Fibrosis is a chronic and progressive process characterized by an excessive accumulation of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue. Intestinal fibrosis may develop in several different enteropathies, including inflammatory bowel disease. It develops through complex cell, extracellular matrix, cytokine and growth factor interactions. Distinct cell types are involved in intestinal fibrosis, such as resident mesenchymal cells (fibroblasts, myofibroblasts and smooth muscle cells) but also ECM-producing cells derived from epithelial and endothelial cells (through a process termed epithelialand endothelial-mesenchymal transition), stellate cells, pericytes, local or bone marrow-derived stem cells. The most important soluble factors that regulate the activation of these cells include cytokines, chemokines, growth factors, components of the renin-angiotensin system, angiogenic factors, peroxisome proliferator-activated receptors, mammalian target of rapamycin, and products of oxidative stress. It soon becomes clear that although inflammation is responsible for triggering the onset of the fibrotic proc-ess, it only plays a minor role in the progression of this condition, as fibrosis may advance in a self-perpetuating fashion. Definition of the cellular and molecular mechanisms involved in intestinal fibrosis may provide the key to developing new therapeutic approaches.

关键词： Inflammatory bowel disease Intestinal fibrosis Extracellular matrix Molecular mediators Myofibroblasts Inflammatory cells Epithelial cells Mesenchymal cells Endothelial cells

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New therapeutic perspectives in Type 1 Diabetes: dietary interventions prevent β cell-autoimmunity by modifying the gut metabolic environment

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Cellular & Molecular Immunology 2017年第12期14卷 951-953页

作者： Chiara Sorini ilaria Cosorich Marika Falcone Immunology and Allergy Unit Department of MedicineKarolinska InstitutetStockholmSweden Experimental Diabetes Unit-DRI Division of ImmunologyTransplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly

The gut microbiota plays a key role in the pathogenesis of autoimmune diseases such as Type 1 Diabetes(T1D),but the mechanism underlying this modulation is yet to be *** paper highlights the crucial role of the microbiota-induced gut metabolic profile,rather than the presence of single bacterial strains,in T1D *** importantly,it provides the first evidence that dietary interventions can modulate the autoimmune pathogenesis of T1D by altering the gut metabolic environment.

关键词： Diabetes autoimmune pathogenesis

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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN CHURCHILL JAMES C.GATES JAMES HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI JENS H.SCHMID ilaria CRISTIANI PAVEL CHEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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Combination therapy in cancer:effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics

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Chinese Journal of Cancer 2016年第12期35卷 647-656页

作者： ilaria Fuso Nerini Marta Cesca Francesca Bizzaro Raffaella Giavazzi Department of Oncology IRCCS-Mario Negri Institute for Pharmacological ResearchVia La Masa 1920156 MilanItaly

Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor(VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation is far from clear. The most widespread explanation is enhanced delivery of therapeutics due to vascular remodeling, lower interstitial pressure, and increased blood flow. While the antiangiogenic efects on vascular morphology have been fairly consistent in both preclinical and clinical settings, the improvement of tumor vessel function is debated. This review focuses on the efect of anti-VEGF therapy on tumor microenvironment morphology and functions, and its therapeutic beneits when combined with other therapies. The uptake and spatial distribution of chemotherapeutic agents into the tumor after anti-VEGF are examined.

关键词： Combination therapies Angiogenesis inhibitors Drug delivery Tumor microenvironment

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How toxic are gold nanoparticles？ The state-of-the-art

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Nano Research 2015年第6期8卷 1771-1799页

作者： ilaria Fratoddi Iole Venditti Cesare cametti Maria Vittoria Russo Dipartimento di Chimica Universita' di Roma 'La Sapienza' Piazzale A. Moro 5 1-00185 Rome Italy Dipartimento di Fisica and INFM CNR-SOFT Universita' di Roma 'La Sapienza' Piazzale A. Moro 51-00185 Rome Italy

With the growing interest in the applications of gold nanoparticles in biotechnology and their physiological effects, possible toxicity of gold nanoparticles is becoming an increasingly important issue. A large number of studies carried out over the past few years under a variety of experimental conditions and following different protocols have produced conflicting results, leading to divergent views about the actual safety of gold nanoparticles in human applications. This work is intended to provide an overview of the most recent experimental results and thereby summarize current state-of-the-art. Rather than presenting a comprehensive review of the available literature in this field, which would be impractically broad, we have selected representative examples of both in vivo and in vitro studies, which clearly demonstrate the need for urgent and rigorous standardization of experimental protocols. Despite their significant potential, the safety of gold nanoparticles is highly controversial at this time, and important concerns have been raised that need to be properly addressed. Factors such as shape, size, surface charge, coating, and surface functionalization are expected to influence the interactions of particles with biological systems to a different extent, resulting in different outcomes and influencing the potential of gold nanoparticles for biomedical applications. Moreover, despite continuous attempts to establish a correlation between structure of the particles and their interactions with biological systems, we are still far from elucidating the toxicological profile of gold nanoparticles in an indisputable manner. This review is intended to contribute towards this goal, offering a number of suggestions on how to achieve the systematization of data on the most relevant physico-chemical parameters, which govern and control the toxicity of ~old nanot^articles at cellular and whole-organism levels.

关键词： gold nanoparticles nanospheres nanorods nanocages nanostars toxicity

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Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication

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World Journal of Gastroenterology 2006年第35期12卷 5606-5610页

作者： ilaria Peluso Francesco Pallone Giovanni Monteleone Di-partimento di Medicina Interna Università Tor Vergata Rome Italy

Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the gastrointestinal tract that share clinical and pathological characteristics. The most accredited hypothesis is that both CD and UC result from a deregulated mucosal immune response to normal constituents of the gut microflora. Evidence, however, indicates that the main pathological processes in these two diseases are distinct. In CD, the tissue- damaging inflammatory reaction is driven by activated type 1 helper T-cell (Th1), whereas a humoral response predominates in UC. Consistently, a marked accumulation of macrophages making interleukin (IL)-12, the major Th1-inducing factor, is seen in CD but not in UC mucosa. Preliminary studies also indicate that administration of a monoclonal antibody blocking the IL-12/p40 subunit can be useful to induce and maintain clinical remission in CD patients. Notably, the recently described IL-23 shares the p40 subunit with IL-12, raising the possibility that the clinical benefit of the anti-IL-12/p40 antibody in CD may also be due to the neutralization of IL-23 activity. This review summarizes the current information on the expression and functional role of IL-12 and IL- 12-associated signaling pathways both in patients with CD and experimental models of colitis, thus emphasizing major differences between IL-12 and IL-23 activity on the development of intestinal inflammation.

关键词： Interleukin-12 Type 1 helper T-cell cytokines Inflammatory bowel disease

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